GB873995A - Sulfuric acid esters of dextranic acid - Google Patents
Sulfuric acid esters of dextranic acidInfo
- Publication number
- GB873995A GB873995A GB1089159A GB1089159A GB873995A GB 873995 A GB873995 A GB 873995A GB 1089159 A GB1089159 A GB 1089159A GB 1089159 A GB1089159 A GB 1089159A GB 873995 A GB873995 A GB 873995A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- dextranic
- solution
- precipitate
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
The invention comprises sulphuric acid esters of dextranic acid and salts thereof. The dextranic acid sulphate may be made by reacting dextranic acid with chlorosulphonic acid or fuming sulphuric acid. In one method dextranic acid is reacted in pyridine with chlorosulphonic acid at temperatures of from 50 DEG -100 DEG C. Alternatively, the dextranic acid is first dissolved p in formamide and this solution is then added to the chlorosulphonic acid in pyridine solution. Also, thechlorosulphonic acid may be added at a temperature of -15 DEG -5 DEG C. to the dextranic acid in finely divided form cooled to the same temperature. Upon completion of esterification, the mixture is poured into cold water, then into alcohol, neutralized with an alkali metal or alkaline earth metal hydroxide to precipitate the salt which is recovered and dissolved in water, the solution is dialyzed and concentrated and the salt is precipitated with methyl or ethyl alcohol. The free acid of the ester is obtained by acidification of the salt with a mineral acid, followed by dialysis and concentration of the solution. Dextranic acid, used as starting material, is made dissolving native dextran in water together with the dextransplitting enzyme from Aspergillus Wentii and the solution digested at pH 4,3 at 70 DEG F. for 5 1/2 hours. Isopropanol is added and the supernatant liquid is separated from the precipitate so formed and is treated with sodium hydroxide. The precipitate now formed is dissolved in water, acidified, treated with isopropanol and finally with sodium hydroxide to precipitate dextranic acid.ALSO:A blood anti-coagulant composition consists essentially of an aqueous solution of the sodium salt of a dextranic acid sulphuric acid ester adjusted to pH 7.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1089159A GB873995A (en) | 1959-03-31 | 1959-03-31 | Sulfuric acid esters of dextranic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1089159A GB873995A (en) | 1959-03-31 | 1959-03-31 | Sulfuric acid esters of dextranic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB873995A true GB873995A (en) | 1961-08-02 |
Family
ID=9976220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1089159A Expired GB873995A (en) | 1959-03-31 | 1959-03-31 | Sulfuric acid esters of dextranic acid |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB873995A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113087818A (en) * | 2021-05-18 | 2021-07-09 | 华科营养与生物技术(深圳)有限公司 | Dextran sulfate sodium salt or potassium salt and production method thereof |
| CN113512130A (en) * | 2021-04-20 | 2021-10-19 | 汉邦环宇多糖生物科技（河源）有限公司 | Ultra-filtration classification and anticoagulant activity determination method of dextran sulfate |
-
1959
- 1959-03-31 GB GB1089159A patent/GB873995A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113512130A (en) * | 2021-04-20 | 2021-10-19 | 汉邦环宇多糖生物科技（河源）有限公司 | Ultra-filtration classification and anticoagulant activity determination method of dextran sulfate |
| CN113087818A (en) * | 2021-05-18 | 2021-07-09 | 华科营养与生物技术(深圳)有限公司 | Dextran sulfate sodium salt or potassium salt and production method thereof |
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