GB701414A - Improvements in the production of chondroitin polysulphuric acid esters - Google Patents
Improvements in the production of chondroitin polysulphuric acid estersInfo
- Publication number
- GB701414A GB701414A GB24075/51A GB2407551A GB701414A GB 701414 A GB701414 A GB 701414A GB 24075/51 A GB24075/51 A GB 24075/51A GB 2407551 A GB2407551 A GB 2407551A GB 701414 A GB701414 A GB 701414A
- Authority
- GB
- United Kingdom
- Prior art keywords
- chondroitin
- polysulphuric
- acid
- production
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920002567 Chondroitin Polymers 0.000 title abstract 4
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 title abstract 4
- 150000002148 esters Chemical class 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- XTHPWXDJESJLNJ-UHFFFAOYSA-N sulfurochloridic acid Chemical compound OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920000728 polyester Polymers 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Chondroitin polysulphuric acid ester is prepared by reacting chondroitin sulphuric acid with chlorsulphonic acid in formamide at a temperature of about 0 DEG -40 DEG C. Preferably the reaction is effected at 10 DEG -25 DEG C. using a mixture of chlorsulphonic acid and formamide in the ratio of 15-22:100. The reaction mixture is subsequently poured into alcohol, e.g. methanol whereupon the chondroitin polysulphuric ester precipitates. The ester may be converted into salts by means of alkalies. The polyester and its sodium salt have restrictive action on the coagulation of blood and are of low toxicity. An example is given.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH701414X | 1950-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB701414A true GB701414A (en) | 1953-12-23 |
Family
ID=4530054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB24075/51A Expired GB701414A (en) | 1950-10-17 | 1951-10-16 | Improvements in the production of chondroitin polysulphuric acid esters |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB701414A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1634893A1 (en) * | 2004-09-13 | 2006-03-15 | Laboratori Derivati Organici S.P.A. | Process for the sulfation of chondroitin |
-
1951
- 1951-10-16 GB GB24075/51A patent/GB701414A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1634893A1 (en) * | 2004-09-13 | 2006-03-15 | Laboratori Derivati Organici S.P.A. | Process for the sulfation of chondroitin |
| JP2006077227A (en) * | 2004-09-13 | 2006-03-23 | Lab Derivati Organici Spa | Method for sulfating chondroitin |
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