GB701414A - Improvements in the production of chondroitin polysulphuric acid esters - Google Patents

Improvements in the production of chondroitin polysulphuric acid esters

Info

Publication number
GB701414A
GB701414A GB24075/51A GB2407551A GB701414A GB 701414 A GB701414 A GB 701414A GB 24075/51 A GB24075/51 A GB 24075/51A GB 2407551 A GB2407551 A GB 2407551A GB 701414 A GB701414 A GB 701414A
Authority
GB
United Kingdom
Prior art keywords
chondroitin
polysulphuric
acid
production
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24075/51A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of GB701414A publication Critical patent/GB701414A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Chondroitin polysulphuric acid ester is prepared by reacting chondroitin sulphuric acid with chlorsulphonic acid in formamide at a temperature of about 0 DEG -40 DEG C. Preferably the reaction is effected at 10 DEG -25 DEG C. using a mixture of chlorsulphonic acid and formamide in the ratio of 15-22:100. The reaction mixture is subsequently poured into alcohol, e.g. methanol whereupon the chondroitin polysulphuric ester precipitates. The ester may be converted into salts by means of alkalies. The polyester and its sodium salt have restrictive action on the coagulation of blood and are of low toxicity. An example is given.
GB24075/51A 1950-10-17 1951-10-16 Improvements in the production of chondroitin polysulphuric acid esters Expired GB701414A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH701414X 1950-10-17

Publications (1)

Publication Number Publication Date
GB701414A true GB701414A (en) 1953-12-23

Family

ID=4530054

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24075/51A Expired GB701414A (en) 1950-10-17 1951-10-16 Improvements in the production of chondroitin polysulphuric acid esters

Country Status (1)

Country Link
GB (1) GB701414A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1634893A1 (en) * 2004-09-13 2006-03-15 Laboratori Derivati Organici S.P.A. Process for the sulfation of chondroitin

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1634893A1 (en) * 2004-09-13 2006-03-15 Laboratori Derivati Organici S.P.A. Process for the sulfation of chondroitin
JP2006077227A (en) * 2004-09-13 2006-03-23 Lab Derivati Organici Spa Method for sulfating chondroitin

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