GB823827A - Preparation of pteroylglutamic acid - Google Patents

Preparation of pteroylglutamic acid

Info

Publication number
GB823827A
GB823827A GB24853/57A GB2485357A GB823827A GB 823827 A GB823827 A GB 823827A GB 24853/57 A GB24853/57 A GB 24853/57A GB 2485357 A GB2485357 A GB 2485357A GB 823827 A GB823827 A GB 823827A
Authority
GB
United Kingdom
Prior art keywords
trichloroacetone
hydrate
bromo
mol
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24853/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kongo Kagaku KK
Original Assignee
Kongo Kagaku KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kongo Kagaku KK filed Critical Kongo Kagaku KK
Publication of GB823827A publication Critical patent/GB823827A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Pteroylglutamic acid is prepared by dissolving 2,4,5 - triamino - 6 - hydroxy - pyrimidine, or a salt thereof, and p-aminobenzoylglutamic acid in hot water, cooling the resulting solution to 27 DEG to 35 DEG C., and then adding 1-bromo - 1,3,3 - trichloroacetone or 1,1 - dibromo - 3,3 - dichloroacetone, or a hydrate thereof, in the presence of an alkali metal bisulphite, the reaction mixture being maintained at a pH of 4 to 5. It is preferable to employ the reactants in equimolecular proportions. One detailed example is given. 1 - Bromo - 1,3,3 - trichloroacetone is prepared by dropping one mol. of bromine into one mol. of 1,1,3-trichloroacetone with stirring on a boiling water bath. The product may be precipitated as a hydrate by adding water.
GB24853/57A 1956-10-16 1957-08-07 Preparation of pteroylglutamic acid Expired GB823827A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP823827X 1956-10-16

Publications (1)

Publication Number Publication Date
GB823827A true GB823827A (en) 1959-11-18

Family

ID=13773017

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24853/57A Expired GB823827A (en) 1956-10-16 1957-08-07 Preparation of pteroylglutamic acid

Country Status (1)

Country Link
GB (1) GB823827A (en)

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