ES2028766T1 - Un procedimiento para la preparacion de derivados del acido 3-(l-piroglutamil)-l-tazolidin-4-carboxilico. - Google Patents

Un procedimiento para la preparacion de derivados del acido 3-(l-piroglutamil)-l-tazolidin-4-carboxilico.

Info

Publication number
ES2028766T1
ES2028766T1 ES199090119271T ES90119271T ES2028766T1 ES 2028766 T1 ES2028766 T1 ES 2028766T1 ES 199090119271 T ES199090119271 T ES 199090119271T ES 90119271 T ES90119271 T ES 90119271T ES 2028766 T1 ES2028766 T1 ES 2028766T1
Authority
ES
Spain
Prior art keywords
piroglutamil
tazolidin
carboxilico
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES199090119271T
Other languages
English (en)
Other versions
ES2028766T3 (es
Inventor
Stefano Poli
Lucio Del Corona
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Poli Industria Chimica SpA
Original Assignee
Poli Industria Chimica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poli Industria Chimica SpA filed Critical Poli Industria Chimica SpA
Publication of ES2028766T1 publication Critical patent/ES2028766T1/es
Application granted granted Critical
Publication of ES2028766T3 publication Critical patent/ES2028766T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

SON PREPARADOS ACIDOS CARBOXILICOS-4-TIAZOLIDINE-L-(PIROGLUTAMIL-L)-3 Y SUS DERIVADOS, POR CONDENSAR EL ACIDO PIROGLUTAMICO-L O SUS PRODUCTOS DE SUSTITUCION, EN LA PRESENCIA DE DICICLOHEXILCARBOIMIDA O LOS SIMILARES, O POR CONDENSACION DE DERIVADOS ACTIVOS DEL ACIDO PIROGLUTAMICO-L CON DERIVADOS DE ACIDO CARBOXILICO-TIAZOLIDINE-4.
ES90119271T 1989-10-12 1990-10-08 Un procedimiento para la preparacion de derivados de acido 3-(l-piroglutamil)-l-tiazolidina-4-carboxilico. Expired - Lifetime ES2028766T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22003A IT1239029B (it) 1989-10-12 1989-10-12 Processo per la preparazione dell'acido 3-(l-piroglutamil)-l- tiazolidin-4-carbossilico e suoi derivati.

Publications (2)

Publication Number Publication Date
ES2028766T1 true ES2028766T1 (es) 1992-07-16
ES2028766T3 ES2028766T3 (es) 1995-07-01

Family

ID=11190043

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90119271T Expired - Lifetime ES2028766T3 (es) 1989-10-12 1990-10-08 Un procedimiento para la preparacion de derivados de acido 3-(l-piroglutamil)-l-tiazolidina-4-carboxilico.

Country Status (18)

Country Link
US (1) US5110936A (es)
EP (1) EP0422566B1 (es)
JP (1) JP2813450B2 (es)
KR (1) KR100195895B1 (es)
AT (1) ATE121420T1 (es)
AU (1) AU644379B2 (es)
CA (1) CA2027341C (es)
DE (2) DE422566T1 (es)
DK (1) DK0422566T3 (es)
ES (1) ES2028766T3 (es)
FI (1) FI95271C (es)
GR (1) GR910300072T1 (es)
HU (1) HU210213B (es)
IE (1) IE67047B1 (es)
IL (1) IL95949A (es)
IT (1) IT1239029B (es)
NO (1) NO178028C (es)
ZA (1) ZA908097B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1230706B (it) * 1989-02-10 1991-10-29 Poli Ind Chimica Spa Derivati dell'acido 3 piroglutamoil tiazolidin 4 carbossilico e loro proprieta' farmacologiche.
IT1237998B (it) * 1990-01-23 1993-06-21 Poli Ind Chimica Spa Acido 3-l-(5-tioxo-l-prolil)tiazolidin-4-carbossilico e derivati, loro preparazione e composizioni farmaceutiche che li contengono
IT1270017B (it) * 1994-09-27 1997-04-16 Poli Ind Chimica Spa "sintesi quantitativa dell'acido 3-(l-piroglutamil)-l-tiazolidin-4- carbossilico e suoi derivati"
AU4335297A (en) * 1996-09-06 1998-03-26 Eli Lilly And Company Process and novel intermediates
US8404804B2 (en) * 2007-08-28 2013-03-26 Ipsen Pharma S.A.S. Methods and intermediates for chemical synthesis of polypeptides and proteins
CN102167727B (zh) * 2011-01-29 2013-05-15 浙江金立源药业有限公司 一种匹多莫德的合成方法
WO2016112977A1 (en) 2015-01-15 2016-07-21 Polichem S.A. Di-pidotimod benzathine and solid forms thereof
KR101642445B1 (ko) * 2016-01-11 2016-07-26 (주)남양통신 수상태양광 발전장치용 계류장치
CN107383162A (zh) * 2017-07-06 2017-11-24 成都美域高制药有限公司 一种匹多莫德的制备方法
CN108640912A (zh) * 2018-06-19 2018-10-12 广州大光制药有限公司 一种匹多莫德的工业化规模制备方法
CN111233854A (zh) * 2019-12-30 2020-06-05 常州寅盛药业有限公司 一种匹多莫德杂质的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1202426B (it) * 1987-01-26 1989-02-09 Poli Ind Chimica Spa Derivato di acido tiazolidin-4-carbossilico,sua preparazione e composizioni farmaceutiche che lo contengono

Also Published As

Publication number Publication date
NO904404D0 (no) 1990-10-11
DE69018755D1 (de) 1995-05-24
HUT59136A (en) 1992-04-28
AU6452190A (en) 1991-04-18
CA2027341C (en) 2007-10-02
JPH03193799A (ja) 1991-08-23
GR910300072T1 (en) 1991-11-15
NO178028C (no) 1996-01-10
HU210213B (en) 1995-02-28
IL95949A (en) 1995-10-31
ES2028766T3 (es) 1995-07-01
KR910007923A (ko) 1991-05-30
IE903599A1 (en) 1991-04-24
HU906417D0 (en) 1991-04-29
KR100195895B1 (ko) 1999-06-15
FI905011A0 (fi) 1990-10-11
US5110936A (en) 1992-05-05
EP0422566B1 (en) 1995-04-19
IL95949A0 (en) 1991-07-18
NO904404L (no) 1991-04-15
CA2027341A1 (en) 1991-04-13
AU644379B2 (en) 1993-12-09
NO178028B (no) 1995-10-02
IT8922003A1 (it) 1991-04-12
DK0422566T3 (da) 1995-06-26
IE67047B1 (en) 1996-02-21
IT8922003A0 (it) 1989-10-12
FI95271C (fi) 1996-01-10
DE422566T1 (de) 1991-09-05
DE69018755T2 (de) 1995-08-24
EP0422566A1 (en) 1991-04-17
ATE121420T1 (de) 1995-05-15
FI95271B (fi) 1995-09-29
IT1239029B (it) 1993-09-20
ZA908097B (en) 1991-08-28
JP2813450B2 (ja) 1998-10-22

Similar Documents

Publication Publication Date Title
MX9206450A (es) Proceso para la produccion de isoleucina-l.
MX9207489A (es) Aparato para la aplicacion de hilos afelpados, que comprende agujas huecas, para producir articulos textiles estampados.
MX9204625A (es) Composicion farmaceutica para el tratamiento de una especie de mamifero, que sufre de deficiencia cardiaca congestiva.
ES2028766T3 (es) Un procedimiento para la preparacion de derivados de acido 3-(l-piroglutamil)-l-tiazolidina-4-carboxilico.
MX9204546A (es) Proceso para la preparacion de natamicina por fermentacion.
MX19501A (es) Procedimiento para la preparacion de pirroles substituidos y productos obtenidos a partir del mismo.
ATE111090T1 (de) Verfahren zur stereoselektiven herstellung von 8- g(a),12-oxido-13,14,15,16-tetranorlabdan.
MX9201216A (es) Procedimiento para la fabricacion de 2-cloro-1,1,1,2-tetra fluoro etano y penta fluoro etano.
BE868731A (fr) Procede de marquage d'elingues, ainsi que les elingues obtenues par la mise en oeuvre de ce procede
FR2655918B1 (fr) Article de nouveaute modifiable par mouillage.
ES2075234T3 (es) Iminotiazolinas, su produccion y uso como herbicidas, y productos intermedios para su produccion.
IT8921893A0 (it) Procedimento per la produzione di impiallacciatura artificiale ad imitazione della radica, mediante bruciature.
DE59006562D1 (de) Endoskop, insbesondere Resektoskop.
ES2089157T3 (es) Nuevos derivados de la 20,21-dinoreburnamenina, su procedimiento de preparacion y los nuevos productos intermedios asi obtenidos, su aplicacion como medicamentos y composiciones que los contienen.
ES2052105T3 (es) Gilanteno: principio anti-metastasico de sanguijuela de america del sur haementaria ghilianii.
MX9201217A (es) Procedimiento para la fabricacion de 1,1,1,2-tetra fluoro etano.
ES2057792T3 (es) Procedimiento para la preparacion de cetonas terpenicas.
ES2141948T3 (es) Derivados de ciclohexanona, procedimiento para su preparacion y productos intermedios del procedimiento.
MX9200288A (es) Procedimiento para la preparacion del acido 1,2,3,4-tetrahidroisoquinolin-3-carboxilico racemico y opticamente activo asi como sus productos previos.
MX9201219A (es) Procedimiento para la produccion de 2-cloro-1,1,1-trifluoro etano.
ES2071731T3 (es) Procedimiento para la preparacion de 2-acilamino-9-acil-6-halogeno-purinas.
FR2663031B1 (fr) Derives de la pyrrolo-pyridine, ainsi que leur procede de preparation.
IT1244042B (it) Dispositivo per la produzione di filato di fiocco.
NO901315L (no) Fremgangsmaate for fremstilling av modifisert pe40.
ES513560A0 (es) Un procedimiento para la preparacion de acidos benzoxepino 4,3-b)pirrol-2-aceticos sustituidos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 422566

Country of ref document: ES