ES2010745A6 - Procedimiento para la obtencion de un sistema terapeutico para la aplicacion combinada transdermal de estrogenos y de gestagenos. - Google Patents

Procedimiento para la obtencion de un sistema terapeutico para la aplicacion combinada transdermal de estrogenos y de gestagenos.

Info

Publication number
ES2010745A6
ES2010745A6 ES8801003A ES8801003A ES2010745A6 ES 2010745 A6 ES2010745 A6 ES 2010745A6 ES 8801003 A ES8801003 A ES 8801003A ES 8801003 A ES8801003 A ES 8801003A ES 2010745 A6 ES2010745 A6 ES 2010745A6
Authority
ES
Spain
Prior art keywords
layer
components
combinations
active agents
transdermal therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8801003A
Other languages
English (en)
Inventor
Peter Fankhauser
Lotte Schenkel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4206204&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2010745(A6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES2010745A6 publication Critical patent/ES2010745A6/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN SISTEMA TERAPEUTICO PARA LA ADMINISTRACION COMBINADA TRANSDERMAL DE ESTROGENOS Y DE GESTAGENOS, CONSTITUIDO POR: (1) UNA CAPA DE COBERTURA CERRADA E IMPERMEABLE PARA LOS COMPONENTES DE LA FORMULACION DE PRODUCTOS ACTIVOS; (2) UN DEPOSITO CON LOS COMPONENTES FUNDAMENTALES DE LA FORMULACION DE PRODUCTOS ACTIVOS Y, EN CASO DADO UNA MEMBRANA; (3) UNA CAPA ADHESIVA; Y (4) UNA CAPA PROTECTORA DESPRENDIBLE SOBRE LA CAPA ADHESIVA. EL PROCEDIMIENTO COMPRENDE APLICAR, SOBRE LA CAPA PROTECTORA DESPRENDIBLE, DE 0,2 A 20 MG DE UN DERIVADO DE ESTROGENO Y DE 5 A 30 MG DE UN DERIVADO DE GESTAGENO SINTETICO CON LOS COMPONENTES (2) Y (3), Y SOLDAR ESTOS ENTRE SI CON LA CAPA DE COBERTURA (1).
ES8801003A 1987-04-02 1988-03-30 Procedimiento para la obtencion de un sistema terapeutico para la aplicacion combinada transdermal de estrogenos y de gestagenos. Expired ES2010745A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1259/87A CH674618A5 (es) 1987-04-02 1987-04-02

Publications (1)

Publication Number Publication Date
ES2010745A6 true ES2010745A6 (es) 1989-12-01

Family

ID=4206204

Family Applications (2)

Application Number Title Priority Date Filing Date
ES198888810191T Expired - Lifetime ES2032221T3 (es) 1987-04-02 1988-03-24 Procedimiento para la obtencion de un sistema terapeutico transdermal multicapa.
ES8801003A Expired ES2010745A6 (es) 1987-04-02 1988-03-30 Procedimiento para la obtencion de un sistema terapeutico para la aplicacion combinada transdermal de estrogenos y de gestagenos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES198888810191T Expired - Lifetime ES2032221T3 (es) 1987-04-02 1988-03-24 Procedimiento para la obtencion de un sistema terapeutico transdermal multicapa.

Country Status (25)

Country Link
US (2) US4913905A (es)
EP (1) EP0285563B1 (es)
JP (1) JPH0651623B2 (es)
KR (1) KR960009648B1 (es)
AT (2) ATE75402T1 (es)
AU (1) AU612360B2 (es)
BE (1) BE1000696A5 (es)
CA (1) CA1300021C (es)
CH (1) CH674618A5 (es)
DE (2) DE3870504D1 (es)
DK (1) DK174616B1 (es)
ES (2) ES2032221T3 (es)
FR (1) FR2613233A1 (es)
GB (1) GB2208147B (es)
GR (2) GR880100213A (es)
IE (1) IE61114B1 (es)
IL (1) IL85847A (es)
IT (1) IT1219896B (es)
LU (1) LU87184A1 (es)
NL (1) NL8800836A (es)
NZ (1) NZ224115A (es)
PH (1) PH24549A (es)
PT (1) PT87125B (es)
SE (1) SE8801185L (es)
ZA (1) ZA882326B (es)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5560922A (en) * 1986-05-30 1996-10-01 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process
US5023084A (en) * 1986-12-29 1991-06-11 Rutgers, The State University Of New Jersey Transdermal estrogen/progestin dosage unit, system and process
US5077054A (en) * 1987-03-09 1991-12-31 Alza Corporation Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5171576A (en) * 1987-03-09 1992-12-15 Alza Corporation Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
CH674618A5 (es) * 1987-04-02 1990-06-29 Ciba Geigy Ag
DE3738620A1 (de) * 1987-11-13 1989-05-24 Luderschmidt Christoph Verwendung von ethisterone zur topischen behandlung von akne oder androgenetischer alopezie
HUT52382A (en) * 1988-03-14 1990-07-28 Sandoz Ag Process for producing pharmaceutical compositions comprising as active ingredient unsubstituted progestin in 19-position and estrogen in the given case
JPH02149514A (ja) * 1988-04-06 1990-06-08 Nitto Denko Corp 医薬部材
ATE101511T1 (de) * 1988-08-02 1994-03-15 Ciba Geigy Ag Mehrschichtiges pflaster.
JP3238389B2 (ja) * 1988-10-27 2001-12-10 シエーリング アクチエンゲゼルシヤフト ゲストデン含有の経皮適用のための薬剤
US5053227A (en) * 1989-03-22 1991-10-01 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US4973468A (en) * 1989-03-22 1990-11-27 Cygnus Research Corporation Skin permeation enhancer compositions
US5059426A (en) * 1989-03-22 1991-10-22 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5788983A (en) * 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
DE3933460A1 (de) * 1989-10-06 1991-04-18 Lohmann Therapie Syst Lts Oestrogenhaltiges wirkstoffpflaster
JP2849937B2 (ja) * 1990-04-18 1999-01-27 日東電工株式会社 医療用貼付剤
AU633733B2 (en) * 1990-05-17 1993-02-04 Hisamitsu Pharmaceutical Co., Inc. Percutaneous preparation containing estradiol
DK0754456T3 (da) * 1990-06-01 2002-11-11 Population Council Inc Forberedelse af sammensætninger der omfatter ST1435 til topisk anvendelse
US5320850A (en) * 1990-10-29 1994-06-14 Alza Corporation Transdermal delivery of the gestogen ST-1435 and devices therefor
MX9101787A (es) * 1990-10-29 1992-06-05 Alza Corp Formulaciones,metodos y dispositivos anticonceptivos transdermicos
US5122382A (en) * 1990-10-29 1992-06-16 Alza Corporation Transdermal contraceptive formulations, methods and devices
US5314694A (en) * 1990-10-29 1994-05-24 Alza Corporation Transdermal formulations, methods and devices
US5198223A (en) * 1990-10-29 1993-03-30 Alza Corporation Transdermal formulations, methods and devices
TW213418B (es) * 1991-05-02 1993-09-21 Kuko Seiyaku Kk
US5518734A (en) * 1991-09-25 1996-05-21 Beta Pharmaceuticals Co. Transdermal delivery system for estradiol and process for manufacturing said device
US5705185A (en) * 1991-09-25 1998-01-06 Beta Pharmaceuticals Co. Transdermal delivery of estradiol and process for manufacturing said device
US5229130A (en) * 1991-12-20 1993-07-20 Cygnus Therapeutics Systems Vegetable oil-based skin permeation enhancer compositions, and associated methods and systems
US5405614A (en) * 1992-04-08 1995-04-11 International Medical Associates, Inc. Electronic transdermal drug delivery system
US5756117A (en) * 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
US5900250A (en) * 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
US5827245A (en) * 1992-07-16 1998-10-27 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system comprising the active subtance 17-β-Estradiol (Anhydrous)
DE4230588C1 (de) * 1992-09-12 1993-10-07 Lohmann Therapie Syst Lts Dexpanthenol-haltiges Pflaster zur transdermalen Applikation von Steroidhormonen und Verfahren zu seiner Herstellung
WO1994022432A1 (en) * 1993-04-07 1994-10-13 Rexham Industries Corp. Method of coating microporous membranes and resulting products
CA2161004C (en) * 1993-04-20 2004-10-26 Wilfried Fischer Active ingredient patch
DE4336557C2 (de) 1993-05-06 1997-07-17 Lohmann Therapie Syst Lts Estradiolhaltiges transdermales therapeutisches System, Verfahren zu seiner Herstellung und seine Verwendung
NZ275615A (en) * 1993-09-29 1996-11-26 Alza Corp Oxybutynin composition containing monoglyceride and lactate ester as permeability enhancers; device for transdermal administration of oxybutynin
DE4333595A1 (de) * 1993-10-01 1995-04-06 Labtec Gmbh Transdermales therapeutisches System zur Applikation von Arzneimitteln auf die Haut
DE4400770C1 (de) * 1994-01-13 1995-02-02 Lohmann Therapie Syst Lts Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung
JPH09510697A (ja) * 1994-01-27 1997-10-28 シエーリング アクチエンゲゼルシヤフト １４α，１７α−エタノエストラ−１，３，５（１０）−トリエン−３，１７β−ジオールを含有する経皮投与のための薬剤
US5547681A (en) * 1994-07-14 1996-08-20 Union Carbide Chemicals & Plastics Technology Corporation Dermal patch
US5612382A (en) * 1994-07-15 1997-03-18 Frances B. Fike Composition for percutaneous absorption of pharmaceutically active ingredients
JPH0827003A (ja) * 1994-07-22 1996-01-30 Sekisui Chem Co Ltd 経皮吸収製剤
JP3576608B2 (ja) * 1994-11-15 2004-10-13 日東電工株式会社 貼付剤および貼付製剤
DE19500662C2 (de) * 1995-01-12 2001-04-26 Lohmann Therapie Syst Lts Estradiolhaltiges Pflaster und seine Verwendung
US5780050A (en) * 1995-07-20 1998-07-14 Theratech, Inc. Drug delivery compositions for improved stability of steroids
DE19526864A1 (de) * 1995-07-22 1997-01-23 Labtec Gmbh Hormonpflaster
DE19548332A1 (de) * 1995-12-22 1997-07-10 Rotta Res Bv Hormonpflaster
US5730721A (en) * 1996-01-25 1998-03-24 Vesture Corporation Medical applicator and method
ES2177962T3 (es) * 1996-03-25 2002-12-16 Lohmann Therapie Syst Lts Sistema de administracion transdermica de reducido espesor de aplicacion y elevada flexibilidad, y proceso de fabricacion del mismo.
IT1283102B1 (it) * 1996-06-06 1998-04-07 Permatec Nv Composizione terapeutica per la somministrazione transdermica di un principio attivo estrogeno o progestinico o di loro miscele
GB9615350D0 (en) * 1996-07-22 1996-09-04 Resource Medical Limited Hormone replacement therapy
DE19654468C1 (de) * 1996-12-27 1998-01-22 Lohmann Therapie Syst Lts Extrem flexibles, dermal oder transdermal wirkendes Pflaster und Verfahren zu seiner Herstellung
DE19701949A1 (de) * 1997-01-13 1998-07-16 Jenapharm Gmbh Transdermales therapeutisches System
KR100215027B1 (ko) * 1997-01-27 1999-08-16 성재갑 스테로이드계 약물의 경피흡수투여용 조성물 및 이를 포함하는 경피흡수투여용 제형
US6056972A (en) * 1997-02-26 2000-05-02 Dimera, Llc Method for reducing coronary artery reactivity
US5968919A (en) * 1997-10-16 1999-10-19 Macrochem Corporation Hormone replacement therapy drug formulations for topical application to the skin
DE19820151A1 (de) * 1998-05-06 1999-11-11 Hexal Ag Transdermales therapeutisches System zur Anwendung von Candesartan
FR2779062A1 (fr) * 1998-06-02 1999-12-03 Investigations Therapeutiques Preparation sous forme galenique simple visant a limiter les effets induits durant la menopause et posterieurement et traitement avec cette preparation
DE19834007C1 (de) 1998-07-29 2000-02-24 Lohmann Therapie Syst Lts Estradiolhaltiges Pflaster zur transdermalen Applikation von Hormonen und seine Verwendung
DE19834006A1 (de) * 1998-07-29 2000-02-24 Lohmann Therapie Syst Lts Estradiolhaltiges Pflaster zur transdermalen Applikation von Hormonen
AU778992B2 (en) * 1998-12-07 2004-12-23 Agi Therapeutics Research Limited Transdermal patch for delivering volatile liquid drugs
CA2374930C (en) * 1999-07-02 2008-08-05 Lts Lohmann Therapie-Systeme Ag Microreservoir system based on polysiloxanes and ambiphilic solvents
EP2520289B8 (en) 2002-08-09 2014-08-20 Teikoku Seiyaku Co., Ltd. Norethisterone-containing patch
CA2515918C (en) 2003-02-21 2010-11-16 Schering Ag Uv stable transdermal therapeutic plaster
US8668925B2 (en) 2003-12-12 2014-03-11 Bayer Intellectual Property Gmbh Transdermal delivery of hormones without the need of penetration enhancers
US20050202073A1 (en) * 2004-03-09 2005-09-15 Mylan Technologies, Inc. Transdermal systems containing multilayer adhesive matrices to modify drug delivery
EP1616551A1 (fr) 2004-07-13 2006-01-18 L'oreal Procédé de traitement cosmétique pour prévenir ou retarder les signes du vieillissement cutané
US20060147423A1 (en) * 2004-12-07 2006-07-06 Jean-Yves Legendre Transungual device
FR2878745B1 (fr) 2004-12-07 2007-03-09 Oreal Dispositif transungeal
US20060188558A1 (en) * 2005-02-18 2006-08-24 Mylan Technologies, Inc. Transdermal systems having control delivery system
FR2884143B1 (fr) * 2005-04-08 2007-06-22 Millet Innovation Sa Timbre dermique rechargeable
US8962013B2 (en) 2005-05-02 2015-02-24 Bayer Intellectual Property Gmbh Multi-layered transdermal system with triazine UV absorber
US20070259029A1 (en) * 2006-05-08 2007-11-08 Mcentire Edward Enns Water-dispersible patch containing an active agent for dermal delivery
FR2909552B1 (fr) 2006-12-12 2009-11-20 Oreal Utilisation cosmetique de l'acide anisique pour favoriser la desquamation
DE102010040299A1 (de) * 2010-09-06 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Transdermale therapeutische Systeme mit kristallisationsinhibierender Schutzfolie (Release Liner)
DK2613772T3 (en) 2010-09-06 2017-03-06 Bayer Ip Gmbh TRANSDERMAL LOW DOSAGE PATTERNS WITH HIGH PHARMACEUTICAL RELEASE
KR102396906B1 (ko) * 2013-12-31 2022-05-13 존슨 앤드 존슨 컨수머 인코포레이티드 다층의 형상화된 필름을 형성하기 위한 방법
EP3536313B1 (en) 2013-12-31 2022-02-16 Johnson & Johnson Consumer Inc. Process for forming a shaped film product
IT201800009265A1 (it) * 2018-10-09 2020-04-09 Koblenz Spa Assieme di porta scorrevole

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL152819B (nl) 1949-04-07 Swift & Co Werkwijze voor het continu bereiden van mono-ammoniumdiwaterstoffosfaatdeeltjes en zo verkregen deeltjes.
US2863846A (en) 1950-05-04 1958-12-09 Dow Corning Organo silyl-silica filled siloxane elastomers and process for producing same
US2890188A (en) 1951-12-17 1959-06-09 Dow Corning Siloxane elastomers compounded with hydroxylated silanes
NL91756C (es) 1953-11-19
US2927907A (en) 1957-01-07 1960-03-08 Dow Corning Siloxane elastomers
US3035016A (en) 1959-03-16 1962-05-15 Dow Corning Acyloxy siloxanes and a method of using the
US3002951A (en) 1959-04-27 1961-10-03 Dow Corning Method of polymerizing cyclic diorganosiloxanes
NL134681C (es) 1966-04-26
US3546142A (en) 1967-01-19 1970-12-08 Amicon Corp Polyelectrolyte structures
US3797494A (en) 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3968245A (en) * 1973-10-12 1976-07-06 Alza Corporation Sympathomimetic topical and percutaneous administration with halogenated promoters
DE2432925C3 (de) * 1974-07-05 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen Folienförmige Arzneimittel
AR207805A1 (es) 1975-02-06 1976-10-29 Alza Corp Substrato apropiado para formar apositos para la dispensacion continua de escopolamina base por via transdermica
US4262003A (en) 1975-12-08 1981-04-14 Alza Corporation Method and therapeutic system for administering scopolamine transdermally
US4031894A (en) 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
US4438139A (en) * 1979-08-14 1984-03-20 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing estrogens
US4291015A (en) 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4826831A (en) 1983-08-05 1989-05-02 Pre Jay Holdings Limited Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens
CA1248450A (en) * 1984-04-05 1989-01-10 Kazuo Kigasawa Soft patch
US4834978A (en) * 1984-10-01 1989-05-30 Biotek, Inc. Method of transdermal drug delivery
US4810499A (en) * 1984-10-01 1989-03-07 Biotek, Inc. Transdermal drug delivery system and method
US4624665A (en) * 1984-10-01 1986-11-25 Biotek, Inc. Method of transdermal drug delivery
US4597961A (en) 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
US4883669A (en) * 1985-02-25 1989-11-28 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit for estradiol and other estrogenic steroids and process for administration
ATE77962T1 (de) 1985-02-25 1992-07-15 Univ Rutgers Dosierungssystem fuer transdermale absorption von arzneimittelwirkstoffen.
DK174724B1 (da) * 1986-07-15 2003-10-06 Wyeth Corp Anvendelse af et præparat omfattende et østrogen og et progestogen til fremstilling af en dosisform til tilvejebringelse af hormonerstatningsterapi og kontraception til kvinder i præmenopausen samt pakning til tilvejebringelse af præparatet
CN1021196C (zh) * 1986-12-29 1993-06-16 新泽西州州立大学(鲁杰斯) 透皮雌激素/孕激素药剂单元、系统及方法
US4906169A (en) * 1986-12-29 1990-03-06 Rutgers, The State University Of New Jersey Transdermal estrogen/progestin dosage unit, system and process
US4816258A (en) * 1987-02-26 1989-03-28 Alza Corporation Transdermal contraceptive formulations
US4788062A (en) * 1987-02-26 1988-11-29 Alza Corporation Transdermal administration of progesterone, estradiol esters, and mixtures thereof
CH674618A5 (es) * 1987-04-02 1990-06-29 Ciba Geigy Ag
US4764379A (en) * 1987-08-24 1988-08-16 Alza Corporation Transdermal drug delivery device with dual permeation enhancers
US4820720A (en) * 1987-08-24 1989-04-11 Alza Corporation Transdermal drug composition with dual permeation enhancers
US4942158A (en) * 1988-10-13 1990-07-17 Eastman Kodak Transdermal steroid penetrant compositions and methods utilizing isopropanol and isobutanol

Also Published As

Publication number Publication date
BE1000696A5 (fr) 1989-03-14
US5128124A (en) 1992-07-07
ATA87488A (de) 1991-05-15
DK179688A (da) 1988-10-03
SE8801185L (sv) 1989-10-01
ATE75402T1 (de) 1992-05-15
GR880100213A (el) 1989-01-31
GB8807399D0 (en) 1988-05-05
PT87125B (pt) 1992-07-31
IL85847A (en) 1992-05-25
KR880012216A (ko) 1988-11-26
GB2208147B (en) 1991-01-02
DE3810896A1 (de) 1988-10-20
IT1219896B (it) 1990-05-24
LU87184A1 (fr) 1989-04-06
NZ224115A (en) 1990-01-29
ZA882326B (en) 1988-10-03
JPS63258817A (ja) 1988-10-26
AT393624B (de) 1991-11-25
EP0285563A1 (de) 1988-10-05
IE880984L (en) 1988-10-02
JPH0651623B2 (ja) 1994-07-06
PT87125A (pt) 1988-04-01
AU612360B2 (en) 1991-07-11
NL8800836A (nl) 1988-11-01
FR2613233A1 (fr) 1988-10-07
US4913905A (en) 1990-04-03
EP0285563B1 (de) 1992-04-29
CA1300021C (en) 1992-05-05
CH674618A5 (es) 1990-06-29
GR3005038T3 (es) 1993-05-24
IT8847798A0 (it) 1988-03-30
DE3870504D1 (de) 1992-06-04
IE61114B1 (en) 1994-10-05
PH24549A (en) 1990-08-03
DK179688D0 (da) 1988-03-30
IL85847A0 (en) 1988-09-30
GB2208147A (en) 1989-03-08
DK174616B1 (da) 2003-07-21
KR960009648B1 (en) 1996-07-23
AU1532388A (en) 1988-10-13
ES2032221T3 (es) 1993-01-16
SE8801185D0 (sv) 1988-03-30

Similar Documents

Publication Publication Date Title
ES2010745A6 (es) Procedimiento para la obtencion de un sistema terapeutico para la aplicacion combinada transdermal de estrogenos y de gestagenos.
EP0136011A3 (en) A method of hormonal treatment of peri-menopausal, menopausal and post-menopausal disorders and multi-preparation pack therefor
AU539764B2 (en) Rotatable connecting device for i.v. administration set
EP0737477A4 (en) TRANSDERMAL PHARMACEUTICAL PREPARATION
ES8203605A1 (es) Un procedimiento de preparacion de una composicion farmaceu-tica de un esteroide
BG51075A1 (en) Composition and method for effective contraception and breast cancer control
WO1989001342A3 (en) Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound
AU531878B2 (en) Medicated animal feed based on liver meal
AU517497B2 (en) Active agent delivery system
AU497383B2 (en) Method and bandage for administering scopolamine transdermally
NO944838L (no) Arabinogalaktanderivater og anvendelser derav
PH15114A (en) Propanone derivatives,and pharmaceutical composition containing this derivative as active ingredient
EP0137543A3 (en) Pharmaceutical composition for the therapy of peripheral arteriopathies
JPS5579321A (en) Medical composition for local administration
AU528186B2 (en) Microparticles for delivering drugs to female reproductive organs
AU4367679A (en) The detection of steroid hormone receptors in human tissues
DE2961648D1 (en) Corticosteroid anti-inflammatory agents, their use and methods for their preparation
AU5288679A (en) Hormone for stimulation of ovulation
NZ186410A (en) Imidazole derivatives and pharmaceutical compositions
GB1514113A (en) Therapeutic compositions containing dimercapto-diethyl ether derivatives
NZ187676A (en) Benz(f)isoindoline derivatives and pharmaceutical compositions
DE2861474D1 (en) Novel delta-4,9-pregnane derivatives, their use as progestational and/or ovulation-inhibiting agents and process for their preparation
PT94787A (pt) Processo de preparacao de composicoes farmaceuticas para administracao transdermica de corticosteroides e de compostos com actividade fisiologica semelhante
ZA79566B (en) Cytochemical agents and methods for the detection of steroid hormone receptors in human tissues

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991102