ES2009570A6 - Procedimiento para preparar nuevas benzamidas sustituidas. - Google Patents

Procedimiento para preparar nuevas benzamidas sustituidas.

Info

Publication number
ES2009570A6
ES2009570A6 ES8800832A ES8800832A ES2009570A6 ES 2009570 A6 ES2009570 A6 ES 2009570A6 ES 8800832 A ES8800832 A ES 8800832A ES 8800832 A ES8800832 A ES 8800832A ES 2009570 A6 ES2009570 A6 ES 2009570A6
Authority
ES
Spain
Prior art keywords
emetic
benzamides
useful
quinuclidinyl
emesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8800832A
Other languages
English (en)
Inventor
Ivo Monkovic
David Willner
Figura No
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES2009570A6 publication Critical patent/ES2009570A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVAS BENZAMIDAS SUSTITUIDAS DE FORMULA XXI DONDE R1 ES UN GRUPO AMINO LINEAL O CICLICO, R2 ES H, UN GRUPO ALQUILO INFERIOR, OPCIONALMENTE SUSTITUIDO, O UN HETEROCICLO; R3 ES H O ALCOXI INFERIOR; R4 ES H, AMINO, ALQUILAMINO INFERIOR O ALCOXI INFERIOR R5 ES H, HALOGENO, TRIFLUOROMETILO, (ALQUIL INFERIOR)TIO, (ALCANO INFERIOR)SULFINILO, (ALCANO INFERIOR)SULFONILO, SULFAMILO O UN DERIVADO CARBOMILO Y R4 Y R5 UNIDOS ENTRE SI PUEDEN SER -HN-N=N. EL PROCEDIMIENTO CONSISTE EN DESMETILAR UN COMPUESTO DE FORMULA XXII Y POSTERIOR REACCION DEL INTERMEDIO OBTENIDO CON R2-L DONDE L ES UN GRUPO SALIENTE. LAS BENZAMIDAS DE LA INVENCION SON UTILES PARA EL TRATAMIENTO DE LA EMESIS Y PARTICULARMENTE FRENTE A EMESIS PRODUCIDA POR QUIMOTERAPIA EN PACIENTES CANCEROSOS.
ES8800832A 1987-05-18 1988-03-18 Procedimiento para preparar nuevas benzamidas sustituidas. Expired ES2009570A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/051,880 US4820715A (en) 1984-06-28 1987-05-18 Anti-emetic quinuclidinyl benzamides

Publications (1)

Publication Number Publication Date
ES2009570A6 true ES2009570A6 (es) 1989-10-01

Family

ID=21973929

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8800832A Expired ES2009570A6 (es) 1987-05-18 1988-03-18 Procedimiento para preparar nuevas benzamidas sustituidas.

Country Status (33)

Country Link
US (1) US4820715A (es)
JP (1) JP2502343B2 (es)
KR (1) KR880013897A (es)
AR (1) AR245928A1 (es)
AT (1) AT399338B (es)
AU (2) AU621287B2 (es)
BE (1) BE1003571A5 (es)
CA (1) CA1303616C (es)
CH (1) CH678852A5 (es)
CS (1) CS275840B6 (es)
CY (3) CY1662A (es)
DD (1) DD274210A5 (es)
DE (1) DE3816799C2 (es)
DK (1) DK151988A (es)
ES (1) ES2009570A6 (es)
FI (1) FI882233A (es)
FR (1) FR2615512B1 (es)
GB (3) GB2205095B (es)
GR (1) GR1000631B (es)
HK (3) HK72592A (es)
HU (1) HU201731B (es)
IE (1) IE60707B1 (es)
IL (1) IL86244A0 (es)
IT (1) IT1217573B (es)
LU (1) LU87173A1 (es)
NL (1) NL8800683A (es)
NO (1) NO176273C (es)
PT (1) PT87470B (es)
SE (2) SE8801845L (es)
SG (1) SG80592G (es)
SU (1) SU1605925A3 (es)
YU (1) YU46448B (es)
ZA (1) ZA881966B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820715A (en) * 1984-06-28 1989-04-11 Bristol-Myers Company Anti-emetic quinuclidinyl benzamides
GB8718345D0 (en) * 1987-08-03 1987-09-09 Fordonal Sa N-substituted benzamides
EP0303445A1 (en) * 1987-08-13 1989-02-15 Walton S.A. Clebopride transdermal patch
JPH02207065A (ja) * 1989-02-07 1990-08-16 Teikoku Chem Ind Corp Ltd ベンズアミド誘導体
AU632387B2 (en) * 1989-12-05 1992-12-24 Marion Merrell Dow Inc. Pyridinium hydrochloride metoclopramide demethylation
US5236931A (en) * 1992-03-26 1993-08-17 A. H. Robins Company, Incorporated 2-substituted benzamide and benzoate derivatives of 3-aminoquinuclidine and 3-quinuclidinol
CA2165662A1 (en) * 1993-06-23 1995-01-05 Nobuhiro Ohi Benzene derivatives effective on ischemic diseases
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
US5723103A (en) * 1994-12-09 1998-03-03 Vanderbilt University Substituted benzamides and radioligand analogs and methods of use
CN1196681C (zh) * 1997-07-11 2005-04-13 詹森药业有限公司 (+)诺西沙必利用于制备5－ht3和5ht4 介导的疾病的药物中的用途
SE0002531D0 (sv) * 2000-07-05 2000-07-05 Active Biotech Ab Immune Enhancement
WO2002016357A2 (en) 2000-08-18 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
AU2001282874A1 (en) 2000-08-18 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
AU2002251978B2 (en) * 2001-02-09 2007-07-19 Merck & Co., Inc. 2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders
PE20021019A1 (es) 2001-04-19 2002-11-13 Upjohn Co Grupos azabiciclicos sustituidos
MXPA04000779A (es) * 2001-08-24 2004-04-20 Pharmacia & Up John Company 7-aza[2.2.1]bicicloheptanos sustituidos con arilo para el tratamiento de enfermedades.
MXPA04007936A (es) 2002-02-15 2004-11-26 Upjohn Co Compuestos de aril-sustituidos para el tratamiento de enfermedades.
MXPA04007083A (es) * 2002-02-20 2004-10-29 Upjohn Co Compuestos azabiciclicos para el tratamiento de enfermedades.

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1525M (fr) * 1961-07-25 1962-11-16 Ile De France Médicaments antiémétiques nouveaux.
FR2313935A1 (fr) * 1975-06-10 1977-01-07 Ile De France Nouveaux benzamides substitues, leurs derives et leur procede de preparation
US3966957A (en) * 1972-04-03 1976-06-29 A. H. Robins Company, Incorporated Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides
GB1507462A (en) * 1974-03-21 1978-04-12 Gallardo Antonio Sa N-heterocyclic substituted benzamides methods for their preparation and compositions containing them
US4189495A (en) * 1974-09-17 1980-02-19 Synthelabo 2-Methoxy-benzamide derivatives
US4039672A (en) * 1975-01-11 1977-08-02 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France N-(1'-allypyrrolidinyl 2'-methyl) 2-methoxy 4,5-azimido benzamide and its pharmaceutically acceptable salts
US4197243A (en) * 1975-04-02 1980-04-08 Yamanouchi Pharmaceutical Co., Ltd. N-1-Benzyl-3-pyrrolidinyl-4-dimethylamino benzamide derivatives
US4093734A (en) * 1975-11-03 1978-06-06 Boehringer Ingelheim Gmbh Amino-benzoic acid amides
FR2342064A1 (fr) * 1976-02-26 1977-09-23 Andre Buzas Benzamides 2,5 disubstitues, leurs procedes de preparation et leurs applications therapeutiques
GB1574418A (en) * 1976-11-16 1980-09-03 Anphar Sa Piperidine derivatives
US4207327A (en) * 1977-08-19 1980-06-10 A. H. Robins Company, Inc. N-(4-Pyrazolidinyl)benzamides and their amino precursors
EP0067615B1 (en) * 1981-06-17 1986-01-08 Beecham Group Plc Alkylthio derivatives of azabicyclobenzamides, their preparation and pharmaceutical compositions
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
JPS5946281A (ja) * 1982-09-09 1984-03-15 Suntory Ltd １置換ピロリチジン誘導体およびその用途
US4593034A (en) * 1984-04-06 1986-06-03 A. H. Robins Company, Inc. 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides
US4820715A (en) * 1984-06-28 1989-04-11 Bristol-Myers Company Anti-emetic quinuclidinyl benzamides
US4808624A (en) * 1984-06-28 1989-02-28 Bristol-Myers Company Pharmacologically active substituted benzamides
US4605652A (en) * 1985-02-04 1986-08-12 A. H. Robins Company, Inc. Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
DE3689974T2 (de) * 1985-03-14 1994-11-03 Beecham Group Plc Arzneimittel zur Behandlung von Emesis.
US4717563A (en) * 1986-03-05 1988-01-05 A. H. Robins Company, Inc. 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs
GB8718345D0 (en) * 1987-08-03 1987-09-09 Fordonal Sa N-substituted benzamides
EP0311724A1 (en) * 1987-10-16 1989-04-19 Synthelabo Anxiolytic-R-N-(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides

Also Published As

Publication number Publication date
IE880704L (en) 1988-11-18
GB2243833B (en) 1992-02-26
HU201731B (en) 1990-12-28
AR245928A1 (es) 1994-03-30
GR880100329A (en) 1989-02-23
NL8800683A (nl) 1988-12-16
GB2205095A (en) 1988-11-30
SE8801845D0 (sv) 1988-05-17
YU55588A (en) 1989-08-31
DK151988D0 (da) 1988-03-18
SU1605925A3 (ru) 1990-11-07
PT87470B (pt) 1992-09-30
PT87470A (pt) 1989-05-31
FI882233A (fi) 1988-11-19
AU1032992A (en) 1992-03-12
US4820715A (en) 1989-04-11
HK72492A (en) 1992-10-02
HK72392A (en) 1992-10-02
AU1311588A (en) 1988-11-24
GR1000631B (el) 1992-09-11
HK72592A (en) 1992-10-02
FI882233A0 (fi) 1988-05-12
IT1217573B (it) 1990-03-30
CA1303616C (en) 1992-06-16
CS275840B6 (en) 1992-03-18
IT8820550A0 (it) 1988-05-12
KR880013897A (ko) 1988-12-22
GB9113068D0 (en) 1991-08-07
FR2615512A1 (fr) 1988-11-25
GB9113070D0 (en) 1991-08-07
IE60707B1 (en) 1994-08-10
CY1662A (en) 1993-05-14
HUT47238A (en) 1989-02-28
BE1003571A5 (fr) 1992-04-28
LU87173A1 (fr) 1988-11-17
NO881206L (no) 1988-11-21
SE8808452A (sv) 1988-11-19
DK151988A (da) 1988-11-19
NO176273C (no) 1995-03-08
JPS63313757A (ja) 1988-12-21
FR2615512B1 (fr) 1994-02-18
ZA881966B (en) 1989-11-29
DE3816799C2 (de) 1996-07-04
ATA69888A (de) 1994-09-15
IL86244A0 (en) 1988-11-15
CH678852A5 (es) 1991-11-15
SG80592G (en) 1992-10-02
AU640300B2 (en) 1993-08-19
DD274210A5 (de) 1989-12-13
NO881206D0 (no) 1988-03-18
GB2243832A (en) 1991-11-13
YU46448B (sh) 1993-10-20
CY1665A (en) 1993-05-14
SE8801845L (sv) 1988-11-19
NO176273B (no) 1994-11-28
GB8805870D0 (en) 1988-04-13
DE3816799A1 (de) 1988-12-08
GB2243832B (en) 1992-02-26
JP2502343B2 (ja) 1996-05-29
GB2243833A (en) 1991-11-13
GB2205095B (en) 1992-02-26
CY1664A (en) 1993-05-14
AU621287B2 (en) 1992-03-12
CS8801469A2 (en) 1990-09-12
AT399338B (de) 1995-04-25

Similar Documents

Publication Publication Date Title
ES2009570A6 (es) Procedimiento para preparar nuevas benzamidas sustituidas.
ES8609218A1 (es) Un procedimiento para la preparacion de nuevas benzamidas sustituidas.
ZA857274B (en) Diarylacetylenes,their preparation and their use
EP0176032A3 (en) Tetralin derivatives, their preparation and use
MY117090A (en) Substituted benzamidines, their preparation and their use as pharmaceutical compounds
HUT38950A (en) Process for producing 2-substituted-1,3-propylidene-diphosphonate derivatives and pharmaceutical compositions containing them as active agents
GR3005470T3 (es)
AU4482985A (en) Pyrro-1-yl-phenyl-dihydropyridazones
ES8106156A1 (es) Un procedimiento para la preparacion de derivados de oxadia-zolotriazona
JPS57192370A (en) 5,6-dihydro-11-alkylene-morphanthridin-6-one, manufacture and medicine containing same
ES8502128A1 (es) Procedimiento para la preparacion de derivados de 6 -metilprednisolona
HU908017D0 (en) Process for the preparation of naphloxazines and medical preparation made of them
ZA917273B (en) Use of n-(1-hexahydroazepinylalkyl)acetamides in the preparation of medicaments for the treatment of cholinergic transmission disorders
FI882388A (fi) 4-substituerad 10-cyanmetylenpyrrolo /4,3-e/benzoazepin.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991108