ES2001707A6 - Un procedimiento para preparar una sustancia anticoagulante de placenta humana - Google Patents
Un procedimiento para preparar una sustancia anticoagulante de placenta humanaInfo
- Publication number
- ES2001707A6 ES2001707A6 ES8602284A ES8602284A ES2001707A6 ES 2001707 A6 ES2001707 A6 ES 2001707A6 ES 8602284 A ES8602284 A ES 8602284A ES 8602284 A ES8602284 A ES 8602284A ES 2001707 A6 ES2001707 A6 ES 2001707A6
- Authority
- ES
- Spain
- Prior art keywords
- anticoagulating
- substance
- activity
- state
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4721—Lipocortins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
- G03C1/00—Photosensitive materials
- G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
- G03C1/04—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein with macromolecular additives; with layer-forming substances
- G03C1/047—Proteins, e.g. gelatine derivatives; Hydrolysis or extraction products of proteins
- G03C2001/0471—Isoelectric point of gelatine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/842—Skin; hair; nails; sebaceous glands; cerumen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/85—Reproductive organs or embryos
- Y10S530/851—Placenta; amniotic fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UN PROCEDIMIENTO PARA PREPARAR UNA SUSTANCIA ANTICOAGULANTE DE PLACENTA HUMANA. COMPRENDE LAS ETAPAS DE HOMOGENEIZAR PLACENTA HUMANA, SOMETER EL HOMOGENATO RESULTANTE A SEPARACION CENTRIFUGA, EXTRAER UNA SUSTANCIA ANTICOAGULANTE DEL RESIDUO O DE UNA FRACCION MICROSOMICA CONTENIDA EN EL SOBRENADANTE CON UN AGENTE TENSOACTIVO Y/O UN AGENTE QUELATANTE Y PURIFICAR Y AISLAR LA SUSTANCIA DEL EXTRACTO. DICHA SUSTANCIA PRESENTA UN PESO MOLECULAR DE 34.000º 2.000 Y UN PUNTO ISOELECTRICO DE 4,7º 0,1. ESTAS SUSTANCIAS SON UTILES POR SU ACTIVIDAD ANTICOAGULANTE Y PORQUE PRESENTAN EFECTOS SECUNDARIOS REDUCIDOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21751285 | 1985-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2001707A6 true ES2001707A6 (es) | 1988-06-01 |
Family
ID=16705389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8602284A Expired ES2001707A6 (es) | 1985-09-30 | 1986-09-29 | Un procedimiento para preparar una sustancia anticoagulante de placenta humana |
Country Status (7)
Country | Link |
---|---|
US (1) | US4732891A (es) |
EP (1) | EP0217341B2 (es) |
JP (1) | JPH0710880B2 (es) |
KR (1) | KR940003751B1 (es) |
CA (1) | CA1265446A (es) |
DE (1) | DE3676148D1 (es) |
ES (1) | ES2001707A6 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5066788A (en) * | 1984-09-21 | 1991-11-19 | Boehringer Ingelheim International Gmbh | Blood coagulation inhibiting proteins, processes for preparing them and their uses |
US5264550A (en) * | 1985-04-15 | 1993-11-23 | Scios Nova Inc. | Human anti-inflammatory phospholipase inhibitor protein |
DE3750664T2 (de) * | 1986-07-15 | 1995-06-22 | Kowa Co | Throminbindende Substanz und Verfahren zu ihrer Herstellung. |
JPH0764878B2 (ja) * | 1986-10-14 | 1995-07-12 | 興和株式会社 | 抗血液凝固物質及びその製法 |
JPH08840B2 (ja) * | 1986-11-14 | 1996-01-10 | 興和株式会社 | 抗pciモノクローナル抗体、これを用いた抗pciの精製法及び免疫学的測定法 |
DE3643182A1 (de) * | 1986-12-18 | 1988-06-30 | Behringwerke Ag | Arzneimittel enthaltend das gewebeprotein pp4, verfahren zur herstellung von pp4 und zu seiner pasteurisierung sowie die verwendung von pp4 |
US4937324A (en) * | 1987-02-06 | 1990-06-26 | Zymogenetics, Inc. | Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity |
JP2660514B2 (ja) * | 1987-02-20 | 1997-10-08 | 興和株式会社 | 抗血液凝固作用を有するポリペプチド |
PT87083B (pt) * | 1987-03-28 | 1992-07-31 | Boehringer Ingelheim Int | Processo para a preparacao de uma proteina anticoagulante vascular, de adn que codifica para esta proteina e de composicoes farmaceuticas que a contem |
DE3724726A1 (de) * | 1987-07-25 | 1989-02-02 | Behringwerke Ag | Verfahren zur reinigung des plazentaren gewebeproteins pp4 |
DE3737239A1 (de) * | 1987-11-03 | 1989-10-12 | Behringwerke Ag | Gentechnische herstellung von anticoagulatorischem protein pp4 |
DE3737237A1 (de) * | 1987-11-03 | 1989-05-18 | Behringwerke Ag | Anticoagulatorisches protein pp4-x, seine herstellung und verwendung |
JP2660548B2 (ja) * | 1988-06-15 | 1997-10-08 | 興和株式会社 | 膠原病疾患関連抗体検出用試薬及びこれを用いる膠原病疾患関連抗体の検出方法 |
US5202421A (en) * | 1988-12-27 | 1993-04-13 | Mochida Pharmaceutical Co., Ltd. | Anticoagulant substance obtained from urine and process for the preparation thereof |
ATE89169T1 (de) * | 1989-07-15 | 1993-05-15 | Boehringer Ingelheim Int | Antikoagulanz enthaltendes mittel. |
DK0558751T3 (da) * | 1990-11-20 | 2000-05-08 | Kowa Co | Terapeutiske midler til behandling af sår |
US5968477A (en) | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
US20030220233A1 (en) | 1994-01-24 | 2003-11-27 | Neorx Corporation | Radiolabeled annexins |
EP1192270A2 (en) | 1999-06-14 | 2002-04-03 | Novo Nordisk A/S | FVIIa/TF ACTIVITY INHIBITING COMPOUNDS |
KR100841599B1 (ko) * | 2000-07-21 | 2008-06-26 | 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 칼슘 이온-결합 단백질의 정제 방법 |
US7635680B2 (en) * | 2001-02-21 | 2009-12-22 | Alavita Pharmaceuticals, Inc. | Attenuation of reperfusion injury |
US7635676B2 (en) * | 2001-02-21 | 2009-12-22 | Alavita Pharmaccuticals, Inc. | Modified annexin proteins and methods for their use in organ transplantation |
US20090291086A1 (en) * | 2001-02-21 | 2009-11-26 | Alavita Pharmaceuticals, Inc. | Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia |
ES2286247T3 (es) * | 2001-02-21 | 2007-12-01 | Alavita Pharmaceuticals, Inc. | Proteinas anexinicas modificacdas y tratamiento de la trombosis. |
US7645739B2 (en) * | 2001-02-21 | 2010-01-12 | Alavita Pharmaceuticals, Inc. | Modified annexin compositions and methods of using same |
KR20030076705A (ko) * | 2001-02-26 | 2003-09-26 | 교와 가부시키가이샤 | 점안제 |
MXPA03008590A (es) | 2001-03-22 | 2003-12-08 | Novo Nordisk Healthcare Ag | Derivados del factor vii de coagulacion. |
US6982154B2 (en) * | 2002-02-21 | 2006-01-03 | Surromed, Inc. | Modified annexin proteins and methods for treating vaso-occlusive sickle-cell disease |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE636817A (es) * | 1962-08-31 | |||
US3310471A (en) * | 1965-05-13 | 1967-03-21 | Upjohn Co | Placental lactogenic factor process |
US3409605A (en) * | 1965-06-15 | 1968-11-05 | American Cyanamid Co | Concentration and purification of growth factor-placental origin (human) |
BE787961A (fr) * | 1971-08-24 | 1973-02-26 | Behringwerke Ag | Procede d'isolement d'une matiere thromboplastique et medicament contenant ladite matiere |
DE2640387C3 (de) * | 1976-09-08 | 1981-01-22 | Behringwerke Ag, 3550 Marburg | Gewebespezifisches Protein und Verfahren zu dessen Herstellung |
DE2720704C2 (de) * | 1977-05-07 | 1986-09-25 | Behringwerke Ag, 3550 Marburg | Neues Glycoprotein, Verfahren zu seiner Herstellung und seine Verwendung |
IT1114943B (it) * | 1977-12-27 | 1986-02-03 | Sclavo Inst Sieroterapeut | Processo per la preparazione di somatomammotropina corionica umana |
DE2842467A1 (de) * | 1978-09-29 | 1980-04-10 | Behringwerke Ag | Neues ubiquitaeres gewebsprotein pp tief 8 |
DE2952792A1 (de) * | 1979-12-31 | 1981-07-02 | Behringwerke Ag, 3550 Marburg | Neues protein (pp(pfeil abwaerts)15(pfeil abwaerts)) mit immunsuppressiver wirkung |
DE3230996A1 (de) * | 1982-08-20 | 1984-02-23 | Behringwerke Ag, 3550 Marburg | Neues protein (pp(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)3(pfeil abwaerts)), verfahren zu seiner anreicherung und gewinnung sowie seine verwendung |
DE3315000A1 (de) * | 1983-04-26 | 1984-10-31 | Behringwerke Ag, 3550 Marburg | Gewebeprotein pp(pfeil abwaerts)4(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung |
JPS6019719A (ja) * | 1983-07-15 | 1985-01-31 | Asahi Chem Ind Co Ltd | 抗腫瘍活性を有する蛋白質 |
DE3338480A1 (de) * | 1983-10-22 | 1985-05-02 | Behringwerke Ag, 3550 Marburg | Neues protein pp(pfeil abwaerts)2(pfeil abwaerts)(pfeil abwaerts)0(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung |
JPS60152421A (ja) * | 1984-01-23 | 1985-08-10 | Sanwa Kagaku Kenkyusho:Kk | ヒト胎盤性プラスミノ−ゲン活性化因子、及びそれとヒトプラスミノ−ゲン活性化阻害因子との結合物、及びそれらの製法 |
DE3404563A1 (de) * | 1984-02-09 | 1985-08-14 | Behringwerke Ag, 3550 Marburg | Gewebeprotein pp(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)9(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung |
EP0182929A1 (de) * | 1984-11-26 | 1986-06-04 | American Hospital Supply Corporation | Koaktivator zur Aktivierung von Protein C |
-
1986
- 1986-09-17 CA CA000518372A patent/CA1265446A/en not_active Expired - Lifetime
- 1986-09-19 US US06/909,296 patent/US4732891A/en not_active Expired - Lifetime
- 1986-09-25 JP JP22705086A patent/JPH0710880B2/ja not_active Expired - Lifetime
- 1986-09-27 KR KR1019860008120A patent/KR940003751B1/ko not_active IP Right Cessation
- 1986-09-29 ES ES8602284A patent/ES2001707A6/es not_active Expired
- 1986-09-29 DE DE8686113375T patent/DE3676148D1/de not_active Expired - Lifetime
- 1986-09-29 EP EP86113375A patent/EP0217341B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR940003751B1 (ko) | 1994-04-30 |
EP0217341B2 (en) | 1997-12-17 |
KR870002848A (ko) | 1987-04-13 |
EP0217341A2 (en) | 1987-04-08 |
EP0217341B1 (en) | 1990-12-12 |
JPS62174023A (ja) | 1987-07-30 |
JPH0710880B2 (ja) | 1995-02-08 |
US4732891A (en) | 1988-03-22 |
DE3676148D1 (de) | 1991-01-24 |
CA1265446A (en) | 1990-02-06 |
EP0217341A3 (en) | 1988-04-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
SA6 | Expiration date (snapshot 920101) |
Free format text: 2006-09-29 |
|
FD1A | Patent lapsed |
Effective date: 20060930 |