EP3831422B1 - Vorrichtung zur herstellung einer wasserstoffhaltigen peritonealdialyseflüssigkeit - Google Patents

Vorrichtung zur herstellung einer wasserstoffhaltigen peritonealdialyseflüssigkeit Download PDF

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Publication number
EP3831422B1
EP3831422B1 EP19861576.7A EP19861576A EP3831422B1 EP 3831422 B1 EP3831422 B1 EP 3831422B1 EP 19861576 A EP19861576 A EP 19861576A EP 3831422 B1 EP3831422 B1 EP 3831422B1
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EP
European Patent Office
Prior art keywords
hydrogen
dialysate
air supply
supply module
peritoneal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP19861576.7A
Other languages
English (en)
French (fr)
Other versions
EP3831422A1 (de
EP3831422A4 (de
Inventor
Takashi Tachibana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Trim Co Ltd
Original Assignee
Nihon Trim Co Ltd
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Publication date
Application filed by Nihon Trim Co Ltd filed Critical Nihon Trim Co Ltd
Publication of EP3831422A1 publication Critical patent/EP3831422A1/de
Publication of EP3831422A4 publication Critical patent/EP3831422A4/de
Application granted granted Critical
Publication of EP3831422B1 publication Critical patent/EP3831422B1/de
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/243—Dialysis
    • B01D61/244—Dialysis comprising multiple dialysis steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A61M1/287—Dialysates therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/243—Dialysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/90—Additional auxiliary systems integrated with the module or apparatus

Definitions

  • Patent Document 1 Japanese Patent No. 4486157
  • JP 2016 077675 A discloses a peritoneal dialysis fluid manufacturing device including: a container having hydrogen permeability with a pre-set capacity; dialysis fluid accommodated in the container; a hydrogen water storage tank in which the container in which the dialysis fluid is accommodated is immersed for storing hydrogen water containing hydrogen supplied to the dialysis fluid; a hydrogen water generation device connected to the hydrogen water storage tank for generating the hydrogen water; and a circulation passage for circulating the hydrogen water between the hydrogen water storage tank and the hydrogen water generation device.
  • the apparatus for manufacturing hydrogen-containing peritoneal dialysate of the present invention includes: a dialysate bag housing dialysate to be injected into a peritoneal cavity of a patient; and a hydrogen dissolution device interposed between the dialysate bag and the patient and configured to dissolve hydrogen in the dialysate, wherein the hydrogen dissolution device includes: an air supply module connected to the dialysate bag and the patient and configured to dissolve hydrogen in the dialysate; and a hydrogen supply device connected to the air supply module and configured to supply hydrogen to the air supply module.
  • the air supply module body 11 is provided with a hydrogen supply port 12, and hydrogen gas is supplied to the outside of the supply tube 10 by the hydrogen supply device 8 through the hydrogen supply port 12.
  • the hydrogen supply device 8 is not particularly limited as long as it can supply hydrogen to the air supply module 7.
  • a hydrogen generator that electrolyzes water
  • a hydrogen generating agent such as magnesium hydride that reacts with water to generate hydrogen
  • a hydrogen gas cylinder, and the like can be used.
  • the peritoneal dialysis apparatus 40 includes a dialysis apparatus body 41, a supply tube 42 into which the manufactured dialysate 27 is introduced and supplies the dialysate 27 to the dialysis apparatus body 41, and a dialysis catheter 43 connected to the dialysis apparatus body 41 and the peritoneal cavity of a patient 50 and supplying the dialysate 27 to the patient 50. Further, the peritoneal dialysis apparatus 40 includes a waste fluid treatment tank 44 for discarding unused dialysate 27, and a connecting tube 45 connecting the dialysis apparatus body 41 and the waste fluid treatment tank 44.
  • the dialysate 27 is supplied to the dialysis apparatus body 41 via the supply tube 42. Then, the dialysate 27 is injected into the peritoneal cavity of the patient 50 via the dialysis catheter 43 by the dialysis apparatus body 41, which is an injection treatment, and the dialysate 27 is drained from the peritoneal cavity, which is a drainage treatment.
  • the dialysate 27 supplied with hydrogen is supplied to the peritoneal dialysis apparatus 40, the dialysate 27 thus supplied is supplied from the peritoneal dialysis apparatus 40 to the patient 50, and thus the blood of the patient 50 is purified.
  • the hydrogen dissolution device 6 dissolving hydrogen in the dialysate 27 is provided between the dialysate bag 4 and the peritoneal dialysis apparatus 40.
  • dialysate 27 including hydrogen while performing peritoneal dialysis, thereby improving convenience of the peritoneal dialysis.
  • dialysate 27 excellent in terms of hygiene can be obtained.
  • the hydrogen dissolution device 6 only includes the air supply module 7 dissolving hydrogen in the dialysate 27 and the hydrogen supply device 8 supplying hydrogen to the air supply module 7, and thus can supply hydrogen to the dialysate 27 with a simple configuration.
  • the air supply module 7 having the supply tube 10 is used to bring hydrogen into contact with the dialysate 27 to dissolve the hydrogen, and thus hydrogen can be efficiently supplied.
  • the supply tube 10 is wound in a roll shape and housed in the air supply module body 11. This configuration increases a contact area between the supply tube 10 and hydrogen and allows hydrogen to be supplied to the dialysate 27 even more efficiently.
  • an air supply module having a plurality of hollow fibers connected to the dialysate bag 4 and the peritoneal dialysis apparatus 40 may be used.
  • the dialysate 27 housed in the dialysate bag 4 is supplied to the inside of the hollow fibers, and hydrogen is supplied to the outside of the hollow fibers by the hydrogen supply device 8.
  • the air supply module 7 including the supply tube 10 and the air supply module body 11 shown in FIGS. 2 to 3 is used in terms of efficiency in dissolving hydrogen in the dialysate 27 by increasing an atmospheric pressure of the supplied hydrogen gas in a small amount.
  • the dialysate 27 is supplied from the peritoneal dialysis apparatus 40 to the patient 50.
  • the dialysate bag 4 may be connected to a tube (catheter) arranged in the patient 50, and the dialysate 27 housed in the dialysate bag 4 may be directly injected into the peritoneal cavity of the patient 50. In such a configuration, the same effect as that of the above embodiment can be obtained.

Landscapes

  • Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Water Supply & Treatment (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • External Artificial Organs (AREA)

Claims (1)

  1. Vorrichtung (1) zur Herstellung einer wasserstoffhaltigen Peritonealdialyseflüssigkeit, wobei die Vorrichtung (1) umfasst:
    einen Dialyseflüssigkeitsbeutel (4), der eine Dialyseflüssigkeit (27) aufnimmt, die in eine Peritonealhöhle eines Patienten injiziert werden soll; und
    ein Wasserstofflösungsgerät (6), das zwischen dem Dialyseflüssigkeitsbeutel (4) und dem Patienten eingeschoben ist und dazu konfiguriert ist, Wasserstoff in der Dialyseflüssigkeit (27) zu lösen, wobei
    das Wasserstofflösungsgerät (6) beinhaltet: Ein Luftzufuhrmodul (7), das mit dem Dialyseflüssigkeitsbeutel (4) und dem Patienten verbunden ist und dazu konfiguriert ist, Wasserstoff in der Dialyseflüssigkeit (27) zu lösen; und ein Wasserstoffzufuhrgerät (8), das mit dem Luftzufuhrmodul (7) verbunden ist und dazu konfiguriert ist, dem Luftzufuhrmodul (7) Wasserstoff zuzuführen,
    das Luftzufuhrmodul (7) beinhaltet: Einen Zufuhrschlauch (10), der mit dem Dialyseflüssigkeitsbeutel (4) und dem Patienten verbunden ist und dazu konfiguriert ist, dem Patienten die Dialyseflüssigkeit (27) zuzuführen; und ein Luftzufuhrmodulgehäuse (11), das mit dem Wasserstoffzufuhrgerät (8) verbunden ist, den Zufuhrschlauch (10) aufnimmt und dazu konfiguriert ist, dass ihm der Wasserstoff zugeführt wird,
    der Wasserstoff bei der innerhalb des Zufuhrschlauchs (10) zugeführten Dialyseflüssigkeit (27) der Dialyseflüssigkeit (27) durch Leiten innerhalb des Luftzufuhrmodulgehäuses (11) und außerhalb des Zufuhrschlauchs (10) zugeführt wird, und dadurch gekennzeichnet, dass
    der Zufuhrschlauch (10) auf eine rollenartige Weise gewickelt wird und in dem Luftzufuhrmodulgehäuse (11) aufgenommen wird.
EP19861576.7A 2018-09-21 2019-07-08 Vorrichtung zur herstellung einer wasserstoffhaltigen peritonealdialyseflüssigkeit Active EP3831422B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018176943 2018-09-21
PCT/JP2019/027051 WO2020059259A1 (ja) 2018-09-21 2019-07-08 水素含有腹膜透析液の製造装置

Publications (3)

Publication Number Publication Date
EP3831422A1 EP3831422A1 (de) 2021-06-09
EP3831422A4 EP3831422A4 (de) 2021-09-15
EP3831422B1 true EP3831422B1 (de) 2022-09-21

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ID=69888648

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Application Number Title Priority Date Filing Date
EP19861576.7A Active EP3831422B1 (de) 2018-09-21 2019-07-08 Vorrichtung zur herstellung einer wasserstoffhaltigen peritonealdialyseflüssigkeit

Country Status (4)

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EP (1) EP3831422B1 (de)
JP (1) JP7104797B2 (de)
CN (1) CN112638440A (de)
WO (1) WO2020059259A1 (de)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009125654A (ja) * 2007-11-22 2009-06-11 Bio Research Inc 飲料用水素含有水の製造方法
JP4967001B2 (ja) 2009-03-13 2012-07-04 ミズ株式会社 水素含有生体適用液の製造方法、及びそのための装置
JP2014161605A (ja) 2013-02-27 2014-09-08 Nippon Torimu:Kk 水素付加装置および腹膜透析装置
CN103432164B (zh) * 2013-09-11 2015-12-09 华仁药业股份有限公司 腹膜透析液及其制备方法
JP5840248B2 (ja) * 2014-03-19 2016-01-06 株式会社日本トリム 透析液の製造装置
JP2016077675A (ja) * 2014-10-20 2016-05-16 株式会社日本トリム 腹膜透析液の製造装置
CN204563092U (zh) * 2015-02-11 2015-08-19 汪玲果 腹膜透析装置
CN205612789U (zh) * 2016-01-21 2016-10-05 李涛 一种腹膜透析装置
JP5940753B1 (ja) * 2016-03-07 2016-06-29 株式会社日本トリム 水素含有腹膜透析液の製造装置

Also Published As

Publication number Publication date
WO2020059259A1 (ja) 2020-03-26
CN112638440A (zh) 2021-04-09
EP3831422A1 (de) 2021-06-09
JP7104797B2 (ja) 2022-07-21
EP3831422A4 (de) 2021-09-15
JPWO2020059259A1 (ja) 2021-08-30

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