EP3631434A1 - Driftröhre für ionenbeweglichkeitsspektrometr mit integrierter multikapillarsäule - Google Patents
Driftröhre für ionenbeweglichkeitsspektrometr mit integrierter multikapillarsäuleInfo
- Publication number
- EP3631434A1 EP3631434A1 EP18729604.1A EP18729604A EP3631434A1 EP 3631434 A1 EP3631434 A1 EP 3631434A1 EP 18729604 A EP18729604 A EP 18729604A EP 3631434 A1 EP3631434 A1 EP 3631434A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- drift
- capillary column
- drift tube
- driftröhre
- ion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 206010002091 Anaesthesia Diseases 0.000 claims abstract description 4
- 230000037005 anaesthesia Effects 0.000 claims abstract description 4
- 239000012212 insulator Substances 0.000 claims description 10
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 6
- 230000005526 G1 to G0 transition Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 2
- 239000011521 glass Substances 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 238000001949 anaesthesia Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 description 44
- 230000005684 electric field Effects 0.000 description 20
- 230000004888 barrier function Effects 0.000 description 13
- 239000007789 gas Substances 0.000 description 10
- 238000001514 detection method Methods 0.000 description 8
- 239000012491 analyte Substances 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000000306 component Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001871 ion mobility spectroscopy Methods 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 238000000451 chemical ionisation Methods 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000007792 gaseous phase Substances 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000012855 volatile organic compound Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4821—Determining level or depth of anaesthesia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
- H05H7/22—Details of linear accelerators, e.g. drift tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
- A61B2560/0247—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/029—Humidity sensors
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H1/00—Generating plasma; Handling plasma
- H05H1/24—Generating plasma
- H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
- H05H1/2443—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes the plasma fluid flowing through a dielectric tube
- H05H1/2465—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes the plasma fluid flowing through a dielectric tube the plasma being activated by inductive coupling, e.g. using coiled electrodes
Definitions
- the invention relates to an electrode arrangement for a drift tube in one
- Ion mobility spectrometer which is used to monitor anesthesia of a patient during a medical procedure, with a multi-capillary column integrated in the drift tube.
- An ion mobility spectrometer / ion mobility spectrometer is a device for chemical analysis of the
- Composition of gases in the trace range preferably in the range of ng / L to pg / L or ppm v to ppt v ; for volatile organic compounds - preferably in air, nitrogen, carbon dioxide.
- Fields of application are the detection, detection,
- ionization can be carried out by means of radioactive radiation sources, preferably 63 Ni or 3 H, laser, UV light, surface charges or chemical ionization.
- Ion mobility spectrometry is based on the fact that under normal pressure, strictly under ambient pressure generated ions in an electric field against the
- drift gas drift Flow direction of a so-called drift gas drift. Ions of different mass and / or structure absorb energy in the electric field and continuously lose it by collisions with the surrounding air molecules and thus reach comparatively quickly uniform, different drift velocities for each ion species and are ideally separated from one another until they are consecutively timed
- Vdr KE (vdr ftspeed, K elonenmobiltician, E electric field strength).
- the separation of the ions of different analytes over a given distance based on the different drift velocities is referred to as ion mobility spectrometry, where ion current is measured as the time of arrival on the Faraday plate as a function of the drift time.
- Signal intensity of the current on the Faraday plate is a measure of the concentration of the respective analyte.
- the molecules are sampled in their gaseous phase by an ion source, e.g. by means of a radioactive radiation source, a photoionizer (usually 10.6 or 1 1 .8 eV UV lamps or lasers of different wavelengths) or electrical discharges
- the barrier grid for a short period of time, usually between a few s and 1 ms opens and so the electrical transverse field (between the wires of the barrier grid) no longer greater than the longitudinal electrical field of lonisations- and drift space, allowing ions to pass through the barrier.
- Detection device can its drift time and with knowledge of Driftweges (distance barrier grid to Faraday plate) and the constant electric field the
- ionic mobility constant K can be calculated.
- their specific mass can be derived from mobility, which is not usually important. It is essential that different ions of different analytes are detected and in the ideal case can be characterized over the time of drift, which is usually not the case, so that
- the entire drift tube is provided with metal rings / drift rings / annular electrodes, which are usually arranged at regular intervals over the length of the drift tube.
- Electrodes are electrical, e.g. isolated by isolators and by means of
- Resistors are connected together or are e.g. placed externally on a cylindrical drift tube at fixed intervals and then connected to electrical resistors.
- the electrodes connected to a high voltage source generate a linear potential gradient / field gradient across the ionization and drift space at a value of about 100 to 500 V / cm along a central axis of the drift tube.
- the ions in the drift tube move in an axial direction toward the Faraday plate.
- the tubes are constructed in the form of a stack of metal and insulator rings, or electrodes are placed on cylindrical insulators at specific intervals.
- the individual metal rings receive different potentials, whereby any gradients can be set.
- the voltages vary between 1000 and 10000 V, so that, depending on the drift paths, electric field strengths of 100 to 500 V / cm result in the tube.
- the homogeneity of the electric field depends on the radius of the metal rings and their distances from one another, assuming that this applies to the region where the drift velocity is linear to the electric field strength.
- the drift tube is traversed by a drift gas, in the simplest case of air, from the direction of the Faraday plate.
- the drift gas is introduced into the drift region to collide with the sample ions to produce a drift velocity that is ideally unique to each ion. It also prevents uncharged
- Analyte molecules can pass through the barrier, since then the start position would no longer be defined for each type of ion, that is, the drift path would be different. Sometimes a side effect is that the surfaces of the drift tube from there
- Arrived detection device are measured according to their intensity (usually current measurements, alternatively voltage drop across a high-impedance resistor) at an arrival time.
- the detection device analyzes the maxima of the signal intensities to represent a motion signature (a fingerprint) for identification of the sample ions to be determined.
- a barrier grid separates the reaction area / ionization area / reaction space, reaction space in which all the ionization processes take place, and the
- the grid controls the inlet of the ions at certain periodic time intervals.
- a pulsed signal preferably square wave signal, determines the short
- Lattice opening and the longer closing time Two different lattice types are used. While the Tyndall grating consists of two consecutive grids with parallel wires, the Bradbury-Nielsen grating is arranged in one plane, which is not significant for the basic operation. The grid is "open" when the barrier grid has the potential which prevails at the location of the tube (sloping longitudinally towards the Faraday plate)
- the electric field is not disturbed, so that the ions can pass through the grid unhindered. If an additional field is built up between the two sets of wires, which forms perpendicular to the existing field, the grid will "close", since then the electrical cross-field between the wires will be larger than the longitudinal field to the Faraday plate.
- the ions can not pass the grid Depending on their polarity, they migrate to the positive or negative part of the grid and are neutralized or they are flushed out with the drift gas until a new pulse briefly opens the grid again and allows a portion of the ion cloud to enter the drift space The shorter the pulse width at which the grating is opened, the sharper the temporal resolution of the signal, but the smaller it is the signal as such, since the total amount of ions, which by the grating passes is also smaller.
- the barrier grid has a pulse duration of a few microseconds to milliseconds, during which the ions can enter the drift region. After this When the ions enter the drift region, the ions move in the direction of a detection device under the influence of an electric field. Due to the electric field, the ions with different mass and / or structure will reach different drift velocities and thus different
- Time points of the detector registered.
- a recorded ion mobility spectrum thus contains time-dependent current signals.
- this so-called screening grid aperture grid
- the electrometer plate connected downstream as a detector is shielded from the electric field of the incoming ions. If this grid is missing, the detector would not only register the impacting ion charges, but also the approaching ions, which would increase
- a gas chromatographic column is placed in front of the IMS, and a multi-capillary column (MCC) for pre-separation of the gas mixture is also connected upstream in respiratory air examinations.
- MCC multi-capillary column
- This MCC consists of a large number of bundled single capillaries that retain different analytes of different lengths for the same length of time in each individual capillary.
- the measurement data get another dimension: the retention time, which describes the respective delay of the movement of the analytes through the gas chromatographic column.
- multicapillary columns a large number of capillaries are bundled (up to thousands), each with a diameter of
- a multi-capillary column allows a fast and high-resolution analysis at a high flow rate, but above all it can be applied with sample volumes in the range of ⁇ _ to ml_, in particular with moist samples, as in regular breathing air analyzes
- Multi-capillary columns are known in which both components are realized separately in one device.
- An object of the invention is therefore to provide a compact and lightweight analyzer.
- a drift tube has a cylindrical body, in the wall of which at least one multi-capillary column, preferably parallel to the longitudinal axis, is arranged / formed / inserted.
- a drift tube of an ion mobility spectrometer provided and adapted for use in a medical field, preferably in a
- Respiratory gas analyzer a cylindrical body.
- the cylindrical body is at least one, preferably radially centered, through bore /
- Passage opening arranged, which forms the lonisations Scheme and at least one further, preferably parallel, through-hole / passage opening to
- the multi-capillary column has a temperature control element for controlling the temperature in the multi-capillary column.
- a temperature control element for controlling the temperature in the multi-capillary column.
- the temperature control element is provided and adapted to control the temperature of the multi-capillary column.
- a side effect here is that thereby the passage opening, in which the drift region is located, can be temperature controlled indirectly.
- Particularly preferred is a plurality, preferably four, of MCC having through holes around the
- the multi-capillary column is thermally insulated.
- a thermally insulating material / insulator is mounted, preferably annular around the multi-capillary column.
- the thermal insulation is arranged in a ring around the temperature control element of the multi-capillary column.
- Temperature control element as well as the thermal insulator to be made of a non-metallic material. Because electrodes for generating an electric field are formed on the drift tube, a metallic object can disturb this field, or an unintended eddy current can be induced in this object.
- the components multicapillary column, the temperature control element, the thermal insulator are preferably made of a non-conductive / non-metallic
- Material particularly preferably of glass and / or plastic.
- the multicapillary column has a stationary phase, preferably silica gel / alumina, and / or a mobile phase, preferably Hexane / ethyl acetate / dichloromethane / methanol, on.
- the stationary phase can fill the capillaries of the multicapillary columns and / or be attached to the inner wall of the capillaries.
- the multi-capillary column has a frit at its output end. This frit serves as a filter to prevent inadvertently introduced elements distorting the measurement or the
- Such elements include, for example, parts of the stationary phase or foreign bodies / impurities.
- Ion mobility spectrometer which is used to monitor anesthesia of a patient during a medical procedure, a drift tube according to one of the preceding embodiments.
- Embodiment is exemplified, described in more detail.
- Fig. 1 shows a schematic side view of a drift tube according to the invention.
- Fig. 2 shows a schematic side cross-sectional view of a drift tube according to the invention.
- Fig. 3 shows a schematic front view of a drift tube according to the invention.
- FIG. 3 Front view of a drift tube according to the invention from FIG. 3.
- FIG. 1 shows a schematic side view of a drift tube 1 according to the invention.
- the drift tube 1 has a first end 2 or end portion and a second end 4 or end portion, which are interconnected via a central tube 6. Both the first and second ends 2 and 4 are cylindrically shaped, but with The first and second ends 2 and 4f have an outer diameter which is larger than the outer diameter of the central tube 6. The ends 2 and 4 serve to fix the drift tube 1 to a housing (not shown). Through the first end 2, second end 4 and the central tube 6 performs a through hole 8 therethrough. On the lateral surface of the central tube 8 of the drift tube 1, preferably three ring electrodes 10 are arranged at the same distance in the present case. Parallel to the through hole 8, the
- FIG. 2 is a schematic side cross-sectional view of a drift tube 1 according to the invention. Parallel to the through hole 8, which has the drift region, the further through holes 12 are therefore shown, each having a
- an ionization source 16 In the through-hole 8, which forms the drift channel, from the one end 2 to the second end 4 in the sequence, an ionization source 16, a barrier grille 18, a shielding grid 20 and a detector 22 are introduced.
- the first ring electrode 10 is located at the same height of the longitudinal axis of the drift tube as the barrier grille 18.
- the last ring electrode 10 is located at the same height of the longitudinal axis of the drift tube as the screening grid 20 of the detector 22.
- Fig. 3 shows a schematic front view of the drift tube 1 according to the invention. In this case, four more are around the through hole 8 for the drift region
- Through holes 12 for receiving a multi-capillary 14 evenly distributed around them. That is, the through-holes 12 for accommodating each of a multi-capillary column 14 are arranged radially further outside than an inner wall of the through-hole 8 for the drift region and distributed in the wall of the drift tube 1 equiangularly. 4 shows an enlarged view of a partial region of the schematic
- FIG. 3 Front view of a drift tube 1 according to the invention of Figure 3.
- a temperature control element 24 for example a heater (Within the Driftröhrenwandung) is arranged, which in turn is surrounded by a thermal insulator 26.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physiology (AREA)
- Pulmonology (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102017111459 | 2017-05-24 | ||
PCT/EP2018/063723 WO2018215621A1 (de) | 2017-05-24 | 2018-05-24 | Driftröhre für ionenbeweglichkeitsspektrometr mit integrierter multikapillarsäule |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3631434A1 true EP3631434A1 (de) | 2020-04-08 |
Family
ID=64395376
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18728563.0A Withdrawn EP3631433A1 (de) | 2017-05-24 | 2018-05-24 | Driftröhre mit modifizierter oberflächengüte zur verwendung in einem ionenbeweglichkeitsspektrometer |
EP18728562.2A Active EP3629917B1 (de) | 2017-05-24 | 2018-05-24 | Analysevorrichtung zum analysieren von exspirationsluft |
EP18728081.3A Withdrawn EP3629916A1 (de) | 2017-05-24 | 2018-05-24 | Elektrodenanordnung für eine driftröhre |
EP18729604.1A Withdrawn EP3631434A1 (de) | 2017-05-24 | 2018-05-24 | Driftröhre für ionenbeweglichkeitsspektrometr mit integrierter multikapillarsäule |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18728563.0A Withdrawn EP3631433A1 (de) | 2017-05-24 | 2018-05-24 | Driftröhre mit modifizierter oberflächengüte zur verwendung in einem ionenbeweglichkeitsspektrometer |
EP18728562.2A Active EP3629917B1 (de) | 2017-05-24 | 2018-05-24 | Analysevorrichtung zum analysieren von exspirationsluft |
EP18728081.3A Withdrawn EP3629916A1 (de) | 2017-05-24 | 2018-05-24 | Elektrodenanordnung für eine driftröhre |
Country Status (6)
Country | Link |
---|---|
US (1) | US20200170571A1 (de) |
EP (4) | EP3631433A1 (de) |
CN (3) | CN110678121B (de) |
ES (1) | ES2890574T3 (de) |
RU (1) | RU2761078C2 (de) |
WO (4) | WO2018215622A1 (de) |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2217103B (en) * | 1988-04-06 | 1992-09-23 | Graseby Ionics Ltd | Ion mobility detector |
DE4130810C1 (de) * | 1991-09-17 | 1992-12-03 | Bruker Saxonia Analytik Gmbh, O-7050 Leipzig, De | |
US6509562B1 (en) * | 1999-09-16 | 2003-01-21 | Rae Systems, Inc. | Selective photo-ionization detector using ion mobility spectrometry |
DE10121262A1 (de) * | 2001-04-30 | 2002-11-14 | Siemens Ag | Vorrichtung zur quantitativen Messung von Stickoxiden in der Ausatemluft und Verwendung |
ITMI20011193A1 (it) * | 2001-06-06 | 2002-12-06 | Getters Spa | Metodo per la misura mediante spettroscopia di mobilita' ionica dellaconcentrazione di acqua in argon, idrogeno, azoto e elio |
US6685803B2 (en) * | 2001-06-22 | 2004-02-03 | Applied Materials, Inc. | Plasma treatment of processing gases |
US7155812B1 (en) * | 2002-09-05 | 2007-01-02 | Sandia Corporation | Method for producing a tube |
DE102006006683B4 (de) * | 2006-02-14 | 2008-02-21 | Bruker Daltonik Gmbh | Driftröhre für ein Ionenmobilitätsspektrometer mit integriertem Gaskanal |
CN101093211B (zh) * | 2006-06-21 | 2010-05-12 | 中国科学院电子学研究所 | 用于离子迁移率谱仪漂移管的瞬态漂移电场方法 |
JP4677530B2 (ja) * | 2006-12-12 | 2011-04-27 | 国立大学法人大阪大学 | プラズマ生成装置およびプラズマ生成方法 |
DE102007033906A1 (de) * | 2007-07-20 | 2009-01-29 | Gesellschaft zur Förderung der Analytischen Wissenschaften e.V. | Verfahren zur Analyse von Gasen, insbesondere zur Analyse der menschlichen Ausatemluft |
US7880137B2 (en) * | 2007-12-28 | 2011-02-01 | Morpho Detection, Inc. | Electrode design for an ion spectrometer |
US7709788B2 (en) * | 2007-12-31 | 2010-05-04 | Implant Sciences Corporation | Chemical calibration method and system |
DE102008027630A1 (de) * | 2008-06-05 | 2009-12-10 | Filt Lungen- Und Thoraxdiagnostik Gmbh | Transportabler Pneumotachograph zur Messung von Bestandteilen des Exspirationsvolumens |
JP5473001B2 (ja) * | 2009-10-16 | 2014-04-16 | コリア・インスティテュート・オブ・マシナリー・アンド・マテリアルズ | 汚染物質除去用プラズマ反応器及び駆動方法 |
BR112012018936A2 (pt) * | 2010-01-29 | 2017-06-20 | Univ Nebraska | analisador raman, método para analisar luz emitida deuma célula raman e método de diagnosticar um problema de saúde |
WO2011157781A1 (de) * | 2010-06-17 | 2011-12-22 | Step Sensortechnik Und Elektronik Pockau Gmbh | Verfahren für die ionenmobilitätsspektrometrie |
EP2428797B1 (de) * | 2010-09-14 | 2016-05-18 | Airsense Analytics GmbH | Vorrichtung zur detektion und identifizierung von gasen mittels ionenmobilitätsspektrometrie |
US8922219B2 (en) * | 2010-11-30 | 2014-12-30 | General Electric Company | Photo-ionization detectors and associated methods thereof |
CN102539513A (zh) * | 2010-12-09 | 2012-07-04 | 苏州生物医学工程技术研究所 | 一种用于患者疾病的无创检测装置及其检测方法 |
ITMI20110535A1 (it) * | 2011-03-31 | 2012-10-01 | Simone Cristoni | Sistema di analisi per l'analisi chimica quantitativa di campioni, in particolare in ambito medico, con calibrazione della risposta strumentale della strumentazione utilizzata per rilevare i dati quantitativi degli analiti presenti nei campioni anali |
JP2014514574A (ja) * | 2011-04-27 | 2014-06-19 | インプラント サイエンシーズ コーポレイション | Faimsセルを組み込んだイオン移動度分光分析装置 |
US9089279B2 (en) * | 2011-12-29 | 2015-07-28 | General Electric Company | Ion-based breath analysis system |
DE102013112921A1 (de) * | 2013-11-22 | 2015-05-28 | IMSPEX DIAGNOSTICS Ltd. | Verfahren zur Messung der menschlichen Ausatemluft mittels Gaschromatografie-Ionenmobilitätsspektrometrie |
DE202013105685U1 (de) * | 2013-12-13 | 2015-03-17 | B & S Analytik Gmbh | Ionenbeweglichkeitsspektrometer |
CN103776893B (zh) * | 2014-02-17 | 2016-09-21 | 哈尔滨工业大学(威海) | 一种介质阻挡放电电离源离子迁移谱仪 |
CN105353023B (zh) * | 2014-08-20 | 2018-10-16 | 布鲁克道尔顿公司 | 离子迁移谱迁移轴校正方法和仪器 |
CN107249708B (zh) * | 2014-12-24 | 2020-10-20 | 生物统计股份有限公司 | 微型护理点气相色谱测试条和测量分析物的方法 |
CN107093546B (zh) * | 2014-12-31 | 2019-03-19 | 同方威视技术股份有限公司 | 检测设备和检测方法 |
US20180172635A1 (en) * | 2016-12-15 | 2018-06-21 | Rapiscan Systems, Inc. | Methods and devices for moisture-based calibration |
-
2018
- 2018-05-24 WO PCT/EP2018/063724 patent/WO2018215622A1/de unknown
- 2018-05-24 EP EP18728563.0A patent/EP3631433A1/de not_active Withdrawn
- 2018-05-24 WO PCT/EP2018/063721 patent/WO2018215619A1/de unknown
- 2018-05-24 US US16/616,057 patent/US20200170571A1/en not_active Abandoned
- 2018-05-24 EP EP18728562.2A patent/EP3629917B1/de active Active
- 2018-05-24 CN CN201880033302.5A patent/CN110678121B/zh not_active Expired - Fee Related
- 2018-05-24 CN CN201880034232.5A patent/CN110662959A/zh active Pending
- 2018-05-24 EP EP18728081.3A patent/EP3629916A1/de not_active Withdrawn
- 2018-05-24 ES ES18728562T patent/ES2890574T3/es active Active
- 2018-05-24 RU RU2019143086A patent/RU2761078C2/ru active
- 2018-05-24 WO PCT/EP2018/063723 patent/WO2018215621A1/de unknown
- 2018-05-24 WO PCT/EP2018/063720 patent/WO2018215618A1/de unknown
- 2018-05-24 CN CN201880034219.XA patent/CN110662486A/zh active Pending
- 2018-05-24 EP EP18729604.1A patent/EP3631434A1/de not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CN110678121B (zh) | 2022-07-26 |
WO2018215618A1 (de) | 2018-11-29 |
WO2018215622A1 (de) | 2018-11-29 |
EP3629917A1 (de) | 2020-04-08 |
EP3631433A1 (de) | 2020-04-08 |
EP3629916A1 (de) | 2020-04-08 |
CN110662959A (zh) | 2020-01-07 |
RU2019143086A3 (de) | 2021-07-12 |
CN110678121A (zh) | 2020-01-10 |
WO2018215619A1 (de) | 2018-11-29 |
ES2890574T3 (es) | 2022-01-20 |
CN110662486A (zh) | 2020-01-07 |
EP3629917B1 (de) | 2021-07-21 |
RU2019143086A (ru) | 2021-06-24 |
WO2018215621A1 (de) | 2018-11-29 |
RU2761078C2 (ru) | 2021-12-03 |
US20200170571A1 (en) | 2020-06-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69030516T2 (de) | Ionenbeweglichkeitsspektrometer | |
DE102012008250B4 (de) | Ionenmobilitätsseparator für Massenspektrometer | |
EP2232252B1 (de) | Verfahren und vorrichtung zur detektion und identifizierung von gasen | |
DE102007017055B4 (de) | Messung der Mobilität massenselektierter Ionen | |
DE69219618T2 (de) | Coronaentladung-ionenquelle | |
DE102012004398B4 (de) | Spektrenaufnahmearten für Ionenfallen-Mobilitätsspektrometer | |
EP2428797B1 (de) | Vorrichtung zur detektion und identifizierung von gasen mittels ionenmobilitätsspektrometrie | |
DE19513459A1 (de) | Ionenmobilitätsspektrometer mit flexiblen gedruckten Leiterplatten und Verfahren zu dessen Herstellung | |
DE112013003813T5 (de) | Ionenmobilitätsspektrometer mit hohem Durchsatz | |
EP2405254B1 (de) | Optoelektronisches Verfahren zur Gasanalyse | |
DE4341699A1 (de) | Verfahren und Vorrichtung zur Flugzeitspektrometrie | |
DE102005007746B4 (de) | Ionenmobilitätsspektrometer mit parallel verlaufender Driftgas- und Ionenträgergasströmung | |
DE112014006538T5 (de) | Verfahren der gezielten massenspektrometrischen Analyse | |
RU2673792C2 (ru) | Двухполярный искровой источник ионов | |
EP3639289A2 (de) | Vorrichtung und verfahren zur ionisation eines analyten sowie vorrichtung und verfahren zur analyse eines ionisierten analyten | |
DE19635645C2 (de) | Verfahren für die hochauflösende Spektrenaufnahme von Analytionen in einem linearen Flugzeitmassenspektrometer | |
DE112016007051B4 (de) | Ionenanalysevorrichtung | |
EP0002430B1 (de) | Massenspektrometer | |
EP3631434A1 (de) | Driftröhre für ionenbeweglichkeitsspektrometr mit integrierter multikapillarsäule | |
DE2028805C3 (de) | Verfahren und Einrichtung zum Feststellen eines Gasbestandteils | |
DE112014002871B4 (de) | Massenspektrometer | |
DE102011121669B9 (de) | Identifizierung von Analyten mit einem Ionen-Mobilitäts-Spektrometer unter Bildung von Dimer-Analyten | |
WO2001055700A1 (de) | Vorrichtung zur analyse von in tröpfchenförmigen flüssigkeitsproben enthaltenen elementen | |
EP0533682B1 (de) | Verfahren und vorrichtung zum nachweisen von messubstanzen in einer umgebungssubstanz, insbesondere zum nachweisen gasförmiger kampfstoffe in umgebungsluft | |
DE202007010129U1 (de) | Vorrichtung zur Analyse von Gasen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: UNKNOWN |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20191218 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
17Q | First examination report despatched |
Effective date: 20220208 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20231201 |