EP3629916A1 - Elektrodenanordnung für eine driftröhre - Google Patents
Elektrodenanordnung für eine driftröhreInfo
- Publication number
- EP3629916A1 EP3629916A1 EP18728081.3A EP18728081A EP3629916A1 EP 3629916 A1 EP3629916 A1 EP 3629916A1 EP 18728081 A EP18728081 A EP 18728081A EP 3629916 A1 EP3629916 A1 EP 3629916A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- drift tube
- drift
- tube
- ions
- ring electrodes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 206010002091 Anaesthesia Diseases 0.000 claims description 3
- 230000037005 anaesthesia Effects 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000012811 non-conductive material Substances 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims 1
- 208000010513 Stupor Diseases 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 description 49
- 230000005684 electric field Effects 0.000 description 23
- 230000004888 barrier function Effects 0.000 description 13
- 238000001514 detection method Methods 0.000 description 10
- 239000007789 gas Substances 0.000 description 9
- 239000000306 component Substances 0.000 description 6
- 239000012491 analyte Substances 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000005855 radiation Effects 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000012212 insulator Substances 0.000 description 2
- 238000001871 ion mobility spectroscopy Methods 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 238000000451 chemical ionisation Methods 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000007792 gaseous phase Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000012855 volatile organic compound Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4821—Determining level or depth of anaesthesia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H7/00—Details of devices of the types covered by groups H05H9/00, H05H11/00, H05H13/00
- H05H7/22—Details of linear accelerators, e.g. drift tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
- A61B2560/0247—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/029—Humidity sensors
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H1/00—Generating plasma; Handling plasma
- H05H1/24—Generating plasma
- H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
- H05H1/2443—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes the plasma fluid flowing through a dielectric tube
- H05H1/2465—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes the plasma fluid flowing through a dielectric tube the plasma being activated by inductive coupling, e.g. using coiled electrodes
Definitions
- the invention relates to an electrode arrangement for a drift tube in one
- An ion mobility spectrometer which is used to monitor anesthesia of a patient during a medical procedure, with a drift tube of a reduced size.
- An ion mobility spectrometer / ion mobility spectrometer is a device for chemical analysis of the
- Composition of gases in the trace range preferably in the range of ng / L to pg / L or ppm v to ppt v ; for volatile organic compounds - preferably in air, nitrogen, carbon dioxide.
- Fields of application are the detection, detection,
- ionization can be carried out by means of radioactive radiation sources, preferably 63 Ni or 3 H, laser, UV light, surface charges or chemical ionization.
- Ion mobility spectrometry is based on the fact that under normal pressure, strictly under ambient pressure generated ions in an electric field against the
- drift gas drift Flow direction of a so-called drift gas drift. Ions of different mass and / or structure absorb energy in the electric field and continuously lose it by collisions with the surrounding air molecules and thus reach comparatively quickly uniform, different drift velocities for each ion species and are ideally separated from one another until they are consecutively timed
- ion mobility spectrometry The separation of the ions of different analytes over a given distance based on the different drift velocities is referred to as ion mobility spectrometry, where ion current is measured as the time of arrival on the Faraday plate as a function of the drift time.
- Signal intensity of the current on the Faraday plate (usually measured as a voltage drop across a high-impedance resistor) is a measure of the concentration of the respective analyte.
- the molecules are sampled in their gaseous phase by an ion source, e.g. by means of a radioactive radiation source, a photoionizer (usually 10.6 or 1 1 .8 eV UV lamps or lasers of different wavelengths) or electrical discharges
- a radioactive radiation source e.g. a radioactive radiation source
- a photoionizer usually 10.6 or 1 1 .8 eV UV lamps or lasers of different wavelengths
- the barrier grid for a short period of time, usually between a few s and 1 ms opens and so the electrical transverse field (between the wires of the barrier grid) no longer greater than the longitudinal electrical field of lonisations- and drift space, allowing ions to pass through the barrier.
- Detection device can its drift time and with knowledge of Driftweges (distance barrier grid to Faraday plate) and the constant electric field the
- ionic mobility constant K can be calculated.
- their specific mass can be derived from mobility, which is not usually important. It is essential that different ions of different analytes are detected and in the ideal case can be characterized over the time of drift, which is usually not the case, so that
- the entire drift tube is provided with metal rings / drift rings / annular electrodes, which are usually arranged at regular intervals over the length of the drift tube.
- Electrodes are electrical, e.g. isolated by isolators and by means of
- Resistors are connected together or are e.g. placed externally on a cylindrical drift tube at fixed intervals and then connected to electrical resistors.
- the electrodes connected to a high voltage source generate a linear potential gradient / field gradient across the ionization and drift space at a value of about 100 to 500 V / cm along a central axis of the drift tube.
- the ions in the drift tube move in an axial direction toward the Faraday plate.
- the tubes are constructed in the form of a stack of metal and insulator rings, or electrodes are placed on cylindrical insulators at specific intervals.
- the individual metal rings receive different potentials, whereby any gradients can be set.
- the voltages vary between 1000 and 10000 V, so that, depending on the drift paths, electric field strengths of 100 to 500 V / cm result in the tube.
- the homogeneity of the electric field depends on the radius of the metal rings and their distances from one another, assuming that this applies to the region where the drift velocity is linear to the electric field strength.
- the drift tube is traversed by a drift gas, in the simplest case of air, from the direction of the Faraday plate.
- the drift gas is introduced into the drift region to collide with the sample ions to produce a drift velocity that is ideally unique to each ion. It also prevents uncharged
- Analyte molecules can pass through the barrier, since then the start position would no longer be defined for each type of ion, that is, the drift path would be different. Sometimes a side effect is that the surfaces of the drift tube from there
- Arrived detection device are measured according to their intensity (usually current measurements, alternatively voltage drop across a high-impedance resistor) at an arrival time.
- the detection device analyzes the maxima of the signal intensities to represent a motion signature (a fingerprint) for identification of the sample ions to be determined.
- a barrier grid separates the reaction area / ionization area / reaction space, reaction space in which all the ionization processes take place, and the
- the grid controls the inlet of the ions at certain periodic time intervals.
- a pulsed signal preferably square wave signal, determines the short
- the Tyndall grating consists of two consecutive grids with parallel wires
- the Bradbury-Nielsen grating is arranged in one plane, which is not significant for the basic operation.
- the grid is "open" when the barrier has the potential at the location of the tube (decreasing longitudinally to the Faraday plate) In the vicinity of the grid wires, the electric field is not disturbed, so that the ions are the grid If an additional field is established between the two sets of wires, which forms perpendicular to the existing field, the grid will "close", since then the electrical cross-field between the wires will be larger than the longitudinal field towards the Faraday plate. The ions can not pass the grid.
- the barrier grid has a pulse duration of a few microseconds to milliseconds, during which the ions can enter the drift region. After this When the ions enter the drift region, the ions move in the direction of a detection device under the influence of an electric field. Due to the electric field, the ions with different mass and / or structure will reach different drift velocities and thus different
- Time points of the detector registered.
- a recorded ion mobility spectrum thus contains time-dependent current signals.
- this so-called screening grid aperture grid
- the electrometer plate connected downstream as a detector is shielded from the electric field of the incoming ions. If this grid is missing, the detector would not only register the impacting ion charges, but also the approaching ions, which would increase
- a gas chromatographic column is placed in front of the IMS, and a multi-capillary column (MCC) for pre-separation of the gas mixture is also connected upstream in respiratory air examinations.
- MCC multi-capillary column
- This MCC consists of a large number of bundled single capillaries that retain different analytes of different lengths for the same length of time in each individual capillary.
- the measurement data get another dimension: the retention time, which describes the respective delay of the movement of the analytes through the gas chromatographic column.
- multicapillary columns a large number of capillaries are bundled (up to thousands), each with a diameter of
- a multi-capillary column allows a fast and high-resolution analysis at a high flow rate, but above all it can be applied with sample volumes in the range of ⁇ _ to ml_, in particular with moist samples, as in regular breathing air analyzes
- Multi-capillary columns are known in which both components are realized separately in one device.
- An object of the invention is therefore to provide a compact and lightweight analyzer.
- IMS ion mobility spectrometers
- Components leads to a plurality of vulnerable components. Furthermore, a large construction of the drift tube is required by a large number of components, which in turn is associated with a high weight of the device.
- a drift tube having a central tube between a first and second axial end / end portions, a maximum of three ring electrodes, which on the lateral surface of the central tube along its longitudinal axis arranged / spaced.
- the ion mobility spectrometer preferably for use in one
- the drift tube has first and second end portions defining a longitudinal axis.
- the ion source serves to generate ions.
- a ring electrode is mounted substantially in the vicinity of a barrier grid, a ring electrode in
- the ring electrodes are wound around the drift tube, in a preferably circular shape.
- the ring electrodes generate a substantially uniform electric field / uniform potential gradient that conducts the ions through the drift tube.
- the annular electrodes are attached to the lateral surface of the central tube of the cylindrical drift tube. The attachment can be done by gluing to the lateral surface or by attaching the electrodes in grooves in the outer surface of the drift tube. The electrodes are thus axially fixed along the longitudinal axis of the drift tube.
- the drift tube is preferably made of a non-conductive material, preferably of a plastic.
- the drift tube is of a non-conductive housing, which allows the electric field of the ring electrodes to freely enter the drift tube.
- the ring electrodes preferably generate a linear potential gradient along the longitudinal axis of the drift tube.
- the control of the electric field is thus provided and adapted to provide a corresponding high voltage to provide an approximately uniform distribution of the potential gradient across the drift length in the drift tube.
- the ring electrodes are preferably heatable. In other words, the resistance of the electrodes is preferably set so as to be determined by the
- the ring electrodes thus preferably have not only the task to form an electric field, they can also be used by a corresponding configuration of their resistance as heating elements.
- an ion mobility spectrometer which is for monitoring anesthesia of a patient during a
- drift tube as described above.
- the drift tube has a length between 2 to 10 cm, more preferably between 4 to 8 cm, in particular 6 cm, with a homogeneous electric field between 100 to 500 V / cm, preferably between 200 to 400 V / cm and in particular 300 V / cm.
- Embodiment is exemplified, described in more detail.
- Fig. 1 shows a schematic side view of a drift tube according to the invention.
- Fig. 2 shows a schematic side cross-sectional view of a drift tube according to the invention.
- Fig. 3 shows a schematic perspective view of a drift tube according to the invention.
- FIG. 1 shows a schematic side view of a drift tube according to the invention.
- the drift tube 1 has a first end 2 and a second end 4, which are connected to one another via a central tube 6.
- first and second end 2 and 4 cylindrically shaped, but with a length which is shorter than the length of the cylindrical central tube 6.
- the first and second ends 2 and 4 have an outer diameter which is greater than the outer diameter of
- An axial through-bore 8 passes through the first end 2, second end 4 and the central tube 6.
- FIG. 2 is a schematic side cross-sectional view of a drift tube according to the invention.
- an ionization source 12 a blocking grid 14, a screening grid 16 and a detector 18 are introduced from one end 2 to the second end 4 in the sequence.
- the first ring electrode 10 is located at the same height of the longitudinal axis of the drift tube as the barrier grid 14.
- the last ring electrode 10 is located at the same height of the longitudinal axis of the drift tube as the screening grid 16 of the detector 18th
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physiology (AREA)
- Pulmonology (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102017111459 | 2017-05-24 | ||
PCT/EP2018/063724 WO2018215622A1 (de) | 2017-05-24 | 2018-05-24 | Elektrodenanordnung für eine driftröhre |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3629916A1 true EP3629916A1 (de) | 2020-04-08 |
Family
ID=64395376
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18728563.0A Withdrawn EP3631433A1 (de) | 2017-05-24 | 2018-05-24 | Driftröhre mit modifizierter oberflächengüte zur verwendung in einem ionenbeweglichkeitsspektrometer |
EP18728562.2A Active EP3629917B1 (de) | 2017-05-24 | 2018-05-24 | Analysevorrichtung zum analysieren von exspirationsluft |
EP18728081.3A Withdrawn EP3629916A1 (de) | 2017-05-24 | 2018-05-24 | Elektrodenanordnung für eine driftröhre |
EP18729604.1A Withdrawn EP3631434A1 (de) | 2017-05-24 | 2018-05-24 | Driftröhre für ionenbeweglichkeitsspektrometr mit integrierter multikapillarsäule |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18728563.0A Withdrawn EP3631433A1 (de) | 2017-05-24 | 2018-05-24 | Driftröhre mit modifizierter oberflächengüte zur verwendung in einem ionenbeweglichkeitsspektrometer |
EP18728562.2A Active EP3629917B1 (de) | 2017-05-24 | 2018-05-24 | Analysevorrichtung zum analysieren von exspirationsluft |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18729604.1A Withdrawn EP3631434A1 (de) | 2017-05-24 | 2018-05-24 | Driftröhre für ionenbeweglichkeitsspektrometr mit integrierter multikapillarsäule |
Country Status (6)
Country | Link |
---|---|
US (1) | US20200170571A1 (de) |
EP (4) | EP3631433A1 (de) |
CN (3) | CN110678121B (de) |
ES (1) | ES2890574T3 (de) |
RU (1) | RU2761078C2 (de) |
WO (4) | WO2018215622A1 (de) |
Family Cites Families (30)
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GB2217103B (en) * | 1988-04-06 | 1992-09-23 | Graseby Ionics Ltd | Ion mobility detector |
DE4130810C1 (de) * | 1991-09-17 | 1992-12-03 | Bruker Saxonia Analytik Gmbh, O-7050 Leipzig, De | |
US6509562B1 (en) * | 1999-09-16 | 2003-01-21 | Rae Systems, Inc. | Selective photo-ionization detector using ion mobility spectrometry |
DE10121262A1 (de) * | 2001-04-30 | 2002-11-14 | Siemens Ag | Vorrichtung zur quantitativen Messung von Stickoxiden in der Ausatemluft und Verwendung |
ITMI20011193A1 (it) * | 2001-06-06 | 2002-12-06 | Getters Spa | Metodo per la misura mediante spettroscopia di mobilita' ionica dellaconcentrazione di acqua in argon, idrogeno, azoto e elio |
US6685803B2 (en) * | 2001-06-22 | 2004-02-03 | Applied Materials, Inc. | Plasma treatment of processing gases |
US7155812B1 (en) * | 2002-09-05 | 2007-01-02 | Sandia Corporation | Method for producing a tube |
DE102006006683B4 (de) * | 2006-02-14 | 2008-02-21 | Bruker Daltonik Gmbh | Driftröhre für ein Ionenmobilitätsspektrometer mit integriertem Gaskanal |
CN101093211B (zh) * | 2006-06-21 | 2010-05-12 | 中国科学院电子学研究所 | 用于离子迁移率谱仪漂移管的瞬态漂移电场方法 |
JP4677530B2 (ja) * | 2006-12-12 | 2011-04-27 | 国立大学法人大阪大学 | プラズマ生成装置およびプラズマ生成方法 |
DE102007033906A1 (de) * | 2007-07-20 | 2009-01-29 | Gesellschaft zur Förderung der Analytischen Wissenschaften e.V. | Verfahren zur Analyse von Gasen, insbesondere zur Analyse der menschlichen Ausatemluft |
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ITMI20110535A1 (it) * | 2011-03-31 | 2012-10-01 | Simone Cristoni | Sistema di analisi per l'analisi chimica quantitativa di campioni, in particolare in ambito medico, con calibrazione della risposta strumentale della strumentazione utilizzata per rilevare i dati quantitativi degli analiti presenti nei campioni anali |
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CN105353023B (zh) * | 2014-08-20 | 2018-10-16 | 布鲁克道尔顿公司 | 离子迁移谱迁移轴校正方法和仪器 |
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CN107093546B (zh) * | 2014-12-31 | 2019-03-19 | 同方威视技术股份有限公司 | 检测设备和检测方法 |
US20180172635A1 (en) * | 2016-12-15 | 2018-06-21 | Rapiscan Systems, Inc. | Methods and devices for moisture-based calibration |
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2018
- 2018-05-24 WO PCT/EP2018/063724 patent/WO2018215622A1/de unknown
- 2018-05-24 EP EP18728563.0A patent/EP3631433A1/de not_active Withdrawn
- 2018-05-24 WO PCT/EP2018/063721 patent/WO2018215619A1/de unknown
- 2018-05-24 US US16/616,057 patent/US20200170571A1/en not_active Abandoned
- 2018-05-24 EP EP18728562.2A patent/EP3629917B1/de active Active
- 2018-05-24 CN CN201880033302.5A patent/CN110678121B/zh not_active Expired - Fee Related
- 2018-05-24 CN CN201880034232.5A patent/CN110662959A/zh active Pending
- 2018-05-24 EP EP18728081.3A patent/EP3629916A1/de not_active Withdrawn
- 2018-05-24 ES ES18728562T patent/ES2890574T3/es active Active
- 2018-05-24 RU RU2019143086A patent/RU2761078C2/ru active
- 2018-05-24 WO PCT/EP2018/063723 patent/WO2018215621A1/de unknown
- 2018-05-24 WO PCT/EP2018/063720 patent/WO2018215618A1/de unknown
- 2018-05-24 CN CN201880034219.XA patent/CN110662486A/zh active Pending
- 2018-05-24 EP EP18729604.1A patent/EP3631434A1/de not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP3631434A1 (de) | 2020-04-08 |
CN110678121B (zh) | 2022-07-26 |
WO2018215618A1 (de) | 2018-11-29 |
WO2018215622A1 (de) | 2018-11-29 |
EP3629917A1 (de) | 2020-04-08 |
EP3631433A1 (de) | 2020-04-08 |
CN110662959A (zh) | 2020-01-07 |
RU2019143086A3 (de) | 2021-07-12 |
CN110678121A (zh) | 2020-01-10 |
WO2018215619A1 (de) | 2018-11-29 |
ES2890574T3 (es) | 2022-01-20 |
CN110662486A (zh) | 2020-01-07 |
EP3629917B1 (de) | 2021-07-21 |
RU2019143086A (ru) | 2021-06-24 |
WO2018215621A1 (de) | 2018-11-29 |
RU2761078C2 (ru) | 2021-12-03 |
US20200170571A1 (en) | 2020-06-04 |
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