EP3476399A4 - Lag-3-antikörper, antigenbindendes fragment davon und medizinische anwendung davon - Google Patents

Lag-3-antikörper, antigenbindendes fragment davon und medizinische anwendung davon Download PDF

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Publication number
EP3476399A4
EP3476399A4 EP17814733.6A EP17814733A EP3476399A4 EP 3476399 A4 EP3476399 A4 EP 3476399A4 EP 17814733 A EP17814733 A EP 17814733A EP 3476399 A4 EP3476399 A4 EP 3476399A4
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EP
European Patent Office
Prior art keywords
lag
antigen
antibody
binding fragment
pharmaceutical application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP17814733.6A
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English (en)
French (fr)
Other versions
EP3476399A1 (de
EP3476399B1 (de
Inventor
Zhuoxiao CAO
Yayuan FU
Qiyue Hu
Weikang Tao
Lianshan Zhang
Piaoyang Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Priority to PL17814733T priority Critical patent/PL3476399T3/pl
Publication of EP3476399A1 publication Critical patent/EP3476399A1/de
Publication of EP3476399A4 publication Critical patent/EP3476399A4/de
Application granted granted Critical
Publication of EP3476399B1 publication Critical patent/EP3476399B1/de
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP17814733.6A 2016-06-23 2017-06-22 Lag-3-antikörper, antigenbindendes fragment davon und medizinische anwendung davon Active EP3476399B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL17814733T PL3476399T3 (pl) 2016-06-23 2017-06-22 Przeciwciało lag-3, jego fragment wiążący i jego zastosowanie farmaceutyczne

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610465386 2016-06-23
PCT/CN2017/089492 WO2017219995A1 (zh) 2016-06-23 2017-06-22 Lag-3抗体、其抗原结合片段及其医药用途

Publications (3)

Publication Number Publication Date
EP3476399A1 EP3476399A1 (de) 2019-05-01
EP3476399A4 true EP3476399A4 (de) 2020-01-29
EP3476399B1 EP3476399B1 (de) 2022-04-20

Family

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EP17814733.6A Active EP3476399B1 (de) 2016-06-23 2017-06-22 Lag-3-antikörper, antigenbindendes fragment davon und medizinische anwendung davon

Country Status (18)

Country Link
US (2) US11155617B2 (de)
EP (1) EP3476399B1 (de)
JP (1) JP6998895B2 (de)
KR (1) KR102497259B1 (de)
CN (1) CN108472349B (de)
AU (1) AU2017282892B2 (de)
BR (1) BR112018074155A2 (de)
CA (1) CA3024359A1 (de)
DK (1) DK3476399T3 (de)
ES (1) ES2915410T3 (de)
HU (1) HUE058657T2 (de)
MX (1) MX2018015393A (de)
PL (1) PL3476399T3 (de)
PT (1) PT3476399T (de)
RU (1) RU2757813C2 (de)
TW (1) TWI757304B (de)
UA (1) UA127048C2 (de)
WO (1) WO2017219995A1 (de)

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Also Published As

Publication number Publication date
US11981733B2 (en) 2024-05-14
KR102497259B1 (ko) 2023-02-07
EP3476399A1 (de) 2019-05-01
EP3476399B1 (de) 2022-04-20
US20190233513A1 (en) 2019-08-01
JP6998895B2 (ja) 2022-01-18
WO2017219995A1 (zh) 2017-12-28
US20220002405A1 (en) 2022-01-06
RU2018145852A (ru) 2020-07-23
DK3476399T3 (da) 2022-05-30
CN108472349A (zh) 2018-08-31
MX2018015393A (es) 2019-04-29
CA3024359A1 (en) 2017-12-28
HUE058657T2 (hu) 2022-09-28
PT3476399T (pt) 2022-05-31
BR112018074155A2 (pt) 2019-03-06
ES2915410T3 (es) 2022-06-22
PL3476399T3 (pl) 2022-06-20
AU2017282892A1 (en) 2019-01-24
RU2018145852A3 (de) 2020-10-26
TW201800419A (zh) 2018-01-01
CN108472349B (zh) 2022-05-24
UA127048C2 (uk) 2023-03-29
TWI757304B (zh) 2022-03-11
US11155617B2 (en) 2021-10-26
JP2019518459A (ja) 2019-07-04
RU2757813C2 (ru) 2021-10-21
KR20190021248A (ko) 2019-03-05
AU2017282892B2 (en) 2023-10-26

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