EP2971024A4 - Thioestérases et cellules pour la production d'huiles à façon - Google Patents

Thioestérases et cellules pour la production d'huiles à façon

Info

Publication number
EP2971024A4
EP2971024A4 EP14769502.7A EP14769502A EP2971024A4 EP 2971024 A4 EP2971024 A4 EP 2971024A4 EP 14769502 A EP14769502 A EP 14769502A EP 2971024 A4 EP2971024 A4 EP 2971024A4
Authority
EP
European Patent Office
Prior art keywords
thioesterases
cells
production
tailored oils
tailored
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14769502.7A
Other languages
German (de)
English (en)
Other versions
EP2971024A1 (fr
Inventor
George N Rudenko
Jason Casolari
Scott Franklin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corbion Biotech Inc
Original Assignee
TerraVia Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/837,996 external-priority patent/US9290749B2/en
Application filed by TerraVia Holdings Inc filed Critical TerraVia Holdings Inc
Publication of EP2971024A1 publication Critical patent/EP2971024A1/fr
Publication of EP2971024A4 publication Critical patent/EP2971024A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02014—Oleoyl-[acyl-carrier-protein] hydrolase (3.1.2.14), i.e. ACP-thioesterase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Edible Oils And Fats (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Fats And Perfumes (AREA)
EP14769502.7A 2013-03-15 2014-03-13 Thioestérases et cellules pour la production d'huiles à façon Withdrawn EP2971024A4 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361791861P 2013-03-15 2013-03-15
US13/837,996 US9290749B2 (en) 2013-03-15 2013-03-15 Thioesterases and cells for production of tailored oils
US201361917217P 2013-12-17 2013-12-17
PCT/US2014/026644 WO2014151904A1 (fr) 2013-03-15 2014-03-13 Thioestérases et cellules pour la production d'huiles à façon

Publications (2)

Publication Number Publication Date
EP2971024A1 EP2971024A1 (fr) 2016-01-20
EP2971024A4 true EP2971024A4 (fr) 2016-11-16

Family

ID=51581068

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14769502.7A Withdrawn EP2971024A4 (fr) 2013-03-15 2014-03-13 Thioestérases et cellules pour la production d'huiles à façon

Country Status (9)

Country Link
EP (1) EP2971024A4 (fr)
JP (1) JP2016518112A (fr)
KR (1) KR20150128770A (fr)
CN (1) CN105143458A (fr)
AU (2) AU2014236763B2 (fr)
BR (1) BR112015023192A8 (fr)
CA (1) CA2904395A1 (fr)
MX (1) MX2015011507A (fr)
WO (1) WO2014151904A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9816079B2 (en) 2013-01-29 2017-11-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9567615B2 (en) 2013-01-29 2017-02-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9290749B2 (en) 2013-03-15 2016-03-22 Solazyme, Inc. Thioesterases and cells for production of tailored oils
US9783836B2 (en) 2013-03-15 2017-10-10 Terravia Holdings, Inc. Thioesterases and cells for production of tailored oils
CN107087416A (zh) 2014-07-24 2017-08-22 泰拉瑞亚控股公司 变体硫酯酶及使用方法
WO2016044779A2 (fr) * 2014-09-18 2016-03-24 Solazyme, Inc. Acyl-acp thioestérases et leurs mutants
US20180142218A1 (en) 2016-10-05 2018-05-24 Terravia Holdings, Inc. Novel acyltransferases, variant thioesterases, and uses thereof
US20230143841A1 (en) 2020-01-16 2023-05-11 Corbion Biotech, Inc. Beta-ketoacyl-acp synthase iv variants

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992020236A1 (fr) * 1991-05-21 1992-11-26 Calgene, Inc. Thioesterases a chaine moyenne d'origine vegetale
CN102586350A (zh) * 2012-01-09 2012-07-18 北京化工大学 一种c8:0/c10:0/c12:0/c14:0中链脂肪酸及其乙酯的生产方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298421A (en) 1990-04-26 1994-03-29 Calgene, Inc. Plant medium-chain-preferring acyl-ACP thioesterases and related methods
US5344771A (en) 1990-04-26 1994-09-06 Calgene, Inc. Plant thiosterases
US5455167A (en) 1991-05-21 1995-10-03 Calgene Inc. Medium-chain thioesterases in plants
US5639790A (en) 1991-05-21 1997-06-17 Calgene, Inc. Plant medium-chain thioesterases
US5850022A (en) 1992-10-30 1998-12-15 Calgene, Inc. Production of myristate in plant cells
US5654495A (en) 1992-10-30 1997-08-05 Calgene, Inc. Production of myristate in plant cells
CA2169094A1 (fr) * 1993-09-03 1995-03-09 Reinhard Topfer Thioesterases a chaine moyenne specifique
WO1995013390A2 (fr) 1993-11-10 1995-05-18 Calgene, Inc. Sequences de thioesterases vegetales actives sur les substrats acyl-(proteine vectrice d'acyle)
US5807893A (en) 1993-11-18 1998-09-15 Voelker; Toni Alois Plant thioesterases and use for modification of fatty acid composition in plant seed oils
KR101523255B1 (ko) 2007-06-01 2015-05-29 솔라짐, 인코포레이티드 미생물에서 오일의 생성
EP2167667B1 (fr) * 2007-07-09 2015-05-20 Bayer CropScience NV Plante de la famille brassica comprenant des allèles mutants de l'acyle gras-acp thioestérase
US7982035B2 (en) 2007-08-27 2011-07-19 Duquesne University Of The Holy Spirit Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
DE112009001459T5 (de) * 2008-06-20 2011-09-29 Basf Plant Science Gmbh Pflanzen mit gesteigerten ertragsbezogenen Eigenschaften und Verfahren zur Herstellung derselben
KR101888973B1 (ko) 2008-11-28 2018-08-16 테라비아 홀딩스 인코포레이티드 종속영양성 미생물에서 맞춤 오일의 생성
CN102459569B (zh) * 2009-04-10 2018-02-23 Reg生命科学有限责任公司 脂肪酸衍生物的产生
MX352746B (es) 2010-05-28 2017-12-06 Terravia Holdings Inc Aceites específicos producidos a partir de microorganismos heterótrofos recombinantes.
AU2012212079B2 (en) * 2011-02-02 2016-07-28 Corbion Biotech, Inc. Tailored oils produced from recombinant oleaginous microorganisms
US8951762B2 (en) * 2011-07-27 2015-02-10 Iowa State University Research Foundation, Inc. Materials and methods for using an acyl—acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis
US8945908B2 (en) 2012-04-18 2015-02-03 Solazyme, Inc. Tailored oils

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992020236A1 (fr) * 1991-05-21 1992-11-26 Calgene, Inc. Thioesterases a chaine moyenne d'origine vegetale
CN102586350A (zh) * 2012-01-09 2012-07-18 北京化工大学 一种c8:0/c10:0/c12:0/c14:0中链脂肪酸及其乙酯的生产方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2014151904A1 *
YUAN L ET AL: "MODIFICATION OF THE SUBSTRATE SPECIFICITY OF AN ACYL-ACYL CARRIER PROTEIN THIOESTERASE BY PROTEIN ENGINEERING", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 92, 1 November 1995 (1995-11-01), pages 10639 - 10643, XP002014019, ISSN: 0027-8424, DOI: 10.1073/PNAS.92.23.10639 *

Also Published As

Publication number Publication date
AU2018267601A1 (en) 2018-12-06
MX2015011507A (es) 2016-04-07
CN105143458A (zh) 2015-12-09
KR20150128770A (ko) 2015-11-18
AU2014236763B2 (en) 2018-08-23
BR112015023192A8 (pt) 2018-01-02
WO2014151904A1 (fr) 2014-09-25
AU2014236763A1 (en) 2015-10-01
EP2971024A1 (fr) 2016-01-20
JP2016518112A (ja) 2016-06-23
CA2904395A1 (fr) 2014-09-25
BR112015023192A2 (pt) 2017-11-21

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RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 9/00 20060101ALI20160630BHEP

Ipc: C12N 5/02 20060101ALI20160630BHEP

Ipc: C12P 7/64 20060101AFI20160630BHEP

Ipc: C12N 5/00 20060101ALI20160630BHEP

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: TERRAVIA HOLDINGS, INC.

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Effective date: 20161013

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Ipc: C12N 5/00 20060101ALI20161007BHEP

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Ipc: C12N 5/02 20060101ALI20161007BHEP

Ipc: C12N 9/00 20060101ALI20161007BHEP

17Q First examination report despatched

Effective date: 20170711

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CORBION BIOTECH, INC.

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CASOLARI, JASON

Inventor name: FRANKLIN, SCOTT

Inventor name: RUDENKO, GEORGE N.

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