EP2881102B1 - Vorrichtung und Verfahren zum Befüllen von Kapseln - Google Patents

Vorrichtung und Verfahren zum Befüllen von Kapseln Download PDF

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Publication number
EP2881102B1
EP2881102B1 EP14196112.8A EP14196112A EP2881102B1 EP 2881102 B1 EP2881102 B1 EP 2881102B1 EP 14196112 A EP14196112 A EP 14196112A EP 2881102 B1 EP2881102 B1 EP 2881102B1
Authority
EP
European Patent Office
Prior art keywords
capsules
capsule
conveyor wheel
station
drive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP14196112.8A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2881102A1 (de
Inventor
Daniel Malick
Jan Fabian Scheffler
Jörg Gaedecke
Werner Seifert
Thomas Heinrich
Jan-Eric Kruse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fette Compacting GmbH
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Fette Compacting GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fette Compacting GmbH filed Critical Fette Compacting GmbH
Publication of EP2881102A1 publication Critical patent/EP2881102A1/de
Application granted granted Critical
Publication of EP2881102B1 publication Critical patent/EP2881102B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B65/00—Details peculiar to packaging machines and not otherwise provided for; Arrangements of such details
    • B65B65/02—Driving gear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/04—Methods of, or means for, filling the material into the containers or receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/30—Devices or methods for controlling or determining the quantity or quality or the material fed or filled
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B43/00—Forming, feeding, opening or setting-up containers or receptacles in association with packaging
    • B65B43/40—Removing separate lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B61/00—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages
    • B65B61/28—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages for discharging completed packages from machines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B65/00—Details peculiar to packaging machines and not otherwise provided for; Arrangements of such details
    • B65B65/003—Packaging lines, e.g. general layout
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers

Definitions

  • the invention relates to a device for filling capsules composed of an upper capsule part and a lower capsule part, comprising a feed wheel, on the circumference of which a plurality of capsule holders are provided, each of which has a plurality of capsule receptacles for one capsule each, further comprising a feed wheel drive with which the feed wheel can be rotated in cycles, with the feed wheel alternating between idle times and movement times, so that the capsule holders move in cycles along a conveyor track, and comprising a plurality of process stations arranged along the conveyor track, the process stations having at least one feed station for feeding in capsules to be filled into the capsule receptacles, at least one opening station for opening the capsules to be filled by separating the capsule tops from the capsule bottoms, at least one filling station for filling the capsule bottoms with material to be filled, at least one Closing station for closing the filled capsules by connecting the capsule upper parts to the capsule lower parts, and at least one ejection station for ejecting the filled capsules.
  • the invention also relates to a method for filling capsules composed of an upper capsule part and a lower capsule part, in which a conveyor wheel, on the circumference of which a plurality of capsule holders is provided, each of which has a plurality of capsule receptacles for one capsule each, is rotated in cycles, with the conveyor wheel alternately runs through idle times and movement times, so that the capsule holders move cyclically along a plurality of process stations that are arranged along a conveyor track, the process stations at least one feed station for feeding capsules to be filled into the capsule receptacles, at least one opening station for opening the to be filled capsules by separating the capsule shells from the Capsule bottoms, at least one filling station for filling the capsule bottoms with material to be filled, at least one closing station for closing the filled capsules by connecting the capsule tops to the capsule bottoms, and at least one ejection station for ejecting the filled capsules.
  • Clocked capsule filling machines of this type have a conveyor wheel designed, for example, as a turntable, on the circumference of which a plurality of capsule holders are provided for receiving the capsules to be filled.
  • a feed wheel drive moves the feed wheel cyclically along a plurality of process stations arranged along the circumference of the feed wheel, with the capsule holders cyclically passing through the process stations.
  • Such capsule filling machines form so-called rotary machines.
  • the process stations usually provided include at least one feed station for feeding in the capsules to be filled, at least one opening station for opening the capsules to be filled by separating the capsule tops and bottoms, one or more filling stations for filling the capsule bottoms with the respective material, at least one capsule closing station and at least one capsule ejection station.
  • one or more empty stations can be provided for retrofitting of process stations.
  • the conveyor wheel goes through downtimes and movement times.
  • the switching time defines the time in which the capsule holders are moved from one process station to the next process station. This is determined by the movement time of the conveyor wheel.
  • the rest time defines the time in which the capsule holder each to the Process stations remain to carry out the respective process. This is determined by the standstill time of the conveyor wheel.
  • a machine for filling and sealing capsules in which the feed wheel is driven by a drive designed as a servomotor. In this way, the conveying path and the conveying direction should be variably adjustable in a conveying cycle for research purposes. The aim is to reduce the number of machine drives as far as possible.
  • a device for filling capsules in which a filling device is designed as an independent and exchangeable module. This is intended to increase the flexibility of the machine.
  • the filling device designed as a module has its own drive and is mechanically coupled to the machine for operation and is thus integrated into the cycled production process.
  • the clocked movement of the capsule holder is usually realized by an indexing gear, which is driven by the conveyor wheel drive.
  • the indexing gear converts a constant speed of the conveyor wheel drive into stepping movements and thus into switching and dwell times.
  • the sequence of movements from switching and dwell times is mechanically defined by suitable curves.
  • a continuously rotating electric motor of the conveyor wheel drive that drives the indexing gear generates a cycle with each of its revolutions via the indexing gear, in particular corresponding switching angles and locking angles of the cam arrangement are run through.
  • the output of the indexing gear carries out a movement step when the drive passes through the indexing angle and stands still when the drive passes through the detent angle.
  • the rest and switching times are therefore determined by the in mechanically realized detent and switching angle of the indexing gear and are basically in a fixed ratio according to the design of the indexing gear.
  • a mechanical cam coupled to the conveyor wheel drive is provided for each process station to control the movement sequences in the process station. For example, if the conveyor wheel drive is operated at a different rotational speed, this changes the number of cycles and the speed of the respective movement of the process stations accordingly.
  • the conveyor wheel drive driving the indexing gear must be operated more slowly if, for example, a slower filling is required, so that the production of the device is slowed down overall. This increases the total cycle time made up of rest and switching times. The slowest process station accordingly determines the overall production speed of the machine.
  • the invention is based on the object of providing a device and a method of the type mentioned at the outset, with which capsules can be filled in a more efficient and flexible manner compared to the prior art.
  • the invention solves the problem in that by means of the feed wheel drive, the ratio between idle times and movement times of the feed wheel is variably adjustable that at least one of the process stations has at least one drive for its operation that can be controlled independently of the conveyor wheel drive, and that a control device is provided which is designed to control the conveyor wheel drive for variable setting of the ratio between idle times and movement times of the conveyor wheel, and/or which is designed for this purpose to control at least the drive speed and/or the stroke (for example a closing stroke) of the process station, which has at least one drive of its own, independently of the feed wheel drive.
  • a plurality of process stations preferably each of the process stations, has at least one drive of its own, with the control device being designed to control the conveyor wheel drive for variable setting of the ratio between idle times and movement times of the conveyor wheel, and/or being designed to to control at least the drive speed and/or the stroke of the multiple process stations, preferably each process station, independently of the conveyor wheel drive.
  • the process station(s) equipped with their own drive mechanical cam disks are dispensed with as an interface between the conveyor wheel drive and the process stations.
  • one or more of the process stations are equipped with a drive that can be controlled independently of the conveyor wheel drive, so that quasi-electronic cam discs are provided in this respect.
  • the number of drives is deliberately increased in order to increase the productivity of the device in the regular production process.
  • the drives of the process stations can be controlled independently of the feed wheel drive, in particular the drive speed of the feed wheel drive, at least with regard to their drive speed and/or their stroke.
  • the change in the lift can affect a change in the lift speed and/or the lift distance.
  • the drives of the process stations are moved synchronously to the conveyor wheel drive in a defined manner, but can be individually adjusted. It is both possible that a drive that can be controlled independently of the conveyor wheel drive controls several, in particular even all, of the process stations. It is also possible for one or more process stations to have an individual drive that can be controlled independently of the conveyor wheel drive.
  • a feed wheel drive is provided with which the standstill times and movement times of the feed wheel can be variably adjusted.
  • the relationship between rest time and switching time which is generally rigid in the prior art, is resolved.
  • the dwell time and the switching time are decoupled from each other and can be specifically and flexibly defined and adjusted.
  • the conveyor wheel drive accelerates and brakes the z. B. designed as a turntable conveyor wheel in the switching time, so that the capsule holders are moved in the switching time from one process station to the next process station.
  • the switching time is thus predetermined by the movement time of the feed wheel.
  • the feed wheel drive keeps the feed wheel in position.
  • the rest time is predetermined by the standstill time of the feed wheel.
  • the feed wheel drive or an electric motor of the feed wheel drive therefore does not rotate continuously in order to implement the cyclical movement.
  • the feed wheel drive can be designed in such a way that it rotates the feed wheel in only one direction of rotation.
  • the feed wheel drive can also be designed in such a way that it feeds the feed wheel to the Approaching each process station rotates.
  • the ratio of downtimes and movement times of the conveyor wheel can therefore be changed.
  • the one or more process stations equipped with at least one drive of their own can be driven independently of the conveyor wheel drive, in particular operated at different speeds, during the rest time.
  • both the switching angle and the detent angle can be traversed at different speeds.
  • the travel path of the process station(s), which has at least one drive of its own can be controlled by the control device independently of the conveyor wheel drive.
  • the travel path can be controlled independently of the travel path of the feed wheel drive. This applies, for example, to the respective strokes of the process stations, which can be set in a flexible manner, independently of the conveyor wheel drive, specifically for the respective application.
  • the invention solves the problem explained above in that when there is a change in the production parameters affecting the filling of the capsules, the ratio between downtimes and movement times of the conveyor wheel is changed and/or at least the drive speed and/or the stroke of at least one process station is changed becomes. It can be provided that when there is a change in the production parameters relating to the filling of the capsules, the ratio between downtimes and movement times of the conveyor wheel is changed and/or at least the drive speed and/or the stroke of a number of process stations is changed.
  • the control device is designed to change the ratio between idle times and movement times of the conveyor wheel and/or to change at least the drive speed and/or the stroke of at least one process station when there is a change in the production parameters relating to the filling of the capsules.
  • the production parameters relating to the filling of the capsules can in particular include the product to be filled into the capsules.
  • the invention permits flexible adaptation to the respective production parameters, for example the product to be filled, the quantity of product to be filled and/or the capsules filled in each case.
  • Product loss can be minimized and the filling quality can be improved by suitably setting the switching and rest times.
  • the flexible adjustment of the switching and idle times and thus individual optimization of the cycle times achieve more efficient operation and thus an increase in performance with simplified service.
  • Drives of the process stations that can be controlled independently of the conveyor wheel drive enable variability of the movement sequences and movement curves, so that the respective process stations can be optimally adjusted.
  • Productivity is increased. This also applies to process reliability. For example, unseparated capsules are always ejected at the optimal speed.
  • the mechanical stress on the capsules for example when the capsules are closed, can be reduced.
  • a mechanical adjustment of the process stations is no longer necessary, since the process stations can be adjusted individually via their respective actuators.
  • the control device comprises a memory device in which different sets of production parameters are stored, for example for different capsules to be filled and/or different material to be filled and/or different product quantities to be filled.
  • the sets of production parameters can each contain control specifications for the conveyor wheel drive and the drives of the process stations, in particular with regard to their respective timing, drive speed, stroke and/or travel path.
  • the control device can then select the production parameter set that is suitable in each case. A largely automatic setting of the suitable production parameters then takes place.
  • one or more empty stations can be provided in the device according to the invention for subsequent retrofitting of process stations.
  • Several filling stations can also be provided for filling the capsules with possibly different material.
  • process stations of the device it is of course possible for process stations of the device to be combined with one another.
  • a combined feeding and opening station could be provided, in which the capsules to be filled are fed into the capsule receptacles and opened by separating the upper capsule parts from the lower capsule parts.
  • One or more of the process stations can also have multiple drives, all of which can be controlled independently of the conveyor wheel drive.
  • the capsule holders can each have a first and a second row of capsule receptacles. It is then possible to provide only one feed station which is designed to feed capsules to both rows of capsule receptacles of a capsule holder. However, two feed stations can also be provided, one of which feeds capsules to the first row and one to the second row.
  • at least one collecting device can be provided, which is arranged in such a way that the capsules ejected in at least one ejection station are fed to it.
  • at least one testing device can be provided for testing the capsules filled in the process stations.
  • Each of the station groups can then have at least one feed station for feeding capsules to be filled into the capsule receptacles, at least one opening station for opening the capsules to be filled by separating the capsule tops from the capsule bottoms, at least one filling station for filling the capsule bottoms with material to be filled, at least one closing station for closing the filled capsules by connecting the upper capsule parts to the lower capsule parts, and at least one ejection station for ejecting the filled capsules. It can therefore be a so-called multiple rotary machine, in particular a double rotary machine.
  • the feed wheel drive can be a servo drive comprising a servo motor that drives the feed wheel in rotation via a gear. It is also possible for the feed wheel drive to be a direct drive, in particular a torque drive. In this case, the feed wheel drive acts on the feed wheel without a gear. Both types of drive are particularly suitable for a non-continuous drive of the feed wheel, i.e. a process during the switching times and a standstill in the rest times, and offer variable adjustability of the movement times and standstill times of the feed wheel.
  • the drives of the process stations can basically be selected from the group of servo drives, direct drives, linear drives, etc. With these variants, essentially any constellation of switching and dwell times can be implemented.
  • At least one ejection station can include a device for separating good capsules and bad capsules.
  • the method according to the invention can be carried out with a device according to the invention. Accordingly, the device according to the invention can be suitable for carrying out the method according to the invention.
  • the device according to the invention shown comprises a feed wheel 20 designed as a circular turntable in the example shown.
  • a plurality of capsule holders 22 are arranged along the circumference of the feed wheel 20 and are held by the feed wheel.
  • the capsule holders 22 each have two rows of capsule receptacles for one capsule each.
  • a feed wheel drive not shown in detail, for example comprising a torque drive
  • the feed wheel 20 is rotated clockwise in the example shown in cycles, as in FIG 1 illustrated by arrow 24.
  • the capsule holders 22 are moved cyclically along a conveyor track through various process stations, as is known per se.
  • the process stations are in 1 numbered 01 to 12 and shown only partially and very schematically.
  • Stations 01 and 02 are feed stations in which capsules 26 to be filled and pre-closed are fed to the first or second row of capsule receptacles 22 .
  • Station 03 is an opening station in which the capsules to be filled are opened by separating the upper capsule parts from the lower capsule parts.
  • station 04 is an idle station.
  • the opening station is formed by the process station 04 and the process station 03 is an empty station.
  • the process stations 05, 06 and 07 can be filling stations in which the capsule bases are filled with material to be filled. This is an example in 1 shown by the filling wheel 28. It is also possible that one or two of the process stations 05, 06 and 07 are idle stations.
  • the process station 08 can be an empty station or unopened capsules can be ejected in the process station 08 in the opening station.
  • the process stations 05, 06, 07 and 08 in addition to the capsule holders 22, which carry the capsule bases when the capsules are open, there are also capsule holders 30 arranged radially on the inside for holding the Capsule tops shown.
  • the process station 09 is a closing station in which the filled capsules are closed by connecting the upper capsule parts to the lower capsule parts.
  • the process stations 10 and 11 are each ejection stations. For example, bad capsules can be ejected in the process station 10 and good capsules in the process station 11 . The distinction is based on one or more test facilities.
  • the process station 12 can be an empty station or, for example, a cleaning station in which the capsule holders 22 are cleaned of any product residues that may be present.
  • each of the process stations has at least one drive of its own.
  • a control device is provided with which at least the drive speed and the travel path of the drives of the process stations can be controlled independently of the conveyor wheel drive.
  • FIG. 2 is a very schematic and simplified representation of a production cycle over time for a capsule to be filled.
  • the white fields each show rest times in which the conveyor wheel 20 is stationary and the process stations are driven to carry out their respective activities.
  • the black fields each show switching times in which the conveyor wheel 20 is rotated further in order to move the capsule holder 22 from one process station to the next process station.
  • the rest times and switching times are shown as examples of the process steps carried out for supplying and opening (Supply/Opening), filling the capsules (Filling), closing the capsules (Closing) and ejecting the capsules (Discharge).
  • the switching times are denoted by t T , while, for example, the rest time for filling the capsule is denoted by t F .
  • the dwell and switching times are fixed once for a process and are then always the same in relation to each other.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Quality & Reliability (AREA)
  • Basic Packing Technique (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP14196112.8A 2013-12-04 2014-12-03 Vorrichtung und Verfahren zum Befüllen von Kapseln Active EP2881102B1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102013113446.7A DE102013113446B4 (de) 2013-12-04 2013-12-04 Vorrichtung und Verfahren zum Befüllen von Kapseln

Publications (2)

Publication Number Publication Date
EP2881102A1 EP2881102A1 (de) 2015-06-10
EP2881102B1 true EP2881102B1 (de) 2023-03-01

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EP14196112.8A Active EP2881102B1 (de) 2013-12-04 2014-12-03 Vorrichtung und Verfahren zum Befüllen von Kapseln

Country Status (8)

Country Link
US (1) US10464703B2 (es)
EP (1) EP2881102B1 (es)
JP (1) JP6238458B2 (es)
KR (1) KR101784892B1 (es)
CN (1) CN104771315B (es)
DE (1) DE102013113446B4 (es)
ES (1) ES2944325T3 (es)
IN (1) IN2014MU03885A (es)

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Publication number Priority date Publication date Assignee Title
US10894623B2 (en) * 2016-07-21 2021-01-19 Pouch Pac Innovations, Llc Servomotor driven packaging apparatus and method of control
IT201700091504A1 (it) * 2017-08-08 2019-02-08 Gd Spa Unità di riempimento per una macchina confezionatrice per la produzione di cartucce monouso per sigarette elettroniche
IT202000010855A1 (it) * 2020-05-13 2021-11-13 Ima Spa Macchina per riempire capsule.

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07112878B2 (ja) 1985-09-06 1995-12-06 第一製薬株式会社 カプセル充填機
US5761886A (en) * 1996-02-09 1998-06-09 Parkhideh; Shahrooz Apparatus and method for manufacturing encapsulated products
US5826633A (en) 1996-04-26 1998-10-27 Inhale Therapeutic Systems Powder filling systems, apparatus and methods
DE19735942C2 (de) * 1997-08-19 2000-02-03 Elau Elektronik Automations Ag Verfahren zum Betrieb einer Verpackungsmaschine mit elektrischer Königswelle sowie Verpackungsmaschine
JP2002193202A (ja) 2000-12-25 2002-07-10 Ricoh Co Ltd 粉体充填装置
ITBO20020282A1 (it) * 2002-05-13 2003-11-13 Bl Macchine Automatiche Incapsulatrice per il confezionamento di prodotti incoerenti in capsule di gelatina dura
AU2003246206A1 (en) * 2002-07-05 2004-01-23 Shionogi Qualicaps Co., Ltd. Capsule-filling and -sealing apparatus
DE20313807U1 (de) * 2003-09-03 2003-11-06 Harro Höfliger Verpackungsmaschinen GmbH, 71573 Allmersbach Vorrichtung zum Befüllen von Behältnissen, wie insbesondere von Hartgelatinekapseln
US7444197B2 (en) 2004-05-06 2008-10-28 Smp Logic Systems Llc Methods, systems, and software program for validation and monitoring of pharmaceutical manufacturing processes
US7799273B2 (en) 2004-05-06 2010-09-21 Smp Logic Systems Llc Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes
JP4475415B2 (ja) 2005-05-27 2010-06-09 靜甲株式会社 Ｐｔｐシート製品・添付文書集積装置
DE102006035280A1 (de) * 2006-07-31 2008-02-07 Robert Bosch Gmbh Vorrichtung und Verfahren zum Ausstoßen zumindest einer Kapsel
EP2135595A1 (de) * 2008-06-16 2009-12-23 Gavrilovic, Rade Vorrichtung für die Massenfertigung von Wirkstoffkapseln
JP2010094391A (ja) 2008-10-20 2010-04-30 Tosho Inc 薬剤包装装置
DE102010040505A1 (de) * 2009-10-22 2011-04-28 Robert Bosch Gmbh Maschine und Verfahren zum Füllen und Verschließen von insbesondere aus Hartgelatine bestehenden Kapseln
DE102011084555A1 (de) 2010-12-15 2012-06-21 Robert Bosch Gmbh Vorrichtung zum Abfüllen von Füllgut in Kapseln

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Publication number Publication date
KR20150065166A (ko) 2015-06-12
EP2881102A1 (de) 2015-06-10
JP2015110449A (ja) 2015-06-18
IN2014MU03885A (es) 2015-10-09
CN104771315A (zh) 2015-07-15
US20150158614A1 (en) 2015-06-11
KR101784892B1 (ko) 2017-10-12
ES2944325T3 (es) 2023-06-20
DE102013113446B4 (de) 2017-04-13
JP6238458B2 (ja) 2017-11-29
DE102013113446A1 (de) 2015-06-11
US10464703B2 (en) 2019-11-05
CN104771315B (zh) 2018-09-04

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