EP2424896B1 - Anti-ceacam1-antikörper und verfahren zur deren anwendung - Google Patents
Anti-ceacam1-antikörper und verfahren zur deren anwendung Download PDFInfo
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- EP2424896B1 EP2424896B1 EP10721207.8A EP10721207A EP2424896B1 EP 2424896 B1 EP2424896 B1 EP 2424896B1 EP 10721207 A EP10721207 A EP 10721207A EP 2424896 B1 EP2424896 B1 EP 2424896B1
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- antibody
- ceacam1
- cells
- antibody fragment
- cancer
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Claims (15)
- Hybridomzelllinie, hinterlegt unter der ATCC Zugangsnummer PTA-9974.
- Isolierter anti-CEACAM1 Antikörper oder Antikörperfragment umfassend eine Antigenerkennungsdomäne mit den CDK-Sequenzen und der Ausrichtung des Antikörpers hergestellt aus der Hybridomzelllinie, die unter der ATCC Zugangsnummer PTA-9974 hinterlegt wurde.
- Isolierter Antikörper oder Antikörperfragment nach Anspruch 2, wobei der Antikörper oder das Antikörperfragment für CEACAM1 selektiv ist.
- Isolierter Antikörper oder Antikörperfragment nach Anspruch 3, hergestellt aus der Hybridomzelllinie, die unter der ATCC Zugangsnummer PTA-9974 hinterlegt wurde.
- Isolierter Antikörper oder Antikörperfragment nach Anspruch 2, angeordnet an einem zytotoxischen Rest.
- Isolierter Antikörper oder Antikörperfragment nach Anspruch 5, wobei der zytotoxische Rest ein Zytotoxin, ein Chemokin, eine Chemotherapie, ein Pro-Apoptotikum, ein Interferon, einen radioaktiven Rest oder Kombinationen davon umfasst.
- Isolierter Antikörper oder Antikörperfragment nach Anspruch 2, angeordnet an einem identifizierbaren Rest.
- Isolierter Antikörper oder Antikörperfragment nach Anspruch 2 zur Behandlung von Krebs, vorzugsweise eines Melanoms.
- Isolierter Antikörper oder Antikörperfragment nach Anspruch 2 zur Immunmodulation einer Tumorzelle, die CEACAM1 exprimiert, durch eine CEACAM1 exprimierende Lymphozyte, vorzugsweise wobei die CEACAM1 exprimierende Lymphozyte eine zytotoxische T Zelle ist.
- Isolierter Antikörper oder Antikörperfragment nach Anspruch 2 zum Verhindern einer Migration oder Proliferation einer Tumorzelle, die CEACAM1 exprimiert, vorzugsweise wobei die Tumorzelle eine Melanomtumorzelle umfasst.
- Verfahren zum Diagnostizieren einer Krebserkrankung in einem Subjekt, wobei das Verfahren ein Inkontaktbringen einer biologischen Probe des Subjekts mit dem Antikörper oder Antikörperfragment nach Anspruch 2 oder 5 umfasst, wobei Zellen des Krebs durch eine Überexprimierung von CEACAM1 verglichen mit nicht betroffenen Zellen gekennzeichnet sind, und wobei eine Komplexbildung über eine vorbestimmte Schwelle auf einen Krebs in dem Subjekt hinweist.
- Verfahren nach Anspruch 11, wobei der Krebs ein Melanom ist.
- Isolierter Antikörper oder Antikörperfragment nach Anspruch 2 zum Verhindern einer CEACAM1 homotypischen oder heterotypischen Protein-Protein Interaktion einer CEACAM1 exprimierenden Lymphozyte.
- Isolierter Antikörper oder Antikörperfragment nach Anspruch 13,
wobei die CEACAM1 exprimierende Lymphozyte eine tumorinfiltrierende Lymphozyte oder eine NK Zelle ist, oder
wobei die CEACAM1 exprimierende Lymphozyte eine zytotoxische T Zelle ist. - Pharmazeutische Zusammensetzung umfassend als aktiven Bestandteil den Antikörper oder das Antikörperfragment nach Anspruch 2 oder 5.
Priority Applications (6)
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|---|---|---|---|
| EP15183297.9A EP2990421B1 (de) | 2009-04-30 | 2010-04-29 | Anti-ceacam1-antikörper und verfahren zu deren anwendung |
| SI201031069T SI2424896T1 (sl) | 2009-04-30 | 2010-04-29 | Protitelesa anti-ceacam1 in postopki za njihovo uporabo |
| PL15183297T PL2990421T3 (pl) | 2009-04-30 | 2010-04-29 | Przeciwciała anty-ceacam1 oraz sposoby ich stosowania |
| PL10721207T PL2424896T3 (pl) | 2009-04-30 | 2010-04-29 | Przeciwciała anty-ceacam1 oraz sposoby ich stosowania |
| HRP20151099TT HRP20151099T8 (en) | 2009-04-30 | 2015-10-19 | Anti ceacam1 antibodies and methods of using same |
| CY20151101082T CY1117502T1 (el) | 2009-04-30 | 2015-11-27 | Αντι ceacam1 αντισωματα και μεθοδοι χρησης αυτων |
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| US21304009P | 2009-04-30 | 2009-04-30 | |
| PCT/IL2010/000348 WO2010125571A1 (en) | 2009-04-30 | 2010-04-29 | Anti ceacam1 antibodies and methods of using same |
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| EP15183297.9A Division EP2990421B1 (de) | 2009-04-30 | 2010-04-29 | Anti-ceacam1-antikörper und verfahren zu deren anwendung |
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| EP2424896A1 EP2424896A1 (de) | 2012-03-07 |
| EP2424896B1 true EP2424896B1 (de) | 2015-09-09 |
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| EP15183297.9A Active EP2990421B1 (de) | 2009-04-30 | 2010-04-29 | Anti-ceacam1-antikörper und verfahren zu deren anwendung |
| EP10721207.8A Active EP2424896B1 (de) | 2009-04-30 | 2010-04-29 | Anti-ceacam1-antikörper und verfahren zur deren anwendung |
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| EP15183297.9A Active EP2990421B1 (de) | 2009-04-30 | 2010-04-29 | Anti-ceacam1-antikörper und verfahren zu deren anwendung |
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| US (4) | US8598322B2 (de) |
| EP (2) | EP2990421B1 (de) |
| JP (1) | JP5726170B2 (de) |
| KR (2) | KR101875227B1 (de) |
| CN (1) | CN102482354B (de) |
| AU (1) | AU2010243211B2 (de) |
| BR (1) | BRPI1015350B1 (de) |
| CA (1) | CA2760385C (de) |
| DK (1) | DK2424896T3 (de) |
| ES (2) | ES2668874T3 (de) |
| HK (2) | HK1167264A1 (de) |
| HR (1) | HRP20151099T8 (de) |
| HU (1) | HUE028294T2 (de) |
| LT (1) | LT2990421T (de) |
| PL (2) | PL2990421T3 (de) |
| PT (1) | PT2424896E (de) |
| RU (2) | RU2016134843A (de) |
| SI (1) | SI2424896T1 (de) |
| WO (1) | WO2010125571A1 (de) |
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