EP2266943B1 - Method for producing of 2-alkyl-2-cycloalken-1-one - Google Patents

Method for producing of 2-alkyl-2-cycloalken-1-one Download PDF

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Publication number
EP2266943B1
EP2266943B1 EP09729798.0A EP09729798A EP2266943B1 EP 2266943 B1 EP2266943 B1 EP 2266943B1 EP 09729798 A EP09729798 A EP 09729798A EP 2266943 B1 EP2266943 B1 EP 2266943B1
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Prior art keywords
acid
alkyl
reaction
cycloalken
producing
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English (en)
French (fr)
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EP2266943A1 (en
EP2266943A4 (en
Inventor
Makiko Muroi
Atsushi Nagasawa
Kunshi Matsumoto
Mariko Kagaya
Hirotsugu Nishimura
Yoshiharu Ataka
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Kao Corp
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Kao Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Definitions

  • the present invention relates to a process for producing 2-alkyl-2-cycloalken-1-ones, and a process for producing alkyl(3-oxo-2-alkylcycloalkyl)acetates which are useful as perfume materials, by using the 2-alkyl-2-cycloalken-1-ones.
  • the 2-alkyl-2-cycloalken-1-ones are useful substances as an intermediate product for synthesis of physiologically active substances or perfume materials. Hitherto, the 2-alkyl-2-cycloalken-1-ones have been produced by first subjecting 2-(1-hydroxyalkyl)cycloalkanones to dehydration reaction to synthesize 2-(alkylidene)cycloalkanones, and then subjecting the 2-(alkylidene)cycloalkanones to isomerization reaction.
  • Patent Documents 1 and 2 disclose the dehydration reaction using oxalic acid or phosphoric acid.
  • Patent Document 3 discloses the dehydration reaction using a solid acid.
  • Patent Document 4 discloses the isomerization reaction using a platinum group metal catalyst.
  • Patent Document 1 discloses the method in which the dehydration reaction and isomerization reaction are carried out in one step under n-butanol reflux condition using hydrogen chloride or hydrogen bromide.
  • Patent Document 5 discloses the method in which the reactions are carried out using hydrogen halides or sulfonic acids in the presence of an inert solvent while removing water out of the reaction system.
  • Patent Document 6 discloses the method in which the reactions are carried out using sulfonic acids in the presence of a high-boiling solvent while removing water and 2-alkyl-2-cyclopentenone out of the reaction system.
  • the dehydration reaction and the isomerization reaction may be carried out separately from each other.
  • the dehydration reaction may proceed in the presence of an acid as described in Patent Documents 1 to 3
  • the isomerization reaction may proceed in the presence of a metal catalyst as described in Patent Document 4.
  • a metal catalyst as described in Patent Document 4.
  • the present invention relates to a process for producing a 2-alkyl-2-cycloalken-1-one represented by the following general formula (2) by subjecting a 2-(1-hydroxyalkyl)cycloalkan-1-one represented by the following general formula (1) to dehydration and isomerization in the co-existence of an acid and a platinum group metal catalyst.
  • n is an integer of 1 or 2; and R 1 and R 2 are each independently a hydrogen atom or an alkyl group having 1 to 8 carbon atoms with the proviso that R 1 and R 2 may form a cyclopentane ring or a cyclohexane ring through a carbon atom adjacent thereto.
  • the present invention relates to a process for producing a 2-alkyl-2-cycloalken-1-one with a high yield and a high purity, and a process for producing an alkyl(3-oxo-2-alkylcycloalkyl)acetate which is useful as a perfume material, using the 2-alkyl-2-cycloalken-1-one.
  • the present inventors have found that when subjecting a 2-(1-hydroxyalkyl)-cycloalkan-1-one to dehydration and isomerization in the co-existence of an acid and a platinum group metal catalyst, it is possible to synthesize the aimed compound with a high yield and a high purity.
  • the present inventors have found that when the 2-(1-hydroxyalkyl)-cycloalkan-1-one is subjected to dehydration and isomerization in the co-existence of an acid and a platinum group metal catalyst as well as in a hydrogen gas atmosphere in which a concentration of a hydrogen gas varies with time, it is possible to synthesize the aimed compound with a high yield and a high purity.
  • the present invention relates to the following aspects [1] to [3].
  • the compound (1) is used as a raw material thereof.
  • R 1 and R 2 are each independently a hydrogen atom or an alkyl group having 1 to 8 carbon atoms with the proviso that R 1 and R 2 may form a cyclopentane ring or a cyclohexane ring through a carbon atom adjacent thereto.
  • R 1 and R 2 are each preferably a hydrogen atom or a straight-chain or branched alkyl group, and more preferably a hydrogen atom or a straight-chain alkyl group.
  • alkyl group as R 1 and R 2 examples include a methyl group, an ethyl group, a propyl group, an isopropyl group, various butyl groups, various pentyl groups, various hexyl groups, various heptyl groups and various octyl groups.
  • R 1 and R 2 may form a cyclopentane ring or a cyclohexane ring through a carbon atom adjacent thereto
  • R 1 may be bonded to R 2 through the carbon atom, or R 2 may be bonded to R 1 through the carbon atom, to form a 5-membered ring or a 6-membered ring.
  • hydrogen atoms bonded to the carbon atom may be substituted, for example, with a hydrocarbon group such as an alkyl or alkenyl group having 1 to 5 carbon atoms.
  • the compound (1) include 2-(1-hydroxypropyl)-cyclopentanone, 2-(1-hydroxybutyl)-cyclopentanone, 2-(1-hydroxypentyl)-cyclopentanone, 2-(1-hydroxyhexyl)-cyclopentanone, 2-(1-hydroxy-1-methylbutyl)-cyclopentanone, 2-(1-hydroxy-2-methylbutyl)-cyclopentanone, 2-(1-hydroxycyclopentyl)-cyclopentanone, 2-(1-hydroxycyclohexyl)-cyclopentanone, 2-(1-hydroxypropyl)-cyclohexanone, 2-(1-hydroxybutyl)-cyclohexanone, 2-(1-hydroxypentyl)-cyclohexanone, 2-(1-hydroxyhexyl)-cyclohexanone, 2-(1-hydroxy-1-methylbutyl)-cyclohexanone, 2-(1-hydroxy-2-methylbutyl)-cyclohexanone
  • 2-(1-hydroxypropyl)-cyclopentanone preferred are 2-(1-hydroxybutyl)-cyclopentanone, 2-(1-hydroxypentyl)-cyclopentanone and 2-(1-hydroxyhexyl)-cyclopentanone, and especially preferred is 2-(1-hydroxypentyl)-cyclopentanone.
  • the compound (2) include 2-propyl-2-cyclopenten-1-one, 2-butyl-2-cyclopenten-1-one, 2-pentyl-2-cyclopenten-1-one, 2-hexyl-2-cyclopenten-1-one, 2-(1-methylbutyl)-2-cyclopenten-1-one, 2-(2-methylbutyl)-2-cyclopenten-1-one, 2-cyclopentyl-2-cyclopenten-1-one, 2-cyclohexyl-2-cyclopenten-1-one, 2-propyl-2-cyclohexen-1-one, 2-butyl-2-cyclohexen-1-one, 2-pentyl-2-cyclohexen-1-one, 2-hexyl-2-cyclohexen-1-one, 2-(1-methylbutyl)-2-cyclohexen-1-one, 2-(2-methylbutyl)-2-cyclohexen-1-one, 2-cyclopentyl-2-cyclohexen-1-one and 2-cyclohexyl-2-cycl
  • 2-propyl-2-cyclopenten-1-one 2-butyl-2-cyclopenten-1-one
  • 2-pentyl-2-cyclopenten-1-one 2-hexyl-2-cyclopenten-1-one
  • 2-pentyl-2-cyclopenten-1-one 2-butyl-2-cyclopenten-1-one
  • 2-hexyl-2-cyclopenten-1-one 2-hexyl-2-cyclopenten-1-one
  • the compound (1) may be produced by known methods.
  • the compound (1) may be produced by reacting a cycloalkanone having 5 or 6 carbon atoms with an aldehyde or a ketone represented by the following formula (6).
  • the compound (1) produced by the above method may be used as such without being purified, but may also be purified before use by distillation, etc., when the catalyst used in the method is deteriorated in catalytic activity.
  • R 1 and R 2 are the same as defined above.
  • the compound (2) is produced by subjecting the compound (1) to dehydration and isomerization reaction in the co-existence of an acid and a platinum group metal catalyst.
  • the acid there may be used an inorganic acid, an organic acid and a solid acid, etc.
  • the inorganic acid and the organic acid used in the present invention may be ordinary inorganic and organic acids.
  • Specific examples of the acid include inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid, orthophosphoric acid, and condensed phosphoric acids such as metaphosphoric acid, pyrophosphoric acid and tripolyphosphoric acid; and organic acids such as acetic acid, oxalic acid, citric acid, maleic acid, fumaric acid and malic acid.
  • acids having a first acid dissociation constant (pKa) of 0 or more and preferably 0.5 or more as measured at 25°C More specifically, as the preferred acids, there may be mentioned phosphoric acid (first pKa: 2.15), condensed phosphoric acids such as pyrophosphoric acid (first pKa: 0.8) and tripolyphosphoric acid, and organic acids such as acetic acid (first pKa: 4.56), oxalic acid (first pKa: 1.04), citric acid (first pKa: 2.87), maleic acid (first pKa: 1.75), fumaric acid (first pKa: 2.85) and malic acid (first pKa: 3.24).
  • phosphoric acid first pKa: 2.15
  • condensed phosphoric acids such as pyrophosphoric acid (first pKa: 0.8) and tripolyphosphoric acid
  • organic acids such as acetic acid (first pKa: 4.56), oxalic
  • phosphoric acid condensed phosphoric acids such as pyrophosphoric acid and tripolyphosphoric acid
  • organic acids such as oxalic acid, citric acid, maleic acid, fumaric acid and malic acid, and especially preferred are phosphoric acid and oxalic acid.
  • the acid dissociation constant (pKa) as used in the present invention is described, for example, in " Chemical Handbook", The Chemical Society of Japan (revised 3rd edition, published by Maruzen K.K. on June 25, 1984 ).
  • These acids may be supported on a carrier.
  • the carrier include silica and activated carbon.
  • preferred is activated carbon.
  • the acid may be supported on the carrier by the method in which the carrier is impregnated with the acid, and the method in which phosphoric acid is added and penetrated into a wood material (such as sawdust and wood chips) at a high temperature while suppressing generation of tar to erode fibers of the wood material, and then the thus treated wood material is subjected to carbonisation reaction at a temperature of from 500 to 700°C under air-free conditions to obtain a phosphoric acid-supporting activated carbon (also referred to as a "phosphoric acid-activated carbon").
  • the phosphoric acid-supporting activated carbon is especially preferred.
  • Such an acid supported on the carrier can be handled in the same manner as the below-mentioned solid acid, and is readily separated and removed from the reaction mixture.
  • the solid acid there may be used conventionally known solid acids.
  • the solid acid include inorganic metal solids such as activated alumina, zirconia sulfate, metal phosphates, aluminum dihydrogen tripolyphosphate and titanium oxide; cation exchange resins; silica-titania composite oxide, silica-calcium oxide composite oxide, silica-magnesia composite oxide and zeolite.
  • the solid acid used in the present invention preferably satisfies such a condition in which an amount (mmol/g) of acid sites of the solid acid from which NH 3 is desorbed at a temperature of from 100 to 250°C is larger than an amount (mmol/g) of acid sites of the solid acid from which NH 3 is desorbed at a temperature higher than 250°C, as measured by an ammonia temperature-programmed desorption (TPD) method.
  • TTD temperature-programmed desorption
  • the amount of acid sites of the solid acid from which NH 3 is desorbed at a temperature of from 100 to 250°C is preferably 0.3 mmol/g or more, whereas the amount of acid sites of the solid acid from which NH 3 is desorbed at a temperature higher than 250°C is preferably less than 0.3 mmol/g.
  • the TPD temperature-programmed desorption
  • the TPD measurement may be carried out after sequentially conducting a pretreatment, an NH 3 absorption treatment and a vacuum treatment under the following conditions.
  • Pretreatment Temperature is raised up to 200°C in helium atmosphere over 20 min, and maintained at the same temperature for 1 h;
  • NHs absorption treatment NH 3 is absorbed at 50°C under 2.7 kPa for 10 min;
  • Vacuum treatment Treated at 50°C for 4 h; and TPD measurement: While flowing a helium gas at a rate of 50 mL/min, temperature is raised up to 600°C at a rate of 5°C/min.
  • these solid acids preferred are the solid acids having the structure (A) and the metal atom (C), the solid acids having the structure (B) and the metal atom (C), and the solid acids having the structure (A), the structure (B) and the metal atom (C).
  • the structure (A) there may be mentioned the structures derived from orthophosphoric acid, condensed phosphoric acids such as metaphosphoric acid and pyrophosphoric acid, etc.
  • these structures from the viewpoint of good performance, preferred is the structure (A) derived from orthophosphoric acid.
  • Examples of the organic phosphoric acid represented by the general formula (7) or (8) in the structure (B) include phosphonic acid, phosphonic acid monoesters, phosphinic acid, phosphoric acid monoesters, phosphoric acid diesters, phosphorous acid monoesters and phosphorous acid diesters.
  • preferred is the structure (B) derived from phosphonic acid.
  • R 10 is preferably an organic group preferably having 1 to 15 carbon atoms and more preferably 1 to 8 carbon atoms.
  • the organic group as R 14 include an alkyl group such as a methyl group, an ethyl group, a propyl group, an isopropyl group, various butyl groups, various pentyl groups, various hexyl groups and various octyl groups; and an aryl group such as a phenyl group and a 3-methyl phenyl group.
  • the metal atom (C) aluminum is preferred from the viewpoint of good performance and/or low costs. Meanwhile, for the purpose of improving a selectivity and other performances, the metal atom (C) may contain a small amount of a metal atom other than aluminum, gallium and iron. Also, it is not particularly required that a whole of the metal atom (C) contained in the catalyst is bonded to the structure (A) or (B), and only a part of the metal atom (C) may be present in the form of a metal oxide or a metal hydroxide.
  • the solid acid may be produced by a precipitation method, a method of impregnating a metal oxide or a metal hydroxide with an inorganic phosphoric acid and an organic phosphoric acid, a method of substituting an inorganic phosphoric acid group contained in an inorganic aluminum phosphate gel with an organic phosphoric acid group, etc.
  • a precipitation method preferred is the precipitation method.
  • a carrier having a large surface area may be allowed to coexist therewith to obtain a supported catalyst.
  • the carrier include silica, alumina, silica/alumina, titania, zirconia, diatomaceous earth and activated carbon.
  • the content of the carrier in the catalyst is preferably 90% by weight or less.
  • the solid acid may be in the form of either a powder or a molded product.
  • the solid acids may have the same composition or may be used in combination of two or more kinds thereof which are different in composition from each other.
  • the above inorganic acids, organic acid and solid acids may be respectively used alone or in combination of any two or more thereof.
  • the neutralization step may be omitted.
  • the amount of the acid used is preferably 0.0001% by mass or more on the basis of the raw material from the viewpoint of good reactivity
  • the amount of the acid used is preferably 25% by mass or more.
  • the amount of the acid used is more preferably from 0.001 to 12% by mass and still more preferably from 0.01 to 6% by mass.
  • the platinum group metal catalyst used in the present invention contains one or more metal components selected from the group consisting of osmium (Os), ruthenium (Ru), iridium (Ir), rhodium (Rh), platinum (Pt) and palladium (Pd) belonging to elements of Groups 8 to 10 in the 5th and 6th periods of the Periodic Table as main components.
  • metal components selected from the group consisting of osmium (Os), ruthenium (Ru), iridium (Ir), rhodium (Rh), platinum (Pt) and palladium (Pd) belonging to elements of Groups 8 to 10 in the 5th and 6th periods of the Periodic Table as main components.
  • Pt and Pd are preferred, and Pd is more preferred.
  • These metal components may be used alone or in combination of any two or more thereof.
  • containing the metal components as main components means the metal components are preferably contained in an amount of 50 mol% or more, more preferably 70 mol% or more, still more preferably 90 mol% or more, and further still more preferably 95 mol% or more in the catalyst metal components.
  • the platinum group metal catalyst may also contain other metal components or may contain a co-catalyst only in an auxiliary amount.
  • the other metal components include elements of Groups 4 to 11 in the 4th period of the Periodic Table such as Ti, V, Cr, Mn, Fe, Co, Ni and Cu, as well as W, Ag and Au.
  • the catalyst may be formed into an appropriate configuration such as a supporting type, a Raney type, a homogeneous type, a powder type and a granule type when used in the process.
  • the supporting type catalyst is a catalyst of such a type in which the metal components are supported on a carrier in order to improve physical properties thereof such as durability.
  • the supporting type catalyst may be prepared by known methods such as a precipitation method, an ion exchange method, an evaporation-to-dryness method, a spray-drying method and a kneading method.
  • the carrier include carbon (activated carbon), alumina, silica, silica-alumina, barium sulfate and calcium carbonate. Among these carriers, preferred are carbon (activated carbon), silica, alumina and silica-alumina.
  • the palladium catalyst used as the catalyst include palladium on carbon, palladium on alumina, palladium on barium sulfate and palladium on calcium carbonate.
  • palladium-supporting catalysts palladium on carbon and palladium on alumina are preferred because they have a high activity to the reaction and can be readily recovered from the reaction mixture after completion of the reaction, and palladium on carbon is especially preferred from the viewpoints of a good availability. easiness of handing and a high activity to the reaction.
  • the amount of the metal components supported on the carrier in the supporting type catalyst is usually from 0.1 to 70% by mass on the basis of a total amount of the carrier and the metal components supported thereon from the viewpoint of good catalytic activity.
  • the Raney type catalyst is a porous spongy metal catalyst, and may be prepared by the method described, for example, in Teruo KUBOMATSU and Shinichiro KOMATSU "Raney Catalysts", Kyoritsu-Shuppan (1971), etc.
  • an aqueous solution containing a metal salt of an acid such as nitric acid and hydrochloric acid, or a mixed aqueous solution of various metal salts may be added dropwise to the reaction system.
  • the amount of the platinum group metal catalyst used in the above process may be optimized according to the type of the reaction.
  • the platinum group metal catalyst is preferably used in an amount of from 0.0002 to 3% by mass, more preferably from 0.002 to 2% by mass and still more preferably from 0.005 to 1% by mass in terms of an amount of the metal on the basis of the compound (1) as the raw material.
  • the acid and the platinum group metal catalyst may be used in respective separate forms or may be used as an integrated catalyst having one configuration.
  • the platinum group metal catalyst is supported on an acid carrier, it is not required to separately add an additional acid thereto.
  • the acid and the platinum group metal catalyst may also be used either in a suspended bed or a fixed bed.
  • the fixed bed reaction using the carrier-supported acid or the solid acid is effective for mass-production of the aimed compound because no step of separating the catalyst, etc., from the final reaction product is required.
  • the catalyst, etc. may be readily separated by filtration, etc., from the reaction solution, so that the thus separated catalyst can be suitably recycled.
  • the reaction may be carried out in either a liquid phase or a vapor phase, and by either a batch method or a continuous method.
  • the platinum group metal catalyst may be activated by a reducing gas such as a hydrogen gas. Therefore, the dehydration and isomerization reaction may be carried out in the presence of the reducing gas or under a flow of the reducing gas.
  • a reducing gas such as a hydrogen gas.
  • the dehydration and isomerization reaction preferably includes the following step (A) and the following step (B) to be conducted subsequent to the step (A).
  • the concentration of the hydrogen gas used in the former step (A) is from 5 to 45% by volume and preferably from 5 to 40% by volume from the viewpoint of well activating the platinum group metal catalyst. In some cases, the concentration of the hydrogen gas used in the former step (A) is preferably from 15 to 45% by volume and more preferably from 15 to 40% by volume.
  • the concentration of the hydrogen gas used in the latter step (B) is 1% by volume or higher and is lower, by 2% by volume or more, than the concentration of the hydrogen gas used in the step (A), preferably 1.5% by volume or higher and is lower, by 2% by volume or more, than the concentration of the hydrogen gas used in the step (A), and more preferably 2% by volume or higher and is lower, by 3% by volume or more, than the concentration of the hydrogen gas used in the step (A), from the viewpoint of suppressing by-production of the below-mentioned compound (9).
  • the concentration of the hydrogen gas used in the latter step (B) is preferably 5% by volume or higher and is lower, by 2% by volume or more, than the concentration of the hydrogen gas used in the step (A), more preferably 5% by volume or higher and is lower, by 5% by volume or more, than the concentration of the hydrogen gas used in the step (A), and still more preferably 5% by volume or higher and is lower, by 8% by volume or more, than the concentration of the hydrogen gas used in the step (A).
  • the concentration of the hydrogen gas used in the step (A) or (B) may be kept constant or may vary as long as the hydrogen gas concentration lies within the above-specified range.
  • the hydrogen gas is preferably used in the form of a mixed gas with an inert gas.
  • the dehydration and isomerization reaction is more preferably carried out in an atmosphere of a mixed gas composed of a reducing gas such as a hydrogen gas and an inert gas or under a flow of the mixed gas.
  • a mixed gas composed of a reducing gas such as a hydrogen gas and an inert gas or under a flow of the mixed gas.
  • a reducing gas such as a hydrogen gas and an inert gas
  • the preferred inert gas include a nitrogen gas, an argon gas and a helium gas.
  • these inert gases more preferred is a nitrogen gas.
  • the concentration of the reducing gas used in the above atmosphere is preferably 80% or less, more preferably 50% or less and still more preferably 30% or less, whereas the concentration of the reducing gas used under the above gas flow may be adequately optimized depending upon a flowing amount of the gas.
  • the reaction temperature used in the dehydration and isomerization reaction of the present invention is preferably from 70 to 300°C.
  • the reaction temperature is more preferably from 90 to 200°C, still more preferably from 100 to 170°C, and especially preferably from 130 to 160°C, from the viewpoints of completing the reaction for a short period of time and preventing polymerization and decomposition of the compound (2) to enhance a yield thereof.
  • the dehydration and isomerization reaction is allowed to proceed under normal pressures. However, when the dehydration and isomerization reaction is carried out under reduced pressure, it is possible to efficiently distill off water produced out of the reaction system without distilling off the raw material and the reaction product, thereby enabling the reaction to proceed in a more efficient manner.
  • the reaction pressure is preferably adjusted to the range of from 20 to 200 kPa and more preferably from 50 to 150 kPa depending upon the reaction temperature used.
  • the dehydration and isomerization reaction is preferably carried out while distilling off water produced out of the reaction system.
  • the reaction time used in the dehydration and isomerization reaction is controlled such that the reaction time of the step (A) is preferably from 5 to 50%, more preferably from 10 to 40% and still more preferably from 10 to 35% of a total reaction time of the steps (A) and (B).
  • the process of the present invention may be carried out either in the presence of a solvent or under a solvent-free condition.
  • the process of the present invention is advantageously carried out under a solvent-free condition from the viewpoints of a good productivity and economy.
  • the solvent used in the process of the present invention is not particularly limited, and may be an inert organic solvent.
  • inert organic solvent examples include alcohols such as methanol, ethanol, propanol, isopropanol, isobutanol, tert-butanol, n-butanol, 2-butanol, isopentanol, pentanol, hexanol, 2-ethyl butanol, heptanol, 2-heptanol, octanol, 2-octanol, cyclopentanol, cyclohexanol, ethylene glycol, propylene glycol, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, propylene glycol monoethyl ether, diethylene glycol, diethylene glycol monomethyl ether, benzyl alcohol and phenyl ethanol; ketones such as methyl ethyl ketone, methyl isopropyl ketone, methyl propyl ketone, methyl isobutyl
  • the amount of the solvent used in the process of the present invention is preferably from 0.1 to 5 times and more preferably from 0.3 to 2 times by mass on the basis of the compound (1) as the raw material.
  • the process for producing the compound (2) it is possible to prevent polymerization of the 2-(alkylidene)cycloalkanone as the intermediate reaction product and the 2-alkyl-2-cycloalken-1-one as the final reaction product, so that the compound (2) can be produced with a high yield and a high purity.
  • the aimed compound by using the acid and the platinum group metal catalyst which have a low corrosiveness and a low toxicity, reuse the acid and the platinum group metal catalyst, and obtain the aimed compound under a solvent-free condition.
  • an alkyl(3-oxo-alkylcycloalkyl)acetate represented by the following general formula (4) which is useful as a perfume material or a physiologically active substance (hereinafter occasionally referred to merely as a "compound (4)"), for example, by the method as described in JP-A 56-147740 .
  • n, R 1 and R 2 are the same as defined above; and R 3 is an alkyl group having 1 to 3 carbon atoms, preferably a straight-chain or branched alkyl group having 1 to 3 carbon atoms.
  • the compound (2) is first reacted with a malonic acid diester represented by the following general formula (3) in the presence of a base to obtain a compound represented by the following general formula (11) (hereinafter occasionally referred to merely as a "compound (11)").
  • the amount of the compound (3) to be reacted with the compound (2) as the raw material is preferably from 1 to 5 times and preferably from 1.2 to 2 times moles of the compound (2) used.
  • n, R 1 , R 2 and R 3 are the same as defined above, and the two R 3 groups may be the same or different from each other.
  • Examples of the base usable in the above process include alkali metals such as sodium and potassium; and alkali metal alkoxides such as sodium alkoxides and potassium alkoxides.
  • the amount of the base used is preferably from 0.005 to 0.2 time and more preferably from 0.01 to 0.1 time moles of the compound (2) used.
  • the preferred solvent include polar solvents such as alcohols.
  • the reaction temperature used in the above process is preferably from -10 to 30°C and more preferably from -2 to 20°C.
  • the thus obtained compound (11) is reacted with water to produce the compound (4).
  • the amount of water to be reacted is preferably from 1 to 3 times moles of the compound (11) used.
  • the reaction is preferably carried out while adding water dropwise into the reaction system.
  • the reaction temperature is preferably from 150 to 230°C and more preferably from 180 to 220°C.
  • the thus obtained compound (4) has a higher yield and a less content of impurities as compared to those obtained by the conventional professes. Therefore, it is possible to reduce a load for purification of the compound (4) in order to produce the compound (4) having a high purity. Thus, the compound (4) can provide an excellent perfume material.
  • a 6 m 3 reaction vessel equipped with a dropping tank was charged with 2241 kg (26.6 kmol) of cyclopentanone, 1007 kg of water and 11 kg of 48% NaOH.
  • the contents of the reaction vessel were cooled to 15°C while stirring, and then 985 kg (11.4 kmol) of valeraldehyde were added dropwise thereto at the same temperature over 5 h, followed by stirring the resulting mixture for 1 h.
  • an excess amount of cyclopentanone was recovered by distillation.
  • 1868 kg of the final reaction product obtained from an organic layer of the reaction mixture contained 1706 kg of 2-(1-hydroxypentyl)-cyclopentan-1-one.
  • PRODUCTION EXAMPLE 1 (Production of Solid Acid: EtP-AlPO 4 )
  • Ethylphosphonic acid available from Aldrich Corp.; purity: 98%), 85% orthophosphoric acid (available from Kishida Chemical Co., Ltd.) and aluminum nitrate (nonahydrate) (available from Aldrich Corp.; purity: 98%) were weighed in amounts of 9.9 g, 27.7 g and 112.5 g, respectively, and dissolved in 1000 g of water. Then, an ammonia aqueous solution (available from Kishida Chemical Co., Ltd.) was added dropwise to the resulting mixed solution at room temperature to increase a pH of the mixed solution up to 5. In the course of the dropping, a gel-like white precipitate was produced.
  • the thus obtained precipitate was separated from the reaction solution by filtration, washed with water, and then dried at 110°C for 15 h.
  • the resulting dried solid was pulverized into particles having a size of 60 mesh or less and then calcined at 250°C for 3 h to obtain a solid acid: EtP-AlPO 4 .
  • the thus obtained solid acid was measured for contents of metal, phosphorus and carbon therein using an ICP emission spectrophotometer ("ICPS1000III” available from Shimadzu Corp.) and a CHN element analyzer ("2400-2” available from Perkin Elmer Co., Ltd.). As a result, it was confirmed that the solid acid had a metal content of 16%, a phosphorus content of 19% and a carbon content of 2.5%, and an molar ratio (x) of an organic phosphoric acid therein was 0.17.
  • TPD temperature-programmed desorption
  • Example I-3 The final reaction product obtained in Example I-3 was filtered to separate the catalyst therefrom.
  • the thus separated catalyst was mixed with 43.3 g (0.206 mol) of 2-(1-hydroxypentyl)-cyclopentan-1-one (purity: 81%) obtained according to the method described in Synthesis Example 1, and the resulting mixture was mixed under heating in the same conditions as in Example I-3.
  • the contents of the flask were mixed with each other under heating in an atmosphere containing hydrogen and nitrogen at a volume ratio (hydrogen: nitrogen) of 1:7 at 150°C under 101 kPa.
  • a 200 mL four-necked separable flask equipped with a dehydration apparatus was charged with 50.06 g (0.238 mol) of 2-(1-hydroxypentyl)-cyclopentan-1-one (purity: 81%) obtained according to the method described in Synthesis Example 1, and 0.13 g of the solid acid (shape: powder) obtained in Production Example 1.
  • the contents of the flask were mixed with each other under heating in an atmosphere containing hydrogen and nitrogen at a volume ratio (hydrogen: nitrogen) of 1:7 at 150°C under 101 kPa.
  • the solid acid was removed from the resulting final reaction product by filtration to obtain 43.0 g of a filtrate. As a result, it was confirmed that the filtrate contained 29.3 g (0.193 mol) of 2-pentylidenecyclopentan-1-one.
  • the contents of the flask were mixed with each other under heating in an atmosphere containing hydrogen and nitrogen at a volume ratio (hydrogen: nitrogen) of 1:7 at 150°C under 101 kPa.
  • the catalyst was neutralized and removed from the reaction mixture, and then the reaction mixture was subjected to distillation under reduced pressure to distill off methanol and unreacted dimethyl malonate therefrom to obtain 871.6 g of a crude Michael addition product.
  • the thus obtained crude Michael addition product was charged into a reactor equipped with a distilling apparatus and heated to 185°C, followed by adding dropwise water thereto. While distilling off carbon dioxide and methanol generated, the contents of the reactor were subjected to the dropping reaction at 185°C for 11 h. After completion of the reaction, 668.8 g of a crude reaction product was obtained.
  • reaction solution was heated to 140°C under mixing. After reaching the temperature of 140°C, the reaction was carried out for 3 h.
  • step (A) under a stream of a mixed gas having a hydrogen concentration of 12.5% by volume and a nitrogen concentration of 87.5% by volume at a flow rate of 0.2 N-mL/min per 1 g of pure 2-(1-hydroxypentyl)-cyclopentan-1-one as the raw material, the reaction was carried out at a temperature of from 140 to 147°C (average temperature: 146°C) for 12 h.
  • step (B) After completion of the step (B), as a result of subjecting the final reaction product to quantitative determination by GC, it was confirmed that 0.219 mol of 2-pentyl-2-cyclopenten-1-one was produced, and 0.012 mol of 2-pentylcyclopentan-1-one was by-produced. Further, it was confirmed that the yield of 2-pentyl-2-cyclopenten-1-one was 88.6%.
  • Table 2 The results including those for the other by-products are collectively shown in Table 2.
  • reaction solution was heated to 140°C under mixing. After reaching the temperature of 140°C, the reaction was carried out for 3 h.
  • step (A) under a stream of a mixed gas having a hydrogen concentration of 12.5% by volume and a nitrogen concentration of 87.5% by volume at a flow rate of 0.2 N.mL/min per 1 g of pure 2-(1-hydroxypentyl)-cyclopentan-1-one as the raw material, the reaction was carried out at a temperature of from 140 to 147°C (average temperature: 146°C) for 10 h.
  • step (B) After completion of the step (B), as a result of subjecting the final reaction product to quantitative determination by GC, it was confirmed that 0.209 mol of 2-pentyl-2-cyclopenten-1-one was produced, and 0.018 mol of 2-pentylcyclopentan-1-one was by-produced. Further, it was confirmed that the yield of 2-pentyl-2-cyclopenten-1-one was 85.6%.
  • Table 2 The results including those for the other by-products are collectively shown in Table 2.
  • reaction solution was heated to 140°C under mixing. After reaching the temperature of 140°C, the reaction was carried out for 2 h.
  • step (A) under a stream of a mixed gas having a hydrogen concentration of 50% by volume and a nitrogen concentration of 50% by volume at a flow rate of 0.2 N-mL/min per 1 g of pure 2-(1-hydroxypentyl)-cyclopentan-1-one as the raw material, the reaction was carried out at 140°C for 3 h. Further, under a stream of a mixed gas having a hydrogen concentration of 20% by volume and a nitrogen concentration of 80% by volume, the reaction was carried out at 147°C for 3 h.
  • step (B) After completion of the step (B), as a result of subjecting the final reaction product to quantitative determination by GC, it was confirmed that 0.200 mol of 2-pentyl-2-cyclopenten-1-one was produced, and 0.031 mol of 2-pentylcyclopentan-1-one was by-produced. Further, it was confirmed that the yield of 2-pentyl-2-cyclopenten-1-one was 82.8%.
  • Table 2 The results including those for the other by-products are collectively shown in Table 2.
  • reaction solution was heated to 140°C under mixing. After reaching the temperature of 140°C, the reaction was carried out for 3 h.
  • step (A) under a stream of a mixed gas having a hydrogen concentration of 12.5% by volume and a nitrogen concentration of 87.5% by volume at a flow rate of 0.2 N-mL/min per 1 g of pure 2-(1-hydroxypentyl)-cyclopentan-1-one as the raw material, the reaction was carried out at a temperature of from 140°C to 147°C (average temperature: 145°C) for 9 h.
  • step (B) After completion of the step (B), as a result of subjecting the final reaction product to quantitative determination by GC, it was confirmed that 0.205 mol of 2-pentyl-2-cyclopenten-1-one was produced, and 0.022 mol of 2-pentylcyclopentan-1-one was by-produced. Further, it was confirmed that the yield of 2-pentyl-2-cyclopenten-1-one was 84.3%.
  • Table 2 The results including those for the other by-products are collectively shown in Table 2.
  • reaction solution was heated to 150°C under mixing.
  • reaction solution was heated to 140°C under mixing. After reaching the temperature of 140°C, the reaction was carried out for 7 h.
  • step (A) Subsequently to the step (A), under a stream of a mixed gas having a hydrogen concentration of 7.5% by volume and a nitrogen concentration of 92.5% by volume at a flow rate of 0.2 N-mL/min per 1 g of pure 2-(1-hydroxypentyl)-cyclopentan-1-one as the raw material, the reaction was carried out at 150°C for 7 h.
  • step (B) After completion of the step (B), as a result of subjecting the final reaction product to quantitative determination by GC, it was confirmed that 6.13 mol of 2-pentyl-2-cyclopenten-1-one were produced, and 0.30 mol of 2-pentylcyclopentan-1-one was by-produced. Further, it was confirmed that the yield of 2-pentyl-2-cyclopenten-1-one was 88.1%.
  • Table 2 The results including those for the other by-products are collectively shown in Table 2.
  • reaction solution was heated to 140°C under mixing. After reaching the temperature of 140°C, the reaction was carried out for 7 h.
  • step (A) Subsequently to the step (A), under a stream of a nitrogen gas solely at a flow rate of 0.2 N-mL/min per 1 g of pure 2-(1-hydroxypentyl)-cyclopentan-1-one as the raw material, the reaction was carried out at 50°C for 15 h.
  • a process for producing 2-alkyl-cycloalken-1-ones with a high yield and a high purity and a process for producing alkyl(3-oxo-2-alkylcycloalkyl)acetates which are useful as perfume materials, by using the 2-alkyl-2-cycloalken-1-ones.

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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EP09729798.0A 2008-04-11 2009-04-02 Method for producing of 2-alkyl-2-cycloalken-1-one Active EP2266943B1 (en)

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MX370008B (es) * 2013-02-11 2019-11-28 Firmenich & Cie Proceso para la isomerizacion de un doble enlace exo.
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EP2266943A4 (en) 2014-03-12
CN101998946A (zh) 2011-03-30
WO2009125713A1 (ja) 2009-10-15
US20110034722A1 (en) 2011-02-10
CN101998946B (zh) 2013-09-04
ES2614999T3 (es) 2017-06-02
US8394994B2 (en) 2013-03-12

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