EP2006204B1 - Installation destinée à la mise en bouteille de produits pharmaceutiques dans des récipients de types bouteilles - Google Patents

Installation destinée à la mise en bouteille de produits pharmaceutiques dans des récipients de types bouteilles Download PDF

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Publication number
EP2006204B1
EP2006204B1 EP07011867A EP07011867A EP2006204B1 EP 2006204 B1 EP2006204 B1 EP 2006204B1 EP 07011867 A EP07011867 A EP 07011867A EP 07011867 A EP07011867 A EP 07011867A EP 2006204 B1 EP2006204 B1 EP 2006204B1
Authority
EP
European Patent Office
Prior art keywords
containers
container
movement
restraint
pharmaceutical products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP07011867A
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German (de)
English (en)
Other versions
EP2006204A1 (fr
Inventor
Joachim Noe
Michael Kronawitter
Ralf Heim
Rita Hagel
Rolf Armbruster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Uhlmann Pac Systeme GmbH and Co KG
Original Assignee
Uhlmann Pac Systeme GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Uhlmann Pac Systeme GmbH and Co KG filed Critical Uhlmann Pac Systeme GmbH and Co KG
Priority to EP07011867A priority Critical patent/EP2006204B1/fr
Priority to DE502007000739T priority patent/DE502007000739D1/de
Priority to US12/134,641 priority patent/US9399532B2/en
Publication of EP2006204A1 publication Critical patent/EP2006204A1/fr
Application granted granted Critical
Publication of EP2006204B1 publication Critical patent/EP2006204B1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B65/00—Details peculiar to packaging machines and not otherwise provided for; Arrangements of such details
    • B65B65/003—Packaging lines, e.g. general layout
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
    • B65B5/10—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
    • B65B5/101—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity
    • B65B5/103—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity for packaging pills or tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B59/00—Arrangements to enable machines to handle articles of different sizes, to produce packages of different sizes, to vary the contents of packages, to handle different types of packaging material, or to give access for cleaning or maintenance purposes
    • B65B59/04—Machines constructed with readily-detachable units or assemblies, e.g. to facilitate maintenance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B65/00—Details peculiar to packaging machines and not otherwise provided for; Arrangements of such details
    • B65B65/02—Driving gear

Definitions

  • the present invention relates to a system for filling of bottle-like or can-like containers with pharmaceutical products.
  • Such systems have been used for many years to fill a larger number of tablets or a certain amount of powder into bottle-like containers, so that a patient a sufficient amount of drugs, for example for daily use, is available.
  • Such systems for filling bottle-type containers with tablets include a device for introducing a desiccant into each container, a device for counting and introducing the tablets into the containers, a device for introducing a cotton ball into each container, a device for applying a closure on each container, a device for sealing the closures on the containers and a device for sorting out certain containers after a quality check.
  • the individual devices are arranged in a street as a standalone units, the containers are transported between the individual units by means of conventional conveyor belts.
  • a corresponding plant for Affliction of bottle-like containers with powder which has a plurality of stations arranged one after the other, is for example from US 6,755,223 known.
  • a disadvantage of such systems is in particular that the individual devices and conveyor belts must be precisely adjusted to each other, which requires a lot of work.
  • a sorting of containers detected as defective must take place, since a product tracking over several stations of the plant line is very complex.
  • the present invention is therefore an object of the invention to provide a system for filling of bottle-like containers with pharmaceutical products, in which at any time an accurate tracking of the individual containers within the system is possible, opting for a one-time sorting of poorly evaluated containers in the process chain and where the installation and maintenance of the transport equipment is particularly easy.
  • the system for filling bottle-like or can-like containers with pharmaceutical products has a device for dosing the pharmaceutical products and for introducing the pharmaceutical products into the containers.
  • it comprises at least three of the following devices: a device for introducing the containers into the system, a device for introducing a desiccant into each container, a device for introducing a cotton ball into each container, a device for applying a closure to each container, a device for sealing the closures on the containers, and a device for sorting out certain containers and for discharging the remaining containers from the system.
  • a plurality of devices on a transport device for only a continuous, forcibly guided and isolated movement of the container, while at least the device for dosing the pharmaceutical products and for introducing the pharmaceutical products into the container transport means for a partially pulsed, positively driven and isolated Movement of the container has.
  • the respective transport devices of the devices are coupled together in series, so that a positive guidance of the isolated container is ensured by the entire system.
  • each transport device has at least one screw conveyor.
  • each transport device for a continuous, positively guided movement of the individual containers preferably has a guide plate which is parallel to the Worm conveyor is arranged.
  • the transport device for a partially clocked, positively driven movement of the individual containers is designed such that a circulation movement of the container is combined to a carriage controlled by a translational movement of the carriage. This allows a smooth transition from continuous motion to timed motion and back to continuous motion.
  • a simple construction is achieved when the transport means for a partially cycled, positively driven movement of the singulated containers is an endlessly circulating belt with catches directed around pulleys fixed to the carriage.
  • each device is formed as a modular unit, each with a housing, wherein the housing of all modular units are connected in series such that the system is designed as an integral system.
  • a special adjustment of the transport devices in the transition between two modular units can be avoided that projects in a plurality of devices, a first screw conveyor on one side of the respective housing over a predetermined length out in the adjacent housing and that in the adjacent housing a second screw conveyor is arranged in parallel at a predetermined distance from the first screw conveyor, so that the two screw conveyors form a means for transferring the container from one modular unit to the next.
  • the adjustment between two housings takes place by a precisely fitting connection, preferably by means of dowel pins.
  • each housing has a table top over which the transport devices for the containers are arranged and under which, for example, drive and adjustment devices and cables for the respective devices are arranged.
  • Fig. 1 an embodiment of a system for filling of bottle-like or can-like containers is shown with pharmaceutical products.
  • the system is designed in modular design, whereby the individual process steps are integrated into different standard modules, which jointly form the integral system. It is also possible in principle, but at a distance from each other to use arranged modules.
  • the various modular units 2 have in this example in each case a housing 4, which usually corresponds to a standard housing with precisely defined connection dimensions. Even with transversely larger modular units 2, the depth connection dimensions are met.
  • the individual modular units 2 comprise in the present example case Fig. 1 a device 6 for introducing the containers 5 into the system, a device 8 for introducing a desiccant into each container 5, a device 10 for counting tablets and for introducing the tablets into the containers 5, a device 12 for applying a closure to each Container 5, a device 14 for sealing the closures on the containers 5 and a device 16 for sorting out certain containers 5 and for discharging the remaining container 5 from the plant.
  • additional supplemental devices can be integrated into the filling system, for example a device not shown here for introducing a cotton ball into each container 5.
  • Devices in the chain can also be omitted.
  • the modular units 2 can be combined in almost any order to an integral system, there are certain successive sequences that make sense in the flow of the filling and can not be changed. For example, it is imperative that the device 12 for applying a closure is arranged on each container 5 after the apparatus 10 for counting the tablets and for introducing the tablets into the containers 5.
  • the device 6 for introducing the container 5 into the system serves to receive and separate the containers 5 into the transport system of the system, which will be described in detail later.
  • the device 8 for introducing a desiccant into each container 5 known desiccants are placed in the bottle-like containers 5 in order to reduce or maintain the moisture in the container 5 after its sealing to a defined extent.
  • the apparatus 10 for counting tablets and for introducing the tablets into the containers 5 can be carried out in many different ways. In all known devices 10, the tablets are counted out of a reservoir and then filled into the container 5. It is important here that the correct amount of tablets gets into the container 5.
  • the container 5 are preferably torque controlled, each provided with a closure in which an aluminum seal may already be located.
  • the aluminum crucible is inductively heated and fused with the container 5.
  • the device 16 for sorting out certain containers 5 and discharging the remaining containers 5 from the system ultimately serves to convey the containers 5 to a subsequent conveyor belt.
  • here classified as unsuitable container 5 can be sorted out or removed container 5 for process control. It is necessary to provide certain sensors or cameras for monitoring tasks within the plant chain.
  • a housing 4 of a standardized modular unit 2 is illustrated in an example of a unitary design without internals.
  • the housing 4 has a roof 18 which is suitable for the integration of various attachments.
  • receptacles 20 are provided for various structures and attachments in the roof, for example, for devices for dry air, certain lighting or suction.
  • a central area of the roof 18 is designed removable.
  • bushings 22 are provided in which cables and hoses can be passed to the neighboring module.
  • protective doors 24 or protective windows are arranged. These are preferably interchangeable to allow flexible intervention.
  • the protective doors 24 are preferably designed to be transparent. It makes sense if at least partially at transitions between two modular units 2 and in particular at the beginning and at the end of the system also laterally corresponding protective windows or protective doors 24 are arranged. In such a configuration, it is possible, the tablets from the count to the sealing of the container 5 in a transport protected area. It is also possible to isolate particularly sensitive areas of the plant by applying different pressure levels in adjacent modular units 2 of environmental influences. Thus, the system can even be operated in a clean room lesser class.
  • a table top 26 is arranged, which divides the interior of the housing 4 in an upper and a lower region.
  • a transport device 28 described in more detail later for the containers 5 and other active components of the respective device 6, 8, 10, 12, 14, 16 is usually accommodated.
  • the modular units 2 can usually be strung together without adjustment.
  • For connection serve e.g. Dowel pins.
  • FIG. 3 is the entire transport chain of the invention in Fig. 1 shown unit, each individual device 6, 8, 10, 12, 14, 16 has its own transport device 28 in which the container 5, which are fed to the system, isolated and positively guided.
  • a particularly simple type of transport means 28 are screw conveyors 30, 32 which are described with reference to FIG Fig. 4 to be described in more detail.
  • transport devices 28 such as belts with drivers conceivable. It is particularly noteworthy that each individual container 5 is forcibly guided through the entire system and thus a product tracking over all modular units 2 away is possible. As a result, a single excretion of rejected containers 5, for example, at the end of the system, so in device 16, for example, even with multiple studies on the quality of the individual containers 5 possible. Even with active removal of a container 5 from the series, the resulting gap can be detected.
  • a first screw conveyor 30 is in each case arranged in a housing 4 such that it projects beyond a predetermined length out into the adjacent housing, in the present example the housing 4 lying on the left.
  • a second screw conveyor 32 is arranged at a predetermined distance parallel to the first screw conveyor 30, so that the two screw conveyors 30, 32 form a particularly simple means for transferring the container 5 from one modular unit 2 to the next.
  • the further movement of the container 5 is carried out in principle by uniform movement of the screw conveyors 30, 32, wherein the container 5 are included in the exceptions of the screw conveyors 30, 32 and are moved forward by rotation of the screw shafts. It is important that in the transfer areas, the screw conveyors 30, 32 are arranged aligned with each other and are moved synchronously. In contrast, within a modular unit 2 it is sufficient if the container 5 is guided on the side opposite the screw conveyor 30, 32 by a guide plate (not shown). The guide plate ensures that the container 5 does not move out perpendicular to the direction of movement from the receptacles of the screw conveyor 30, 32.
  • transport device 28 The in the apparatus 10 for counting the tablets and for introducing the tablets in the container 5 provided transport device 28 is shown in more detail in plan view Fig. 5 shown.
  • the special feature of this transport device 28 is that here a continuous movement of the container in the inlet region 36 and in the outlet region 38 for filling the container 5 is converted in a central region 40 in a clocked motion form.
  • the transport device 28 has a carriage 42 which is translationally movable in the longitudinal direction of the system controlled by a control device.
  • the description refers to all types of solid medicaments, for example also capsules, dragees, etc.
  • the system is also generally suitable for use with other types of pharmaceutical products, e.g. liquid substances, to dose and to fill in containers.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Basic Packing Technique (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)

Claims (10)

  1. Installation pour le remplissage de récipients (5), de types flacons ou boîtes, en produits pharmaceutiques, comprenant :
    un dispositif (10) pour le dosage des produits pharmaceutiques et pour l'introduction des produits pharmaceutiques dans les récipients (5) ; et
    au moins trois des dispositifs suivants :
    un dispositif (6) pour faire passer les récipients (5) dans l'installation ;
    un dispositif (8) pour introduire un agent déshydratant dans chaque récipient (5) ;
    un dispositif pour introduire une pelote de coton dans chaque récipient ;
    un dispositif (12) pour appliquer un bouchon sur chaque récipient (5) ;
    un dispositif (14) pour sceller les bouchons sur les récipients (5) ; et
    un dispositif (16) pour trier des récipients définis (5) et pour faire passer les autres récipients (5) hors de l'installation ;
    caractérisée en ce que
    une pluralité des dispositifs (6, 8, 12, 14, 16) présente un dispositif de transport pour uniquement un déplacement continu, à guidage forcé et séparé, des récipients (5) ;
    au moins le dispositif (10) pour le dosage des produits pharmaceutiques et pour l'introduction des produits pharmaceutiques dans les récipients (5) présente un dispositif de transport (28) pour un déplacement cadencé dans des zones partielles, à guidage forcé et séparé, des récipients (5) ; et
    les dispositifs de transport respectifs (28) des dispositifs (6, 8, 10, 12, 14, 16) sont couplés entre eux en ligne, de sorte qu'un guidage forcé des récipients séparés (5) est garanti au travers de l'ensemble de l'installation.
  2. Installation suivant la revendication 1, caractérisée en ce que chaque dispositif de transport (28) présente au moins un convoyeur à vis (30, 32) pour un déplacement continu, à guidage forcé, des récipients séparés (5).
  3. Installation suivant la revendication 2, caractérisée en ce que chaque dispositif de transport (28) présente une plaque de guidage, disposée parallèlement au convoyeur à vis (30, 32), pour un déplacement continu, à guidage forcé, des récipients (5) séparés.
  4. Installation suivant l'une des revendications précédentes, caractérisée en ce que le dispositif de transport (28) est configuré pour un déplacement en partie cadencé, à guidage forcé, des récipients séparés (5) de telle sorte qu'un mouvement circulaire des récipients (5) autour d'un chariot (42) est combiné de façon contrôlée à un mouvement de translation du chariot (42).
  5. Installation suivant la revendication 4, caractérisée en ce que le dispositif de transport (28) présente pour un déplacement en partie cadencé, à guidage forcé, des récipients (5) séparés, une courroie (46) tournant sans fin avec des entraîneurs, déviée autour de poulies à courroie (44) fixées sur le chariot (42).
  6. Installation suivant l'une des revendications précédentes, caractérisée en ce que chaque dispositif (6, 8, 10, 12, 14, 16) est réalisé sous forme d'unité modulaire (2) avec chacune un carter (4), les carters (4) de toutes les unités modulaires (2) étant assemblés entre eux en ligne de telle sorte que l'installation est réalisée sous forme d'une installation intégrale.
  7. Installation suivant la revendication 6, caractérisée en ce que, dans une multitude des dispositifs (6, 8, 10, 12, 14, 16), un premier convoyeur à vis (30) pénètre sur un côté, hors du carter respectif (4) sur une longueur prédéfinie, dans le carter voisin (4) et un second convoyeur à vis (32) est disposé dans le carter voisin (4), parallèlement et à une distance prédéfinie du premier, convoyeur à vis (30), de sorte que les deux convoyeurs à vis (30, 32) forment un moyen de transfert des récipients (5) d'une unité modulaire (2) à la suivante.
  8. Installation suivant l'une des revendications 6 et 7, caractérisée en ce que l'assemblage entre respectivement deux carters (4) est créé avec un ajustage de précision, de préférence au moyen de goupilles de positionnement.
  9. Installation suivant l'une des revendications 6 à 8, caractérisée en ce que l'installation intégrale a une réalisation essentiellement fermée en direction de l'extérieur.
  10. Installation suivant l'une des revendications 6 à 9, caractérisée en ce que chaque carter (4) présente un plateau (26), au-dessus duquel sont disposés les dispositifs de transport (28) pour les récipients (5) et au-dessous duquel sont disposés des dispositifs d'entraînement et de réglage, ainsi que des câbles, pour les dispositifs respectifs (6, 8, 10, 12, 14, 16).
EP07011867A 2007-06-18 2007-06-18 Installation destinée à la mise en bouteille de produits pharmaceutiques dans des récipients de types bouteilles Active EP2006204B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP07011867A EP2006204B1 (fr) 2007-06-18 2007-06-18 Installation destinée à la mise en bouteille de produits pharmaceutiques dans des récipients de types bouteilles
DE502007000739T DE502007000739D1 (de) 2007-06-18 2007-06-18 Anlage zur Abfüllung pharmazeutischer Produkte in flaschenartige Behälter
US12/134,641 US9399532B2 (en) 2007-06-18 2008-06-06 System for filling pharmaceutical products into bottle-shaped containers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07011867A EP2006204B1 (fr) 2007-06-18 2007-06-18 Installation destinée à la mise en bouteille de produits pharmaceutiques dans des récipients de types bouteilles

Publications (2)

Publication Number Publication Date
EP2006204A1 EP2006204A1 (fr) 2008-12-24
EP2006204B1 true EP2006204B1 (fr) 2009-05-13

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ID=38645873

Family Applications (1)

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EP07011867A Active EP2006204B1 (fr) 2007-06-18 2007-06-18 Installation destinée à la mise en bouteille de produits pharmaceutiques dans des récipients de types bouteilles

Country Status (3)

Country Link
US (1) US9399532B2 (fr)
EP (1) EP2006204B1 (fr)
DE (1) DE502007000739D1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITBO20080413A1 (it) * 2008-06-27 2009-12-28 Gaetano Castiglione Macchina per la produzione di flaconi con dosi di prodotto.
EP2154073B1 (fr) * 2008-08-13 2011-02-09 Uhlmann Pac-Systeme GmbH & Co. KG Procédé et dispositif de remplissage cadencé d'une multitude de récipients
EP2495190B1 (fr) 2011-03-04 2013-06-05 UHLMANN PAC-SYSTEME GmbH & Co. KG Dispositif de transport rectiligne de récipients verticaux
ITBO20110180A1 (it) 2011-04-06 2012-10-07 Mg 2 Srl Macchina per il riempimento di flaconi con forme solide di prodotti farmaceutici, in particolare capsule, pillole, pastiglie, e/o compresse
DE102012212882A1 (de) * 2012-07-23 2014-01-23 Krones Ag Modulare Produktionsanlage und Verfahren zum Herstellen und/oder Abfüllen von Behältern
DE102016205255A1 (de) * 2016-03-30 2017-10-05 Krones Aktiengesellschaft Modulsystem zum Umgang mit Getränkebehältnissen und entsprechendes Verfahren hierfür
US11673698B2 (en) 2020-03-10 2023-06-13 Blue Sky Ventures (Ontario) Inc. Continuous motion filling system and filling machine and methods

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US6755223B1 (en) * 2001-05-15 2004-06-29 I.M.A. Industria Macchine Automatiche S.P.A. Automatic machine for filling bottles with powered material and the relative drive mechanism

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Also Published As

Publication number Publication date
US20080307750A1 (en) 2008-12-18
US9399532B2 (en) 2016-07-26
EP2006204A1 (fr) 2008-12-24
DE502007000739D1 (de) 2009-06-25

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