EP1981637B1 - Procédé de fabrication d'un récipient d'échantillonnage servant à contenir de petites quantités de liquide pour analyses - Google Patents
Procédé de fabrication d'un récipient d'échantillonnage servant à contenir de petites quantités de liquide pour analyses Download PDFInfo
- Publication number
- EP1981637B1 EP1981637B1 EP07702363A EP07702363A EP1981637B1 EP 1981637 B1 EP1981637 B1 EP 1981637B1 EP 07702363 A EP07702363 A EP 07702363A EP 07702363 A EP07702363 A EP 07702363A EP 1981637 B1 EP1981637 B1 EP 1981637B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cap
- sample
- membrane
- liquid
- analyses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004458 analytical method Methods 0.000 title claims description 6
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 239000007788 liquid Substances 0.000 title description 5
- 239000012528 membrane Substances 0.000 claims abstract description 25
- 238000007789 sealing Methods 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims 1
- 238000002372 labelling Methods 0.000 abstract description 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229920001971 elastomer Polymers 0.000 description 6
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 238000011109 contamination Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/042—Caps; Plugs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
Definitions
- the invention relates to a method for producing a sample vessel for receiving small quantities of liquid for analysis, comprising a closed at its one end tube and the other, open end sealingly occlusive, by a pierceable from a tip of a withdrawal cannula, a membrane disc having cap the membrane disc is inserted from below into the cap and supported by the inner surface of an outer flat, flat top wall of the cap as supported by the EP 1 211 184 A1 known.
- a disc inserted or mounted from below into a closure cap of a vessel is likewise known from US Pat JP 7 075 663 A known.
- the caps closing the open end are all pierceable sealing plugs, which extend with a cylindrical sealing portion into the open end of the tube and are sealed against the inner wall of the tube. They are suitable for the fully automatic removal of analysis samples, for which within the closure stopper a top-mounted, pierceable by the tip of a sampling cannula, made of rubber / rubber or an elastomeric plastic insert is disposed within the sealing plug.
- This use of the sealing plug which consists of a completely elastically re-deforming material, is readily pierceable for the removal cannula of the analyzer, whereby the temporarily formed The piercing opening completely closes again after pulling out the cannula.
- the occlusion device occluding the open end of the sample vessel, in particular blood sample tubes, comprises a stopper cap with a special top-mounted sealing stopper.
- a retaining ring or a lock washer is mounted in this from the outer, free end side.
- sample tags should be attached in such a way that it is visible even if many sample containers are stored tightly in a rack for storage.
- the closed systems of the prior art are used, for example, for the field of blood collection or blood collection and comprise primary vessels which receive large quantities of blood, at least 2 ml and usually much more. In the case of direct adaptation, small sample volumes of a few ⁇ l are taken from the closed system. In these primary vessels, it is also already known to provide for these screw closures with pierceable and resealable membrane (see. DE 30 49 503 C ).
- the extraction tube at its front end cap has a cylindrical, axially projecting dome, which has a top-mounted pierceable sealing stopper which rests on a provided with a central bore end plate of the dome and is held by a flanged collar.
- this supernatant rules out that the lid surface can be provided with a labeling or sample identification.
- the invention is therefore an object of the invention to provide a method of the type mentioned above, which allows for simple production and handling even with no liquid quantities a closed system and at the same time a visible sample identification.
- the membrane disc is held supported by a flanged by hot deformation edge of the inner collar of the cap. It is hereby a suitable for commercial sample vessels closure with positionally secure seat or support and support of the membrane disc achieved that can be run as a screw or Stopfkappenver gleich, and in which the cap or headboard outer surface is always fully unrestricted available to without impairment, as is inevitable in the case of the usual from the top inserted into a correspondingly large opening membrane discs, to be provided with a label, a film or the like.
- the insertable from below or inside, pierceable membrane disc is accessible from the outside, optionally via a small diameter piercing Duchgangsö réelle, unhindered for a sampling cannula, which allows a simple sample and Reagenzein- or output, with a repeated repetition of a Removal process, the membrane disc can not be pushed out of the closure. Because this is securely held in its position by their supported by the hot edge deformation of the end edge of the inner collar flanged edge of the cap supported.
- This position-secure seat or the support and support of the membrane disk can be achieved, for example, by an inwardly beaded edge of an inner collar of the closure cap and / or a perforated disk inserted into and held by the inner collar supporting the membrane disk.
- the membrane disc advantageously made of rubber, can not be pushed down out of the inner collar.
- the flanging can be advantageously produced by hot deformation of the end edge of the inner collar.
- An advantageous embodiment of the invention provides that the top wall of the closure cap is formed with a plastic membrane covering a piercing passage opening of the top wall of the closure cap. In this embodiment, too, there is a flat, flat, for a sample identification unreservedly full-surface outer surface of the cap before and is provided by the thin film at the same time with a contamination protection.
- sample vessel 1 consists of a closed at its lower end from the outset tube 2 for receiving small amounts of liquid. At its upper end, the tube 2 is temporarily closed by a sealingly screw-on cap 3 - hereinafter referred to as a screw cap closure - closed.
- the sortedkappenver gleich 3 has an inner collar 4 and concentric to this in its top wall 5 a small sized piercing passage opening 6. From inside or below is in the erkrappenverschluß 3 in the inner collar 4 with contact with the inner surface of the top wall 5 Vietnamesestechbare membrane disc. 7 used. This is held securely in its installed position by a flanged by hot deformation edge 8 of the inner collar 4.
- a sealing bead can be provided, which ensures a liquid-tight fit of the closure, even in the event of a slight slight overpressure, e.g. by adding reagents can be ensured.
- O-rings, sealing lips, sealing washers or the like it is possible by using e.g. O-rings, sealing lips, sealing washers or the like to achieve a liquid-tight closure.
- the in Fig. 2 illustrated sterkappenverschluß 3 differs from the above-described embodiment in that the piercing through hole 6 is covered by a thin plastic membrane 10, which has only film thickness and, for example, is 0.1 mm.
- the screw cap closures 3 have in common that they close a tube 2 for small amount of sample, which does not need to be opened for the repeated removal of a part or a subset of the sample or for the multiple addition of reagents.
- the installation position of the highly elastic, resilient, easily penetrated by a cannula membrane disc 7 is not leaking even with repeated insertion and withdrawal of a cannula or sampling needle, and the membrane disc 7 can not be pushed out of the fferkappenver gleich 3.
- the membrane plate 7 from below a flat, flat outside of the head wall and thus always a sufficiently large area for unobstructed attachment of a sample marking available. This also in the execution of the screw cap closure with a piercing passage opening, which can be covered by a plastic membrane. '
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Mechanical Engineering (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Closures For Containers (AREA)
Claims (1)
- Procédé de fabrication d'un récipient à échantillon (1) pour recevoir de petites quantités de liquide pour des analyses, comprenant un petit tube (2) fermé sur l'une de ses extrémités, et un bouchon de fermeture (3) fermant de manière étanche l'autre extrémité ouverte, pouvant être traversé par la pointe d'une canule de prélèvement, présentant un disque membrane (7), sachant que le disque membrane (7) est introduit par le bas dans le bouchon de fermeture (3) et est appuyé en reposant sur la face intérieure d'une paroi de tête (5) plane et plate extérieure du bouchon de fermeture (3),
caractérisé en ce que
le disque membrane (7) est maintenu appuyé par un bord (8) bordé par déformation à chaud du col intérieur (4) du bouchon de fermeture (3).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL07702363T PL1981637T3 (pl) | 2006-02-07 | 2007-01-18 | Sposób wytwarzania naczynia do pobierania próbek do pobierania małych ilości płynu do analizy |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE202006001995U DE202006001995U1 (de) | 2006-02-07 | 2006-02-07 | Probengefäß zur Aufnahme von kleinen Flüssigkeitsmengen für Analysen |
PCT/DE2007/000082 WO2007090362A1 (fr) | 2006-02-07 | 2007-01-18 | Récipient d'échantillonnage servant à contenir de petites quantités de liquide pour analyses |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1981637A1 EP1981637A1 (fr) | 2008-10-22 |
EP1981637B1 true EP1981637B1 (fr) | 2012-04-25 |
Family
ID=36599848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07702363A Active EP1981637B1 (fr) | 2006-02-07 | 2007-01-18 | Procédé de fabrication d'un récipient d'échantillonnage servant à contenir de petites quantités de liquide pour analyses |
Country Status (14)
Country | Link |
---|---|
US (1) | US20070183937A1 (fr) |
EP (1) | EP1981637B1 (fr) |
JP (1) | JP5015964B2 (fr) |
CN (1) | CN101378837B (fr) |
AT (1) | ATE554858T1 (fr) |
AU (1) | AU2007214142B2 (fr) |
BR (1) | BRPI0707525B1 (fr) |
CA (1) | CA2641777C (fr) |
DE (1) | DE202006001995U1 (fr) |
DK (1) | DK1981637T3 (fr) |
ES (1) | ES2386821T3 (fr) |
PL (1) | PL1981637T3 (fr) |
RU (1) | RU2384369C1 (fr) |
WO (1) | WO2007090362A1 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007024539A1 (de) * | 2007-05-24 | 2008-11-27 | Fresenius Kabi Deutschland Gmbh | Verschlusskappe für ein Behältnis zur Aufnahme von Flüssigkeiten, insbesondere einer enteralen Nährlösung und Behältnis mit einer derartigen Verschlusskappe |
GB0722385D0 (en) * | 2007-11-14 | 2007-12-27 | Novathera Ltd | Vessel cap |
DE102008060995A1 (de) * | 2008-12-09 | 2010-06-10 | West Pharmaceutical Services Deutschland Gmbh & Co. Kg | Verschluss für ein Medikamentenbehältnis |
IT1393104B1 (it) * | 2009-02-25 | 2012-04-11 | Sentinel Ch S P A | Provetta perfezionata per la raccolta, il trasporto e l'estrazione di campioni di feci |
US8550273B2 (en) | 2010-08-31 | 2013-10-08 | Wheaton Industries, Inc. | Cryogenic vials |
US20140315325A1 (en) * | 2011-11-16 | 2014-10-23 | Epistem Limited | Assembly comprising a reaction vessel and a sample matrix, sample matrix comprising an upper adsorbent layer and a lower lateral flow layer |
CN103071549A (zh) * | 2012-06-15 | 2013-05-01 | 郑州安图绿科生物工程有限公司 | 试剂瓶 |
DE102012110111A1 (de) | 2012-10-23 | 2014-04-24 | Rpc Formatec Gmbh | Gefäß |
AU2013202805B2 (en) | 2013-03-14 | 2015-07-16 | Gen-Probe Incorporated | System and method for extending the capabilities of a diagnostic analyzer |
CN113350278B (zh) * | 2013-10-24 | 2023-03-24 | 阿斯利康(瑞典)有限公司 | 稳定的水性抗体配制品 |
WO2017112596A1 (fr) * | 2015-12-23 | 2017-06-29 | Chico Technologies Llc | Impression dans le moule de tubes |
WO2017161058A1 (fr) * | 2016-03-15 | 2017-09-21 | Abbott Laboratories | Systèmes d'enceinte de réaction et procédés et systèmes pour les utiliser |
CA3130654A1 (fr) | 2020-09-15 | 2022-03-15 | Norgen Biotek Corp. | Appareil de collecte d'echantillons et utilisations connexes |
CN112619718B (zh) * | 2020-11-17 | 2022-06-14 | 浙江省海洋水产研究所 | 一种免开盖离心管 |
CN113184356A (zh) * | 2021-03-16 | 2021-07-30 | 李亚峰 | 一种密封性好的炎症生化检测试剂盒 |
CN115138413B (zh) * | 2022-08-02 | 2023-09-22 | 石家庄元鼎医疗器械有限公司 | 一种便于取样的穿刺型尿管 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH361086A (de) * | 1957-09-20 | 1962-03-31 | Astra Apotekarnes Kem Fab | Verschlusspfropfen an Behälter für Injektionsflüssigkeit |
DE1935952U (de) * | 1966-02-08 | 1966-03-31 | J A Schmalbach Aktiengesellsch | Verschluss fuer Kunststoffpackungen |
SE388178B (sv) * | 1974-09-06 | 1976-09-27 | Pharmacia Ab | Tetande forslutning for behallare |
US4254884A (en) * | 1978-10-20 | 1981-03-10 | Toppan Printing Co., Ltd. | Plug body for a container |
US4312349A (en) * | 1979-07-23 | 1982-01-26 | Cohen Milton J | Filter device for injectable fluid |
DE3049503C2 (de) | 1980-12-30 | 1983-04-28 | Walter Sarstedt Kunststoff-Spritzgußwerk, 5223 Nümbrecht | "Blutentnahmevorrichtung" |
JPH02212768A (ja) * | 1989-02-13 | 1990-08-23 | Terumo Corp | 採液管 |
AT401341B (de) | 1990-03-09 | 1996-08-26 | Greiner & Soehne C A | Verschlussvorrichtung für ein, insbesondere evakuierbares gehäuse |
US5016771A (en) * | 1990-09-04 | 1991-05-21 | J. G. Finneran Associates | Cap closure and liner |
DE4112209A1 (de) * | 1991-04-13 | 1992-10-15 | Behringwerke Ag | Behaelterverschluss mit durchstossbarem verschlusskoerper |
JPH0775663A (ja) | 1993-06-25 | 1995-03-20 | Nissho Corp | 医療用容器の栓体 |
US5361921A (en) * | 1993-06-29 | 1994-11-08 | Becton Dickinson And Company | Combination stopper-shield closure |
DE19739369C2 (de) * | 1997-09-09 | 2000-04-06 | Sarstedt Ag & Co | Blutentnahmevorrichtung |
DE60043734D1 (de) * | 1999-04-20 | 2010-03-11 | Jms Co Ltd | Verschlusskappe für behälter sowie flüssigkeitsübertragungsvorrichtung |
US6426049B1 (en) * | 1999-07-09 | 2002-07-30 | Becton, Dickinson And Company | Collection assembly |
EP1066881A3 (fr) * | 1999-07-09 | 2002-07-03 | Becton Dickinson and Company | Dispositif de prélèvement d'échantillons avec capuchon |
DK1795263T4 (da) | 2001-03-09 | 2017-11-13 | Gen Probe Inc | Fremgangsmåde til fjernelse af en fluid fra en beholder omfattende en gennembrydelig hætte |
JP3727554B2 (ja) * | 2001-06-14 | 2005-12-14 | 昭和電工株式会社 | 輸液容器用口栓体 |
CN2494699Y (zh) * | 2001-09-12 | 2002-06-12 | 江苏电分析仪器厂 | 防腐玻璃密封管 |
DE10340538B4 (de) | 2003-09-03 | 2005-07-07 | Kabe-Labortechnik Gmbh | Probenbehälter zur Aufnahme von Flüssigkeiten für medizinische Analysen |
-
2006
- 2006-02-07 DE DE202006001995U patent/DE202006001995U1/de not_active Expired - Lifetime
- 2006-08-08 US US11/501,164 patent/US20070183937A1/en not_active Abandoned
-
2007
- 2007-01-18 AU AU2007214142A patent/AU2007214142B2/en active Active
- 2007-01-18 CA CA2641777A patent/CA2641777C/fr active Active
- 2007-01-18 DK DK07702363.8T patent/DK1981637T3/da active
- 2007-01-18 WO PCT/DE2007/000082 patent/WO2007090362A1/fr active Application Filing
- 2007-01-18 ES ES07702363T patent/ES2386821T3/es active Active
- 2007-01-18 AT AT07702363T patent/ATE554858T1/de active
- 2007-01-18 EP EP07702363A patent/EP1981637B1/fr active Active
- 2007-01-18 RU RU2008135973/04A patent/RU2384369C1/ru active
- 2007-01-18 CN CN2007800047839A patent/CN101378837B/zh active Active
- 2007-01-18 JP JP2008553605A patent/JP5015964B2/ja active Active
- 2007-01-18 PL PL07702363T patent/PL1981637T3/pl unknown
- 2007-01-18 BR BRPI0707525-1A patent/BRPI0707525B1/pt active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
BRPI0707525A2 (pt) | 2011-05-03 |
AU2007214142B2 (en) | 2013-01-17 |
CN101378837A (zh) | 2009-03-04 |
PL1981637T3 (pl) | 2012-11-30 |
CA2641777A1 (fr) | 2007-08-16 |
CN101378837B (zh) | 2011-11-23 |
JP5015964B2 (ja) | 2012-09-05 |
DK1981637T3 (da) | 2012-07-30 |
RU2384369C1 (ru) | 2010-03-20 |
BRPI0707525B1 (pt) | 2018-01-16 |
CA2641777C (fr) | 2014-03-25 |
AU2007214142A1 (en) | 2007-08-16 |
US20070183937A1 (en) | 2007-08-09 |
DE202006001995U1 (de) | 2006-06-08 |
ATE554858T1 (de) | 2012-05-15 |
EP1981637A1 (fr) | 2008-10-22 |
WO2007090362A1 (fr) | 2007-08-16 |
ES2386821T3 (es) | 2012-08-31 |
JP2009526210A (ja) | 2009-07-16 |
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