EP1981637B1 - Procédé de fabrication d'un récipient d'échantillonnage servant à contenir de petites quantités de liquide pour analyses - Google Patents

Procédé de fabrication d'un récipient d'échantillonnage servant à contenir de petites quantités de liquide pour analyses Download PDF

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Publication number
EP1981637B1
EP1981637B1 EP07702363A EP07702363A EP1981637B1 EP 1981637 B1 EP1981637 B1 EP 1981637B1 EP 07702363 A EP07702363 A EP 07702363A EP 07702363 A EP07702363 A EP 07702363A EP 1981637 B1 EP1981637 B1 EP 1981637B1
Authority
EP
European Patent Office
Prior art keywords
cap
sample
membrane
liquid
analyses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP07702363A
Other languages
German (de)
English (en)
Other versions
EP1981637A1 (fr
Inventor
Walter Sarstedt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sarstedt AG and Co KG
Original Assignee
Sarstedt AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarstedt AG and Co KG filed Critical Sarstedt AG and Co KG
Priority to PL07702363T priority Critical patent/PL1981637T3/pl
Publication of EP1981637A1 publication Critical patent/EP1981637A1/fr
Application granted granted Critical
Publication of EP1981637B1 publication Critical patent/EP1981637B1/fr
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Anticipated expiration legal-status Critical

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00Closures not otherwise provided for
    • B65D51/002Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082Test tubes per se
    • B01L3/50825Closing or opening means, corks, bungs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/041Connecting closures to device or container
    • B01L2300/042Caps; Plugs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/041Connecting closures to device or container
    • B01L2300/044Connecting closures to device or container pierceable, e.g. films, membranes

Definitions

  • the invention relates to a method for producing a sample vessel for receiving small quantities of liquid for analysis, comprising a closed at its one end tube and the other, open end sealingly occlusive, by a pierceable from a tip of a withdrawal cannula, a membrane disc having cap the membrane disc is inserted from below into the cap and supported by the inner surface of an outer flat, flat top wall of the cap as supported by the EP 1 211 184 A1 known.
  • a disc inserted or mounted from below into a closure cap of a vessel is likewise known from US Pat JP 7 075 663 A known.
  • the caps closing the open end are all pierceable sealing plugs, which extend with a cylindrical sealing portion into the open end of the tube and are sealed against the inner wall of the tube. They are suitable for the fully automatic removal of analysis samples, for which within the closure stopper a top-mounted, pierceable by the tip of a sampling cannula, made of rubber / rubber or an elastomeric plastic insert is disposed within the sealing plug.
  • This use of the sealing plug which consists of a completely elastically re-deforming material, is readily pierceable for the removal cannula of the analyzer, whereby the temporarily formed The piercing opening completely closes again after pulling out the cannula.
  • the occlusion device occluding the open end of the sample vessel, in particular blood sample tubes, comprises a stopper cap with a special top-mounted sealing stopper.
  • a retaining ring or a lock washer is mounted in this from the outer, free end side.
  • sample tags should be attached in such a way that it is visible even if many sample containers are stored tightly in a rack for storage.
  • the closed systems of the prior art are used, for example, for the field of blood collection or blood collection and comprise primary vessels which receive large quantities of blood, at least 2 ml and usually much more. In the case of direct adaptation, small sample volumes of a few ⁇ l are taken from the closed system. In these primary vessels, it is also already known to provide for these screw closures with pierceable and resealable membrane (see. DE 30 49 503 C ).
  • the extraction tube at its front end cap has a cylindrical, axially projecting dome, which has a top-mounted pierceable sealing stopper which rests on a provided with a central bore end plate of the dome and is held by a flanged collar.
  • this supernatant rules out that the lid surface can be provided with a labeling or sample identification.
  • the invention is therefore an object of the invention to provide a method of the type mentioned above, which allows for simple production and handling even with no liquid quantities a closed system and at the same time a visible sample identification.
  • the membrane disc is held supported by a flanged by hot deformation edge of the inner collar of the cap. It is hereby a suitable for commercial sample vessels closure with positionally secure seat or support and support of the membrane disc achieved that can be run as a screw or Stopfkappenver gleich, and in which the cap or headboard outer surface is always fully unrestricted available to without impairment, as is inevitable in the case of the usual from the top inserted into a correspondingly large opening membrane discs, to be provided with a label, a film or the like.
  • the insertable from below or inside, pierceable membrane disc is accessible from the outside, optionally via a small diameter piercing Duchgangsö réelle, unhindered for a sampling cannula, which allows a simple sample and Reagenzein- or output, with a repeated repetition of a Removal process, the membrane disc can not be pushed out of the closure. Because this is securely held in its position by their supported by the hot edge deformation of the end edge of the inner collar flanged edge of the cap supported.
  • This position-secure seat or the support and support of the membrane disk can be achieved, for example, by an inwardly beaded edge of an inner collar of the closure cap and / or a perforated disk inserted into and held by the inner collar supporting the membrane disk.
  • the membrane disc advantageously made of rubber, can not be pushed down out of the inner collar.
  • the flanging can be advantageously produced by hot deformation of the end edge of the inner collar.
  • An advantageous embodiment of the invention provides that the top wall of the closure cap is formed with a plastic membrane covering a piercing passage opening of the top wall of the closure cap. In this embodiment, too, there is a flat, flat, for a sample identification unreservedly full-surface outer surface of the cap before and is provided by the thin film at the same time with a contamination protection.
  • sample vessel 1 consists of a closed at its lower end from the outset tube 2 for receiving small amounts of liquid. At its upper end, the tube 2 is temporarily closed by a sealingly screw-on cap 3 - hereinafter referred to as a screw cap closure - closed.
  • the sortedkappenver gleich 3 has an inner collar 4 and concentric to this in its top wall 5 a small sized piercing passage opening 6. From inside or below is in the erkrappenverschluß 3 in the inner collar 4 with contact with the inner surface of the top wall 5 Vietnamesestechbare membrane disc. 7 used. This is held securely in its installed position by a flanged by hot deformation edge 8 of the inner collar 4.
  • a sealing bead can be provided, which ensures a liquid-tight fit of the closure, even in the event of a slight slight overpressure, e.g. by adding reagents can be ensured.
  • O-rings, sealing lips, sealing washers or the like it is possible by using e.g. O-rings, sealing lips, sealing washers or the like to achieve a liquid-tight closure.
  • the in Fig. 2 illustrated sterkappenverschluß 3 differs from the above-described embodiment in that the piercing through hole 6 is covered by a thin plastic membrane 10, which has only film thickness and, for example, is 0.1 mm.
  • the screw cap closures 3 have in common that they close a tube 2 for small amount of sample, which does not need to be opened for the repeated removal of a part or a subset of the sample or for the multiple addition of reagents.
  • the installation position of the highly elastic, resilient, easily penetrated by a cannula membrane disc 7 is not leaking even with repeated insertion and withdrawal of a cannula or sampling needle, and the membrane disc 7 can not be pushed out of the fferkappenver gleich 3.
  • the membrane plate 7 from below a flat, flat outside of the head wall and thus always a sufficiently large area for unobstructed attachment of a sample marking available. This also in the execution of the screw cap closure with a piercing passage opening, which can be covered by a plastic membrane. '

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Closures For Containers (AREA)

Claims (1)

  1. Procédé de fabrication d'un récipient à échantillon (1) pour recevoir de petites quantités de liquide pour des analyses, comprenant un petit tube (2) fermé sur l'une de ses extrémités, et un bouchon de fermeture (3) fermant de manière étanche l'autre extrémité ouverte, pouvant être traversé par la pointe d'une canule de prélèvement, présentant un disque membrane (7), sachant que le disque membrane (7) est introduit par le bas dans le bouchon de fermeture (3) et est appuyé en reposant sur la face intérieure d'une paroi de tête (5) plane et plate extérieure du bouchon de fermeture (3),
    caractérisé en ce que
    le disque membrane (7) est maintenu appuyé par un bord (8) bordé par déformation à chaud du col intérieur (4) du bouchon de fermeture (3).
EP07702363A 2006-02-07 2007-01-18 Procédé de fabrication d'un récipient d'échantillonnage servant à contenir de petites quantités de liquide pour analyses Active EP1981637B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL07702363T PL1981637T3 (pl) 2006-02-07 2007-01-18 Sposób wytwarzania naczynia do pobierania próbek do pobierania małych ilości płynu do analizy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE202006001995U DE202006001995U1 (de) 2006-02-07 2006-02-07 Probengefäß zur Aufnahme von kleinen Flüssigkeitsmengen für Analysen
PCT/DE2007/000082 WO2007090362A1 (fr) 2006-02-07 2007-01-18 Récipient d'échantillonnage servant à contenir de petites quantités de liquide pour analyses

Publications (2)

Publication Number Publication Date
EP1981637A1 EP1981637A1 (fr) 2008-10-22
EP1981637B1 true EP1981637B1 (fr) 2012-04-25

Family

ID=36599848

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07702363A Active EP1981637B1 (fr) 2006-02-07 2007-01-18 Procédé de fabrication d'un récipient d'échantillonnage servant à contenir de petites quantités de liquide pour analyses

Country Status (14)

Country Link
US (1) US20070183937A1 (fr)
EP (1) EP1981637B1 (fr)
JP (1) JP5015964B2 (fr)
CN (1) CN101378837B (fr)
AT (1) ATE554858T1 (fr)
AU (1) AU2007214142B2 (fr)
BR (1) BRPI0707525B1 (fr)
CA (1) CA2641777C (fr)
DE (1) DE202006001995U1 (fr)
DK (1) DK1981637T3 (fr)
ES (1) ES2386821T3 (fr)
PL (1) PL1981637T3 (fr)
RU (1) RU2384369C1 (fr)
WO (1) WO2007090362A1 (fr)

Families Citing this family (16)

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DE102007024539A1 (de) * 2007-05-24 2008-11-27 Fresenius Kabi Deutschland Gmbh Verschlusskappe für ein Behältnis zur Aufnahme von Flüssigkeiten, insbesondere einer enteralen Nährlösung und Behältnis mit einer derartigen Verschlusskappe
GB0722385D0 (en) * 2007-11-14 2007-12-27 Novathera Ltd Vessel cap
DE102008060995A1 (de) * 2008-12-09 2010-06-10 West Pharmaceutical Services Deutschland Gmbh & Co. Kg Verschluss für ein Medikamentenbehältnis
IT1393104B1 (it) * 2009-02-25 2012-04-11 Sentinel Ch S P A Provetta perfezionata per la raccolta, il trasporto e l'estrazione di campioni di feci
US8550273B2 (en) 2010-08-31 2013-10-08 Wheaton Industries, Inc. Cryogenic vials
US20140315325A1 (en) * 2011-11-16 2014-10-23 Epistem Limited Assembly comprising a reaction vessel and a sample matrix, sample matrix comprising an upper adsorbent layer and a lower lateral flow layer
CN103071549A (zh) * 2012-06-15 2013-05-01 郑州安图绿科生物工程有限公司 试剂瓶
DE102012110111A1 (de) 2012-10-23 2014-04-24 Rpc Formatec Gmbh Gefäß
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
CN113350278B (zh) * 2013-10-24 2023-03-24 阿斯利康(瑞典)有限公司 稳定的水性抗体配制品
WO2017112596A1 (fr) * 2015-12-23 2017-06-29 Chico Technologies Llc Impression dans le moule de tubes
WO2017161058A1 (fr) * 2016-03-15 2017-09-21 Abbott Laboratories Systèmes d'enceinte de réaction et procédés et systèmes pour les utiliser
CA3130654A1 (fr) 2020-09-15 2022-03-15 Norgen Biotek Corp. Appareil de collecte d'echantillons et utilisations connexes
CN112619718B (zh) * 2020-11-17 2022-06-14 浙江省海洋水产研究所 一种免开盖离心管
CN113184356A (zh) * 2021-03-16 2021-07-30 李亚峰 一种密封性好的炎症生化检测试剂盒
CN115138413B (zh) * 2022-08-02 2023-09-22 石家庄元鼎医疗器械有限公司 一种便于取样的穿刺型尿管

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Also Published As

Publication number Publication date
BRPI0707525A2 (pt) 2011-05-03
AU2007214142B2 (en) 2013-01-17
CN101378837A (zh) 2009-03-04
PL1981637T3 (pl) 2012-11-30
CA2641777A1 (fr) 2007-08-16
CN101378837B (zh) 2011-11-23
JP5015964B2 (ja) 2012-09-05
DK1981637T3 (da) 2012-07-30
RU2384369C1 (ru) 2010-03-20
BRPI0707525B1 (pt) 2018-01-16
CA2641777C (fr) 2014-03-25
AU2007214142A1 (en) 2007-08-16
US20070183937A1 (en) 2007-08-09
DE202006001995U1 (de) 2006-06-08
ATE554858T1 (de) 2012-05-15
EP1981637A1 (fr) 2008-10-22
WO2007090362A1 (fr) 2007-08-16
ES2386821T3 (es) 2012-08-31
JP2009526210A (ja) 2009-07-16

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