Classifications

• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
  • G01N30/02—Column chromatography
  • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P35/00—Antineoplastic agents
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
  • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
  • G01N30/02—Column chromatography
  • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
  • G01N2030/8881—Modular construction, specially adapted therefor
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
  • G01N2035/00178—Special arrangements of analysers
  • G01N2035/00326—Analysers with modular structure
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
  • G01N35/00584—Control arrangements for automatic analysers
  • G01N35/00722—Communications; Identification
  • G01N35/00871—Communications between instruments or with remote terminals
• • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
  • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
  • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
  • Y10T436/00—Chemistry: analytical and immunological testing
  • Y10T436/11—Automated chemical analysis

Definitions

• the invention relates to an arrangement and a method for processing of chemical substances, a computer program for controlling such an arrangement and a corresponding computer-readable storage medium, which are particularly useful to Synthesemaschine- especially for radiochemicals or
• Radiopharmaceuticals - adapt flexibly to different process sequences and thus make them usable for research and routine operation.
• radiopharmaceuticals are a set of procedural chemical
• such basic operations include extraction, heating / cooling, mixing, diluting, dosing, etc.
• PET positron emission tomography
• kits prepared by the manufacturer are partly process steps such as mixing, diluting, cooking, etc. to realize.
• a short-lived radionuclide produced in the cyclotron is coupled to a biomolecule to be injected into the human body during the PET study.
• Another feature of existing concepts is that it is either oriented to suitability as a routine aseptic production equipment using fixed disposable sterile materials, which is then not suitable for flexible process development or research operation requirements; or but
• the device software does not communicate with the control software of the upstream synthesis devices.
• .0 include the subsequent filling process.
• automated synthesizers are provided for the production of one of the popular PET tracers such as 18-F-FDG.
• specialized devices for .5 either
• the available facilities are dedicated facilities for a particular synthesis.
• US Patent Application 2004/0028573 A1 describes a device for synthesizing radiopharmaceutical products based on chemical reagents, which are in bottles, the device comprising: various reaction chambers, transfer elements between the bottles and the reaction cartridges and mechanical elements that allow the transfer of chemical components to be monitored and controlled mechanically.
• the transfer elements are formed as removable elements, which can be removed after use and possibly disposed of.
• the 10 generally includes a reaction vessel and a block, the block comprising a vessel containment vessel, upper and lower temperature altering elements.
• the vessel receptacle forms an upper and a lower zone and is so
• reaction vessel may be received therein so as to define an upper zone space between an outer side of the reaction vessel and an inner wall of the vessel receiving vessel in the upper zone. Likewise, a lower zone space between an outer side of the reaction vessel
• the upper temperature-changing element is used to change the gas temperature in the upper zone room and the lower temperature-changing element is used to change the gas temperature in said lower zone space.
• the method contains the
• $ 5 for the multiple batch production of FDG contains a reagent delivery system, a reaction vessel, a filter arrangement and a system of rules.
• the combination of these ingredients provides a method capable of producing multiple batches of a radiopharmaceutical with minimal operator intervention and hence minimal exposure to radiation through automatic (self-) cleaning and automatic screening of components such as membrane filters ,
• HPLC High Performance Liquid Chromatography
• HPLC column an HPLC column.
• the marking component contains a loop and valves which have different orientations (rotary loop
• the object of the invention is thus to provide an arrangement and a method for processing chemical substances Computer program for controlling such an arrangement as well as to provide a corresponding computer-readable storage medium, which remedy the above-mentioned deficiencies and in particular allow simple and flexible reshaping of laboratory facilities and thereby make it usable for different sequences of method steps.
• a particular advantage of the arrangement according to the invention for the processing of chemical substances in the laboratory sector comprising assemblies for carrying out process-chemical basic operations.
• NEN is that the arrangement is flexibly expandable and retrofittable by the modules can be modularly combined according to predetermined sequences of process steps for the processing of chemical substances. It is provided that the modules have a coordinated pitch and / or
• .5 are preferably executed cuboid, each self-supporting boxes, preferably per box or per module a procedural-chemical operation is realized.
• a further preferred embodiment provides that the modules are provided with corresponding connecting elements, through
• modules can be assembled stable solvable. However, assemblies can also be positioned spatially separated. With the help of such corresponding fasteners, the modules can be a self-standing and-bearing system
• Assemble $ 5 manages without a standard in the art stator wall.
• These fasteners may be, for example, from the surface of the Assembly housing protruding elements and corresponding recesses or openings act.
• the protruding elements are designed as handles which facilitate the transport of the assemblies.
• Grips of a first assembly are received during assembly of the system of corresponding openings of a second assembly.
• the modules can be plugged together as a modular plug-in system.
• each module is a process-chemical
• the modules have their own internal logic, which communicate with each other via the intelligent bus system and with .0 a central control unit (for example, an industrial PC).
• This internal logic allows, for example, a mutual logon or the management of modules or an evaluation of feedback signals.
• the chemical substances to be processed may be, for example, radioactive substances, in particular pharmaceuticals and / or diagnostic agents.
• the arrangement according to the invention can be used particularly advantageously if the processing 5 also comprises the synthesis of chemical substances.
• radiochemical or radiopharmaceutical syntheses are in many cases carried out automatically.
• a remotely operated modular device system is a remotely operated modular device system
• the plant is suitable for carrying out syntheses or other operations in the (batch) batch process, wherein the reactants are supplied initially and then
• the basic chemical operations can be: 0 • Transport of vessels / syringes,
• Vessel transport module 15 • Vessel shaker module,
• Dosing module such as a syringe module
• units for JO filling can be combined with assemblies for carrying out process-chemical basic operations.
• the reactor cooling is designed as a liquid-nitrogen-free reactor cooling, wherein preferably a purely electronic cooling taking advantage of the Peltier effect is used.
• a purely electronic cooling taking advantage of the Peltier effect is used.
• modules can be combined in a modular manner such that, for the replacement of method steps in the sequence of method steps, modules for carrying out process-chemical basic operations are interchangeable and / or to supplement the sequence of connections.
• Arrangement according to claim 1 is expandable by adding at least one assembly for performing basic chemical process operations.
• the arrangement has an intelligent bus system which detects connected modules. It proves to be advantageous if standard connection cables are used, which are only available through different lengths.
• the assemblies are equipped with their own internal logic; This additionally enables the evaluation of feedback signals.
• the terminals are formed as coded connection cables, which are connected to a control power strip.
• predetermined sequence of process steps for the processing of chemical substances can be modular combined and configured accordingly, and the processing of the chemical substances is at least partially controlled by a computer program.
• configuration and control takes place under one
• the computer program uses a uniform database in the configuration of the modular combined assemblies.
• the computer program comprises program modules for control, operation and / or display for modules.
• Claim 22 is downloaded from an electronic data network such as from the Internet to a data processing device connected to the data network. Additionally or alternatively, computer-readable storage media
• Claim 22 or parts of a computer program according to claim 22 are stored.
• the modular device system for synthesis and filling of radiopharmaceuticals and chemicals described here represents a JO integrated system managed under a common software user interface.
• the user is burdened only with a software that can be controlled intuitively by using graphical symbols.
• the use of the device system is not limited to the PET $ 5 tracers.
• the modular device system according to the invention is further distinguished by optionally automated or user-oriented driving style, high user-friendliness and variability. Special mention should be made in particular of the flexibility concept, the subsequent expandability, the creation of an integrated, graphically-oriented and easily recognizable software user interface, as well as a number of technical features such as the intended liquid-nitrogen-free reactor cooling and self-recognizing modules bus system.
• the present concept assumes a new approach. It includes an integrated device system consisting of synthesis modules and, if appropriate, a filling unit for use, in particular, in the radiopharmaceutical field, which is subject to a common
• the invention is based on flexibility, expandability, research and routine operation, single use assemblies and individual elements. As a result, the modular arrangement according to the invention differs from previously provided devices
• Cooling processes are realized in the previously available devices via liquid nitrogen supply lines and then electrically heated counter. Although this allows rapid cooling, but requires handling and regular
• the present concept provides pure electrical cooling elements, for example Peltier elements, which enable true remote operation in clean room environments.
• a preferred embodiment of the reactor module according to the invention provides an internal thermocouple for determining the actual temperature in the Reactor liquid. Furthermore, it proves to be advantageous if a camera is integrated in the reactor module for the monitoring state of the reactor vessel. Likewise with advantage in the reactor module, but also in other modules 5 means for measuring selected properties of the reactants used (educts) and / or the compound to be synthesized (product) may be provided, for example, a detector for measuring the radioactivity, or UV or IR spectroscopic measuring cells.
• Pinch valve technology preferably used motor-driven pinch valves.
• roller technology proves to be particularly advantageous since this ensures a gentle hose load. This can be done in a
• pinch valve technology can be pressed about a pivotally mounted roller with a predeterminable pivot angle against a hose, whereby the system can be adapted to variable hose diameter. In this way is an adjustable squeezing force, a
• Hose holder for different hose diameters possible.
• the pinch valves are either normally closed or open.
• the arrangement according to the invention provides the flexible expandability and retrofittability of the modules.
• An intelligent bus system has been created to which the modular assemblies such as reactors, valves, etc. are connected and recognized by the system itself. It thus eliminates the tedious application
• the modularity includes all components, in particular, for example, valves and vessel holder assemblies form modular, freely combinable assemblies.
• FIG. 2 Assembly variant in front view, Fig. 2 illustrating the structure of a modular
• FIG. 3 shows an illustration of the structure of a modular synthesis device system in an exploded view
• FIG. 4 illustrating the structure of a modular
• Fig. 5 illustrates the structure of a modular JO syringe module-based device system for preparing Tc-99m MIBI
• Fig. 6 illustrates the structure of a modular one
• FIG. 1-3 An exemplary modular device system-as shown symbolically in FIG. 1-3-consists, inter alia, of the following individual modules:
• Reactor module 1 5 cartridge module 2 (chromatography, extraction or
• Valve module in embodiment pinch valve 5 10 valve module in embodiment 3/2 way valve 6 or 6a,
• Vacuum / pressure system here vacuum pump 9 with valves.
• FIG. 4 shows the structure of a modular synthesizer system for the production of, for example, 18 F-FDG (2-deoxy-2-fluoro-D-glucose), wherein the HPLC 160 depicted therein represents an optional additional embodiment which is used only in other syntheses or in the art Rebuilding process parameters is needed.
• FIG. 5 illustrates the structure of a modular syringe module-based device system for the preparation of, for example, Tc-99m-MIBI. Any combination of the individual modules is possible.
• the vascular transport module 180 is used for transport and
• the vascular transport module also includes a detector for checking the dosed activity.
• the syringe module 181 - here executed as a double syringe module - the liquids are taken from a vessel and added to another. The volumes to be dosed are freely selectable.
• the dual syringe module has brackets for holding two syringes. For each syringe type is
• This dual-syringe module has 4 linear axes, so that individually the pistons of the syringes and the syringes can be moved vertically.
• the vessel shaker module 182 has a rotatable gripper for mixing the solution.
• the reaction vial can be gripped, rotated at a variable angle (up to 180 °) and with variable speed and set down again on the vessel transport axis.
• the heating module 183 has an integrated heating device for heating the solution up to 100 ° C.
• Figure 6 illustrates the construction of a modular synthesizer system for making 68 Ga-DOTA conjugated peptides.
• the system consists of a module for holding vessels 190, three different valve modules (tap bank 191, solenoid valve 192, single tap 193), a reactor module 194 and a peristaltic pump. The operation is explained in Example 5.
• FIG. 7 shows an exemplary user interface of the hardware configuration present in FIG.
• the system enables both sterile operation using sterilized disposable components (especially suitable for routine production) and a flexible one Research or multiple operation using reusable modules.
• the basis is a freely configurable, graphically oriented user interface.
• Modules or assemblies include:
• Valve module 2-W / 3-W solenoid valves 6, crimping technology
• Vascular module 4 for placing / holding vials, e.g. for starting materials
• JO • Vessel module in active version with interfaces for connection of external sensors and devices
• Distribution module for distribution / consolidation of hose lines, partly combined with valves or realized by means of multi-way valves
• Reactor module 1 includes reactor vessel, heating / cooling, stirrer, activity measurement, observation camera • Cartridge Module 2: for placing / holding filter, chromatography or extraction cartridges or cartridges, separation columns, sometimes combined with valves or vials
• Vacuum / pressure system the solution transport through the lines is realized by vacuum or overpressure
• Dosing module 10 for dosing fluid volumes, consisting of one or more elements moved by means of linear actuators
• Disposable modules can optionally be mounted on the base modules
• the software is used for:
• Standard reactions e.g., F18-FDG
• F18-FDG Standard reactions
• the software has the following specific features:
• the software is simple and clear and tailored as a technology package to the target group.
• the software contains the components required for configuration, programming and operation.
• control sequence can be carried out with function blocks (function blocks) or as text (table or script language).
• the display modules have suitable dynamic visualization properties.
• a macro recorder allows the creation of individual sections of the control sequence (eg emptying, cleaning ). By simply clicking on the blocks / assemblies, a dialog window is opened, which contains the Poll process required parameters. After confirmation, the process step is then inserted directly into the program sequence as a graphic symbol.
• the macros are reusable and can be used during the
• the software allows easy system reconfiguration and reprogramming of the control flow and user interface if there are changes in the process and / or .0 adding / removing modules.
• a system for synthesizing the PET tracer 18 F-FDG may, for example, four modules 111, 112, 113, 114 for holding
• valve modules 121, 122, 123, 124, 125, 126 (each with three valves), a reactor module 130 and a module 140 for vacuum generation (vacuum pump with cold trap 150 and filter) are assembled.
• the transport of the media can either be done with sterile disposable parts or it
• the four modules 111, 112, 113, 114 for holding vessels or cartridges are each provided with a valve module 121, 122, 123, 124, 125 and 126 for controlling the media flow to a
• the first functional unit 111, 121 with two vessels and a cartridge effects a separation of the 18 coming from the cyclotron fluoride from the water and a transfer to the reactor in an aprotic solvent.
• the second functional unit 112, 122 contains three vessels for adding the
• Reactor module 130 all reaction steps such as azeotropic distillation, nucleophilic substitution and removal of the protective groups are performed. Via a valve module 125, the crude product from the reactor optionally via an HPLC separation process
• the HPLC separation process is in the routine
• the fourth functional unit 114, 124 contains three vessels for adding the required solutions for purification, elution from the cartridge and dilution of the product.
• the transport of solutions is accomplished by applying over or under pressure at defined points of the system by means of vacuum module 140 and controlled by a valve module 126. 5 All reaction steps as well as the purification and separation of
• Reaction residues are carried out fully automatically and a product ready for filling is obtained.
• a system for preparing Zevalin® from the Zevalin® kit consists of a module for holding vessels, two valve modules (tap bank), a dosing module, a reactor module and a vacuum generation module (vacuum pump with filter).
• connection of the individual parts for the transport of media is effected by means of hoses which, by means of quick connectors, either on needles which pierce the vessel lids with septa or directly e.g. to be connected to taps, valves.
• hoses which, by means of quick connectors, either on needles which pierce the vessel lids with septa or directly e.g. to be connected to taps, valves.
• a system for preparing Tc-99m MIBI from the Tc-99m MIBI $ 5 kit consists of a vessel holding module, a valve module (tap bank), a reactor module, and a module for Vacuum generation (vacuum pump with filter).
• the connection of the individual parts to the media transport via hoses by means of quick connector either on needles, which pierce into the vessel lid with septa or directly as to taps,
• valves are connected. These are all sterile disposable parts that are disposed of after the reaction.
• the Tc-99m MIBI vial from the kit is introduced into the reactor block and radioactive solution is added.
• the transport and mixing of the solutions is done by applying negative pressure in the
• reaction vessel accomplished by the module for vacuum generation.
• the reactor is heated to carry out the synthesis and cooled to room temperature after the end of the reaction.
• the temperature profile is controlled by the controlling computer via the described software.
• .0 Kit consists of a vessel transport module for mounting
• the dosage is determined by the
• the reaction vial moves to the vessel shaker module, where it is picked up and shaken with the gripper. After shaking, the heater of the heating module moves under the still gripped container and the
• a system for producing 68 Ga-DOTA conjugated peptides consists of a module for holding vessels 190, three different valve modules (tap bank 191, solenoid valve 192, single tap 193), a reactor module 194 and a peristaltic pump.
• the peristaltic pump delivers the radioactive 68 gallium solution from a generator into the valve module (solenoid valve 192). This controls the addition of the 68 gallium solution to the reactor 194.
• the reaction of the gallium solution with the submitted reactants to the product takes place by heating.
• the crude product is transported via the valve module (solenoid valve 192) to the valve module (single tap 193).
• the media transport (except 68 gallium solution) takes place via externally applied pressure.
• the pressure conditions in the system are controlled via the valve module (Hahnbank 191).
• the system has a sterile filter integrity test and a fully automatic cleaning procedure for all permanent components in contact with media.
• valve module in the embodiment of the valve bank
• valve module in embodiment 3/2 way valve, in addition laterally mounted vessel holder

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• Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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• Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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• 2005
  • 2005-06-17 DE DE102005028897A patent/DE102005028897A1/de not_active Ceased
• 2006
  • 2006-06-01 EP EP06763471A patent/EP1756588A1/de not_active Withdrawn
  • 2006-06-01 JP JP2008516273A patent/JP2009501138A/ja active Pending
  • 2006-06-01 WO PCT/EP2006/062850 patent/WO2006134035A1/de not_active Application Discontinuation
  • 2006-06-01 US US11/817,840 patent/US20080233653A1/en not_active Abandoned

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