EP1752459A4 - Procédé de production de composés de 3-alcénylcéphème - Google Patents

Procédé de production de composés de 3-alcénylcéphème

Info

Publication number
EP1752459A4
EP1752459A4 EP05751538A EP05751538A EP1752459A4 EP 1752459 A4 EP1752459 A4 EP 1752459A4 EP 05751538 A EP05751538 A EP 05751538A EP 05751538 A EP05751538 A EP 05751538A EP 1752459 A4 EP1752459 A4 EP 1752459A4
Authority
EP
European Patent Office
Prior art keywords
production
cephem
methylthiazol
vinyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP05751538A
Other languages
German (de)
English (en)
Japanese (ja)
Other versions
EP1752459B1 (fr
EP1752459A1 (fr
Inventor
Yoichi Nishioka
Masahiro Ito
Yutaka Kameyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Chemical Co Ltd
Meiji Seika Pharma Co Ltd
Original Assignee
Otsuka Chemical Co Ltd
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Chemical Co Ltd, Meiji Seika Kaisha Ltd filed Critical Otsuka Chemical Co Ltd
Publication of EP1752459A1 publication Critical patent/EP1752459A1/fr
Publication of EP1752459A4 publication Critical patent/EP1752459A4/fr
Application granted granted Critical
Publication of EP1752459B1 publication Critical patent/EP1752459B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procédé de production de l’acide 7-amino-3-[(E/Z)-2- (4-méthylthiazol-5-yl)vinyl]-3-céphèm-4-carboxylique de formule (1) et de sels de métaux alcalins de cet acide qui ont des teneurs plus élevées d’acide 7-amino-3-[(Z)-2-(4-méthylthiazol-5-yl)vinyl]-3-céphèm-4-carboxylique de formule (2) et de sels de métaux alcalins de cet acide, caractérisé par l’addition d’un polymère à porosité élevée et/ou de charbon actif à une solution aqueuse d’un sel de métal alcalin d’acide 7-amino-3-[(E/Z)-2-(4-méthylthiazol-5-yl)vinyl]-3-céphèm-4-carboxylique de formule (1) pour traiter la solution avec le polymère à porosité élevée et/ou avec le charbon actif. (1) (2)
EP05751538.9A 2004-06-04 2005-06-03 Procédé de production de composés de 3-alcénylcéphème Active EP1752459B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004167581A JP4046708B2 (ja) 2004-06-04 2004-06-04 ３−アルケニルセフェム化合物の製造方法
PCT/JP2005/010621 WO2005118595A1 (fr) 2004-06-04 2005-06-03 Procédé de production de composés de 3-alcénylcéphème

Publications (3)

Publication Number Publication Date
EP1752459A1 EP1752459A1 (fr) 2007-02-14
EP1752459A4 true EP1752459A4 (fr) 2008-01-02
EP1752459B1 EP1752459B1 (fr) 2017-05-10

Family

ID=35462876

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05751538.9A Active EP1752459B1 (fr) 2004-06-04 2005-06-03 Procédé de production de composés de 3-alcénylcéphème

Country Status (8)

Country Link
US (1) US7893254B2 (fr)
EP (1) EP1752459B1 (fr)
JP (1) JP4046708B2 (fr)
KR (2) KR100882067B1 (fr)
CN (1) CN1964981B (fr)
ES (1) ES2632500T3 (fr)
HK (1) HK1105968A1 (fr)
WO (1) WO2005118595A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7459550B2 (en) * 2003-07-04 2008-12-02 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of Cefditoren
JP4064948B2 (ja) * 2004-06-04 2008-03-19 明治製菓株式会社 ３−アルケニルセフェム化合物及び製造方法
JP4659074B2 (ja) * 2008-07-15 2011-03-30 日本化学工業株式会社 ３−アルケニルセフェム化合物の製造方法
CN101735248A (zh) * 2008-11-07 2010-06-16 日本化学工业株式会社 3-链烯基头孢烯化合物的制造方法
KR101618874B1 (ko) * 2008-11-07 2016-05-09 니폰 가가쿠 고교 가부시키가이샤 3-알케닐세펨 화합물의 제조 방법
CN102725297A (zh) * 2010-01-27 2012-10-10 日本化学工业株式会社 头孢菌素衍生物的制造方法

Family Cites Families (34)

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US3979383A (en) * 1975-03-07 1976-09-07 Eli Lilly And Company Purification process for 7-aminocephalosporins
DE2620094A1 (de) * 1975-05-12 1976-12-02 Takeda Chemical Industries Ltd Cephalosporinverbindungen und verfahren zu ihrer herstellung
US4311698A (en) * 1979-03-12 1982-01-19 Haskell Theodore H Aminoacid derivatives of cephalosporin compounds
JPS5643288A (en) * 1979-09-18 1981-04-21 Meiji Seika Kaisha Ltd Cephalosporin derivative and its preparation
EP0081971A3 (fr) * 1981-12-08 1984-09-26 Tanabe Seiyaku Co., Ltd. Dérivé de céphalosporine et procédé pour sa préparation
US4699979A (en) 1985-04-22 1987-10-13 Bristol-Meyers Company 7-amino-3-propenylcephalosporanic acid and esters thereof
FR2580652B1 (fr) * 1985-04-22 1989-01-06 Bristol Myers Co Acide 7-amino-3-propenylcephalosporanique et ses esters
CN1012812B (zh) * 1986-01-31 1991-06-12 三菱化成株式会社 镓的回收方法
US5061371A (en) 1990-04-06 1991-10-29 Nippon Rensui Co. Chromatographic separation apparatus
DE4026630A1 (de) * 1990-08-23 1992-02-27 Hoechst Ag Verfahren zur herstellung von kristalliner tacs
IT1252308B (it) * 1990-12-21 1995-06-08 Antibioticos Spa Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati
US5194371A (en) 1991-07-31 1993-03-16 Bristol-Myers Squibb Company Production of pradimicin antibiotics
JPH0798752B2 (ja) * 1991-08-09 1995-10-25 株式会社ツムラ β−グルクロニダーゼ阻害剤
PT630380E (pt) 1992-02-05 2002-02-28 Biochemie Gmbh Processo para a purificacao de um derivado do acido 3-cefem-4-carboxilico
DE69427312T2 (de) * 1993-11-17 2001-08-23 Biochemie Gmbh Trennung von Cephalosporinisomeren
CN1195269A (zh) * 1996-06-12 1998-10-07 协和发酵工业株式会社 脂质代谢改善剂
JPH10101679A (ja) * 1996-10-02 1998-04-21 Otsuka Chem Co Ltd セファゾリンの製造法
ES2182330T3 (es) 1997-06-24 2003-03-01 Meiji Seika Kaisha Procedimiento para la preparacion selectiva de isomeros z de 3-(2-vinil-sustituido) cefalosporina.
JPH11171895A (ja) 1997-12-11 1999-06-29 Ajinomoto Co Inc アスパルテームとアスパルテーム誘導体の分離精製方法
US5945542A (en) * 1998-02-26 1999-08-31 Robert L. Pollack Isolation of natural L-β-3-indolylalanine and enrichment of natural aliphatic amino acid mixtures with natural L-β-3-indolylalanine
EP1104459A1 (fr) * 1998-08-12 2001-06-06 Maxygen, Inc. Rearrangement d'adn de genes de monoxygenase en vue de la production de produits chimiques industriels
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
AU2001280208A1 (en) * 2000-08-31 2002-03-13 The Kitasato Institute Vaccine preparation containing fatty acid as component
JP4401775B2 (ja) * 2001-10-25 2010-01-20 協和発酵バイオ株式会社 酸化型グルタチオンの結晶およびその製造方法
CA2472239A1 (fr) 2002-01-22 2003-07-31 Pfizer Inc. Acides 3-(imidazolyl)-2-aminopropanoiques servant d'inhibiteurs tafia pour traiter des maladies thrombotiques
WO2003064538A1 (fr) * 2002-02-01 2003-08-07 San-Ei Gen F.F.I., Inc. Couleur de mais rouge purifiee et procede de preparation de celle-ci
TWI344371B (en) 2003-03-18 2011-07-01 Suntory Holdings Ltd Angiotensin-converting enzyme inhibitory peptides
JPWO2005033053A1 (ja) * 2003-10-01 2006-12-14 株式会社東洋新薬 プロアントシアニジン高含有物の製造方法
US7087423B2 (en) * 2003-12-23 2006-08-08 Dainippon Ink And Chemicals, Inc. Process for producing sporangia of Bacillus popilliae
JP4064948B2 (ja) * 2004-06-04 2008-03-19 明治製菓株式会社 ３−アルケニルセフェム化合物及び製造方法
EP1693471A1 (fr) * 2005-02-16 2006-08-23 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Méthode de séparation des liqueurs contenant une solution d'hydrates de carbone
CN101151369B (zh) * 2005-03-29 2017-02-15 协和发酵生化株式会社 二肽的结晶及其制备方法
TW200741005A (en) * 2005-08-10 2007-11-01 Kyowa Hakko Kogyo Kk A purification method of cytidine diphosphate
US20070161784A1 (en) * 2006-01-11 2007-07-12 Aminopath Labs, Llc Methods and products of amino acid isolation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
WO2005118595A1 (fr) 2005-12-15
CN1964981B (zh) 2011-08-17
KR20080086554A (ko) 2008-09-25
ES2632500T3 (es) 2017-09-13
HK1105968A1 (en) 2008-02-29
KR100882067B1 (ko) 2009-02-10
KR20070030261A (ko) 2007-03-15
KR100870804B1 (ko) 2008-11-27
EP1752459B1 (fr) 2017-05-10
US20080033166A1 (en) 2008-02-07
CN1964981A (zh) 2007-05-16
JP4046708B2 (ja) 2008-02-13
EP1752459A1 (fr) 2007-02-14
US7893254B2 (en) 2011-02-22
JP2005343854A (ja) 2005-12-15

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