EP1635849A1 - Heilmittel zur inneren anwendung; insbesondere gegen krebserkrankungen - Google Patents
Heilmittel zur inneren anwendung; insbesondere gegen krebserkrankungenInfo
- Publication number
- EP1635849A1 EP1635849A1 EP04733761A EP04733761A EP1635849A1 EP 1635849 A1 EP1635849 A1 EP 1635849A1 EP 04733761 A EP04733761 A EP 04733761A EP 04733761 A EP04733761 A EP 04733761A EP 1635849 A1 EP1635849 A1 EP 1635849A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- surfactants
- polydimethylsiloxane
- weight
- proportion
- medicinal product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract 6
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 18
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 18
- -1 polydimethylsiloxane Polymers 0.000 claims abstract description 18
- 239000004094 surface-active agent Substances 0.000 claims abstract description 18
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- 229940126601 medicinal product Drugs 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 9
- 201000011510 cancer Diseases 0.000 claims description 8
- 229910021536 Zeolite Inorganic materials 0.000 claims description 7
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 7
- 239000010457 zeolite Substances 0.000 claims description 7
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims description 6
- 239000003945 anionic surfactant Substances 0.000 claims description 6
- 239000010459 dolomite Substances 0.000 claims description 6
- 229910000514 dolomite Inorganic materials 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000002280 amphoteric surfactant Substances 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000002736 nonionic surfactant Substances 0.000 claims description 5
- 125000000129 anionic group Chemical group 0.000 claims description 3
- 239000007795 chemical reaction product Substances 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 229910052710 silicon Inorganic materials 0.000 description 6
- 239000010703 silicon Substances 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 238000002663 nebulization Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- LIKFHECYJZWXFJ-UHFFFAOYSA-N dimethyldichlorosilane Chemical compound C[Si](C)(Cl)Cl LIKFHECYJZWXFJ-UHFFFAOYSA-N 0.000 description 2
- 230000009969 flowable effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000006199 nebulizer Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 239000005046 Chlorosilane Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- KOPOQZFJUQMUML-UHFFFAOYSA-N chlorosilane Chemical compound Cl[SiH3] KOPOQZFJUQMUML-UHFFFAOYSA-N 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 239000010779 crude oil Substances 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000013101 initial test Methods 0.000 description 1
- 230000010226 intestinal metabolism Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 239000003345 natural gas Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 229910017464 nitrogen compound Inorganic materials 0.000 description 1
- 150000002830 nitrogen compounds Chemical class 0.000 description 1
- 210000004789 organ system Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000011034 rock crystal Substances 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 150000004756 silanes Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Definitions
- the present invention relates to a remedy for internal use, especially against cancer.
- This object is achieved by a remedy which has polydimethylsiloxane and surfactants, the proportion of polydimethylsiloxane exceeding the proportion of surfactants.
- the special feature of the invention is that the effect according to the invention is achieved only by adding surfactants.
- Mixing the polydimethylsiloxane with surfactants means that the body is given the opportunity to emulsify the siloxane and make it usable. This is achieved by the surfactants breaking up the molecular structure of the polydimethylsiloxane.
- the proportion of surfactants, based on the weight of the solution, can be significantly lower than the proportion of polydimethylsiloxane.
- Anionic, amphoteric and nonionic surfactants can be used, the proportion by weight of the anionic surfactants exceeding the proportion by weight of the amphoteric and nonionic.
- Polydimethylsiloxane is made from raw silicon.
- Raw silicon is obtained from sand and coal, which is further processed into the desired silicones in a continuous process.
- Natural gas or crude oil are used to produce methanol (synthesis gas), another starting material for silicone synthesis.
- Chlorine is obtained by electrolysis of rock salt solutions and is added to the process in the form of HC1.
- methanol is converted to chloromethane with HC1 (chloromethane synthesis).
- a mixture of crude silanes (chlorosilane synthesis) is then obtained by reacting chloromethane with silicon. These are separated by distillation, dichlorodimethylsilane (CH3) 2SiC12 then being converted into polydimethylsiloxane by hydrolysis.
- the remedy is nebulized using suitable nebulization techniques.
- suitable nebulization techniques Various devices are available for this:
- Compressed air operated Venturi nozzle nebulizer a) direct nebulization b) with aerosol reservoir c) with positive pressure inhalation 2.
- Mechanical single-component jet nebulizer a) direct nebulization b) with aerosol reservoir c) with positive pressure inhalation 2.
- aluminum silicate in particular natural zeolite with a grain size of 10 ⁇ m to 70 ⁇ m, in particular 40 ⁇ m and dolomite powder with a grain size of 2 ⁇ m to 30 ⁇ m, in particular 10 ⁇ m, can also be added. This results in powder that can be administered in capsules.
- the basic skeleton of the crystal lattice of the zeolite consists primarily of SiÜ4 tetrahedra. It has cavities in which ions, e.g. B. are sodium, potassium and calcium, which can be easily exchanged with themselves and with their substrate environment.
- This mineral-specific crystal structure (cage structure) of zeolite has the excellent property in living organisms, toxic substances, such as. B. ammonia and other nitrogen compounds, but also heavy metals, to bind (absorb) and excrete via the intestinal metabolism. The extracted toxic substances are exchanged for minerals that the body urgently needs. In this way, the homeostasis of the organism, in particular that of the mineral metabolism, is maintained or restored.
- the zeolite also has a positive stimulating effect on the entire metabolism and in the growth and healing processes of the organism.
- zeolite Because of its open molecular structure, zeolite also has the ability to absorb large quantities of liquids. This is advantageous since, despite mixing with the additional components mentioned above, a flowable powder can be formed.
- the additional components may have the proportions in the end product:
- Aluminum silicate 50 to 90, in particular 70% by weight,
- the resulting mixture is a flowable powder and can be processed into a remedy in a variety of ways. It is thus possible to encapsulate the powdery mixture, for example in the form of the widely used gelatin capsules, which dissolve in the digestive tract. In addition, it is readily possible to press tablets from the powdered mixture, which can be taken with or without liquid.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10323758A DE10323758A1 (de) | 2003-05-22 | 2003-05-22 | Heilmittel zur inneren Anwendung, insbesondere gegen Krebserkrankungen |
| PCT/DE2004/001048 WO2004105776A1 (de) | 2003-05-22 | 2004-05-19 | Heilmittel zur inneren anwendung; insbesondere gegen krebserkrankungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1635849A1 true EP1635849A1 (de) | 2006-03-22 |
Family
ID=33441299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP04733761A Withdrawn EP1635849A1 (de) | 2003-05-22 | 2004-05-19 | Heilmittel zur inneren anwendung; insbesondere gegen krebserkrankungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20070172435A1 (enExample) |
| EP (1) | EP1635849A1 (enExample) |
| JP (1) | JP2006528211A (enExample) |
| CN (1) | CN1795001A (enExample) |
| AU (1) | AU2004243524A1 (enExample) |
| CA (1) | CA2526175A1 (enExample) |
| DE (1) | DE10323758A1 (enExample) |
| RU (1) | RU2005140097A (enExample) |
| WO (1) | WO2004105776A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10323759A1 (de) * | 2003-05-22 | 2004-12-16 | Bauer, Wulf, Dr. | Heilmittel zur inneren Anwendung, insbesondere gegen Krebserkrankungen |
| BE1018537A3 (fr) | 2007-09-13 | 2011-03-01 | Basf Se | Procede d'exploitation d'une separation en continu d'un produit cible x sous la forme d'un cristallisat finement divise. |
| DE102007043748A1 (de) | 2007-09-13 | 2008-09-11 | Basf Se | Verfahren zur kontinuierlichen Abtrennung eines Zielproduktes X in Form von feinteiligem Kristallisat |
| DE102007043758A1 (de) | 2007-09-13 | 2008-10-23 | Basf Se | Verfahren zum Betreiben einer kontinuierlichen Abtrennung eines Zielproduktes X in Form von feinteiligem Kristallisat des Zielproduktes X |
| DE102007043759A1 (de) | 2007-09-13 | 2008-09-11 | Basf Se | Verfahren zum Betreiben einer kontinuierlichen Abtrennung eines Zielproduktes X in Form von feinteiligem Kristallisat |
| DE102010030279A1 (de) | 2010-06-18 | 2010-10-28 | Basf Se | Verfahren der Inbetriebnahme eines Trennverfahrens zur reinigenden Abtrennung von Acrylsäurekristallen aus einer Suspension S ihrer Kristalle in Mutterlauge |
| US8461383B2 (en) | 2009-10-16 | 2013-06-11 | Basf Se | Process for starting up a separating process for purifying removal of acrylic acid crystals from a suspension S of crystals thereof in mother liquor |
| DE102009045767A1 (de) | 2009-10-16 | 2010-08-12 | Basf Se | Verfahren der Inbetriebnahme eines Trennverfahrens zur reinigenden Abtrennung von Acrylsäurekristallen aus einer Suspension S ihrer Kristalle in Mutterlauge |
| US10398727B2 (en) | 2014-11-24 | 2019-09-03 | University Of Technology, Sydney | Methods for the treatment and prevention of asbestos-related diseases |
| CN104606261B (zh) * | 2015-03-05 | 2018-02-09 | 潘友长 | 一种沸石药物组合物及其制备方法和用途 |
| CN105837734A (zh) * | 2016-05-09 | 2016-08-10 | 上海惠昌化工厂 | 有机硅改性丙烯酸聚酯钾盐及制备方法和防癌治癌用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5310572A (en) * | 1987-02-03 | 1994-05-10 | Dow Corning Corporation | Process for forming a coated active agent-containing article |
| US5418220A (en) * | 1994-03-08 | 1995-05-23 | Schmidt; Alfred | Method for treating constipation using dimethicone |
| US5587149A (en) * | 1995-02-06 | 1996-12-24 | R.P. Scherer Corporation | Topical application emulsions |
| DE59707063D1 (de) * | 1996-03-25 | 2002-05-23 | Bauer Wulf | Heilmittel zur äusserlichen anwendung und verwendung einer wässrigen öl-emulsion für ein derartiges heilmittel |
| US6347408B1 (en) * | 1998-11-05 | 2002-02-19 | Allegiance Corporation | Powder-free gloves having a coating containing cross-linked polyurethane and silicone and method of making the same |
| EP1107826A1 (de) * | 1999-04-26 | 2001-06-20 | Tihomir Lelas | Vorrichtung zum mikronisieren von materialien |
-
2003
- 2003-05-22 DE DE10323758A patent/DE10323758A1/de not_active Withdrawn
-
2004
- 2004-05-19 EP EP04733761A patent/EP1635849A1/de not_active Withdrawn
- 2004-05-19 RU RU2005140097/15A patent/RU2005140097A/ru unknown
- 2004-05-19 JP JP2006529603A patent/JP2006528211A/ja not_active Withdrawn
- 2004-05-19 WO PCT/DE2004/001048 patent/WO2004105776A1/de not_active Ceased
- 2004-05-19 US US10/557,317 patent/US20070172435A1/en not_active Abandoned
- 2004-05-19 CA CA002526175A patent/CA2526175A1/en not_active Abandoned
- 2004-05-19 CN CNA2004800140406A patent/CN1795001A/zh active Pending
- 2004-05-19 AU AU2004243524A patent/AU2004243524A1/en not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| See references of WO2004105776A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004105776A1 (de) | 2004-12-09 |
| CN1795001A (zh) | 2006-06-28 |
| AU2004243524A1 (en) | 2004-12-09 |
| CA2526175A1 (en) | 2004-12-09 |
| RU2005140097A (ru) | 2006-08-10 |
| JP2006528211A (ja) | 2006-12-14 |
| US20070172435A1 (en) | 2007-07-26 |
| DE10323758A1 (de) | 2004-12-16 |
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Legal Events
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| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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| DAX | Request for extension of the european patent (deleted) | ||
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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| 18D | Application deemed to be withdrawn |
Effective date: 20091201 |