WO2004105776A1 - Heilmittel zur inneren anwendung; insbesondere gegen krebserkrankungen - Google Patents

Heilmittel zur inneren anwendung; insbesondere gegen krebserkrankungen Download PDF

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Publication number
WO2004105776A1
WO2004105776A1 PCT/DE2004/001048 DE2004001048W WO2004105776A1 WO 2004105776 A1 WO2004105776 A1 WO 2004105776A1 DE 2004001048 W DE2004001048 W DE 2004001048W WO 2004105776 A1 WO2004105776 A1 WO 2004105776A1
Authority
WO
WIPO (PCT)
Prior art keywords
surfactants
polydimethylsiloxane
weight
proportion
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2004/001048
Other languages
German (de)
English (en)
French (fr)
Inventor
Gerd THÖNE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU2004243524A priority Critical patent/AU2004243524A1/en
Priority to EP04733761A priority patent/EP1635849A1/de
Priority to CA002526175A priority patent/CA2526175A1/en
Priority to JP2006529603A priority patent/JP2006528211A/ja
Priority to US10/557,317 priority patent/US20070172435A1/en
Publication of WO2004105776A1 publication Critical patent/WO2004105776A1/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/80Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Definitions

  • the present invention relates to a remedy for internal use, especially against cancer.
  • This object is achieved by a remedy which has polydimethylsiloxane and surfactants, the proportion of polydimethylsiloxane exceeding the proportion of surfactants.
  • the special feature of the invention is that the effect according to the invention is achieved only by adding surfactants.
  • Mixing the polydimethylsiloxane with surfactants means that the body is given the opportunity to emulsify the siloxane and make it usable. This is achieved by the surfactants breaking up the molecular structure of the polydimethylsiloxane.
  • the proportion of surfactants, based on the weight of the solution, can be significantly lower than the proportion of polydimethylsiloxane.
  • Anionic, amphoteric and nonionic surfactants can be used, the proportion by weight of the anionic surfactants exceeding the proportion by weight of the amphoteric and nonionic.
  • Polydimethylsiloxane is made from raw silicon.
  • Raw silicon is obtained from sand and coal, which is further processed into the desired silicones in a continuous process.
  • Natural gas or crude oil are used to produce methanol (synthesis gas), another starting material for silicone synthesis.
  • Chlorine is obtained by electrolysis of rock salt solutions and is added to the process in the form of HC1.
  • methanol is converted to chloromethane with HC1 (chloromethane synthesis).
  • a mixture of crude silanes (chlorosilane synthesis) is then obtained by reacting chloromethane with silicon. These are separated by distillation, dichlorodimethylsilane (CH3) 2SiC12 then being converted into polydimethylsiloxane by hydrolysis.
  • the remedy is nebulized using suitable nebulization techniques.
  • suitable nebulization techniques Various devices are available for this:
  • Compressed air operated Venturi nozzle nebulizer a) direct nebulization b) with aerosol reservoir c) with positive pressure inhalation 2.
  • Mechanical single-component jet nebulizer a) direct nebulization b) with aerosol reservoir c) with positive pressure inhalation 2.
  • aluminum silicate in particular natural zeolite with a grain size of 10 ⁇ m to 70 ⁇ m, in particular 40 ⁇ m and dolomite powder with a grain size of 2 ⁇ m to 30 ⁇ m, in particular 10 ⁇ m, can also be added. This results in powder that can be administered in capsules.
  • the basic skeleton of the crystal lattice of the zeolite consists primarily of SiÜ4 tetrahedra. It has cavities in which ions, e.g. B. are sodium, potassium and calcium, which can be easily exchanged with themselves and with their substrate environment.
  • This mineral-specific crystal structure (cage structure) of zeolite has the excellent property in living organisms, toxic substances, such as. B. ammonia and other nitrogen compounds, but also heavy metals, to bind (absorb) and excrete via the intestinal metabolism. The extracted toxic substances are exchanged for minerals that the body urgently needs. In this way, the homeostasis of the organism, in particular that of the mineral metabolism, is maintained or restored.
  • the zeolite also has a positive stimulating effect on the entire metabolism and in the growth and healing processes of the organism.
  • zeolite Because of its open molecular structure, zeolite also has the ability to absorb large quantities of liquids. This is advantageous since, despite mixing with the additional components mentioned above, a flowable powder can be formed.
  • the additional components may have the proportions in the end product:
  • Aluminum silicate 50 to 90, in particular 70% by weight,
  • the resulting mixture is a flowable powder and can be processed into a remedy in a variety of ways. It is thus possible to encapsulate the powdery mixture, for example in the form of the widely used gelatin capsules, which dissolve in the digestive tract. In addition, it is readily possible to press tablets from the powdered mixture, which can be taken with or without liquid.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PCT/DE2004/001048 2003-05-22 2004-05-19 Heilmittel zur inneren anwendung; insbesondere gegen krebserkrankungen Ceased WO2004105776A1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2004243524A AU2004243524A1 (en) 2003-05-22 2004-05-19 Medicament for internal application, in particular against cancerous diseases
EP04733761A EP1635849A1 (de) 2003-05-22 2004-05-19 Heilmittel zur inneren anwendung; insbesondere gegen krebserkrankungen
CA002526175A CA2526175A1 (en) 2003-05-22 2004-05-19 Medicament for internal application, in particular against cancerous diseases
JP2006529603A JP2006528211A (ja) 2003-05-22 2004-05-19 癌治療用の内服用の薬
US10/557,317 US20070172435A1 (en) 2003-05-22 2004-05-19 Medicament for internal application, in particular against cancerous diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10323758A DE10323758A1 (de) 2003-05-22 2003-05-22 Heilmittel zur inneren Anwendung, insbesondere gegen Krebserkrankungen
DE10323758.5 2003-05-22

Publications (1)

Publication Number Publication Date
WO2004105776A1 true WO2004105776A1 (de) 2004-12-09

Family

ID=33441299

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2004/001048 Ceased WO2004105776A1 (de) 2003-05-22 2004-05-19 Heilmittel zur inneren anwendung; insbesondere gegen krebserkrankungen

Country Status (9)

Country Link
US (1) US20070172435A1 (enExample)
EP (1) EP1635849A1 (enExample)
JP (1) JP2006528211A (enExample)
CN (1) CN1795001A (enExample)
AU (1) AU2004243524A1 (enExample)
CA (1) CA2526175A1 (enExample)
DE (1) DE10323758A1 (enExample)
RU (1) RU2005140097A (enExample)
WO (1) WO2004105776A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10323759A1 (de) * 2003-05-22 2004-12-16 Bauer, Wulf, Dr. Heilmittel zur inneren Anwendung, insbesondere gegen Krebserkrankungen
BE1018537A3 (fr) 2007-09-13 2011-03-01 Basf Se Procede d'exploitation d'une separation en continu d'un produit cible x sous la forme d'un cristallisat finement divise.
DE102007043748A1 (de) 2007-09-13 2008-09-11 Basf Se Verfahren zur kontinuierlichen Abtrennung eines Zielproduktes X in Form von feinteiligem Kristallisat
DE102007043758A1 (de) 2007-09-13 2008-10-23 Basf Se Verfahren zum Betreiben einer kontinuierlichen Abtrennung eines Zielproduktes X in Form von feinteiligem Kristallisat des Zielproduktes X
DE102007043759A1 (de) 2007-09-13 2008-09-11 Basf Se Verfahren zum Betreiben einer kontinuierlichen Abtrennung eines Zielproduktes X in Form von feinteiligem Kristallisat
DE102010030279A1 (de) 2010-06-18 2010-10-28 Basf Se Verfahren der Inbetriebnahme eines Trennverfahrens zur reinigenden Abtrennung von Acrylsäurekristallen aus einer Suspension S ihrer Kristalle in Mutterlauge
US8461383B2 (en) 2009-10-16 2013-06-11 Basf Se Process for starting up a separating process for purifying removal of acrylic acid crystals from a suspension S of crystals thereof in mother liquor
DE102009045767A1 (de) 2009-10-16 2010-08-12 Basf Se Verfahren der Inbetriebnahme eines Trennverfahrens zur reinigenden Abtrennung von Acrylsäurekristallen aus einer Suspension S ihrer Kristalle in Mutterlauge
US10398727B2 (en) 2014-11-24 2019-09-03 University Of Technology, Sydney Methods for the treatment and prevention of asbestos-related diseases
CN104606261B (zh) * 2015-03-05 2018-02-09 潘友长 一种沸石药物组合物及其制备方法和用途
CN105837734A (zh) * 2016-05-09 2016-08-10 上海惠昌化工厂 有机硅改性丙烯酸聚酯钾盐及制备方法和防癌治癌用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996024325A1 (en) * 1995-02-06 1996-08-15 R.P. Scherer Corporation Improved topical application emulsions
WO1997035558A1 (de) * 1996-03-25 1997-10-02 Bauer, Wulf Heilmittel zur äusserlichen anwendung und verwendung einer wässrigen öl-emulsion für ein derartiges heilmittel
WO2000064586A1 (de) * 1999-04-26 2000-11-02 Tihomir Lelas Vorrichtung zum mikronisieren von materialien

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310572A (en) * 1987-02-03 1994-05-10 Dow Corning Corporation Process for forming a coated active agent-containing article
US5418220A (en) * 1994-03-08 1995-05-23 Schmidt; Alfred Method for treating constipation using dimethicone
US6347408B1 (en) * 1998-11-05 2002-02-19 Allegiance Corporation Powder-free gloves having a coating containing cross-linked polyurethane and silicone and method of making the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996024325A1 (en) * 1995-02-06 1996-08-15 R.P. Scherer Corporation Improved topical application emulsions
WO1997035558A1 (de) * 1996-03-25 1997-10-02 Bauer, Wulf Heilmittel zur äusserlichen anwendung und verwendung einer wässrigen öl-emulsion für ein derartiges heilmittel
WO2000064586A1 (de) * 1999-04-26 2000-11-02 Tihomir Lelas Vorrichtung zum mikronisieren von materialien

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PAVELIC KRESIMIR ET AL: "Natural zeolite clinoptilolite: new adjuvant in anticancer therapy", JOURNAL OF MOLECULAR MEDICINE, SPRINGER VERLAG, DE, vol. 78, 2001, pages 708 - 720, XP002191937, ISSN: 0946-2716 *
SCHELLER S ET AL: "ANTITUMORAL EFFECT OF BLEOMYCIN + DOLOMITE COMBINATION TREATMENT, IN MICE BEARING EHRLICH ASCITES CARCINOMA", ZEITSCHRIFT FUER NATURFORSCHUNG. C, A JOURNAL OF BIOSCIENCES, TUEBINGEN, DE, vol. 48, no. 9/10, 1993, pages 818 - 820, XP001183448, ISSN: 0939-5075 *

Also Published As

Publication number Publication date
EP1635849A1 (de) 2006-03-22
CN1795001A (zh) 2006-06-28
AU2004243524A1 (en) 2004-12-09
CA2526175A1 (en) 2004-12-09
RU2005140097A (ru) 2006-08-10
JP2006528211A (ja) 2006-12-14
US20070172435A1 (en) 2007-07-26
DE10323758A1 (de) 2004-12-16

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