EP1598113A1 - Pipette - Google Patents

Pipette Download PDF

Info

Publication number
EP1598113A1
EP1598113A1 EP05007928A EP05007928A EP1598113A1 EP 1598113 A1 EP1598113 A1 EP 1598113A1 EP 05007928 A EP05007928 A EP 05007928A EP 05007928 A EP05007928 A EP 05007928A EP 1598113 A1 EP1598113 A1 EP 1598113A1
Authority
EP
European Patent Office
Prior art keywords
pressure sensor
control knob
lifting rod
drive motor
electrical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP05007928A
Other languages
German (de)
English (en)
Other versions
EP1598113B1 (fr
Inventor
Herbert Belgardt
Peter Molitor
Bernd Jagdhuber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eppendorf SE filed Critical Eppendorf SE
Publication of EP1598113A1 publication Critical patent/EP1598113A1/fr
Application granted granted Critical
Publication of EP1598113B1 publication Critical patent/EP1598113B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0234—Repeating pipettes, i.e. for dispensing multiple doses from a single charge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0227—Details of motor drive means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/087—Ergonomic aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/146—Employing pressure sensors

Definitions

  • the invention relates to a pipette.
  • Bubble pipettes are used in the laboratory for dosing liquids. They are in different versions known. Bubble pipettes have an integrated Cylinder with a piston arranged therein. The cylinder is over with a channel an opening in a mounting lug connected. A pipette tip is detachable with connectable to the attachment approach. By moving the piston in the cylinder is Sample liquid sucked into the pipette tip or expelled from this. in this connection piston and cylinder do not come in contact with the liquid, because the piston the Fluid indirectly moved over an air cushion. Only the pipette tip, which is usually is made of plastic, is contaminated and can be replaced after use.
  • the pipette When pipetting, the pipette delivers the liquid picked up by the tip or syringe in one step. When dispensing, the syringe or tip picked up by the syringe or tip Delivered liquid in small quantities.
  • Multi-channel pipettes have several channels, by means of which is metered simultaneously.
  • Pipettes can be designed as a handheld device and / or as a stationary device.
  • Manual pipettes have an operating button that is directly or via a gear with the piston in a cylinder or other displacement device for an air cushion or sample liquid is connected.
  • Working with manual pipettes is tiring.
  • an electric drive motor is over Gear coupled with a displacement device.
  • the user controls the Functions of electronic pipettes by pressing a button.
  • Working with electronic Pipettes are therefore less tiring.
  • the handling is for users getting used to manual pipettes. In particular, it lacks one with the movement the displacement means synchronized actuation of a control knob.
  • the object of the invention is to provide a pipette to put a less tiring work while largely maintaining the Handling a manual pipette allows.
  • a drive motor assisted axial movement of the piston i. a servo-assisted Piston movement.
  • This movement lasts as long as the user on the Control button presses. Consequently, the user moves the piston during pipetting, dispensing or similar functions only with a reduced effort.
  • the Return movement of the piston and the lifting rod is after relieving the control knob caused by the user of the piston spring.
  • the piston spring also cause the return movement of the drive spindle.
  • the drive spindle is preferred at a signaled by the pressure sensor relief of the control knob of the electrical control device by applying an electrical voltage to the moved back electric drive motor.
  • the operation of the pipette corresponds to one conventional manual pipette, with the effort required for the operation similar to an electronic pipette. Since the piston spring the Piston presses against the end of the lifting rod, the pipette is free of play and must therefore do not make a reverse stroke for game compensation.
  • the pipette can only be used for working in pipetting mode or for working in dispensing mode or for working in both modes.
  • the user can pipette or dispense liquid manually Press and release the control knob so that the piston travels travels.
  • the upward movements of the piston in the pipetting or Dispensing mode not manually but electronically limited.
  • the electrical control device displaces in the pipetting mode at a signaled by the pressure sensor pressure on the control knob Applying an electrical voltage to the electric drive motor, the drive spindle in the direction of the displacement of the control knob by the pressure to the concern the Anzziwulstes at a lower stop, relocates the electrical control device also at a signaled by the pressure sensor relief of the control knob the drive spindle by applying an electrical voltage to the electric drive motor in the opposite direction to a pipetting volume corresponding position and relocates the electrical control device another pressure signaled by the pressure sensor on the control knob Applying an electrical voltage to the electric drive motor, the drive spindle again in the direction of the shift of the control knob by the pressure until Concern of the stop bead on the lower stop.
  • the piston By first pressing the Control knob, the piston is in its starting position for the suction of liquid brought after discharge of the control button, the piston sucks liquid and the final press of the control button ejects the liquid.
  • the piston strokes required to pipette a particular pipetting volume are limited by the electrical control device.
  • the movements of the piston in the dispensing mode become electronic controlled.
  • the pipette for this purpose a device for Lock the control knob against axial movement.
  • the control button only serves as a button for controlling dispensing operations.
  • the pipette has a connected to the electrical control device Switch to switch between pipetting mode and dispensing mode.
  • the switch with the means for locking the Control button coupled, so that when you lock the control button automatically the Dispensing mode is turned on.
  • the locking device one the control knob in the axial direction against a pressure on the Control button supporting spring element. The user thus does not oppose a rigid stop. This is advantageous for the tactile sensation of the user.
  • the electrical control device shifts by applying an electrical voltage to the electric drive motor the drive spindle until the abutment of a stop bead of the lifting rod on a bottom stop, at a pressure signaled by the pressure sensor on the control knob the drive spindle by applying an electrical voltage to the electric drive motor in the opposite direction up to a total dispensing volume corresponding position, at another pressure signaled by the pressure sensor the control knob, the drive spindle by applying an electrical voltage to the electric drive motor in the direction of the lower stop to an individual Dispensing volume corresponding position and repeats this if necessary another pressure signaled by the pressure sensor until a predetermined number of Dispensier suitsen is done.
  • Working in dispensing mode is done by the user controlled only by pressing the control button. The ones intended for dispensing Dispensing volumes required piston strokes are from the electrical Control device controlled.
  • the electric control device sets at one of Pressure sensor signaled reduced pressure on the control knob no electrical Voltage to the electric drive motor on. This allows the user to Stop the pipette by reducing the pressure on the control knob.
  • the pipette has a lower stop which coincides with the stop bead the lift rod cooperates and is spring-loaded and shifts the electrical Control device at a signaled by the pressure sensor pressure on the control knob when concerns the stop bead on the lower stop by applying a electrical voltage to the drive motor, the drive spindle continues towards the bottom stop, so that the stop bead compresses the lower stop resiliently. This makes it possible, overcoming the spring force, an overstroke of Perform piston, which causes a discharge of residual fluid.
  • the extent of the overstroke and the return to the Sprung state of the lower stop manually controlled.
  • another Design controls the electrical control device to a pressure on the Pressure sensor the process so that the stop resiliently by a certain extent is compressed.
  • the return to the rebound Automatically controls state relocates the electrical control device a signaled by the pressure sensor relief of the control knob by applying a electrical voltage to the drive motor, the drive spindle until the lower Stop is rebounded. As a result, the lower stop position is found clearly.
  • the pipette may be designed to pipette fixed volumes or in a fixed volume Number of steps to be dispensed.
  • the one Adjustment of the pipetting or dispensing volumes or of the dispensing steps is the electrical control device with at least one input device for entering a pipetting volume and / or a dispensing volume and a Number of dispensing steps connected.
  • the electrical control device comprises a Display device, e.g. for displaying set pipetting volumes and / or dispensing volumes and dispensing steps.
  • the display device can also be used for viewing the operating state of the pipette can be used.
  • the pipette has a releasably secured lower part, in which the piston and the cylinder are arranged.
  • the lower part can be detached from the pipette.
  • the lower part has a shaft with the passage opening on.
  • the shaft may e.g. to fix a pipette tip.
  • the lower part is a syringe.
  • the syringe can also with a shaft for the targeted picking up and dispensing of liquid be provided.
  • an angle encoder arranged with the electrical control device connected is.
  • top and bottom refer to a substantially vertical orientation of the pipetting device, wherein the control knob the top and the pipette tip is arranged at the bottom, as is usually the case Intake and discharge of liquid is the case.
  • the metering device has a control button 1 with a - not shown - Pressure sensor for simultaneously controlling a drive motor 2 and a lifting rod. 3 on.
  • the control knob 1 has a button base 4.
  • the button base 4 and the lifting rod 3 are loosely guided into each other and by a play compensation spring 5 in permanent Plant held together.
  • a user controls the movement of the lifting rod 3 downwards by pressing on the Control button 1 presses.
  • an angle encoder 7 is attached on a shaft 6 of the drive motor 2, an angle encoder 7 is attached.
  • the wave 6 is about drive pulleys 8, 9 and a - not shown - drive belt with a drive nut 10 coupled.
  • the drive nut 10 is in threaded engagement with a drive spindle 11 and drives the drive spindle 11 in the axial direction.
  • One Turning the drive spindle 11 is rotated by a rotation 12 for the drive spindle 11 prevented.
  • the anti-rotation 12 cooperates with a guide sleeve 13.
  • the anti-rotation 12 is seated by a on the drive spindle 11 Polygonal formed in a receptacle with a corresponding cross section of the Guide sleeve 13 is guided.
  • the drive motor 2, a bearing 14 supporting the shaft 6, the angle encoder 7, the drive pulleys 8, 9, the drive nut 10, the guide sleeve 13, the drive nut 10 bearing drive bearings 15, 16 and the drive spindle 11 are on a drive carrier 17 mounted, which is fixed in a housing 18.
  • the drive carrier 17 has two parallel, spaced-apart plates 19, 20, between which the drive pulleys 8, 9 and the drive nut 10 are arranged.
  • the lower side of the drive spindle 11 acts with a stop bead 21 of the lifting rod 3 together and limits the stroke of the lifting rod 3 upwards.
  • the drive motor 2 starts to run when the laboratory person controls the control button 1 with the pressure sensor actuated. Consequently, the axial movement of the drive spindle 11 supports the movement the lifting rod 3 down, which is controlled manually by the operator.
  • the lifting rod 3 abuts against a piston 22, which is movable within a cylinder 23 is arranged, which is present in a lower part 24 of the metering device.
  • a piston 22 which is movable within a cylinder 23 is arranged, which is present in a lower part 24 of the metering device.
  • a displacement device 25th is part of the Piston 22 and the cylinder 23.
  • the lifting rod 3 and the piston 22 are not connected to each other.
  • the piston 22 is solely by a piston spring 26 up into contact with the lower end the lifting rod 3 pressed.
  • the lower stop 27 is part of a Matterhubsystems 28, which an overstroke spring 29, a screw 30 and a nut 31st includes.
  • the lower stop 27 is axially movable downwards in a receptacle of a Carrier 32 is arranged.
  • the screw 30 is screwed from below into the receptacle.
  • the over-stroke spring 29 is clamped between the lower stop 27 and the screw 30.
  • the carrier 32 is by means of a flange present at its upper edge and the screwed onto the carrier 32 nut 31 on a projection in the housing 18th fixed.
  • the lifting rod 3 can counteract the action of the over-stroke spring 29 by an overstroke continue to move down.
  • the lower part 24 of the metering device comprises a sealing system 33 for sealing Inserting the piston 22 in the upper opening of the cylinder 23, the piston 22, the supported in the lower part 24 on a retaining ring 34 of the sealing system 33 and against the piston 22 pressing piston spring 26, a restraining the piston 22 in the lower part 24 Piston holder 35 and a cone 36 for attaching a pipette tip.
  • a sealing system 33 for sealing Inserting the piston 22 in the upper opening of the cylinder 23, the piston 22, the supported in the lower part 24 on a retaining ring 34 of the sealing system 33 and against the piston 22 pressing piston spring 26, a restraining the piston 22 in the lower part 24 Piston holder 35 and a cone 36 for attaching a pipette tip.
  • Of the Cylinder 23 is via a channel 37 with an opening 38 in the lower end of the cone 36th connected.
  • the lower part 24 is a detachably connected to the housing 18 unit, in particular for cleaning the dosing device.
  • the basic position of the dosing device in pipetting mode and similar functions is shown in FIG.
  • the position of the piston 22 corresponds to the volume of the liquid to be pipetted.
  • the drive motor 2 moves the drive spindle 11 and the Piston 22 in this position.
  • the play compensation spring 5 the lifting rod is the third permanently pressed into contact against the button base 4 of the control knob 1. Because the Piston spring 26 is stronger than the play compensation spring 5, the piston 22 pushes the lift rod 3 up until the stop bead 21 of the lifting rod 3 at the bottom of the drive spindle 11 is present.
  • the laboratory person By pressing the control button 1, the laboratory person moves the lifting rod 3 and the Piston 22 down.
  • the piston 22 displaces an air column within the base 24, which in turn displaces air or liquid from a pipette tip on is fixed to the working cone 36.
  • the pressure sensor measures the force of the user is exercised on the control button 1 and a - not shown - Microprocessor starts the drive motor 2.
  • the position of the shaft 6 by means of Angle encoder 7 detected.
  • the microprocessor evaluates the signals of the angle encoder 7 and includes the position of the shaft 6 in the control of the drive motor 2 a.
  • the drive motor 2 moves the drive spindle 11 axially downwards.
  • the drive spindle 11 pushes the stop bead 21 of the lifting rod 3 down, causing the force is reduced, which must be exerted by the user to the control knob. 1 to press down.
  • the manual dosing device thus has a servo drive on.
  • the piston For pipetting a selected volume of liquid, the piston is first 22 moves down until the stop bead 21 meets the lower stop 27. After that the pipette tip is immersed in the liquid. After relieving the control button 1, the drive spindle 11 moves back and the piston spring 26 presses the piston 22 up until the stop bead 21 against the underside of the drive spindle eleventh meets. During the upward movement of the piston 22 becomes the set volume the liquid is sucked into the pipette tip. To eject the liquid from the The control button 1 is pressed again until the stop bead 21 on the bottom stop 27 hits. To remove residual amounts of the liquid from the Pipette tip is performed an overstroke.
  • the user To switch to the dispensing mode, the user must control button 1 with the knob base 4 with a circular disc segment 37 attached to the lower end pull against a cover 38 'of the housing 18 and the button base 4 to a turn certain angle. By this rotation, the control knob 1 against a axial displacement locked because the annulus segment 37 between cover 38 'and top of the drive motor 2 is caught.
  • One from the annulus segment 37 actuated micro-switch 39 for the detection of the working mode signals the Microcomputer that the dispensing mode is set.
  • the drive motor 2 moves the drive spindle 11 and the lifting rod 3 with the stop bead 21 against the bottom stop 27.
  • the piston 22 is in the receiving position, as in of Fig. 6 is shown.
  • the control knob 1 In Fig. 4, the control knob 1 in the pipetting mode and in Fig. 7 after rotation in dispensing mode.
  • a spring element 40 allows a small residual stroke, which serves the tactile sensibility of the laboratory person.
  • the serves Control knob 1 only as a switch.
  • the lifting rod 3 is only from the Drive spindle 11 moves down and from the piston spring 26 upwards.
  • the microprocessor calculates the total volume to be recorded.
  • the drive motor 2 moves the Drive spindle 11 in the position corresponding to the entire volume to be absorbed and an extra volume.
  • the piston 22 is from the piston spring 26 upwards pressed, and the metering device takes up the total volume.
  • the drive motor 2 moves the drive spindle 11 down, whereby the stop bead 21, the lifting rod 3 and the piston 22 are moved down.
  • the drive motor 2 stops when the position corresponding the first dispensing volume is reached. While moving down the first dispensing volume is expelled from the pipette tip.
  • This process is repeated with each actuation of the control button 1 until the entire Dispensing volume is dispensed or dispensed.
  • the drive motor 2 moves the drive spindle 11 and the piston spring 26 the piston 22 automatically in the receiving position shown in FIG. 6 back.
  • the System is ready for a new dispensing sequence.
  • Fig. 9 drives the drive motor 2, the lifting rod 3, when the user press the control button 1. Since the servo drive relieves the control knob 1, the "Press" user to another drive by the drive motor 2 to guarantee. This leads to a sawtooth course of the force about a force threshold, in which the movement of the piston 22 by the electric drive motor. 2 is supported. Due to this sawtooth profile, pressure differences occur over time, which are recognized by the electrical control device and for the Switching on the electric drive motor can be used.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP05007928A 2004-05-06 2005-04-12 Pipette Active EP1598113B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004022419 2004-05-06
DE102004022419A DE102004022419B4 (de) 2004-05-06 2004-05-06 Pipette

Publications (2)

Publication Number Publication Date
EP1598113A1 true EP1598113A1 (fr) 2005-11-23
EP1598113B1 EP1598113B1 (fr) 2009-09-23

Family

ID=34935006

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05007928A Active EP1598113B1 (fr) 2004-05-06 2005-04-12 Pipette

Country Status (3)

Country Link
US (1) US7421913B2 (fr)
EP (1) EP1598113B1 (fr)
DE (2) DE102004022419B4 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2165765A1 (fr) * 2008-09-12 2010-03-24 Eppendorf Ag Dispositif de pipetage avec filetage double
CN105289770A (zh) * 2014-06-20 2016-02-03 哈美顿博纳图斯股份公司 具有模块式移液头的移液装置
EP1846506B2 (fr) † 2005-01-17 2018-02-21 DSM IP Assets B.V. Composition de moulage thermostabilisee
CN108786947A (zh) * 2017-05-05 2018-11-13 埃佩多夫股份公司 电子配量驱动装置

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10610406B2 (en) * 2004-07-21 2020-04-07 Vanderbilt University Drug delivery device and applications of same
DE102005033378B4 (de) * 2005-07-16 2012-05-31 Eppendorf Ag Kolbenhubpipette
US9044749B2 (en) * 2012-02-29 2015-06-02 Eppendorf Ag Pipette
US9358538B2 (en) 2012-04-30 2016-06-07 The Regents Of The University Of Michigan High resolution pipette
JP6353635B2 (ja) * 2013-05-13 2018-07-04 株式会社アイカムス・ラボ 分注装置
CN104101684B (zh) * 2014-07-25 2015-11-18 合肥安鼎生物科技有限公司 一种伺服式滴定管
CN104370242B (zh) * 2014-10-31 2017-05-10 湖州上电科电器科学研究有限公司 一种用于agv机器人的定轴旋升机构和agv机器人
CN104677672B (zh) * 2015-03-13 2017-03-08 上海宝冶工程技术有限公司 一种高温腐蚀性介质的取样器
FR3057182B1 (fr) * 2016-10-10 2021-07-09 Gilson Sas Pipettes monocanal ou multicanal a actionnement manuel et bouton de commande destine a equiper de telles pipettes
US10144537B2 (en) 2016-11-30 2018-12-04 Mallinckrodt Nuclear Medicine Llc Systems and methods for dispensing radioactive liquids
US11781953B2 (en) 2019-08-20 2023-10-10 Restek Corporation Solid phase microextraction device, repository, and manipulator
WO2021045043A1 (fr) * 2019-09-03 2021-03-11 京セラ株式会社 Pipette
EP4268960A3 (fr) 2020-02-14 2024-01-03 Denovix, Inc. Pipette dynamique a large plage volumetrique
CN113145195A (zh) * 2021-04-12 2021-07-23 烟台海深威软件有限公司 一种移液通道及移液方法
EP4334970A1 (fr) 2021-05-03 2024-03-13 Restek Corporation Dispositif de manipulation automatisée de dispositif émetteur à cône de taylor, système de manipulation automatisée de dispositif émetteur à cône de taylor et procédé d'analyse d'un échantillon
WO2024088988A1 (fr) * 2022-10-27 2024-05-02 Integra Biosciences Ag Ensemble pipette

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399712A (en) * 1981-02-09 1983-08-23 Nichiryo Co., Ltd. Semi-automatic electro-mechanical pipette with controlled tip remover
EP0576967A2 (fr) * 1992-06-24 1994-01-05 Labsystems Oy Corporation Pipette motorisée
JPH08215584A (ja) * 1995-02-15 1996-08-27 Sanyo Electric Co Ltd ピペッタ
WO2001057490A1 (fr) * 2000-02-03 2001-08-09 Rainin Instrument Llc. Dispositif de pipette pourvu d'un ejecteur de pointe utilisant de l'energie stockee
US20020020233A1 (en) * 2000-08-03 2002-02-21 Nobuyuki Baba Hybrid pipette
EP1439002A2 (fr) * 2003-01-16 2004-07-21 Eppendorf Ag Dispositif de dosage

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4519258A (en) * 1983-10-11 1985-05-28 Eastman Kodak Company Motorized pipette
FI86969C (fi) * 1991-02-05 1992-11-10 Biohit Oy Pipett
US6175369B1 (en) * 1998-10-31 2001-01-16 Hewlett-Packard Company High performance surface normal decompression
US6299841B1 (en) * 1999-03-05 2001-10-09 Rainin Instrument Co., Inc. Bilaterally symmetrical battery powered microprocessor controlled lightweight hand-holdable electronic pipette
AU2001275194A1 (en) * 2000-06-26 2002-01-08 Vistalab Technologies, Inc. Improved hand-held pipette

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399712A (en) * 1981-02-09 1983-08-23 Nichiryo Co., Ltd. Semi-automatic electro-mechanical pipette with controlled tip remover
EP0576967A2 (fr) * 1992-06-24 1994-01-05 Labsystems Oy Corporation Pipette motorisée
JPH08215584A (ja) * 1995-02-15 1996-08-27 Sanyo Electric Co Ltd ピペッタ
WO2001057490A1 (fr) * 2000-02-03 2001-08-09 Rainin Instrument Llc. Dispositif de pipette pourvu d'un ejecteur de pointe utilisant de l'energie stockee
US20020020233A1 (en) * 2000-08-03 2002-02-21 Nobuyuki Baba Hybrid pipette
EP1439002A2 (fr) * 2003-01-16 2004-07-21 Eppendorf Ag Dispositif de dosage

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 1996, no. 12 26 December 1996 (1996-12-26) *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1846506B2 (fr) † 2005-01-17 2018-02-21 DSM IP Assets B.V. Composition de moulage thermostabilisee
EP2165765A1 (fr) * 2008-09-12 2010-03-24 Eppendorf Ag Dispositif de pipetage avec filetage double
CN105289770A (zh) * 2014-06-20 2016-02-03 哈美顿博纳图斯股份公司 具有模块式移液头的移液装置
CN108786947A (zh) * 2017-05-05 2018-11-13 埃佩多夫股份公司 电子配量驱动装置
CN108786947B (zh) * 2017-05-05 2021-10-29 埃佩多夫股份公司 电子配量驱动装置

Also Published As

Publication number Publication date
US20050247141A1 (en) 2005-11-10
EP1598113B1 (fr) 2009-09-23
DE102004022419A1 (de) 2005-12-15
US7421913B2 (en) 2008-09-09
DE502005008168D1 (de) 2009-11-05
DE102004022419B4 (de) 2007-01-25

Similar Documents

Publication Publication Date Title
EP1598113B1 (fr) Pipette
EP1557222B1 (fr) Pipette avec éjecteur d'embouts de pipette
EP1825915B1 (fr) Système et procédé de titrage de liquides
EP1559480B1 (fr) Pipette avec mécanisme de déplacement fixé de façon détachable au mécanisme d'actionnement
DE2736532C3 (de) Automatische Sprühvorrichtung
EP1753536B1 (fr) Dispositif destine a recevoir et distribuer des liquides
DE102007010299B4 (de) Handpipettiervorrichtung
EP1859869B1 (fr) Appareil électrique de dosage pour liquide
EP3680016B1 (fr) Pipette destinée à une utilisation avec une pointe de pipette
EP2633913A1 (fr) Dispositif de pipetage et dispositif de pipetage multi-canal
EP2659978B1 (fr) Pipette avec systeme de blockage
EP1974819B1 (fr) Dispositif de dosage
DE102006037213A1 (de) Elektronische Dosiervorrichtung zum Dosieren von Flüssigkeiten
EP2319623A2 (fr) Dispositif de dosage pour liquides et procédé de dosage de liquides
DE2309547C3 (de) Gerät zum Füllen und Entleeren eines Flüssigkeitsbehälters, z.B. einer Pipette
DE102012002169B4 (de) Pipette
EP3831487B1 (fr) Pipette à utiliser avec une pointe de pipette et pointe de pipette à utiliser avec une pipette
DE19915771C1 (de) System zum Aufnehmen und Abgeben von Fluidvolumina
DE2808650C3 (de) Feinstausgabe- und Verdunnungsvorrichtung
DE2227930C2 (de) Spritzgerät, insbesondere für Kitt
DE102022105534A1 (de) Luftpolsterpipette
DE10355914B3 (de) Pipettiervorrichtung mit einer Abwurfeinrichtung für Pipettenspitzen
DE3411204C2 (de) Dosiervorrichtung für die Abgabe einer genau vorgegebenen Flüssigkeitsmenge
DE102004055562B4 (de) Handhabbares Dosiersystem

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR LV MK YU

17P Request for examination filed

Effective date: 20051027

AKX Designation fees paid

Designated state(s): DE FR GB IT

17Q First examination report despatched

Effective date: 20070629

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): DE FR GB IT

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REF Corresponds to:

Ref document number: 502005008168

Country of ref document: DE

Date of ref document: 20091105

Kind code of ref document: P

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20100506

Year of fee payment: 6

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20100624

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20090923

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20111230

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110502

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 502005008168

Country of ref document: DE

Owner name: EPPENDORF SE, DE

Free format text: FORMER OWNER: EPPENDORF AG, 22339 HAMBURG, DE

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230527

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20230420

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20230419

Year of fee payment: 19