EP1514928A4 - Procede de construction d'anticorps - Google Patents

Procede de construction d'anticorps

Info

Publication number
EP1514928A4
EP1514928A4 EP03733287A EP03733287A EP1514928A4 EP 1514928 A4 EP1514928 A4 EP 1514928A4 EP 03733287 A EP03733287 A EP 03733287A EP 03733287 A EP03733287 A EP 03733287A EP 1514928 A4 EP1514928 A4 EP 1514928A4
Authority
EP
European Patent Office
Prior art keywords
producing antibodies
antibodies
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP03733287A
Other languages
German (de)
English (en)
Other versions
EP1514928B1 (fr
EP1514928A1 (fr
Inventor
Tatsuhiko Kodama
Kou-Ichi Jishage
Nobuo Kamada
Yoshiki Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of EP1514928A1 publication Critical patent/EP1514928A1/fr
Publication of EP1514928A4 publication Critical patent/EP1514928A4/fr
Application granted granted Critical
Publication of EP1514928B1 publication Critical patent/EP1514928B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
EP03733287.1A 2002-06-05 2003-06-04 Procede de production d'anticorps a l'aide de baculovirus Expired - Lifetime EP1514928B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2002164834 2002-06-05
JP2002164834 2002-06-05
JP2002180351 2002-06-20
JP2002180351 2002-06-20
PCT/JP2003/007071 WO2003104453A1 (fr) 2002-06-05 2003-06-04 Procede de construction d'anticorps

Publications (3)

Publication Number Publication Date
EP1514928A1 EP1514928A1 (fr) 2005-03-16
EP1514928A4 true EP1514928A4 (fr) 2009-08-05
EP1514928B1 EP1514928B1 (fr) 2013-07-31

Family

ID=29738328

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03733287.1A Expired - Lifetime EP1514928B1 (fr) 2002-06-05 2003-06-04 Procede de production d'anticorps a l'aide de baculovirus

Country Status (5)

Country Link
US (2) US7750204B2 (fr)
EP (1) EP1514928B1 (fr)
JP (1) JP3991280B2 (fr)
AU (1) AU2003242024A1 (fr)
WO (1) WO2003104453A1 (fr)

Families Citing this family (56)

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WO2003033024A1 (fr) * 2001-10-16 2003-04-24 Chugai Seiyaku Kabushiki Kaisha Inhibiteur de proliferation cellulaire
EP1462113B1 (fr) 2001-12-04 2010-02-24 Chugai Seiyaku Kabushiki Kaisha Inhibiteur de la proliferation cellulaire contenant un anticorps dirige contre pept
WO2003083116A1 (fr) 2002-03-29 2003-10-09 Chugai Seiyaku Kabushiki Kaisha Procede de criblage d'inhibiteurs de transporteurs
JP3991280B2 (ja) 2002-06-05 2007-10-17 中外製薬株式会社 抗体作製方法
WO2004087762A1 (fr) * 2003-03-28 2004-10-14 Chugai Seiyaku Kabushiki Kaisha Anticorps inhibant l'activite de transport d'un transporteur peptidique
EP1731032B1 (fr) 2004-03-31 2016-10-19 Chugai Seiyaku Kabushiki Kaisha SOURIS TRANSGÉNIQUES COMPORTANT UN GÈNE POUR UNE FORME SOLUBLE DE PROTéINE MEMBRANAIRE, UTILES POUR LA PRODUCTION D'ANTICORPS CONTRE UN ANTIGÈNE CIBLE
EP2011513B1 (fr) * 2006-04-25 2016-10-19 The University of Tokyo Agents thérapeutiques employés dans le cadre de la maladie d'alzheimer et du cancer
AU2007285217B2 (en) 2006-08-14 2013-02-07 Forerunner Pharma Research Co., Ltd Diagnosis and treatment of cancer using anti-desmoglein-3 antibodies
NZ576855A (en) 2006-10-12 2012-08-31 Forerunner Pharma Res Co Ltd Diagnosis and treatment of cancer using anti-ereg antibody
EP2078731A4 (fr) 2006-10-20 2012-08-01 Forerunner Pharma Res Co Ltd Composition pharmaceutique comprenant un anticorps anti-hb-egf comme ingrédient actif
CN101589059A (zh) 2006-10-20 2009-11-25 株式会社未来创药研究所 包含抗hb-egf抗体作为活性成分的药物组合物
AU2007332473B2 (en) 2006-12-14 2012-09-27 Forerunner Pharma Research Co., Ltd. Anti-Claudin-3 monoclonal antibody, and treatment and diagnosis of cancer using the same
US20100111851A1 (en) 2007-01-05 2010-05-06 The University Of Tokyo Diagnosis and treatment of cancer by using anti-prg-3 antibody
CN101951953A (zh) 2007-02-27 2011-01-19 株式会社未来创药研究所 含抗grp78抗体作为有效成分的药物组合物
JP5117765B2 (ja) 2007-05-28 2013-01-16 国立大学法人 東京大学 抗ｒｏｂｏ１抗体を含むｐｅｔ用腫瘍診断剤
CA2705509A1 (fr) 2007-11-14 2009-05-22 Forerunner Pharma Research Co., Ltd. Diagnostic et traitement du cancer a l'aide d'un anticorps anti-gpr49
CN101918452A (zh) 2007-11-15 2010-12-15 中外制药株式会社 与Anexelekto结合的单克隆抗体及其利用
RU2531521C2 (ru) 2007-12-05 2014-10-20 Чугаи Сейяку Кабусики Кайся Антитело против nr10 и его применение
MX2010006097A (es) 2007-12-05 2010-08-04 Chugai Pharmaceutical Co Ltd Agentes terapeuticos para tratar el prurito.
CN101918450A (zh) 2008-01-11 2010-12-15 国立大学法人东京大学 抗cldn6抗体
JP5756292B2 (ja) 2008-12-22 2015-07-29 中外製薬株式会社 抗ｈｓ６ｓｔ２抗体及びその用途
JP6009733B2 (ja) 2008-12-25 2016-10-19 国立大学法人 東京大学 抗ｔｍ４ｓｆ２０抗体を用いた癌の診断と治療
MX2011006908A (es) 2008-12-26 2011-10-06 Univ Tokio Diagnosis y tratamiento del cancer utilizando el anticuerpo anti-lgr7.
JP2010210772A (ja) 2009-03-13 2010-09-24 Dainippon Screen Mfg Co Ltd 液晶表示装置の製造方法
EP2420515A4 (fr) 2009-04-16 2013-08-28 Univ Tokyo Diagnostic et traitement du cancer au moyen d'un anticorps anti-tmprss11e
JP5808052B2 (ja) 2009-05-29 2015-11-10 中外製薬株式会社 Ｅｇｆファミリーリガンドのアンタゴニストを成分とする医薬組成物
CN102574917A (zh) 2009-08-17 2012-07-11 株式会社未来创药研究所 含有抗hb-egf抗体作为有效成分的药物组合物
RS62387B1 (sr) 2010-01-29 2021-10-29 Chugai Pharmaceutical Co Ltd Anti-dll3 antitelo
US20120321557A1 (en) 2010-02-26 2012-12-20 Forerunner Pharma Research Co., Ltd. Anti-icam3 antibody and use thereof
BR112013013311A2 (pt) 2010-11-30 2017-09-19 Chugai Pharmaceutical Co Ltd agente terapêutico de indução de citotoxicidade
SG190727A1 (en) 2010-11-30 2013-07-31 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
EP2698431B1 (fr) 2011-03-30 2020-09-09 Chugai Seiyaku Kabushiki Kaisha Rétention de molécules de liaison à l'antigène dans le plasma sanguin et procédé de modification du caractère immunogène
US20140193420A1 (en) 2011-04-18 2014-07-10 Chugai Seiyaku Kabushiki Kaisha Diagnosis and treatment of cancer using anti-itm2a antibody
BR122019017005B1 (pt) 2011-04-22 2022-03-29 Wyeth Llc Composições que se relacionam a uma toxina de clostridium difficile mutante
TWI827333B (zh) 2011-09-30 2023-12-21 日商中外製藥股份有限公司 促進抗原消失的抗原結合分子
KR102366029B1 (ko) 2011-09-30 2022-02-23 추가이 세이야쿠 가부시키가이샤 표적 항원에 대한 면역응답을 유도하는 항원 결합 분자
EP2765192A4 (fr) 2011-10-05 2015-04-15 Chugai Pharmaceutical Co Ltd Molécule se liant à l'antigène pour favoriser la clairance du plasma d'un antigène comprenant un domaine de liaison aux récepteurs de type chaîne saccharidique
GB2496375A (en) * 2011-10-28 2013-05-15 Kymab Ltd A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof
TWI593705B (zh) 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
KR102219987B1 (ko) 2012-02-24 2021-02-25 추가이 세이야쿠 가부시키가이샤 ＦｃγＲＩＩＢ를 매개로 항원의 소실을 촉진하는 항원 결합 분자
JPWO2013180200A1 (ja) 2012-05-30 2016-01-21 中外製薬株式会社 標的組織特異的抗原結合分子
US9616101B2 (en) 2012-07-06 2017-04-11 Kyoto Prefectural Public University Corporation Differentiation marker and differentiation control of eye cell
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
JPWO2014208482A1 (ja) 2013-06-24 2017-02-23 中外製薬株式会社 ヒト化抗Ｅｐｉｒｅｇｕｌｉｎ抗体を有効成分として含む腺癌以外の非小細胞肺癌の治療剤
JP7060317B2 (ja) 2013-12-04 2022-04-26 中外製薬株式会社 化合物の濃度に応じて抗原結合能の変化する抗原結合分子及びそのライブラリ
JP6535133B2 (ja) * 2015-05-15 2019-06-26 リーバー ジェネティクス シーオー．， エルティーディー．Ｒｅｂｅｒ Ｇｅｎｅｔｉｃｓ Ｃｏ．， Ｌｔｄ． 新規のバキュロウイルスベクター及び使用の方法
CA3014208A1 (fr) 2016-02-16 2017-08-24 Regeneron Pharamaceuticals, Inc. Animaux non humains ayant un gene de kynureninase mutant
AU2017233658B2 (en) 2016-03-14 2023-09-21 Chugai Seiyaku Kabushiki Kaisha Cell injury inducing therapeutic drug for use in cancer therapy
KR102533814B1 (ko) 2016-11-28 2023-05-19 추가이 세이야쿠 가부시키가이샤 리간드 결합 활성을 조정 가능한 리간드 결합 분자
JP7266532B2 (ja) 2017-11-28 2023-04-28 中外製薬株式会社 リガンド結合活性が調整可能なリガンド結合分子
US20210253672A1 (en) 2018-05-30 2021-08-19 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule containing single domain antibody
US11878065B2 (en) * 2018-08-08 2024-01-23 Xiaofeng Xia Reporter protein fused antibodies
EP3943108A4 (fr) 2019-03-19 2023-01-04 Chugai Seiyaku Kabushiki Kaisha Molécule de liaison à l'antigène contenant un domaine de liaison à l'antigène dont l'activité de liaison à l'antigène est modifiée en fonction de la mta, et banque pour obtenir ledit domaine de liaison à l'antigène
JPWO2020246567A1 (fr) 2019-06-05 2020-12-10
KR20220017430A (ko) 2019-06-05 2022-02-11 추가이 세이야쿠 가부시키가이샤 항체 절단 부위 결합 분자
CN116194124A (zh) 2020-07-31 2023-05-30 中外制药株式会社 包含表达嵌合受体的细胞的药物组合物

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See also references of WO03104453A1 *

Also Published As

Publication number Publication date
US20050222391A1 (en) 2005-10-06
JP3991280B2 (ja) 2007-10-17
EP1514928B1 (fr) 2013-07-31
EP1514928A1 (fr) 2005-03-16
AU2003242024A1 (en) 2003-12-22
US8013208B2 (en) 2011-09-06
US20100218267A1 (en) 2010-08-26
WO2003104453A1 (fr) 2003-12-18
JPWO2003104453A1 (ja) 2005-10-06
US7750204B2 (en) 2010-07-06

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