EP1317438A1 - Derives de chromanone - Google Patents

Derives de chromanone

Info

Publication number
EP1317438A1
EP1317438A1 EP01962976A EP01962976A EP1317438A1 EP 1317438 A1 EP1317438 A1 EP 1317438A1 EP 01962976 A EP01962976 A EP 01962976A EP 01962976 A EP01962976 A EP 01962976A EP 1317438 A1 EP1317438 A1 EP 1317438A1
Authority
EP
European Patent Office
Prior art keywords
formula
compound
chroman
compounds
chromanone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP01962976A
Other languages
German (de)
English (en)
Inventor
Heinz-Hermann Bokel
Christoph Mürmann
Uschi Schmid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of EP1317438A1 publication Critical patent/EP1317438A1/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

L'invention concerne des dérivés de chromanone de formule (I) dans laquelle, R<1> à R<4> désignent, indépendamment l'un de l'autre H, A, CH, Hal, OR<5>, COOR<5>, CH<3>, OCF<3>, NO<2>, Ar, Oar, N(R<5>)2 ou CON(R<5>)2, R<5> désigne H ou A, A désigne un alkyle de 1 à 6 atomes de C, Ar désigne un phényle non substitué, ou substitué par A, OR<5>, Cn Hal, CF3, OCF3, NO2 ou N(R<5>)2, Hal désigne F, Cl, Br ou I. L'invention concerne également des sels de ces dérivés. Les dérivés et leurs sels conviennent comme produits intermédiaires pour la synthèse de médicaments.
EP01962976A 2000-09-07 2001-08-28 Derives de chromanone Ceased EP1317438A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10044091A DE10044091A1 (de) 2000-09-07 2000-09-07 Chromanonderivate
DE10044091 2000-09-07
PCT/EP2001/009900 WO2002020507A1 (fr) 2000-09-07 2001-08-28 Derives de chromanone

Publications (1)

Publication Number Publication Date
EP1317438A1 true EP1317438A1 (fr) 2003-06-11

Family

ID=7655302

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01962976A Ceased EP1317438A1 (fr) 2000-09-07 2001-08-28 Derives de chromanone

Country Status (19)

Country Link
US (1) US6812353B2 (fr)
EP (1) EP1317438A1 (fr)
JP (1) JP2004508363A (fr)
KR (1) KR20030040402A (fr)
CN (1) CN1249044C (fr)
AR (1) AR030625A1 (fr)
AU (1) AU2001284039A1 (fr)
BR (1) BR0113584A (fr)
CA (1) CA2421287A1 (fr)
DE (1) DE10044091A1 (fr)
HU (1) HUP0302065A3 (fr)
MY (1) MY133893A (fr)
NO (1) NO20031034D0 (fr)
PL (1) PL362761A1 (fr)
RU (1) RU2273638C2 (fr)
SK (1) SK3332003A3 (fr)
UA (1) UA75892C2 (fr)
WO (1) WO2002020507A1 (fr)
ZA (1) ZA200302632B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10044091A1 (de) 2000-09-07 2002-04-04 Merck Patent Gmbh Chromanonderivate
BR0213030A (pt) 2001-10-05 2004-10-05 Wyeth Corp Processo estereoespecìfico para a sìntese de derivados de 2-il cromano
US6700001B2 (en) 2001-10-05 2004-03-02 Wyeth Process for stereoselective synthesis of 2-hydroxymethyl chromans
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
CA2605587A1 (fr) * 2005-04-22 2006-11-02 Wyeth Derives de chromane et de chromene, et leurs utilisations
US7528267B2 (en) 2005-08-01 2009-05-05 Girindus America, Inc. Method for enantioselective hydrogenation of chromenes
WO2007051735A1 (fr) * 2005-11-03 2007-05-10 F. Hoffmann-La Roche Ag Dérivés d'indolylmaléimide en tant qu'inhibiteurs de protéine kinase
RU2468018C1 (ru) * 2011-10-06 2012-11-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) Способ получения производных 4-оксо-4h-хроменов, содержащих винильную и енаминную группировки
DK2929880T3 (da) * 2013-07-18 2017-01-02 Toyama Chemical Co Ltd Terapeutisk middel til sygdom baseret på hæmmende effekt af makrofag-migrationshæmmende faktor
WO2015106789A1 (fr) * 2014-01-17 2015-07-23 Merck Patent Gmbh Matières pour dispositifs électroluminescents organiques
WO2019212211A1 (fr) * 2018-04-30 2019-11-07 Gachon University Of Industry-Academic Cooperation Foundation Dérivé de chromane anti-angiogénique et utilisations associées

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2611910A1 (de) 1976-03-20 1977-09-22 Bayer Ag Chromanone-(4)
CH619701A5 (fr) * 1975-08-07 1980-10-15 Bayer Ag
PT707007E (pt) * 1994-10-14 2002-06-28 Merck Patent Gmbh Derivados amino(tio)eter como agentes activos no snc
DE19858341A1 (de) 1998-12-17 2000-06-21 Merck Patent Gmbh Chromanderivate
DE10044091A1 (de) 2000-09-07 2002-04-04 Merck Patent Gmbh Chromanonderivate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0220507A1 *

Also Published As

Publication number Publication date
US20040092579A1 (en) 2004-05-13
JP2004508363A (ja) 2004-03-18
BR0113584A (pt) 2003-07-15
RU2273638C2 (ru) 2006-04-10
NO20031034L (no) 2003-03-06
SK3332003A3 (en) 2003-07-01
AU2001284039A1 (en) 2002-03-22
NO20031034D0 (no) 2003-03-06
CN1249044C (zh) 2006-04-05
DE10044091A1 (de) 2002-04-04
CN1451001A (zh) 2003-10-22
WO2002020507A1 (fr) 2002-03-14
AR030625A1 (es) 2003-08-27
PL362761A1 (en) 2004-11-02
UA75892C2 (en) 2006-06-15
US6812353B2 (en) 2004-11-02
HUP0302065A3 (en) 2005-07-28
KR20030040402A (ko) 2003-05-22
CA2421287A1 (fr) 2003-03-05
MY133893A (en) 2007-11-30
ZA200302632B (en) 2004-09-02
HUP0302065A2 (hu) 2003-09-29

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20021228

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

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Effective date: 20030915

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18R Application refused

Effective date: 20061016