EP1296142A2 - Composés capables de moduler l'activité du récepteur de calcium - Google Patents
Composés capables de moduler l'activité du récepteur de calcium Download PDFInfo
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- EP1296142A2 EP1296142A2 EP02027563A EP02027563A EP1296142A2 EP 1296142 A2 EP1296142 A2 EP 1296142A2 EP 02027563 A EP02027563 A EP 02027563A EP 02027563 A EP02027563 A EP 02027563A EP 1296142 A2 EP1296142 A2 EP 1296142A2
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- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
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US74945191A | 1991-08-23 | 1991-08-23 | |
US83404492A | 1992-02-11 | 1992-02-11 | |
US749451 | 1992-02-11 | ||
US834044 | 1992-02-11 | ||
US93416192A | 1992-08-21 | 1992-08-21 | |
EP92919933A EP0657029A4 (fr) | 1991-08-23 | 1992-08-21 | Molecules agissant sur les recepteurs de calcium. |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EP92919933A Division EP0657029A4 (fr) | 1991-08-23 | 1992-08-21 | Molecules agissant sur les recepteurs de calcium. |
Publications (3)
Publication Number | Publication Date |
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EP1296142A2 true EP1296142A2 (fr) | 2003-03-26 |
EP1296142A3 EP1296142A3 (fr) | 2003-05-02 |
EP1296142B1 EP1296142B1 (fr) | 2005-12-07 |
Family
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Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
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EP02016612A Expired - Lifetime EP1281702B1 (fr) | 1991-08-23 | 1992-08-21 | Composés capables de moduler l'activité du récepteur de calcium |
EP92919933A Ceased EP0657029A4 (fr) | 1991-08-23 | 1992-08-21 | Molecules agissant sur les recepteurs de calcium. |
EP02027563A Expired - Lifetime EP1296142B1 (fr) | 1991-08-23 | 1992-08-21 | Procédé de criblage de composés capables de moduler l'activité du récepteur de calcium |
EP05077693A Withdrawn EP1632470A3 (fr) | 1991-08-23 | 1992-08-21 | Composés capables de moduler l'activité du récepteur de calcium |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
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EP02016612A Expired - Lifetime EP1281702B1 (fr) | 1991-08-23 | 1992-08-21 | Composés capables de moduler l'activité du récepteur de calcium |
EP92919933A Ceased EP0657029A4 (fr) | 1991-08-23 | 1992-08-21 | Molecules agissant sur les recepteurs de calcium. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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EP05077693A Withdrawn EP1632470A3 (fr) | 1991-08-23 | 1992-08-21 | Composés capables de moduler l'activité du récepteur de calcium |
Country Status (17)
Country | Link |
---|---|
EP (4) | EP1281702B1 (fr) |
JP (5) | JP2728564B2 (fr) |
KR (1) | KR100251995B1 (fr) |
CN (1) | CN1067550C (fr) |
AT (2) | ATE312347T1 (fr) |
AU (1) | AU711247B2 (fr) |
CA (1) | CA2115828C (fr) |
DE (2) | DE69233572T2 (fr) |
DK (1) | DK1281702T3 (fr) |
ES (1) | ES2256370T3 (fr) |
HK (1) | HK1053303A1 (fr) |
IL (3) | IL102917A (fr) |
MX (1) | MX9204881A (fr) |
NO (1) | NO940581L (fr) |
RU (1) | RU2147574C1 (fr) |
WO (1) | WO1993004373A1 (fr) |
ZA (1) | ZA926360B (fr) |
Cited By (9)
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WO2010104882A1 (fr) | 2009-03-10 | 2010-09-16 | Amgen Inc. | Procédés de modulation de la motilité des spermatozoïdes |
WO2010136037A1 (fr) | 2009-05-27 | 2010-12-02 | Leo Pharma A/S | Nouveaux composés modulant le récepteur sensible au calcium, et leur utilisation pharmaceutique |
WO2010136035A2 (fr) | 2009-05-27 | 2010-12-02 | Leo Pharma A/S | Composés inédits modulant les récepteurs du calcium et leur utilisation pharmaceutique |
WO2012069421A1 (fr) | 2010-11-26 | 2012-05-31 | Leo Pharma A/S | Composés actifs sur les récepteurs du calcium |
WO2012069420A2 (fr) | 2010-11-26 | 2012-05-31 | Leo Pharma A/S | Composés actifs sur le récepteur sensible au calcium |
WO2012069419A1 (fr) | 2010-11-26 | 2012-05-31 | Leo Pharma A/S | Composés actifs sur le récepteur sensible au calcium |
WO2012069402A1 (fr) | 2010-11-26 | 2012-05-31 | Leo Pharma A/S | Cyclopentylazines substituées en tant que composés casr-actifs |
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Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2173747C (fr) * | 1991-08-23 | 2006-05-23 | Edward F. Nemeth | Arylalkylamines agissant sur les recepteurs du calcium |
ATE312347T1 (de) * | 1991-08-23 | 2005-12-15 | Nps Pharma Inc | Screening-verfahren für kalzium-rezeptor aktive verbindungen |
US6031003A (en) * | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US6001884A (en) * | 1991-08-23 | 1999-12-14 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US5763569A (en) * | 1991-08-23 | 1998-06-09 | The Brigham And Women's Hospital, Inc | Calcium receptor-active molecules |
US6313146B1 (en) | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US5688938A (en) * | 1991-08-23 | 1997-11-18 | The Brigham & Women's Hospital, Inc. | Calcium receptor-active molecules |
US5858684A (en) * | 1991-08-23 | 1999-01-12 | The Brigham And Women's Hospital, Inc. | Method of screening calcium receptor-active molecules |
CA2145866C (fr) * | 1992-09-30 | 2001-11-27 | Emma E. Moore | Recepteur de la calcitonine humaine |
US7087765B2 (en) | 1995-06-07 | 2006-08-08 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
US6750244B2 (en) | 1993-02-08 | 2004-06-15 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
US6071970A (en) * | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
US6211245B1 (en) | 1993-02-08 | 2001-04-03 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
US6017965A (en) * | 1993-02-08 | 2000-01-25 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
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US5962314A (en) * | 1993-02-23 | 1999-10-05 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
ATE267009T1 (de) * | 1993-02-23 | 2004-06-15 | Brigham & Womens Hospital | Calciumrezeptoraktive moleküle |
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US5504253A (en) * | 1994-07-15 | 1996-04-02 | Nps Pharmaceuticals, Inc. | Amine preparation |
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US5648541A (en) * | 1995-09-28 | 1997-07-15 | Nps Pharmaceuticals, Inc. | Chiral reductions of imines leading to the syntheses of optically active amines |
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CN112250598B (zh) * | 2020-11-06 | 2023-07-25 | 河南科技大学 | 一种丹皮酚腙类衍生物及其制备方法和应用、杀虫剂 |
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DD144050A5 (de) * | 1978-06-05 | 1980-09-24 | Ciba Geigy Ag | Verfahren zur herstellung von n-alkylierten aminoalkoholen |
DK268779A (da) * | 1978-07-03 | 1980-01-04 | Lilly Co Eli | Fremgangsmaade til fremstilling af phenethanolaminer |
ZA794872B (en) * | 1978-09-20 | 1980-11-26 | Schering Corp | A phenylalkylaminoethylsalicylamide,its preparation and pharmaceutical compositions containing it |
DD150456A5 (de) * | 1979-03-01 | 1981-09-02 | Ciba Geigy Ag | Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols |
CA1258454A (fr) * | 1982-08-10 | 1989-08-15 | Leo Alig | Phenethanolamines |
HU200591B (en) * | 1986-07-11 | 1990-07-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing new diphenyl propylamine derivatives and pharmaceutical compositions comprising such compounds |
US5386025A (en) * | 1990-02-20 | 1995-01-31 | The Salk Institute Biotechnology/Industrial Associates | Calcium channel compositions and methods |
DD298412A5 (de) * | 1989-04-28 | 1992-02-20 | ������@���Kk�� | Verfahren zur herstellung von polypeptiden, die geeignet sind als antagonisten exzitatorischer aminosaeure-neurotransmitter und/oder blocker der calciumkanaele |
CA2062810A1 (fr) * | 1989-07-03 | 1991-01-04 | Bruce D. Cherksey | Utilisation de polyamines comme agents de regulation de la circulation ionique trans-membranaire |
ATE312347T1 (de) * | 1991-08-23 | 2005-12-15 | Nps Pharma Inc | Screening-verfahren für kalzium-rezeptor aktive verbindungen |
-
1992
- 1992-08-21 AT AT02027563T patent/ATE312347T1/de not_active IP Right Cessation
- 1992-08-21 DK DK02016612T patent/DK1281702T3/da active
- 1992-08-21 WO PCT/US1992/007175 patent/WO1993004373A1/fr not_active Application Discontinuation
- 1992-08-21 CA CA2115828A patent/CA2115828C/fr not_active Expired - Lifetime
- 1992-08-21 DE DE69233572T patent/DE69233572T2/de not_active Expired - Lifetime
- 1992-08-21 MX MX9204881A patent/MX9204881A/es unknown
- 1992-08-21 KR KR1019940700536A patent/KR100251995B1/ko active Protection Beyond IP Right Term
- 1992-08-21 EP EP02016612A patent/EP1281702B1/fr not_active Expired - Lifetime
- 1992-08-21 RU RU94020394A patent/RU2147574C1/ru active Protection Beyond IP Right Term
- 1992-08-21 AT AT02016612T patent/ATE313321T1/de active
- 1992-08-21 EP EP92919933A patent/EP0657029A4/fr not_active Ceased
- 1992-08-21 EP EP02027563A patent/EP1296142B1/fr not_active Expired - Lifetime
- 1992-08-21 JP JP5504650A patent/JP2728564B2/ja not_active Expired - Lifetime
- 1992-08-21 DE DE69233586T patent/DE69233586T2/de not_active Expired - Lifetime
- 1992-08-21 ES ES02016612T patent/ES2256370T3/es not_active Expired - Lifetime
- 1992-08-21 EP EP05077693A patent/EP1632470A3/fr not_active Withdrawn
- 1992-08-22 CN CN92111580A patent/CN1067550C/zh not_active Expired - Lifetime
- 1992-08-23 IL IL10291792A patent/IL102917A/xx active Protection Beyond IP Right Term
- 1992-08-23 IL IL12295892A patent/IL122958A/en not_active IP Right Cessation
- 1992-08-24 ZA ZA926360A patent/ZA926360B/xx unknown
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1994
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1996
- 1996-09-02 JP JP8232165A patent/JP2887201B2/ja not_active Expired - Lifetime
- 1996-09-02 JP JP8232130A patent/JP2860285B2/ja not_active Expired - Lifetime
- 1996-11-25 AU AU71977/96A patent/AU711247B2/en not_active Expired
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1998
- 1998-01-16 IL IL12295898A patent/IL122958A0/xx active IP Right Grant
- 1998-11-04 JP JP31363198A patent/JP3256502B2/ja not_active Expired - Lifetime
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2000
- 2000-12-26 JP JP2000394979A patent/JP2001220356A/ja active Pending
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2003
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WO1982004052A1 (fr) * | 1981-05-12 | 1982-11-25 | Szejtli Jozsef | Procede de preparation de complexes d'inclusion derives de n-(1-phenyle-ethyle)-3,3-diphenyle-propylamine respectivement de son chlorhydrate et de cyclodextrine |
US4728660A (en) * | 1984-06-11 | 1988-03-01 | University Of Miami | Method of treating diseases arising from platelet hyperactivation |
WO1989009834A1 (fr) * | 1988-04-04 | 1989-10-19 | The Salk Institute Biotechnology/Industrial Associ | Compositions a canal de calcium et procedes associes |
EP0384740A2 (fr) * | 1989-02-21 | 1990-08-29 | Dana Farber Cancer Institute | Procédé pour tester l'effet d'une molécule sur la fonction des lymphocytes-B |
Non-Patent Citations (5)
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8779004B2 (en) | 2006-04-20 | 2014-07-15 | Amgen, Inc. | Stable emulsion formulations |
WO2008121386A2 (fr) | 2007-03-30 | 2008-10-09 | Amgen Inc. | Procédés de traitement de troubles intestinaux |
WO2010104882A1 (fr) | 2009-03-10 | 2010-09-16 | Amgen Inc. | Procédés de modulation de la motilité des spermatozoïdes |
WO2010136037A1 (fr) | 2009-05-27 | 2010-12-02 | Leo Pharma A/S | Nouveaux composés modulant le récepteur sensible au calcium, et leur utilisation pharmaceutique |
WO2010136035A2 (fr) | 2009-05-27 | 2010-12-02 | Leo Pharma A/S | Composés inédits modulant les récepteurs du calcium et leur utilisation pharmaceutique |
WO2012069421A1 (fr) | 2010-11-26 | 2012-05-31 | Leo Pharma A/S | Composés actifs sur les récepteurs du calcium |
WO2012069420A2 (fr) | 2010-11-26 | 2012-05-31 | Leo Pharma A/S | Composés actifs sur le récepteur sensible au calcium |
WO2012069419A1 (fr) | 2010-11-26 | 2012-05-31 | Leo Pharma A/S | Composés actifs sur le récepteur sensible au calcium |
WO2012069402A1 (fr) | 2010-11-26 | 2012-05-31 | Leo Pharma A/S | Cyclopentylazines substituées en tant que composés casr-actifs |
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