IL122958A0 - Method of identifying a calcimimetic compound - Google Patents
Method of identifying a calcimimetic compoundInfo
- Publication number
- IL122958A0 IL122958A0 IL12295898A IL12295898A IL122958A0 IL 122958 A0 IL122958 A0 IL 122958A0 IL 12295898 A IL12295898 A IL 12295898A IL 12295898 A IL12295898 A IL 12295898A IL 122958 A0 IL122958 A0 IL 122958A0
- Authority
- IL
- Israel
- Prior art keywords
- sup
- cells
- antagonist
- receptors
- patient
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/13—Amines
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K31/275—Nitriles; Isonitriles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
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- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
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- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- G01N2800/00—Detection or diagnosis of diseases
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US74945191A | 1991-08-23 | 1991-08-23 | |
US83404492A | 1992-02-11 | 1992-02-11 | |
US93416192A | 1992-08-21 | 1992-08-21 | |
IL10291798 | 1998-01-16 |
Publications (1)
Publication Number | Publication Date |
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IL122958A0 true IL122958A0 (en) | 1998-08-16 |
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IL12295892A IL122958A (en) | 1991-08-23 | 1992-08-23 | A method for detecting a clasimimic compound |
IL10291792A IL102917A (en) | 1991-08-23 | 1992-08-23 | Calcium receptor active compound and pharmaceutical composition comprising such compound |
IL12295898A IL122958A0 (en) | 1991-08-23 | 1998-01-16 | Method of identifying a calcimimetic compound |
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Application Number | Title | Priority Date | Filing Date |
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IL12295892A IL122958A (en) | 1991-08-23 | 1992-08-23 | A method for detecting a clasimimic compound |
IL10291792A IL102917A (en) | 1991-08-23 | 1992-08-23 | Calcium receptor active compound and pharmaceutical composition comprising such compound |
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Country | Link |
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EP (4) | EP1632470A3 (xx) |
JP (5) | JP2728564B2 (xx) |
KR (1) | KR100251995B1 (xx) |
CN (1) | CN1067550C (xx) |
AT (2) | ATE313321T1 (xx) |
AU (1) | AU711247B2 (xx) |
CA (1) | CA2115828C (xx) |
DE (2) | DE69233586T2 (xx) |
DK (1) | DK1281702T3 (xx) |
ES (1) | ES2256370T3 (xx) |
HK (1) | HK1053303A1 (xx) |
IL (3) | IL122958A (xx) |
MX (1) | MX9204881A (xx) |
NO (1) | NO940581L (xx) |
RU (1) | RU2147574C1 (xx) |
WO (1) | WO1993004373A1 (xx) |
ZA (1) | ZA926360B (xx) |
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DE69433714T2 (de) * | 1991-08-23 | 2005-03-31 | NPS Pharmaceuticals, Inc., Salt Lake City | Kalzium - receptor aktive arylalkylamine |
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US6031003A (en) * | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US5858684A (en) * | 1991-08-23 | 1999-01-12 | The Brigham And Women's Hospital, Inc. | Method of screening calcium receptor-active molecules |
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EP1366764B1 (en) * | 1993-02-23 | 2006-06-28 | The Brigham & Women's Hospital, Inc. | Method of screening for calcium receptor-active molecules |
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AU710575B2 (en) | 1994-02-08 | 1999-09-23 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
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KR100771092B1 (ko) | 1996-07-08 | 2007-10-30 | 기린 파마 가부시끼가이샤 | 칼슘 수용체 활성 화합물 |
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FR2812875B1 (fr) * | 2000-08-08 | 2003-12-12 | Centre Nat Rech Scient | Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation |
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AU2003282867A1 (en) * | 2002-10-22 | 2004-05-13 | Genzyme Corporation | Amine polymers for promoting bone formation |
DK1663182T4 (da) | 2003-09-12 | 2020-02-17 | Amgen Inc | Hurtigt opløsende formulering af cinacalcet HCI |
WO2005065050A2 (ja) | 2003-12-25 | 2005-07-21 | Asahi Kasei Pharma Corporation | 2環化合物 |
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EP1937233B1 (en) | 2005-09-02 | 2013-01-09 | Amgen Inc. | Modulating intestinal fluid balance using calcimimetics |
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ES2449340T3 (es) | 2007-03-30 | 2014-03-19 | Amgen Inc. | Compuestos calcimiméticos para su uso en el tratamiento de trastornos intestinales |
WO2010104882A1 (en) | 2009-03-10 | 2010-09-16 | Amgen Inc. | Methods of modulating sperm motility |
WO2010103429A1 (en) | 2009-03-10 | 2010-09-16 | Pfizer Inc. | 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists |
WO2010136035A2 (en) | 2009-05-27 | 2010-12-02 | Leo Pharma A/S | Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof |
US8765676B2 (en) | 2009-05-27 | 2014-07-01 | Leo Pharma A/S | Calcium sensing receptor modulating compounds and pharmaceutical use thereof |
US8946474B2 (en) | 2010-06-30 | 2015-02-03 | Leo Pharma A/S | Polymorphic form of a calcimimetic compound |
CN102958907A (zh) | 2010-06-30 | 2013-03-06 | 利奥制药有限公司 | 钙敏感受体激动化合物的新多晶型 |
JP2014508104A (ja) | 2010-11-26 | 2014-04-03 | レオ ファーマ アクティーゼルスカブ | カルシウム感知受容体活性化合物 |
EP2643290A1 (en) | 2010-11-26 | 2013-10-02 | Leo Pharma A/S | Calcium-sensing receptor-active compounds |
EP2643292A1 (en) | 2010-11-26 | 2013-10-02 | Leo Pharma A/S | Calcium-sensing receptor-active compounds |
WO2012069402A1 (en) | 2010-11-26 | 2012-05-31 | Leo Pharma A/S | Substituted cyclopentyl - azines as casr- active compounds |
US9895325B2 (en) * | 2012-12-21 | 2018-02-20 | Synthon B.V. | Tablet composition comprising cinacalcet hydrochloride |
RU2532355C1 (ru) * | 2013-07-10 | 2014-11-10 | Общество с ограниченной ответственностью "Пробиотик Центр" | Способ лечения с.-х. птиц с помощью поликатионного соединения "тривирон" (triviron) |
EP3204772B2 (en) * | 2014-10-10 | 2023-12-20 | Mars, Incorporated | Methods for identifying modulators of calcium-sensing receptors |
US11450405B2 (en) * | 2018-10-18 | 2022-09-20 | Fresenius Medical Care Holdings, Inc. | Techniques for modeling parathyroid gland functionality and calcimimetic drug activity |
CN112250598B (zh) * | 2020-11-06 | 2023-07-25 | 河南科技大学 | 一种丹皮酚腙类衍生物及其制备方法和应用、杀虫剂 |
Family Cites Families (14)
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FI791727A (fi) * | 1978-06-05 | 1979-12-06 | Ciba Geigy Ag | Foerfarande foer framstaellning av n-alkylerade aminoalkoholer |
CA1142954A (en) * | 1978-07-03 | 1983-03-15 | Jack Mills | Phenethanolamines, compositions containing the same, and method for effecting weight control |
ZA794872B (en) * | 1978-09-20 | 1980-11-26 | Schering Corp | A phenylalkylaminoethylsalicylamide,its preparation and pharmaceutical compositions containing it |
DD150456A5 (de) * | 1979-03-01 | 1981-09-02 | Ciba Geigy Ag | Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols |
HU183430B (en) * | 1981-05-12 | 1984-05-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing cyclodextrine inclusion complexes of n-bracket-1-phenylethyl-bracket closed-3,3-diphenylpropylamine or n-bracket-1-phenylethyl-bracket closed-3,3-diphenylpropylamine-hydrochloride |
CA1258454A (en) * | 1982-08-10 | 1989-08-15 | Leo Alig | Phenethanolamines |
US4728660A (en) * | 1984-06-11 | 1988-03-01 | University Of Miami | Method of treating diseases arising from platelet hyperactivation |
HU200591B (en) * | 1986-07-11 | 1990-07-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing new diphenyl propylamine derivatives and pharmaceutical compositions comprising such compounds |
US5386025A (en) * | 1990-02-20 | 1995-01-31 | The Salk Institute Biotechnology/Industrial Associates | Calcium channel compositions and methods |
EP0424397B1 (en) * | 1988-04-04 | 1996-06-19 | The Salk Institute Biotechnology Industrial Associates, Inc. | Calcium channel compositions and methods |
US4987084A (en) * | 1989-02-21 | 1991-01-22 | Dana Farber Cancer Institute | Method of testing the effect of a molecule on B lymphocyte function |
DD298412A5 (de) * | 1989-04-28 | 1992-02-20 | ������@���Kk�� | Verfahren zur herstellung von polypeptiden, die geeignet sind als antagonisten exzitatorischer aminosaeure-neurotransmitter und/oder blocker der calciumkanaele |
AU5957390A (en) * | 1989-07-03 | 1991-02-06 | New York University | Use of polyamines as ionic-channel regulating agents |
JP2728564B2 (ja) * | 1991-08-23 | 1998-03-18 | エヌピーエス・ファーマシウティカルズ・インコーポレイテッド | カルシウム受容体活性化分子 |
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1992
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- 1992-08-21 EP EP92919933A patent/EP0657029A4/en not_active Ceased
- 1992-08-21 CA CA2115828A patent/CA2115828C/en not_active Expired - Lifetime
- 1992-08-21 KR KR1019940700536A patent/KR100251995B1/ko active Protection Beyond IP Right Term
- 1992-08-21 DE DE69233572T patent/DE69233572T2/de not_active Expired - Lifetime
- 1992-08-21 RU RU94020394A patent/RU2147574C1/ru active Protection Beyond IP Right Term
- 1992-08-21 AT AT02027563T patent/ATE312347T1/de not_active IP Right Cessation
- 1992-08-21 ES ES02016612T patent/ES2256370T3/es not_active Expired - Lifetime
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- 1992-08-21 MX MX9204881A patent/MX9204881A/es unknown
- 1992-08-21 WO PCT/US1992/007175 patent/WO1993004373A1/en not_active Application Discontinuation
- 1992-08-22 CN CN92111580A patent/CN1067550C/zh not_active Expired - Lifetime
- 1992-08-23 IL IL12295892A patent/IL122958A/en not_active IP Right Cessation
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1994
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1996
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1998
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2000
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2003
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