EP1257473B1 - Dispositif de fermeture pour flacons de perfusion et de transfusion - Google Patents

Dispositif de fermeture pour flacons de perfusion et de transfusion Download PDF

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Publication number
EP1257473B1
EP1257473B1 EP01909622A EP01909622A EP1257473B1 EP 1257473 B1 EP1257473 B1 EP 1257473B1 EP 01909622 A EP01909622 A EP 01909622A EP 01909622 A EP01909622 A EP 01909622A EP 1257473 B1 EP1257473 B1 EP 1257473B1
Authority
EP
European Patent Office
Prior art keywords
plastic cover
closure cap
cap according
desired bending
bending line
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP01909622A
Other languages
German (de)
English (en)
Other versions
EP1257473A2 (fr
Inventor
Roland Amschlinger
Udo BÄCHLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Datwyler Pharma Packaging Belgium NV
Original Assignee
Helvoet Pharma NV
Helvoet Pharma Belgium NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helvoet Pharma NV, Helvoet Pharma Belgium NV filed Critical Helvoet Pharma NV
Publication of EP1257473A2 publication Critical patent/EP1257473A2/fr
Application granted granted Critical
Publication of EP1257473B1 publication Critical patent/EP1257473B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/03—Medical

Definitions

  • the invention relates to a closure cap for Infusion and transfusion bottles, with one Flaring neck around the bottle, a stopper in the bottle securing crimp cap, which has a central recess from the central area a plastic lid is closed such that an annular zone of the plastic cover the edge of the central recess engages, with at least one through Material thinning formed, radially running nominal crease line of the plastic cover is formed.
  • a cap of this kind is through the EP 0 291 658 A1 is known.
  • the radial there for example
  • the target bend line makes it easier to remove of the plastic cover, which is the most used as an overcap metal crimp cap protectively overlaid. About their then the exposed central recess becomes a puncture area of the sealing plug can be accessed through the spikes.
  • the radial nominal bending line implemented as a groove, sits down according to an embodiment of the above Precursor as a radial breakthrough in the wall of the cap-shaped plastic lid. The breakthrough opens on the front of the plastic lid edge.
  • the invention has Task, a generic cap from the point of view of a commissioning train advantageous.
  • the desired effect is further increased by that the radially running nominal crease line is on the outside edge in an axial weakening of the plastic cover continues, the target crease line extending into the axially shaped inner surface of the plastic cover is.
  • This axially oriented weakening occurs as an additional Crack on.
  • the shape of the weakening on the inner surface makes the appropriate means Securing the originality from the outside practically not recognizable.
  • the crack immediately opens. It brings further Invention in proposal that the material dilution in The range of the nominal buckling lines is stronger than in the Extensive weakening. That has advantages with regard to one easier opening of the bottle, i.e. Kinking the Plastic lid from the periphery.
  • the circumferential weakening one in cross section seen, is U-shaped groove. It creates one kind of trench. Its width can be chosen that the kink axis is accommodated as a tendon. in the With regard to crack formation, it proves to be advantageous that the radial nominal bending line as, in Seen cross section, V-recess is designed. The forms a notch valley that is easy to separate.
  • a further education results from the fact that the Bottom of the V-recess is lower than the sole the perimeter weakening. Leave fracture crack and white fracture reach each other so clearly and effectively. In detail the related training looks like that the wall thickness of the Plastic cover radially outside is larger than radial Inside.
  • the crimp cap supports the plastic cover is thereby ensured that the greater wall thickness penetrated by the nominal bending line the plastic cover from the outside radially, distributed over the circumference, continuing in ribs that height-compensating in the area of lower wall thickness raise and reach to the extent weakening.
  • the ribs in the bisector of the Target crease lines are continuously formed. The latter lie ideally spaced from six equally spaced Target crease lines, or the ones forming them V-recesses.
  • the illustrated closure cap 1 consists of a overlapping plastic cover 2 with underlying metallic crimp cap 3.
  • the crimp cap which holds the plastic cover 2 astride 3 is a collar 4 of the flared neck 5 of a bottle 6, for example an infusion bottle, crimped.
  • the beaded rim bears the reference number 7.
  • the overlying crimp edge is 3 ' designated.
  • the bottle 6 is made of glass, for example.
  • metal crimp cap 3 With regard to the metal crimp cap 3 is appropriate resort to plastically deformable aluminum.
  • a Sealing plug 8 It is a hollow plug. The sits sealingly in a mouth 9 of the flange neck 5 of the bottle 6.
  • the opening of a cavity 10 of the sealing plug 8 is facing the interior 11 of the bottle 6.
  • the cave 10 lies in the actual plug-forming section and closes recognizably with a horizontal End face 12 of the collar 4 of the flared neck 5.
  • the End face 12 is of one, the sealing plug 8 in the upper area, a peripherally molded ring flange 13 attacked, which by means of the associated crimp cap 3 firm and thus sealing against said end face 12 is pressed.
  • the sealing plug 8 is pierceable Closure body realized. It is made of elastomeric Material such as butyl rubber. The stinging is favored by the cave 10. This way given thin-walled zone of the sealing plug 8 declared as puncture area 14. As a piercing tool can be seen from Figure 9 cannula 15 of a syringe 16 can be viewed. On the other hand, the content extraction the liquid shown there in dashed lines 17 also done via the infusion set, this under more common hanging, neck down Arrangement of the infusion bottle or transfusion bottle. The related spike is not shown.
  • the ring zone 21 has one from the level of the ceiling 20 protruding stand height of approximately the thickness of the material the crimp cap 3.
  • the recess 23 is such that also the plastic cover 2 on the crimp cap 3 anchoring sub-tongues 24 are accommodated.
  • Said lower gripping tongues 24 go from a ring collar realized as a ring zone 21. You are in Demoulded state as essentially an imaginary Row of teeth taking cylindrical course realized (see Figures 1 and 2). Accordingly, originally axially oriented sub-tongues 24 are interrupted by gaps 25. It is a total six lower gripping tongues 24, each of the same width, and smaller gaps 25 than the circumferential length of the lower gripping tongues Is 24. The ratio of gaps to Tongue is between 1: 2 and 1: 5, preferably 1 : 3.
  • the lower gripping tongues 24 can be easily flared, so that a thermally / mechanically induced spreading for the underhand direction is well prepared.
  • Cap 1 and bottle 6 are rotationally symmetrical Structure.
  • the relevant longitudinal central axis bears the reference symbol x-x.
  • the plastic cover 2 has radially extending set buckling lines I on. They are on the inside the cover 20 of the plastic cover 2 and are center-oriented. Said set buckling lines I are due to material thinning generated, this when injection molding the Plastic cover 2.
  • Target buckling lines I at a clear radial distance y starting at a center z of the plastic cover 2, realized.
  • This distance y corresponds approximately to that half the radius of the flat pot-shaped plastic cover 2.
  • the material thinning ends in the center one concentric to the center z of the plastic cover 2 circumferential weakening S in which they flows openly.
  • the target bending lines I end peripherally close to the edge.
  • the radially oriented set buckling line I is as, im Cross-section seen, V-recess designed. It deals around notch valleys. These are peripheral in cross-section Connection to the equally profiled axial weakening S 'in the inner surface 26 of the cap wall 27. Im Seen in cross-section, the same V-recess lies before, so a notched valley. The latter is of such depth that only a rudimentary wall thickness - about a third - that remains with moderate forces can be opened by breaking crack. Just like with a fastened Plastic cover 2 the V-recess on the bottom the ceiling 20 is hidden from view, is also the V-recess, forming the weakening S ', practical from the outside not visible.
  • Circumferential weakening S is another cross section based, in the profile namely a U-shaped groove. their The depth is more than two thirds of the basic thickness Blanket 20.
  • the V-recesses of the nominal bending lines I are radial Penetrations one of the circumferential weakening S radially upstream stage 29. Accordingly, the material thinning stronger in the area of the nominal buckling lines I. than recognizable in the circumferential weakening S. namely the valley bottom 30 of the V-recess of the desired crease line I deeper than the bottom 31 of the circular circumferential weakening S. That means that above the bottom of the valley 30 a thinner residual wall remains on ceiling 20 than above the sole 31 of the ring trench. The latter is due to the small amount of material, even more stable, while the former zone tear down more easily leaves.
  • a corresponding height compensation In the area of level 29, however, at least partially, a corresponding height compensation. That embodies formed in that step-compensating ribs 32 are. The details in this regard are such that from the V-recess of the nominal bending line I penetrated greater wall thickness of the plastic cover 2 from the outside radially, distributed over the circumference, in the ribs 32 continues, which is smaller in the area Raise wall thickness to compensate for height and up to circular circumferential weakening S, the groove 28, pass.
  • Ribs 32 each lie in the bisector adjacent target bending lines I running. All in all are six nominal crease lines distributed at equal angles I trained.
  • the broken ceiling as shown in Figure 4, can also destroy an applied logo serve and so the reuse of the closure also exclude from this optical-visual side.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)

Claims (12)

  1. Capuchon de fermeture (1) pour des flacons de perfusion et de transfusion, avec un capuchon bordelé (3) entourant un col bordelé (5) du flacon (6), assurant un bouchon de fermeture (8) dans le flacon (6), capuchon bordelé comprenant un évidement central (18), fermé par la zone centrale (19) d'un couvercle en matière synthétique (2), de manière qu'une zone annulaire (21) du couvercle en matière synthétique (2) saisisse par le dessous le bord (22) de l'évidement central (18), dans lequel au moins une ligne destinée à l'inflexion (I) du couvercle en matière synthétique (2), s'étendant radialement, formée par un amincissement du matériau, est réalisée, caractérisé en ce que la ligne destinée à l'inflexion (I) débouche, dans un affaiblissement périphérique (S), s'étendant à distance radiale (y) par rapport au centre (z) du couvercle en matière synthétique (2).
  2. Capuchon de fermeture selon la revendication 1, caractérisé en ce que la ligne destinée à l'inflexion (I) s'étendant radialement se prolonge du côté du bord extérieur, en un affaiblissement axial (S') du couvercle en matière synthétique (2), dans lequel la ligne destinée à l'inflexion (I) est formée jusqu'à la face intérieure axiale (26) du couvercle en matière synthétique (2).
  3. Capuchon de fermeture selon l'une des revendications précédentes,
    caractérisé en ce que l'amincissement du matériau, dans la zone des lignes destinées à l'inflexion (I), est plus important à ce qu'il est dans la zone de l'affaiblissement périphérique (S).
  4. Capuchon de fermeture selon l'une des revendications précédentes,
    caractérisé en ce que l'affaiblissement périphérique (S) est une gorge (28) en forme de U, si on l'observe en vue en coupe.
  5. Capuchon de fermeture selon l'une des revendications précédentes,
    caractérisé en ce que la ligne destinée à l'inflexion (I) radiale est conformée en un évidement en V, si on l'observe en vue en coupe.
  6. Capuchon de fermeture selon la revendication 5, caractérisé en ce que la sole de vallée (30) de l'évidement en V est située plus bas que la sole (31) de l'affaiblissement périphérique (S).
  7. Capuchon de fermeture selon l'une des revendications précédentes,
    caractérisé en ce que l'épaisseur de paroi du couvercle en matière synthétique (2) traversée par la ligne destinée à l'inflexion (I) est plus forte, radialement extérieurement, que radialement intérieurement.
  8. Capuchon de fermeture selon la revendication 7, caractérisé en ce que la plus grande épaisseur de paroi du couvercle en matière synthétique (2), traversée par la ligne destinée à l'inflexion (I), se prolonge, depuis radialement extérieurement, en étant répartie sur la périphérie, en donnant des nervures (32) qui, dans la zone de la plus faible épaisseur de paroi, sont en relief en équilibrant la hauteur et arrivent jusqu'à l'affaiblissement périphérique (S).
  9. Capuchon de fermeture selon la revendication 8, caractérisé en ce que les nervures (32) s'étendent dans la direction angulairement bissectrice des lignes destinées à l'inflexion (I).
  10. Capuchon de fermeture selon l'une des revendications précédentes,
    caractérisé par des lignes destinées à l'inflexion (I), réparties suivant des angles égaux.
  11. Capuchon de fermeture selon l'une des revendications précédentes,
    dans lequel, dans une zone centrale du couvercle en matière synthétique (2), en face inférieure, est réalisée une collerette annulaire conformée en zone annulaire (21), pour saisir par le dessous le capuchon bordelé (3), depuis l'évidement central (18),
    caractérisé en ce que la collerette annulaire se prolonge en des languettes de saisie par le dessous (24), qui saisissent par le dessous le capuchon bordelé (3).
  12. Capuchon de fermeture selon la revendication 11, caractérisé en ce que les languettes de saisie par le dessous (24), lors du déchirement du couvercle en matière synthétique (2), se détachent du capuchon bordelé (3), sans entraíner celui-ci.
EP01909622A 2000-02-18 2001-01-13 Dispositif de fermeture pour flacons de perfusion et de transfusion Expired - Lifetime EP1257473B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10007367 2000-02-18
DE10007367A DE10007367A1 (de) 2000-02-18 2000-02-18 Verschlusskappe für Infusions- und Transfusionsflaschen
PCT/EP2001/000376 WO2001060699A2 (fr) 2000-02-18 2001-01-13 Dispositif de fermeture pour flacons de perfusion et de transfusion

Publications (2)

Publication Number Publication Date
EP1257473A2 EP1257473A2 (fr) 2002-11-20
EP1257473B1 true EP1257473B1 (fr) 2004-09-15

Family

ID=7631384

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01909622A Expired - Lifetime EP1257473B1 (fr) 2000-02-18 2001-01-13 Dispositif de fermeture pour flacons de perfusion et de transfusion

Country Status (7)

Country Link
US (1) US6868978B2 (fr)
EP (1) EP1257473B1 (fr)
JP (1) JP2003532591A (fr)
CN (1) CN1205092C (fr)
AU (1) AU2001237300A1 (fr)
DE (2) DE10007367A1 (fr)
WO (1) WO2001060699A2 (fr)

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Publication number Priority date Publication date Assignee Title
DE10127823C1 (de) * 2001-06-07 2002-08-22 West Pharm Serv Drug Res Ltd Verschluss für eine Medikamentenflasche sowie Verfahren zu dessen Herstellung
US7611026B1 (en) 2002-08-12 2009-11-03 Rexam Closure Systems Inc. Tamper-evident closure having a sealing disk and package for high-temperature applications
US6874647B2 (en) * 2002-08-12 2005-04-05 Owens-Illinois Closure Inc. Plastic closure, closure and container package, and method of manufacture
TWI303565B (en) * 2002-08-16 2008-12-01 Glaxosmithkline Biolog Sa Closure system,vial having the closure system,method of closing a vial,method of filling a pharmaceutical vial, and vial closure
US20040118802A1 (en) * 2002-12-19 2004-06-24 Lysfjord John Peter Safety seal for potent product
WO2005011495A1 (fr) * 2003-07-18 2005-02-10 Sekisui Chemical Co., Ltd. Recipient ferme hermetiquement et recipient collecteur de substance d'essai sous vide
DE102004035162A1 (de) * 2004-07-20 2006-02-16 Helvoet Pharma Belgium N.V. Pharmazieprodukt-Behältnis
DE102004051300C5 (de) 2004-10-20 2013-01-24 Fresenius Kabi Deutschland Gmbh Verschlusskappe für mit medizinischen Flüssigkeiten befüllte Behältnisse
US20060090671A1 (en) * 2004-10-29 2006-05-04 Len Ekkert Tamper-evident lid for container
EP1888424A4 (fr) * 2005-01-25 2016-09-21 Medical Instill Tech Inc Fermeture de recipient avec une partie sus-jacente pouvant etre penetree par une aiguille et thermiquement rescellable et une partie sous-jacente compatible avec un produit liquide gras et procede correspondant
US20090084804A1 (en) * 2007-10-01 2009-04-02 Hospira, Inc. Snap-over port cap
US8091727B2 (en) * 2007-11-08 2012-01-10 Hospira, Inc. Snap-over clamshell protective port cap
US20090166311A1 (en) * 2007-12-27 2009-07-02 Helvoet Pharma Belgium N.V. Pharmaceutical closure with a laser-applied marking
US8210377B2 (en) * 2008-03-20 2012-07-03 Crown Packaging Technology, Inc. Closure edge protection via polymer coated metal
FR2950035B1 (fr) 2009-09-15 2011-09-02 Raymond A & Cie Coiffe de verrouillage pour recipient a col
FR2950865B1 (fr) 2009-10-01 2011-10-28 Raymond A & Cie Coiffe de verrouillage pour recipient a col avec une capsule a pattes de fixation
DE102011002189A1 (de) * 2011-04-20 2012-10-25 Helvoet Pharma Belgium N.V. Verschlusskappe
ES2678545T3 (es) * 2011-09-29 2018-08-13 Ge Healthcare As Envase
JP6310855B2 (ja) 2011-12-15 2018-04-11 ジーイー・ヘルスケア・アクスイェ・セルスカプ パッケージ
FR2986782B1 (fr) * 2012-02-13 2014-03-07 Raymond A & Cie Dispositif de verrouillage de bouchon sur recipient a collerette, recipient a collerette obture par bouchon pourvu d'un tel dispositif de verrouillage
EP2842884A1 (fr) * 2013-08-27 2015-03-04 F. Hoffmann-La Roche AG Fermeture de récipient
CN106963641B (zh) * 2016-01-14 2024-03-01 雷诺丽特恒迅包装科技（北京）有限公司 一种组合盖和具有该组合盖的输液容器
US11161633B2 (en) * 2017-12-22 2021-11-02 West Pharmaceutical Services, Inc. Packaging system for aseptic filling of small volume vials
FR3098504B1 (fr) * 2019-07-09 2021-06-04 A Raymond Et Cie coiffe de verrouillage pour récipient à col

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JPS5859749U (ja) * 1981-10-16 1983-04-22 オリンパス光学工業株式会社 容器用キヤツプ
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DE3715175C1 (de) * 1987-05-07 1988-11-24 Pohl Metall Kunststoff Verschlusskappe fuer Infusions- und Transfusionsflaschen
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DE4204427C1 (en) * 1992-02-14 1993-07-08 Matthias Faensen Gmbh & Co. Kg, 5190 Stolberg, De Bottle closure with bottle neck closed by elastomer sealing element - involves holder cap with through hole in its face wall and tear-off element on upper side of face wall
DE4238983C1 (fr) * 1992-11-19 1993-09-23 Pohl Gmbh & Co Kg, 7500 Karlsruhe, De
DE4415679A1 (de) * 1994-05-04 1995-12-21 Hoechst Ag Verschluß mit Originalitätskappe für Injektions- und Infusionsflaschen
DE4446182A1 (de) * 1994-12-23 1996-06-27 Hali Handels Und Lizenzverwert Verschluß an Flaschen für Injektionsflüssigkeiten oder dergleichen
JP3817704B2 (ja) * 1995-08-08 2006-09-06 エーザイ株式会社 薬用瓶の蓋

Also Published As

Publication number Publication date
AU2001237300A1 (en) 2001-08-27
US6868978B2 (en) 2005-03-22
DE50103622D1 (de) 2004-10-21
CN1205092C (zh) 2005-06-08
EP1257473A2 (fr) 2002-11-20
JP2003532591A (ja) 2003-11-05
US20030029828A1 (en) 2003-02-13
CN1431967A (zh) 2003-07-23
WO2001060699A2 (fr) 2001-08-23
WO2001060699A3 (fr) 2002-04-25
DE10007367A1 (de) 2001-08-23

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