EP1140969A4 - Fragmente des wachstumsfaktors für bindegewebe und verfahren und anwendungen davon - Google Patents

Fragmente des wachstumsfaktors für bindegewebe und verfahren und anwendungen davon

Info

Publication number
EP1140969A4
EP1140969A4 EP99965256A EP99965256A EP1140969A4 EP 1140969 A4 EP1140969 A4 EP 1140969A4 EP 99965256 A EP99965256 A EP 99965256A EP 99965256 A EP99965256 A EP 99965256A EP 1140969 A4 EP1140969 A4 EP 1140969A4
Authority
EP
European Patent Office
Prior art keywords
methods
ctgf
growth factor
connective tissue
tissue growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP99965256A
Other languages
English (en)
French (fr)
Other versions
EP1140969B1 (de
EP1140969A1 (de
Inventor
Gary R Grotendorst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Miami
Original Assignee
University of Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Miami filed Critical University of Miami
Publication of EP1140969A1 publication Critical patent/EP1140969A1/de
Publication of EP1140969A4 publication Critical patent/EP1140969A4/de
Application granted granted Critical
Publication of EP1140969B1 publication Critical patent/EP1140969B1/de
Priority to CY20071101018T priority Critical patent/CY1108860T1/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
EP99965256A 1998-12-14 1999-12-14 Fragmente des wachstumsfaktors für bindegewebe (ctgf) und verfahren und anwendungen davon Expired - Lifetime EP1140969B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CY20071101018T CY1108860T1 (el) 1998-12-14 2007-07-31 Θραυσματα αυξητικου παραγοντα συνδετικου ιστου και μεθοδοι και χρησεις τους

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11224098P 1998-12-14 1998-12-14
US11224198P 1998-12-14 1998-12-14
US112241P 1998-12-14
US112240P 1998-12-14
PCT/US1999/029652 WO2000035936A1 (en) 1998-12-14 1999-12-14 Connective tissue growth factor fragments and methods and uses thereof

Publications (3)

Publication Number Publication Date
EP1140969A1 EP1140969A1 (de) 2001-10-10
EP1140969A4 true EP1140969A4 (de) 2003-07-23
EP1140969B1 EP1140969B1 (de) 2007-06-13

Family

ID=26809725

Family Applications (2)

Application Number Title Priority Date Filing Date
EP99965256A Expired - Lifetime EP1140969B1 (de) 1998-12-14 1999-12-14 Fragmente des wachstumsfaktors für bindegewebe (ctgf) und verfahren und anwendungen davon
EP99966224A Expired - Lifetime EP1140964B1 (de) 1998-12-14 1999-12-14 Fragment des "connective tissue growth factor" (ctgf)

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP99966224A Expired - Lifetime EP1140964B1 (de) 1998-12-14 1999-12-14 Fragment des "connective tissue growth factor" (ctgf)

Country Status (16)

Country Link
US (3) US6492129B1 (de)
EP (2) EP1140969B1 (de)
JP (2) JP4634614B2 (de)
KR (2) KR100664625B1 (de)
CN (3) CN1660911A (de)
AT (2) ATE391724T1 (de)
AU (3) AU773278B2 (de)
CA (2) CA2354456A1 (de)
CY (1) CY1108860T1 (de)
DE (2) DE69936315T2 (de)
DK (1) DK1140969T3 (de)
ES (2) ES2304811T3 (de)
HK (2) HK1041268B (de)
MX (1) MXPA01005949A (de)
PT (1) PT1140969E (de)
WO (2) WO2000035936A1 (de)

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US7026299B2 (en) 1994-07-12 2006-04-11 Human Genome Sciences, Inc. Connective tissue growth factor-2
NZ271488A (en) 1994-07-12 1998-01-26 Human Genome Sciences Inc Connective tissue growth factor-2 (ctgf-2)
WO2000035936A1 (en) * 1998-12-14 2000-06-22 University Of Miami Connective tissue growth factor fragments and methods and uses thereof
US7115390B1 (en) * 1998-12-14 2006-10-03 Fibrogen, Inc. Connective tissue growth factor fragments and methods and uses thereof
AU2001276868A1 (en) * 2000-07-11 2002-01-21 Human Genome Sciences, Inc. Connective tissue growth factor-2
US20030113816A1 (en) * 2001-09-18 2003-06-19 Weitz Stephen L. Methods of assaying connective tissue growth factor
WO2003035083A1 (de) * 2001-10-26 2003-05-01 Ribopharma Ag Medikament zur behandlung einer fibrotischen erkrankung durch rna interferenz
US6965025B2 (en) 2001-12-10 2005-11-15 Isis Pharmaceuticals, Inc. Antisense modulation of connective tissue growth factor expression
EP1463531B1 (de) * 2001-12-11 2011-09-28 Fibrogen, Inc. Verfahren zur hemmung okularer vorgänge
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US7405274B2 (en) 2003-06-04 2008-07-29 Fibrogen, Inc. Connective tissue growth factor antibodies
US20050153395A1 (en) * 2003-09-29 2005-07-14 Children's Hospital Inc. Unique integrin binding site in connective tissue growth factor (CTGF)
EP1687410A4 (de) 2003-10-07 2008-04-09 Isis Pharmaceuticals Inc Für das nieren-targeting optimierte antisense-oligonukleotide
US20050191653A1 (en) 2003-11-03 2005-09-01 Freier Susan M. Modulation of SGLT2 expression
GB0326778D0 (en) * 2003-11-18 2003-12-24 Imp College Innovations Ltd Biological materials and uses thereof
DK1715890T3 (da) 2004-02-11 2008-11-17 Fibrogen Inc CTGF som mål for mikroalbuminuriterapi hos patienter med diabetisk nefropati
ZA200607588B (en) * 2004-02-11 2008-05-28 Fibrogen Inc CTGF as target for the therapy of diabetic nephropathy
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US8252762B2 (en) 2008-08-25 2012-08-28 Excaliard Pharmaceuticals, Inc. Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
WO2010027830A2 (en) * 2008-08-25 2010-03-11 Excaliard Pharmaceuticals, Inc. Methods for modulation of connective tissue growth factor expression by administering antisense oligonucleotides through a delivery system so as to reduce scarring from wound healing and threat fibrotic diseases
US8946172B2 (en) 2008-08-25 2015-02-03 Excaliard Pharmaceuticals, Inc. Method for reducing scarring during wound healing using antisense compounds directed to CTGF
EP3336188B1 (de) 2008-09-22 2020-05-06 Phio Pharmaceuticals Corp. Selbstfreisetzende rnai-verbindungen von reduzierter grösse
CN102666587A (zh) 2009-07-02 2012-09-12 菲布罗根有限公司 用于治疗肌营养不良的方法
WO2011056234A1 (en) 2009-11-06 2011-05-12 Fibrogen, Inc. Treatment for radiation-induced disorders
CN106074591B (zh) 2010-03-24 2020-01-14 菲奥医药公司 眼部症候中的rna干扰
IL265674B2 (en) 2010-03-24 2024-05-01 Phio Pharm Corp Rana disorder in cutaneous and fibrotic symptoms
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KR101249041B1 (ko) 2010-04-28 2013-03-29 포항공과대학교 산학협력단 결합조직 성장인자를 이용한 약학적 조성물
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JP6177692B2 (ja) * 2011-02-02 2017-08-09 エクスカリアード・ファーマシューティカルズ，インク 結合組織増殖因子（ｃｔｇｆ）をターゲティングするアンチセンス化合物を用いた、ケロイドまたは肥厚性瘢痕の治療法
KR20140107507A (ko) 2011-12-22 2014-09-04 아스텔라스세이야쿠 가부시키가이샤 신규 항 인간 ctgf 항체
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CN111424035A (zh) * 2020-04-13 2020-07-17 西南大学 基于家蚕丝腺表达具有生物学活性的人结缔组织生长因子的方法及其产品和应用

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US5780263A (en) * 1995-06-05 1998-07-14 Human Genome Sciences, Inc. Human CCN-like growth factor

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Title
DATABASE EMBL [online] EBI; 14 July 1998 (1998-07-14), HASTINGS & ADAMS: "Human CCN-like growth factor", XP002238117, Database accession no. AAC91583 *
DATABASE EMBL [online] EBI; 31 May 1997 (1997-05-31), GROTENDORST GR: "Connective tissue growth factor composition", XP002238116, Database accession no. AAW12694 *
FRAZIER KEN ET AL: "Stimulation of fibroblast cell growth, matrix production and granulation tissue formation by connective tissue growth factor.", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 107, no. 3, 1996, pages 404 - 411, XP009009184, ISSN: 0022-202X *
SHIMO TSUYOSHI ET AL: "Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells.", JOURNAL OF BIOCHEMISTRY (TOKYO), vol. 124, no. 1, July 1998 (1998-07-01), pages 130 - 140, XP009009314, ISSN: 0021-924X *
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DE69936315T2 (de) 2008-02-14
JP2002532082A (ja) 2002-10-02
CN1170849C (zh) 2004-10-13
EP1140964B1 (de) 2008-04-09
AU2004205171A1 (en) 2004-09-16
US7718177B2 (en) 2010-05-18
JP4634614B2 (ja) 2011-02-16
ATE391724T1 (de) 2008-04-15
WO2000035936A1 (en) 2000-06-22
CY1108860T1 (el) 2014-07-02
KR100664626B1 (ko) 2007-01-04
US6492129B1 (en) 2002-12-10
DE69936315D1 (de) 2007-07-26
KR20010101207A (ko) 2001-11-14
KR100664625B1 (ko) 2007-01-04
CN1187370C (zh) 2005-02-02
JP4722290B2 (ja) 2011-07-13
CN1334819A (zh) 2002-02-06
CN1660911A (zh) 2005-08-31
HK1041005A1 (en) 2002-06-28
EP1140964A4 (de) 2003-06-18
AU3121100A (en) 2000-07-03
AU773278B2 (en) 2004-05-20
AU2004205171B2 (en) 2007-08-09
WO2000035939A3 (en) 2000-10-12
EP1140969B1 (de) 2007-06-13
KR20010101194A (ko) 2001-11-14
DE69938507D1 (en) 2008-05-21
CA2354456A1 (en) 2000-06-22
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EP1140964A2 (de) 2001-10-10
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CA2354422A1 (en) 2000-06-22
EP1140969A1 (de) 2001-10-10
CN1334820A (zh) 2002-02-06
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