DE69534847D1 - Knochen-vorläufer-zellen: zusammensetzungen und methoden - Google Patents

Knochen-vorläufer-zellen: zusammensetzungen und methoden

Info

Publication number
DE69534847D1
DE69534847D1 DE69534847T DE69534847T DE69534847D1 DE 69534847 D1 DE69534847 D1 DE 69534847D1 DE 69534847 T DE69534847 T DE 69534847T DE 69534847 T DE69534847 T DE 69534847T DE 69534847 D1 DE69534847 D1 DE 69534847D1
Authority
DE
Germany
Prior art keywords
methods
bone
precursor cells
compositions
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69534847T
Other languages
English (en)
Other versions
DE69534847T2 (de
Inventor
Michael W Long
Kenneth G Mann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan filed Critical University of Michigan
Application granted granted Critical
Publication of DE69534847D1 publication Critical patent/DE69534847D1/de
Publication of DE69534847T2 publication Critical patent/DE69534847T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69534847T 1994-08-12 1995-08-11 Knochen-vorläufer-zellen: zusammensetzungen und methoden Expired - Fee Related DE69534847T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/289,794 US5972703A (en) 1994-08-12 1994-08-12 Bone precursor cells: compositions and methods
PCT/US1995/010293 WO1996005290A1 (en) 1994-08-12 1995-08-11 Bone precursor cells: compositions and methods
US289794 1999-04-09

Publications (2)

Publication Number Publication Date
DE69534847D1 true DE69534847D1 (de) 2006-05-04
DE69534847T2 DE69534847T2 (de) 2006-11-16

Family

ID=23113132

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69534847T Expired - Fee Related DE69534847T2 (de) 1994-08-12 1995-08-11 Knochen-vorläufer-zellen: zusammensetzungen und methoden

Country Status (7)

Country Link
US (3) US5972703A (de)
EP (1) EP0804551B1 (de)
AT (1) ATE319812T1 (de)
AU (1) AU712247B2 (de)
CA (1) CA2200197A1 (de)
DE (1) DE69534847T2 (de)
WO (1) WO1996005290A1 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719058A (en) * 1995-04-10 1998-02-17 Merck & Co., Inc. Method for producing a highly enriched population of osteoclast cells
WO1997026326A1 (en) * 1996-01-16 1997-07-24 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and non-hematopoietic tissues and their use
CA2198978A1 (en) * 1996-03-01 1997-09-01 Clemens Antoni Van Blitterswijk Method for the in vitro production of bone
US20040224300A1 (en) * 1997-01-24 2004-11-11 Shuji Terashima Method for separating nucleated cells
ES2178102T3 (es) 1997-07-16 2002-12-16 Isotis Nv Dispositivo para la generacion de tejido oseo, que comprende un termoplastico de copoliester biodegradable y celulas cultivadas.
WO1999024557A1 (en) * 1997-11-10 1999-05-20 The Regents Of The University Of Michigan Human bone accessory cells
US6391297B1 (en) 1997-12-02 2002-05-21 Artecel Sciences, Inc. Differentiation of adipose stromal cells into osteoblasts and uses thereof
US6326507B1 (en) * 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
IT1302534B1 (it) 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
ATE283349T1 (de) * 1999-10-06 2004-12-15 Tigenix Nv Isolierung von vorläuferzellen und deren verwendung zum wiederaufbau von bindegewebe
DE19956503A1 (de) * 1999-11-24 2001-06-21 Universitaetsklinikum Freiburg Spritzbares Knochenersatzmaterial
DK1234031T3 (en) 1999-11-30 2017-07-03 Mayo Foundation B7-H1, AN UNKNOWN IMMUNE REGULATORY MOLECULE
WO2001048148A1 (en) * 1999-12-28 2001-07-05 The Regents Of The University Of Michigan Process for ex vivo formation of mammalian bone and uses thereof
US6811776B2 (en) 2000-12-27 2004-11-02 The Regents Of The University Of Michigan Process for ex vivo formation of mammalian bone and uses thereof
US20090233270A9 (en) * 2000-08-02 2009-09-17 St Croix Brad Secreted and cytoplasmic tumor endothelial markers
US20030228687A1 (en) * 2000-08-07 2003-12-11 The Regents Of The University Of Michigan Human bone accessory cells
US7435755B2 (en) * 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
US20030008328A1 (en) * 2001-07-03 2003-01-09 Wironen John F. Quantitative in vitro bone induction assay
GB2392674B (en) * 2001-07-06 2005-08-10 Geron Corp Mesenchymal cells and osteoblasts from human embryonic stem cell
US20070141036A1 (en) * 2002-01-09 2007-06-21 Alberto Gorrochategui Barrueta Composition and procedure for tissue creation, regeneration and repair by a cell-bearing biological implant enriched with platelet concentrate and supplements
AU2002226426A1 (en) * 2002-01-09 2003-07-24 Alberto Gorrochategui Barrueta Composition and method of creating, regenerating and repairing tissues using a cell-carrying biological implant which is enriched with a platelet concentrate and supplements
US7176237B2 (en) * 2002-01-15 2007-02-13 The Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US7744597B2 (en) * 2002-06-26 2010-06-29 Lifenet Health Device and process for producing fiber products and fiber products produced thereby
US7498040B2 (en) 2005-10-12 2009-03-03 Lifenet Health Compositions for repair of defects in osseous tissues, and methods of making the same
US20040193274A1 (en) * 2003-03-28 2004-09-30 Trieu Hai H. Materials and methods for augmenting and/or repairing intervertebral discs
US7494811B2 (en) 2003-05-01 2009-02-24 Lifenet Health In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby
EP1713513B1 (de) 2004-01-16 2014-06-04 Carnegie Mellon University Zell-markierung für kernspin-techniken
CN101080486B (zh) 2004-04-23 2012-05-16 佰欧益股份有限公司 多谱系祖细胞
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
MX2007004176A (es) 2004-10-06 2007-06-15 Mayo Foundation B7-h1 y metodos de diagnosis, prognosis, y tratamiento de cancer.
KR100702250B1 (ko) * 2005-06-13 2007-04-03 세원셀론텍(주) 피브린 혼합형 골절 유합용 반고형성 뼈세포 조성물 및이의 제조방법
WO2007038471A2 (en) * 2005-09-27 2007-04-05 Regenetech, Inc. Rotatable time varying electromagnetic force bioreactor and method of using the same
WO2007082144A2 (en) * 2006-01-05 2007-07-19 Mayo Foundation For Medical Education And Research B7-h1 and survivin in cancer
WO2007082154A2 (en) * 2006-01-05 2007-07-19 Mayo Foundation For Medical Education And Research B7-h1 and b7-h4 in cancer
ATE531792T1 (de) * 2006-03-30 2011-11-15 Mark Clarke Dreidimensionale mineralisierte knochenkonstrukte
US20070258886A1 (en) * 2006-04-14 2007-11-08 Celsense Inc. Methods for assessing cell labeling
CA2649333C (en) * 2006-04-14 2016-10-04 Carnegie Mellon University Cellular labeling and quantification for nuclear magnetic resonance techniques
WO2007119240A2 (en) * 2006-04-17 2007-10-25 Hepacore Ltd. Methods for bone regeneration using endothelial progenitor cell preparations
US7727763B2 (en) * 2006-04-17 2010-06-01 Bioe, Llc Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
WO2007124361A2 (en) * 2006-04-20 2007-11-01 Mayo Foundation For Medical Education And Research Soluble b7-h1
US8299046B2 (en) * 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
WO2008064133A1 (en) * 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
EP2170975B1 (de) * 2007-07-10 2018-05-02 Carnegie Mellon University Zusammensetzungen und verfahren zur herstellung von zellmarkern für kernresonanztechniken
WO2009015343A2 (en) * 2007-07-25 2009-01-29 Bioe, Inc. Differentiation of multi-lineage progenitor cells to chondrocytes
US20090048205A1 (en) * 2007-08-15 2009-02-19 Colin Meyer Combination therapy with synthetic triterpenoids and gemcitabine
US20110086080A1 (en) * 2007-11-14 2011-04-14 Osteosphere, Llc Ex-vivo production of human demineralized bone matrix
WO2009064917A2 (en) * 2007-11-14 2009-05-22 Osteosphere, Llc Generation of an hla-negative osteogenic precursor cell line
WO2009064956A1 (en) * 2007-11-14 2009-05-22 Osteosphere, Llc A novel tissue culture platform for screening of potential bone remodeling agents
US8506982B2 (en) * 2007-11-14 2013-08-13 Osteosphere, Llc Development of a human colloidal bone graft material
CN101903031A (zh) * 2007-12-21 2010-12-01 骨治疗公司 人骨形成细胞治疗炎性风湿性疾病
JP4923146B2 (ja) * 2008-01-11 2012-04-25 リアタ ファーマシューティカルズ インコーポレイテッド 合成トリテルペノイドおよび疾患の治療における使用方法
US20100278788A1 (en) * 2008-01-11 2010-11-04 Bone Therapeutics, S.A. Osteogenic Differentiation Of Bone Marrow Stem Cells And Mesenchymal Stem Cells Using A Combination Of Growth Factors
US20110020325A1 (en) * 2008-02-29 2011-01-27 Kwon Eugene D Methods for reducing granulomatous inflammation
CN102164941B (zh) 2008-04-18 2015-05-27 里亚塔医药公司 抗氧化剂炎症调节剂:具有饱和c环的齐墩果酸衍生物
EP2271658B1 (de) 2008-04-18 2016-11-09 Reata Pharmaceuticals, Inc. Antioxidationsmittel als entzündungsmodulierende substanzen: c-17-homologierte oleanolsäurederivate
WO2009146216A2 (en) 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
ES2703274T3 (es) 2008-04-18 2019-03-07 Reata Pharmaceuticals Inc Moduladores de la inflamación antioxidantes: derivados del ácido oleanólico con modificaciones amino y otras en C-17
JP5564490B2 (ja) * 2008-04-18 2014-07-30 リアタ ファーマシューティカルズ インコーポレイテッド 抗炎症性ファルマコアを含む化合物および使用法
CA2723171C (en) * 2008-05-02 2018-03-27 Celsense, Inc. Emulsion compositions and methods for nuclear magnetic resonance and other imaging
DK2297304T3 (da) * 2008-05-07 2017-11-06 Bone Therapeutics Sa Humane knogledannende celler til behandling af tilstande og knoglesygdomme forbundet med immunodefekt eller immunsuppression
KR20110013450A (ko) 2008-05-07 2011-02-09 본 테라퓨틱스 소시에테아노님 간엽 줄기 세포 및 골-형성 세포
EP2297305A4 (de) * 2008-05-15 2013-03-13 Univ Miami Isolierung von stammzellenvorläufern und expansion unter nichtanhaftungsbedingungen
EP2294187A2 (de) * 2008-05-21 2011-03-16 BioE LLC Differenzierung von mehrlinien-vorläuferzellen zu pankreaszellen
US8314137B2 (en) 2008-07-22 2012-11-20 Trustess Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
US20110142810A1 (en) * 2008-08-19 2011-06-16 Osaka University Cell preparation for bone tissue regeneration
AU2009333489A1 (en) * 2008-12-30 2010-07-08 Centocor Ortho Biotech Inc. Serum markers predicting clinical response to anti-TNF antibodies in patients with ankylosing spondylitis
ES2702049T3 (es) 2009-04-24 2019-02-27 Univ Vanderbilt Inducción anti-TGF-beta de crecimiento óseo
EP2625263B1 (de) 2010-10-08 2020-03-11 Terumo BCT, Inc. Konfigurierbare verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem
BE1020528A3 (fr) 2011-10-11 2013-12-03 Bone Therapeutics Sa Utilisations du facteur de croissance et differenciation 8 (gdf 8).
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
NO2900247T3 (de) 2012-09-26 2018-06-16
KR102193283B1 (ko) 2013-02-22 2020-12-23 라이프넷 헬스 조직 및 세포 물질을 저장하기 위한 패키징 어셈블리
US9302005B2 (en) 2013-03-14 2016-04-05 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
EP3052131B1 (de) 2013-10-01 2018-12-05 Mayo Foundation for Medical Education and Research Verfahren zur krebsbehandlung bei patienten mit erhöhtem bim-spiegel
US10172911B2 (en) 2013-10-01 2019-01-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of modulating erythropoiesis with arginine vasopressin receptor 1B molecules
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
JP2015097506A (ja) * 2013-11-19 2015-05-28 国立大学法人大阪大学 細胞表面マーカーをフローサイトメトリーで分析可能な骨芽細胞又は骨芽細胞に分化し得る細胞を得る方法
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
WO2015179654A1 (en) 2014-05-22 2015-11-26 Mayo Foundation For Medical Education And Research Distinguishing antagonistic and agonistic anti b7-h1 antibodies
EP3171896A4 (de) 2014-07-23 2018-03-21 Mayo Foundation for Medical Education and Research Abzielung auf dna-pkcs und b7-h1 zur behandlung von krebs
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
CN107250795B (zh) * 2015-02-20 2021-07-30 艾德克斯实验室公司 带有对背景信号的补偿的均相免疫测定
CN107592789A (zh) 2015-04-23 2018-01-16 骨治疗公司 治疗性细胞的体外保存
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017075045A2 (en) 2015-10-30 2017-05-04 Mayo Foundation For Medical Education And Research Antibodies to b7-h1
US11406721B2 (en) 2016-02-22 2022-08-09 The Regents Of The University Of California Compositions and methods for imaging cell populations
EP3464565A4 (de) 2016-05-25 2020-01-01 Terumo BCT, Inc. Zellexpansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
CN117247899A (zh) 2017-03-31 2023-12-19 泰尔茂比司特公司 细胞扩增
BR112020007775A2 (pt) 2017-10-20 2020-10-20 Bone Therapeutics Sa métodos para obter células derivadas de células-tronco mesenquimais (msc) a partir de msc, método para obter células derivadas de msc com propriedades de transplante aprimoradas a partir de msc, populações de células derivadas de msc e composição farmacêutica
WO2019099615A1 (en) 2017-11-17 2019-05-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of copeptin to modulate the immune response and hematopoiesis, and stimulate bone growth
MX2021003383A (es) 2018-09-25 2021-10-26 Bone Therapeutics Sa Metodos para diferenciar celulas troncales mesenquimales.
KR20220008289A (ko) 2019-05-13 2022-01-20 본 테라퓨틱스 소시에테아노님 히알루론산 및 혈장 단백질을 포함하는 개선된 동결건조 제형 및 이의 용도

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56145222A (en) * 1980-04-28 1981-11-11 Toshiyuki Hamaoka Improved antibody and its preparation
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4714680B1 (en) * 1984-02-06 1995-06-27 Univ Johns Hopkins Human stem cells
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US4904259A (en) * 1988-04-29 1990-02-27 Samuel Itay Compositions and methods for repair of cartilage and bone
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5622853A (en) * 1990-05-01 1997-04-22 Becton Dickinson And Company T lymphocyte precursor
US5541072A (en) * 1994-04-18 1996-07-30 Immunivest Corporation Method for magnetic separation featuring magnetic particles in a multi-phase system
US5197985A (en) * 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
EP0592521B1 (de) * 1991-06-18 2003-05-02 Arnold I. Caplan Menschliche mesenchym-stammzellen aus dem mark und monoklonale antikörper spezifisch gegen diese zellen
US5286642A (en) * 1992-06-24 1994-02-15 The Procter & Gamble Company Rat osteosarcoma cell line OSR5TR2
EP0672064A1 (de) * 1992-11-03 1995-09-20 Creative Biomolecules, Inc. Op 3 - induzierte morphogenese

Also Published As

Publication number Publication date
ATE319812T1 (de) 2006-03-15
DE69534847T2 (de) 2006-11-16
WO1996005290A1 (en) 1996-02-22
US20040214241A1 (en) 2004-10-28
US7498170B2 (en) 2009-03-03
US6740493B1 (en) 2004-05-25
US5972703A (en) 1999-10-26
EP0804551A1 (de) 1997-11-05
AU712247B2 (en) 1999-11-04
AU3244295A (en) 1996-03-07
CA2200197A1 (en) 1996-02-22
EP0804551B1 (de) 2006-03-08

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