EP1135655B1 - Procede et dispositif pour conduire de l'air dans un espace de travail - Google Patents

Procede et dispositif pour conduire de l'air dans un espace de travail Download PDF

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Publication number
EP1135655B1
EP1135655B1 EP00975809A EP00975809A EP1135655B1 EP 1135655 B1 EP1135655 B1 EP 1135655B1 EP 00975809 A EP00975809 A EP 00975809A EP 00975809 A EP00975809 A EP 00975809A EP 1135655 B1 EP1135655 B1 EP 1135655B1
Authority
EP
European Patent Office
Prior art keywords
air
treatment space
lock
area
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP00975809A
Other languages
German (de)
English (en)
Other versions
EP1135655A1 (fr
Inventor
Berthold Duethorn
Thomas Hertfelder
Eberhard Jost
Lothar Gail
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robert Bosch GmbH
Original Assignee
Robert Bosch GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert Bosch GmbH filed Critical Robert Bosch GmbH
Publication of EP1135655A1 publication Critical patent/EP1135655A1/fr
Application granted granted Critical
Publication of EP1135655B1 publication Critical patent/EP1135655B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F3/00—Air-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatment; Apparatus specially designed for such systems
    • F24F3/12—Air-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatment; Apparatus specially designed for such systems characterised by the treatment of the air otherwise than by heating and cooling
    • F24F3/16—Air-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatment; Apparatus specially designed for such systems characterised by the treatment of the air otherwise than by heating and cooling by purification, e.g. by filtering; by sterilisation; by ozonisation
    • F24F3/167—Clean rooms, i.e. enclosed spaces in which a uniform flow of filtered air is distributed

Definitions

  • the invention relates to a method and a device for air guidance in a processing room.
  • a method and apparatus for filling Pharmaceuticals or similar products in Packaging container within a housing of a Packaging machine affected.
  • Such known Devices are often in so-called isolator technology constructed, i.e., that the filling and closing of the Packaging container under clean room conditions, so that neither the previously sterilized packaging container still the contents are contaminated by external influences can.
  • These are in particular the bottling and Closing region of the device surrounded by a housing, its interior air either through a Pure air filter is circulated or it is by a Clean air filter supplied from the outside constantly cleaned air (EP 0 604 925 B1).
  • Intervention possibilities by means of gloves EP 0 604 925 B1
  • free intervention possibilities without Gloves In the latter intervention possibilities There is always the risk of contamination, be it from Contamination of the production area from the outside or from Contaminations of the outer area from the production area out.
  • the object of the invention is therefore to provide a method and a Device for air guidance in a processing space such form that contaminants of both the Processing room or the production room and the Outside, from which manipulations in the Production room to be made, excluded or at least reduced to a certain, tolerable level are.
  • This task is done with a procedure and a Device having the features of the independent claims solved.
  • the inventive method and the Device according to the invention are characterized in that at the moment, especially by a gap between the production room and the outside interventions into the production room, from the production room in Direction of the outside air flowing and vice versa a space is sucked and thus not in the can reach each other area.
  • the device 10 for filling especially dry Pharmaceuticals or similar products in Packaging containers such as vials 1 and Closing the same has a housing 11.
  • the housing 11 encloses a production room 12, where not illustrated, because not essential to the invention Treatment facilities, in particular bottling and Closing devices are arranged.
  • the vials 1 be by means of a conveyor along a Transport path 13 passed through the production room 12, wherein the housing 11 is an entrance lock 15 and a Outlet lock 16 has.
  • the entrance lock 15 and the outlet lock 16 each form one Lock area 17, 18 off, the first openings 19 of Exterior 20 of the device 10 in the lock area 17, 18, and second openings 21 from the lock area 17, 18th in the production area 12 have.
  • the size of the openings 19, 21 is preferably adapted to the size of the vials 1 or changeable, so that the size of the openings 19, 21st as small as possible, to avoid excessive air exchange between to avoid the individual areas.
  • the housing 11 To make manual intervention in the production room 12 can, is on one side of the housing 11 a Accessibility in the form of a double-pane door 22 educated.
  • the door 22 faces the production room 12 a first disc 24 and to the outer region 20 a second Slice 23 on.
  • the distance between the two discs 23, 24th is for example about 40mm.
  • the housing 11 is not airtight closes column 26, 27 in the region of the two discs 23, 24 for Housing wall marked, on which a more targeted Air exchange between the production room 12 and the Interspace 25 between the two discs 23, 24 as well between the exterior 20 and the gap 25 he follows.
  • Access to the production room 12 takes place in particular by the fact that the door 22 displaceable or raised can be lowered, so that a slot or Free space is created by the manual in the production room 12 can be intervened. If the door 22 is open, so can air over the slot or space formed thereby get into the gap 25. It is also conceivable at least in addition in the one disc 24 a hole form, by one on the other disc 23 (on the production room 12 side facing)) Glove is feasible.
  • a ventilation system 28th arranged from the production room 12 in the Embodiment by an air-permeable device 29 is separated.
  • the ventilation system 28 has a fan 31 and a downstream filter in the form of a Clean air filter 32.
  • a first adjustable flap 33 to the controlled feed of Allow air from the outside area 20.
  • a second adjustable Flap 34 provided to the outlet of purified air in to allow the outdoor area 20.
  • the Device 10 To prevent both contamination of the production room 12 from To avoid outdoor 20 ago as well as vice versa, is the Device 10 specially designed. This is the Interspace 25 between the two discs 23, 24 via a suction or suction with the suction side the blower 31 connected so that a flow path 36 for Air is created. Other flow paths 37 for air are formed by the entrance lock 15 and the Outlet lock 16 towards the suction side of the blower 31. From Blower 31 is cleaned in the clean air filter 32 air in passed the production room 12, wherein a substantially horizontally extending, laminar air flow 38 generated which is above the treatment rooms or treatment areas the vial 1 flows in the direction of the gap 25.
  • Essential are the different ones Air pressure conditions in the individual rooms or Areas: So there is a higher in the production room 12 Pressure as in the intermediate area 25 and the entrance lock 15 and the outlet lock 16. Furthermore, the pressure in the intermediate region 25, the entrance lock 15 and the Outlet lock 16 lower than in the outer area 20, i. in these areas prevails in relation to the outdoor area 20 a negative pressure. It follows that both air from Exterior 20 via the first openings 19 in the Entry lock 15 and the exit lock 16, as well Air over the column 27 or when opening the door 22 via the thus formed gap or clearance in the intermediate area 25 flows, which is illustrated by the flow arrows 39 should be.
  • Contaminations of the Intermediate 25 and the lock areas 17, 18 by from the production room 12 leaking air or through entering the outer region 20 in the intermediate region 25 Air is removed by extracting the air from the top mentioned areas to the suction side of the blower 31 out avoided.
  • Embodiment of the invention is the device 10a designed as a filling plant for liquid pharmaceuticals.
  • the Bottling takes place in ampoules 2, but it can also be vials etc. be bottled.
  • the Entry lock 15a is integrated into the housing 11a and has an intermediate wall 43 for production or Insulator interior 12a on. Below the transport level 41 a suction grille 44 is arranged, which is a Suction channel 45 limited.
  • the device 10a accordingly the first embodiment, one of the entrance lock 15a corresponding air flow or a corresponding structure also on the exit side of the device 10a having. Furthermore, the air flow is in Isolator interior 12a also as a laminar air flow formed, however, the ampoules 2 substantially flows vertically from top to bottom. Such However, air ducting is already available in isolator technology well known.

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Ventilation (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
  • Duct Arrangements (AREA)
  • Central Air Conditioning (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)

Claims (10)

  1. Procédé pour conduire de l'air dans une chambre de traitement (12 ; 12a), selon lequel on produit dans un boítier fermé (11 ; 11a) vis à vis d'une zone extérieure (20 ; 20a) à l'exception essentiellement de zones de sas (17, 18), une circulation d'air qui conduit de l'air purifié au moyen d'un filtre (32 ; 48) dans la chambre de traitement (12 ; 12a) à l'intérieur du boítier (11 ; 11a), en particulier au-dessus de la zone de remplissage et de fermeture de récipients d'emballage (1 ; 2) afin d'empêcher les contaminations de la matière de remplissage et des récipients d'emballage (1 ; 2), et avec une zone intermédiaire (25) permettant des manipulations dans la chambre de traitement (12 ; 12a), avec entre la chambre de traitement (12 ; 12a) et la zone intermédiaire (25) une première circulation d'air (flèche de circulation 40), et entre la zone intermédiaire (25) et le filtre (32 ; 48) une seconde circulation d'air (flèche de circulation 36), pour avoir dans la chambre de traitement (12 ; 12a) une pression d'air plus élevée que dans la zone intermédiaire (25),
    caractérisé par
    des fentes (27) formées entre la zone intermédiaire (25) et la zone extérieure (20 ; 20a) et par une pression plus élevée dans la zone extérieure (20 ; 20a) que dans la zone intermédiaire (25), de manière que l'air pénétrant dans l'espace intermédiaire (25) par les fentes (27) soit aspiré et guidé vers le filtre (32 ; 48).
  2. Procédé selon la revendication 1,
    caractérisé en ce que
    les zones de sas (17, 18) pour les récipients d'emballage (1, 2) présentent des premières ouvertures (19 ; 19a) menant de la zone extérieure (20 ; 20a) vers les zones de sas (17, 18) et des secondes ouvertures (21 ; 21a) menant de la chambre de traitement (12 ; 12a) vers les zones de sas (17, 18), de l'air provenant des zones de sas (17, 18) est aspiré (flèches de circulation 37 ; 49) vers le filtre (32 ; 48) et de l'air provenant de la chambre de traitement (12 ; 12a) et de la zone extérieure (20 ; 20a) circule (flèches de circulation 39, 40 ; 50, 51) vers les zones de sas (17, 18).
  3. Procédé selon la revendication 1,
    caractérisé en ce que
    les zones de sas (17, 18) pour les récipients d'emballage (2) présentent des premières ouvertures (19a) menant de la zone extérieure (20a) vers les zones de sas (17, 18) et des secondes ouvertures (21a) menant de la chambre de traitement (12a) vers les zones de sas (17, 18), l'air provenant des zones de sas (17, 18) est aspiré (flèche de circulation 49) vers le filtre (48), de l'air provenant de la chambre de traitement (12a) pénètre (flèche de circulation 50) dans les zones de sas (17, 18) et l'air provenant de la zone extérieure (20a) pénètre (flèche de circulation 51) dans les zones de sas (17, 18).
  4. Dispositif (10 ; 10a) pour la conduite d'air dans une chambre de traitement (12 ; 12a), muni d'un boítier (11 ; 11a), à travers lequel des récipients d'emballage (1 ; 2) peuvent passer en suivant une trajectoire de transport (13) afin d'être remplis et fermés, avec pour conserver propre la chambre de traitement (12 ; 12a) à l'intérieur du boítier (11 ; 11a), un dispositif (28) comprenant au moins un dispositif soufflant (31 ; 31a, 47) et un filtre (32 ; 48), avec une cloison mobile (22) afin de permettre des opérations manuelles depuis une zone extérieure (20 ; 20a) dans la chambre de traitement (12 ; 12a), la cloison (22) formant un espace intermédiaire (25) relié à la chambre de traitement (12 ; 12a) et à la zone extérieure (20, 20a) par des fentes (26, 27), alors que la zone intermédiaire (25) présente des moyens pour aspirer l'air pénétrant dans la zone intermédiaire (25) et le conduire vers le dispositif soufflant (31 ; 31a, 47) et vers le filtre (32 ; 48).
  5. Dispositif selon la revendication 4,
    caractérisé en ce que
    le boítier (11 ; 11a) présente un sas d'entrée (15 ; 15a) et un sas de sortie (16) pour les récipients d'emballage (1 ; 2), sas qui possèdent des premières ouvertures (19 ; 19a) menant vers la zone extérieure (20 ; 20a) et des secondes ouvertures (21 ; 21a) menant à la chambre de traitement (12 ; 12a), et des moyens sont prévus pour conduire l'air provenant du sas d'entrée (15 ; 15a) et du sas de sortie (16) vers le dispositif soufflant (31 ; 31a, 47), pour avoir dans le sas d'entrée (15 ; 15a) et le sas de sortie (16) une pression inférieure à la pression dans la chambre de traitement de traitement (12 ; 12a) et dans la zone extérieure (20 ; 20a).
  6. Dispositif selon la revendication 4 ou 5,
    caractérisé en ce qu'
    on peut produire dans la chambre de traitement (12) au moyen du dispositif soufflant (31), une circulation d'air (flèche de circulation 38) dirigée essentiellement horizontalement et perpendiculairement à la direction de transport des récipients d'emballage (1).
  7. Dispositif selon la revendication 6,
    caractérisé en ce que
    le dispositif soufflant (31) est disposé sur le côté opposé à la zone intermédiaire (25), moyennant quoi la trajectoire de transport (13) des récipients d'emballage (1) est située entre le dispositif soufflant (31) et la zone intermédiaire (25).
  8. Dispositif selon la revendication 4 ou 5,
    caractérisé en ce qu'
    on peut produire dans la chambre de traitement (12a) à l'aide du dispositif soufflant (31), une circulation d'air dirigée essentiellement verticalement par rapport à la direction de transport des récipients d'emballage (2).
  9. Dispositif selon la revendication 4, 5 ou 8,
    caractérisé en ce qu'
    on peut produire dans les zones de sas (17, 18) à l'aide du dispositif soufflant (31a), une circulation d'air qui contourne verticalement les récipients d'emballage (2).
  10. Dispositif selon l'une quelconque des revendications 6 à 9,
    caractérisé en ce qu'
    au moins dans la chambre de traitement (12 ; 12a) (flèches circulation 38 ; 53) la circulation d'air est laminaire.
EP00975809A 1999-10-02 2000-09-27 Procede et dispositif pour conduire de l'air dans un espace de travail Expired - Lifetime EP1135655B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19947781A DE19947781C1 (de) 1999-10-02 1999-10-02 Verfahren und Vorrichtung zur Luftführung in einem Bearbeitungsraum
DE19947781 1999-10-02
PCT/DE2000/003396 WO2001025694A1 (fr) 1999-10-02 2000-09-27 Procede et dispositif pour conduire de l'air dans un espace de travail

Publications (2)

Publication Number Publication Date
EP1135655A1 EP1135655A1 (fr) 2001-09-26
EP1135655B1 true EP1135655B1 (fr) 2004-04-21

Family

ID=7924458

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00975809A Expired - Lifetime EP1135655B1 (fr) 1999-10-02 2000-09-27 Procede et dispositif pour conduire de l'air dans un espace de travail

Country Status (7)

Country Link
US (1) US6619901B1 (fr)
EP (1) EP1135655B1 (fr)
JP (1) JP4574929B2 (fr)
CN (1) CN1149356C (fr)
AT (1) ATE265028T1 (fr)
DE (2) DE19947781C1 (fr)
WO (1) WO2001025694A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6726947B1 (en) * 1999-08-14 2004-04-27 The Procter & Gamble Co. Process for providing customized varieties and strengths of fresh-brewed coffee on demand
US6759072B1 (en) * 1999-08-14 2004-07-06 The Procter + Gamble Co. Methods and systems for utilizing delayed dilution, mixing and filtration for providing customized beverages on demand
ITBO20060183A1 (it) * 2006-03-15 2007-09-16 Pietro Dovesi Metodo per il confezionamento di flaconi in ambiente sterile ed apparato che attua tale metodo
DE102006034156B3 (de) * 2006-07-24 2007-09-13 Siemens Ag Anordnung zur Belüftung von Baugruppen
JP2008032335A (ja) * 2006-07-31 2008-02-14 Hitachi High-Technologies Corp ミニエンバイロメント装置、検査装置、製造装置、及び空間の清浄化方法
WO2008037326A2 (fr) * 2006-09-26 2008-04-03 CFS Bühl GmbH Traitement sanitaire des aliments, chaîne de transport et d'emballage pour réaliser des produits allongés et pour déterminer la durée de stockage d'un produit
DE102009003205A1 (de) * 2009-05-19 2010-11-25 Robert Bosch Gmbh Kombifüllstation
DE102012209961A1 (de) 2012-01-11 2013-07-11 Robert Bosch Gmbh Verschließbare Einheit für einen Isolator oder Reinraum
CN102658887A (zh) * 2012-05-14 2012-09-12 楚天科技股份有限公司 基于rabs系统的出料装置
DE102012208574A1 (de) 2012-05-22 2013-11-28 Robert Bosch Gmbh Filtereinheit für ein Barrieresystem

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FR2578474B1 (fr) * 1985-03-08 1989-05-05 Calhene Installation pour travaux hors poussiere, notamment pour la fabrication et le controle de composants electroniques, et son procede de mise en oeuvre
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JPH0794252B2 (ja) * 1991-07-04 1995-10-11 東洋製罐株式会社 無菌充填方法
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Also Published As

Publication number Publication date
CN1322285A (zh) 2001-11-14
JP2003511646A (ja) 2003-03-25
EP1135655A1 (fr) 2001-09-26
WO2001025694A1 (fr) 2001-04-12
DE50006147D1 (de) 2004-05-27
JP4574929B2 (ja) 2010-11-04
DE19947781C1 (de) 2000-12-21
CN1149356C (zh) 2004-05-12
US6619901B1 (en) 2003-09-16
ATE265028T1 (de) 2004-05-15

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