EP1135655B1 - Method and device for introduction of air into a processing chamber - Google Patents

Method and device for introduction of air into a processing chamber Download PDF

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Publication number
EP1135655B1
EP1135655B1 EP00975809A EP00975809A EP1135655B1 EP 1135655 B1 EP1135655 B1 EP 1135655B1 EP 00975809 A EP00975809 A EP 00975809A EP 00975809 A EP00975809 A EP 00975809A EP 1135655 B1 EP1135655 B1 EP 1135655B1
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EP
European Patent Office
Prior art keywords
air
treatment space
lock
area
flow
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Expired - Lifetime
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EP00975809A
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German (de)
French (fr)
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EP1135655A1 (en
Inventor
Berthold Duethorn
Thomas Hertfelder
Eberhard Jost
Lothar Gail
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Robert Bosch GmbH
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Robert Bosch GmbH
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F24—HEATING; RANGES; VENTILATING
    • F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
    • F24F3/00—Air-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatment; Apparatus specially designed for such systems
    • F24F3/12—Air-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatment; Apparatus specially designed for such systems characterised by the treatment of the air otherwise than by heating and cooling
    • F24F3/16—Air-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatment; Apparatus specially designed for such systems characterised by the treatment of the air otherwise than by heating and cooling by purification, e.g. by filtering; by sterilisation; by ozonisation
    • F24F3/167—Clean rooms, i.e. enclosed spaces in which a uniform flow of filtered air is distributed

Definitions

  • the invention relates to a method and a device for air guidance in a processing room.
  • a method and apparatus for filling Pharmaceuticals or similar products in Packaging container within a housing of a Packaging machine affected.
  • Such known Devices are often in so-called isolator technology constructed, i.e., that the filling and closing of the Packaging container under clean room conditions, so that neither the previously sterilized packaging container still the contents are contaminated by external influences can.
  • These are in particular the bottling and Closing region of the device surrounded by a housing, its interior air either through a Pure air filter is circulated or it is by a Clean air filter supplied from the outside constantly cleaned air (EP 0 604 925 B1).
  • Intervention possibilities by means of gloves EP 0 604 925 B1
  • free intervention possibilities without Gloves In the latter intervention possibilities There is always the risk of contamination, be it from Contamination of the production area from the outside or from Contaminations of the outer area from the production area out.
  • the object of the invention is therefore to provide a method and a Device for air guidance in a processing space such form that contaminants of both the Processing room or the production room and the Outside, from which manipulations in the Production room to be made, excluded or at least reduced to a certain, tolerable level are.
  • This task is done with a procedure and a Device having the features of the independent claims solved.
  • the inventive method and the Device according to the invention are characterized in that at the moment, especially by a gap between the production room and the outside interventions into the production room, from the production room in Direction of the outside air flowing and vice versa a space is sucked and thus not in the can reach each other area.
  • the device 10 for filling especially dry Pharmaceuticals or similar products in Packaging containers such as vials 1 and Closing the same has a housing 11.
  • the housing 11 encloses a production room 12, where not illustrated, because not essential to the invention Treatment facilities, in particular bottling and Closing devices are arranged.
  • the vials 1 be by means of a conveyor along a Transport path 13 passed through the production room 12, wherein the housing 11 is an entrance lock 15 and a Outlet lock 16 has.
  • the entrance lock 15 and the outlet lock 16 each form one Lock area 17, 18 off, the first openings 19 of Exterior 20 of the device 10 in the lock area 17, 18, and second openings 21 from the lock area 17, 18th in the production area 12 have.
  • the size of the openings 19, 21 is preferably adapted to the size of the vials 1 or changeable, so that the size of the openings 19, 21st as small as possible, to avoid excessive air exchange between to avoid the individual areas.
  • the housing 11 To make manual intervention in the production room 12 can, is on one side of the housing 11 a Accessibility in the form of a double-pane door 22 educated.
  • the door 22 faces the production room 12 a first disc 24 and to the outer region 20 a second Slice 23 on.
  • the distance between the two discs 23, 24th is for example about 40mm.
  • the housing 11 is not airtight closes column 26, 27 in the region of the two discs 23, 24 for Housing wall marked, on which a more targeted Air exchange between the production room 12 and the Interspace 25 between the two discs 23, 24 as well between the exterior 20 and the gap 25 he follows.
  • Access to the production room 12 takes place in particular by the fact that the door 22 displaceable or raised can be lowered, so that a slot or Free space is created by the manual in the production room 12 can be intervened. If the door 22 is open, so can air over the slot or space formed thereby get into the gap 25. It is also conceivable at least in addition in the one disc 24 a hole form, by one on the other disc 23 (on the production room 12 side facing)) Glove is feasible.
  • a ventilation system 28th arranged from the production room 12 in the Embodiment by an air-permeable device 29 is separated.
  • the ventilation system 28 has a fan 31 and a downstream filter in the form of a Clean air filter 32.
  • a first adjustable flap 33 to the controlled feed of Allow air from the outside area 20.
  • a second adjustable Flap 34 provided to the outlet of purified air in to allow the outdoor area 20.
  • the Device 10 To prevent both contamination of the production room 12 from To avoid outdoor 20 ago as well as vice versa, is the Device 10 specially designed. This is the Interspace 25 between the two discs 23, 24 via a suction or suction with the suction side the blower 31 connected so that a flow path 36 for Air is created. Other flow paths 37 for air are formed by the entrance lock 15 and the Outlet lock 16 towards the suction side of the blower 31. From Blower 31 is cleaned in the clean air filter 32 air in passed the production room 12, wherein a substantially horizontally extending, laminar air flow 38 generated which is above the treatment rooms or treatment areas the vial 1 flows in the direction of the gap 25.
  • Essential are the different ones Air pressure conditions in the individual rooms or Areas: So there is a higher in the production room 12 Pressure as in the intermediate area 25 and the entrance lock 15 and the outlet lock 16. Furthermore, the pressure in the intermediate region 25, the entrance lock 15 and the Outlet lock 16 lower than in the outer area 20, i. in these areas prevails in relation to the outdoor area 20 a negative pressure. It follows that both air from Exterior 20 via the first openings 19 in the Entry lock 15 and the exit lock 16, as well Air over the column 27 or when opening the door 22 via the thus formed gap or clearance in the intermediate area 25 flows, which is illustrated by the flow arrows 39 should be.
  • Contaminations of the Intermediate 25 and the lock areas 17, 18 by from the production room 12 leaking air or through entering the outer region 20 in the intermediate region 25 Air is removed by extracting the air from the top mentioned areas to the suction side of the blower 31 out avoided.
  • Embodiment of the invention is the device 10a designed as a filling plant for liquid pharmaceuticals.
  • the Bottling takes place in ampoules 2, but it can also be vials etc. be bottled.
  • the Entry lock 15a is integrated into the housing 11a and has an intermediate wall 43 for production or Insulator interior 12a on. Below the transport level 41 a suction grille 44 is arranged, which is a Suction channel 45 limited.
  • the device 10a accordingly the first embodiment, one of the entrance lock 15a corresponding air flow or a corresponding structure also on the exit side of the device 10a having. Furthermore, the air flow is in Isolator interior 12a also as a laminar air flow formed, however, the ampoules 2 substantially flows vertically from top to bottom. Such However, air ducting is already available in isolator technology well known.

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Ventilation (AREA)
  • Duct Arrangements (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
  • Central Air Conditioning (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)

Abstract

An apparatus for air guidance in a processing chamber has a housing with an entrance gate and an exit gate. Inside the housing the processing chamber is embodied for filling and sealing small bottles or ampules. The processing chamber is separated from an outside region via an intermediate region. The intermediate region having a movable door by means of which manual interventions in the processing chamber can be made. The apparatus also has a ventilation system with a blower and a clean-air filter which inside the processing chamber generates a laminar air flow. By means of special air pressure ratios in the processing chamber the intermediate region the entrance gate and the exit gate, the occurrence of contamination, or its exceeding a tolerable amount, in the processing chamber (12) and the outside region is avoided.

Description

Die Erfindung betrifft ein Verfahren und eine Vorrichtung zur Luftführung in einem Bearbeitungsraum. Insbesondere ist ein Verfahren und eine Vorrichtung zum Abfüllen von Pharmazeutika oder ähnlichen Produkten in Verpackungsbehälter innerhalb eines Gehäuses einer Verpackungsmaschine betroffen. Derartige bekannte Vorrichtungen sind oftmals in sogenannter Isolatortechnik aufgebaut, d.h., daß das Abfüllen und Verschließen der Verpackungsbehälter unter Reinraumbedingungen erfolgt, so daß weder die zuvor sterilisierten Verpackungsbehälter noch das Füllgut durch äußere Einflüsse kontaminiert werden können. Dazu sind insbesondere der Abfüll- und Verschließbereich der Vorrichtung von einem Gehäuse umgeben, dessen im Inneren befindliche Luft entweder durch einen Reinluftfilter umgewälzt wird oder aber es wird durch einen Reinluftfilter von außen ständig gereinigte Luft zugeführt (EP 0 604 925 B1). Bei derartigen Vorrichtungen ist es weiterhin oftmals erforderlich, in dem Produktionsraum von außen manuelle Eingriffe vornehmen zu können, zum Beispiel um Einrichtungen zu justieren. Bekannt sind zum einen Eingriffsmöglichkeiten mittels Handschuhen (EP 0 604 925 B1), zum anderen auch freie Eingriffsmöglichkeiten ohne Handschuhe. Bei letztgenannten Eingriffsmöglichkeiten besteht stets die Gefahr von Kontaminationen, sei es von Kontaminationen des Produktionsraums von außen oder aber von Kontaminationen des äußeren Bereichs aus dem Produktionsraum heraus.The invention relates to a method and a device for air guidance in a processing room. In particular a method and apparatus for filling Pharmaceuticals or similar products in Packaging container within a housing of a Packaging machine affected. Such known Devices are often in so-called isolator technology constructed, i.e., that the filling and closing of the Packaging container under clean room conditions, so that neither the previously sterilized packaging container still the contents are contaminated by external influences can. These are in particular the bottling and Closing region of the device surrounded by a housing, its interior air either through a Pure air filter is circulated or it is by a Clean air filter supplied from the outside constantly cleaned air (EP 0 604 925 B1). In such devices it is still often required in the production room of outside manual intervention, for example to adjust facilities. Are known on the one hand Intervention possibilities by means of gloves (EP 0 604 925 B1), on the other hand also free intervention possibilities without Gloves. In the latter intervention possibilities There is always the risk of contamination, be it from Contamination of the production area from the outside or from Contaminations of the outer area from the production area out.

Aufgabe der Erfindung ist es daher, ein Verfahren und eine Vorrichtung zur Luftführung in einem Bearbeitungsraum derart auszubilden, daß Kontaminationen sowohl des Bearbeitungsraums bzw. des Produktionsraums als auch des Außenbereichs, von dem aus Manipulationen in dem Produktionsraum vorgenommen werden, ausgeschlossen oder zumindest auf ein bestimmtes, tolerierbares Maß reduziert sind. Diese Aufgabe wird mit einem Verfahren und einer Vorrichtung mit den Merkmalen der unabhängigen Ansprüche gelöst. Das erfindungsgemäße Verfahren und die erfindungsgemäße Vorrichtung zeichnen sich dadurch aus, daß in dem Augenblick, indem insbesondere durch einen Spalt zwischen dem Produktionsraum und dem Außenbereich Eingriffe in den Produktionsraum erfolgen, aus dem Produktionsraum in Richtung des Außenbereichs strömende Luft und umgekehrt über einen Zwischenraum abgesaugt wird und somit nicht in den jeweils anderen Bereich gelangen kann.The object of the invention is therefore to provide a method and a Device for air guidance in a processing space such form that contaminants of both the Processing room or the production room and the Outside, from which manipulations in the Production room to be made, excluded or at least reduced to a certain, tolerable level are. This task is done with a procedure and a Device having the features of the independent claims solved. The inventive method and the Device according to the invention are characterized in that at the moment, especially by a gap between the production room and the outside interventions into the production room, from the production room in Direction of the outside air flowing and vice versa a space is sucked and thus not in the can reach each other area.

Weitere vorteilhafte Weiterbildungen des erfindungsgemäßen Verfahren und deren Vorrichtung ergeben sich aus den Unteransprüchen und der Beschreibung.Further advantageous developments of the invention Process and their device will be apparent from the Subclaims and the description.

Zwei Ausführungsbeispiele der Erfindung sind in der Zeichnung dargestellt und werden nachfolgend näher erläutert. Es zeigen:

  • Figur 1 eine Vorrichtung zum Abfüllen von Pharmazeutika oder ähnlichen Produkten in Verpackungsbehälter in einem Prinzipschaubild in Draufsicht,
  • Figur 2 eine vereinfachte Vorderansicht auf eine Abfüllanlage in Isolatorbauweise und
  • Figur 3 einen Teilschnitt in der Ebene III-III der Figur 2 im Einlaufbereich der Abfüllanlage.
    • Two embodiments of the invention are illustrated in the drawing and are explained in more detail below. Show it:
  • 1 shows an apparatus for filling pharmaceuticals or similar products in packaging containers in a schematic diagram in plan view,
  • Figure 2 is a simplified front view of a filling plant in isolator design and
  • 3 shows a partial section in the plane III-III of Figure 2 in the inlet region of the filling plant.

    • Die Vorrichtung 10 zum Abfüllen insbesondere von trockenen Pharmazeutika oder ähnlichen Produkten in Verpackungsbehälter wie zum Beispiel Fläschchen 1 und Verschließen derselben weist ein Gehäuse 11 auf. Das Gehäuse 11 umschließt einen Produktionsraum 12, in dem nicht dargestellte, weil nicht erfindungswesentliche Behandlungseinrichtungen, insbesondere Abfüll- und Verschließeinrichtungen angeordnet sind. Die Fläschchen 1 werden mittels einer Fördereinrichtung entlang eines Transportweges 13 durch den Produktionsraum 12 geschleust, wobei das Gehäuse 11 eine Eintrittsschleuse 15 und eine Austrittschleuse 16 aufweist. Die Eintrittsschleuse 15 und die Austrittsschleuse 16 bilden jeweils einen Schleusenbereich 17, 18 aus, die erste Öffnungen 19 vom Außenbereich 20 der Vorrichtung 10 in den Schleusenbereich 17, 18, und zweite Öffnungen 21 vom Schleusenbereich 17, 18 in den Produktionsbereich 12 haben. Die Größe der Öffnungen 19, 21 ist vorzugsweise der Größe der Fläschchen 1 angepaßt bzw. veränderbar, so daß die Größe der Öffnungen 19, 21 möglichst klein ist, um übermäßigen Luftaustausch zwischen den einzelnen Bereichen zu vermeiden.The device 10 for filling especially dry Pharmaceuticals or similar products in Packaging containers such as vials 1 and Closing the same has a housing 11. The housing 11 encloses a production room 12, where not illustrated, because not essential to the invention Treatment facilities, in particular bottling and Closing devices are arranged. The vials 1 be by means of a conveyor along a Transport path 13 passed through the production room 12, wherein the housing 11 is an entrance lock 15 and a Outlet lock 16 has. The entrance lock 15 and the outlet lock 16 each form one Lock area 17, 18 off, the first openings 19 of Exterior 20 of the device 10 in the lock area 17, 18, and second openings 21 from the lock area 17, 18th in the production area 12 have. The size of the openings 19, 21 is preferably adapted to the size of the vials 1 or changeable, so that the size of the openings 19, 21st as small as possible, to avoid excessive air exchange between to avoid the individual areas.

    Um manuelle Eingriffe im Produktionsraum 12 vornehmen zu können, ist an einer Seite des Gehäuses 11 eine Zugriffsmöglichkeit in Form einer doppelscheibigen Tür 22 ausgebildet. Die Tür 22 weist zum Produktionsraum 12 hin eine erste Scheibe 24 und zum Außenbereich 20 eine zweite Scheibe 23 auf. Der Abstand der beiden Scheiben 23, 24 beträgt beispielsweise ca. 40mm. Um anzudeuten, daß die Tür 22 das Gehäuse 11 nicht luftdicht verschließt sind Spalte 26, 27 im Bereich der beiden Scheiben 23, 24 zur Gehäusewandung eingezeichnet, über die ein gezielter Luftaustausch zwischen dem Produktionsraum 12 und dem Zwischenraum 25 zwischen den beiden Scheiben 23, 24 sowie zwischen dem Außenbereich 20 und dem Zwischenraum 25 erfolgt.To make manual intervention in the production room 12 can, is on one side of the housing 11 a Accessibility in the form of a double-pane door 22 educated. The door 22 faces the production room 12 a first disc 24 and to the outer region 20 a second Slice 23 on. The distance between the two discs 23, 24th is for example about 40mm. To indicate that the door 22, the housing 11 is not airtight closes column 26, 27 in the region of the two discs 23, 24 for Housing wall marked, on which a more targeted Air exchange between the production room 12 and the Interspace 25 between the two discs 23, 24 as well between the exterior 20 and the gap 25 he follows.

    Die Zugriffsmöglichkeit in den Produktionsraum 12 erfolgt insbesondere dadurch, daß die Tür 22 verschiebbar bzw. hebund senkbar ausgebildet ist, so daß ein Schlitz bzw. Freiraum entsteht, durch den manuell in den Produktionsraum 12 eingegriffen werden kann. Ist die Tür 22 geöffnet, so kann Luft über den dadurch gebildeten Schlitz bzw. Freiraum in den Zwischenraum 25 gelangen. Es ist auch denkbar, zumindest zusätzlich in der einen Scheibe 24 ein Loch auszubilden, durch das ein an der anderen Scheibe 23 (auf der dem Produktionsraum 12 zugewandten Seite) befestigter Handschuh führbar ist.Access to the production room 12 takes place in particular by the fact that the door 22 displaceable or raised can be lowered, so that a slot or Free space is created by the manual in the production room 12 can be intervened. If the door 22 is open, so can air over the slot or space formed thereby get into the gap 25. It is also conceivable at least in addition in the one disc 24 a hole form, by one on the other disc 23 (on the production room 12 side facing)) Glove is feasible.

    Auf der der Tür 22 gegenüberliegenden Seite des Transportwegs 13 ist im Gehäuse 11 eine Lüftungsanlage 28 angeordnet, die vom Produktionsraum 12 im Ausführungsbeispiel durch eine luftdurchlässige Einrichtung 29 abgetrennt ist. Die Lüftungsanlage 28 hat ein Gebläse 31 und einen nachgeschalteten Filter in Form eines Reinluftfilters 32. Im Bereich der Lüftungsanlage 28 hat das Gehäuse 11 auf der Saugseite des Gebläses 31 eine erste verstellbare Klappe 33, um die kontrollierte Zuführung von Luft aus dem Außenbereich 20 zuzulassen. Weiterhin ist auf der Druckseite des Gebläses 31 eine zweite verstellbare Klappe 34 vorgesehen, um den Austritt gereinigter Luft in den Außenbereich 20 zu ermöglichen.On the opposite side of the door 22 Transport path 13 is in the housing 11 a ventilation system 28th arranged from the production room 12 in the Embodiment by an air-permeable device 29 is separated. The ventilation system 28 has a fan 31 and a downstream filter in the form of a Clean air filter 32. In the area of the ventilation system 28 has the Housing 11 on the suction side of the blower 31, a first adjustable flap 33 to the controlled feed of Allow air from the outside area 20. Continue on the pressure side of the blower 31 a second adjustable Flap 34 provided to the outlet of purified air in to allow the outdoor area 20.

    Um sowohl Kontaminationen des Produktionsraums 12 vom Außenbereich 20 her als auch umgekehrt zu vermeiden, ist die Vorrichtung 10 besonders ausgebildet. Dazu ist der Zwischenraum 25 zwischen den beiden Scheiben 23, 24 über eine Absaugeinrichtung bzw. Absaugleitung mit der Saugseite des Gebläses 31 verbunden, so daß ein Strömungsweg 36 für Luft entsteht. Weitere Strömungswege 37 für Luft sind gebildet von der Eintrittsschleuse 15 und der Austrittsschleuse 16 hin zur Saugseite des Gebläses 31. Vom Gebläse 31 wird die im Reinluftfilter 32 gereinigte Luft in den Produktionsraum 12 geleitet, wobei eine im wesentlichen horizontal verlaufende, laminare Luftströmung 38 erzeugt wird, die über die Behandlungsräume bzw. Behandlungsflächen der Fläschchen 1 in Richtung des Zwischenraums 25 strömt.To prevent both contamination of the production room 12 from To avoid outdoor 20 ago as well as vice versa, is the Device 10 specially designed. This is the Interspace 25 between the two discs 23, 24 via a suction or suction with the suction side the blower 31 connected so that a flow path 36 for Air is created. Other flow paths 37 for air are formed by the entrance lock 15 and the Outlet lock 16 towards the suction side of the blower 31. From Blower 31 is cleaned in the clean air filter 32 air in passed the production room 12, wherein a substantially horizontally extending, laminar air flow 38 generated which is above the treatment rooms or treatment areas the vial 1 flows in the direction of the gap 25.

    Wesentlich sind dabei die unterschiedlichen Luftdruckverhältnisse in den einzelnen Räumen bzw. Bereichen: So herrscht im Produktionsraum 12 ein höherer Druck als im Zwischenbereich 25 sowie der Eintrittsschleuse 15 und der Austrittsschleuse 16. Weiterhin ist der Druck in dem Zwischenbereich 25, der Eintrittsschleuse 15 sowie der Austrittsschleuse 16 geringer als im Außenbereich 20, d.h. in diesen Bereichen herrscht im Verhältnis zum Außenbereich 20 ein Unterdruck vor. Daraus folgt, daß sowohl Luft vom Außenbereich 20 über die ersten Öffnungen 19 in die Eintrittsschleuse 15 und die Austrittsschleuse 16, als auch Luft über die Spalte 27 oder beim Öffnen der Tür 22 über den somit gebildeten Spalt bzw. Freiraum in den Zwischenbereich 25 strömt, was durch die Strömungspfeile 39 verdeutlicht sein soll. Weierhin strömt Luft aus dem Produktionsraum 12 über die zweiten Öffnungen 21 in die Eintrittsschleuse 15 und die Austrittsschleuse 16 sowie Luft über die Spalte 26 in den Zwischenbereich 25 hinein, was durch die Strömungspfeile 40 angedeutet ist. Somit findet keine Luftströmung ungereinigter oder kontaminierter Luft aus dem Bereich außerhalb des Produktionsraums 12 in den Produktionsraum 12 hinein statt. Ferner tritt auch keine ungereinigte oder kontaminierte Luft aus dem Produktionsraum 12 in den Außenbereich 20 hinaus. Kontaminationen des Zwischenbereichs 25 und der Schleusenbereiche 17, 18 durch aus dem Produktionsraum 12 austretende Luft oder durch über den Außenbereich 20 in den Zwischenbereich 25 eintretende Luft werden durch die Absaugung der Luft aus den oben genannten Bereichen zur Saugseite des Gebläses 31 hin vermieden.Essential are the different ones Air pressure conditions in the individual rooms or Areas: So there is a higher in the production room 12 Pressure as in the intermediate area 25 and the entrance lock 15 and the outlet lock 16. Furthermore, the pressure in the intermediate region 25, the entrance lock 15 and the Outlet lock 16 lower than in the outer area 20, i. in these areas prevails in relation to the outdoor area 20 a negative pressure. It follows that both air from Exterior 20 via the first openings 19 in the Entry lock 15 and the exit lock 16, as well Air over the column 27 or when opening the door 22 via the thus formed gap or clearance in the intermediate area 25 flows, which is illustrated by the flow arrows 39 should be. Weierhin flows air from the production room 12 via the second openings 21 in the inlet lock 15th and the exit lock 16 and air over the gaps 26 into the intermediate area 25, which is due to the Flow arrows 40 is indicated. Thus, none finds Air flow of unpurified or contaminated air from the Area outside the production room 12 in the Production room 12 in place. Furthermore, none occurs Uncleaned or contaminated air from the production room 12 in the outdoor area 20 addition. Contaminations of the Intermediate 25 and the lock areas 17, 18 by from the production room 12 leaking air or through entering the outer region 20 in the intermediate region 25 Air is removed by extracting the air from the top mentioned areas to the suction side of the blower 31 out avoided.

    Bei dem in den Figuren 2 und 3 dargestellten zweiten Ausführungsbeispiel der Erfindung ist die Vorrichtung 10a als Abfüllanlage für flüssige Pharmazeutika ausgebildet. Die Abfüllung erfolgt in Ampullen 2, es können jedoch auch Vials o.ä. abgefüllt werden. Man erkennt das kastenförmige Gehäuse 11a, durch das die Ampullen 2 in Höhe der Transportebene 41 in Transportrichtung 42 (welche in der Figur 2 senkrecht zur Zeichenebene verläuft) hindurchgeschleußt werden. Die Eintrittsschleuse 15a ist in das Gehäuse 11a integriert und weist eine Zwischenwand 43 zum Produktions- bzw. Isolatorinnenraum 12a auf. Unterhalb der Transportebene 41 ist ein Absauggitter 44 angeordnet, welches einen Absaugkanal 45 begrenzt. Über das Absauggitter 44 und den Absaugkanal 45 wird Luft aus dem Bereich der Eintrittschleuse 15a mittels des Gebläses 31a angesaugt, welche anschließend in einen abgetrennten Zwischenraum 46 oberhalb des Isolatorinnenraumes 12a gelangt. In dem Zwischenraum 46 ist ein Umluftgebläse 47 angeordnet, welches über einen Reinluftfilter 48 Luft im Isolatorinnenraum 12a zirkulieren läßt.In the second shown in Figures 2 and 3 Embodiment of the invention is the device 10a designed as a filling plant for liquid pharmaceuticals. The Bottling takes place in ampoules 2, but it can also be vials etc. be bottled. One recognizes the box-shaped housing 11a, through which the ampoules 2 at the level of the transport plane 41 in the transport direction 42 (which in the figure 2 perpendicular to Drawing plane runs) are passed through. The Entry lock 15a is integrated into the housing 11a and has an intermediate wall 43 for production or Insulator interior 12a on. Below the transport level 41 a suction grille 44 is arranged, which is a Suction channel 45 limited. About the suction grille 44 and the Suction duct 45 will vent air from the area Inlet lock 15a sucked by the blower 31a, which then into a separate space 46th passes above the insulator interior 12a. By doing Interspace 46 is a circulating air fan 47 is arranged, which via a clean air filter 48 air in the insulator interior 12a circulate.

    Wie aus der Figur 2 anhand der Strömungspfeile 49 zu erkennen ist, wird die Luft aus der Eintrittsschleuse 15a im wesentlichen nach unten in den Absaugkanal 45 abgesaugt, und im Absaugkanal 45 im bodennahen Randbereich des Gehäuses 11a nach oben Richtung Gebläse 31a umgelenkt. As shown in Figure 2 using the flow arrows 49 to is recognized, the air from the entrance lock 15a in essentially sucked down into the suction channel 45, and in the suction channel 45 in the bottom edge region of the housing 11a upwards towards the blower 31a deflected.

    Ferner ist aus der Figur 3 ersichtlich, daß Luft aus dem Isolatorinnenraum 12a in die Eintrittsschleuse 15a einströmt (Strömungspfeil 50). Dies rührt daher, daß analog zum ersten Ausführungsbeispiel entsprechend der Figur 1 im Isolatorinnenraum 12a ein höherer Druck herrscht als in der Eintrittsschleuse 15a. Durch diese gezielte Absaugung der Luft aus dem Isolatorinnenraum 12a entsprechend des ersten Ausführungsbeispiels wird der Eintritt von kontaminierter Luft in den Isolatorinnenraum 12a vermieden.Furthermore, it is apparent from the figure 3 that air from the Insulator interior 12a flows into the inlet lock 15a (Flow arrow 50). This is because, analogous to the first Embodiment according to the figure 1 in Isolator interior 12 a higher pressure prevails than in the Entry lock 15a. Through this targeted extraction of the Air from the insulator interior 12a corresponding to the first Embodiment, the entry of contaminated Air in the insulator interior 12a avoided.

    Ferner erkennt man entsprechend der Strömungspfeile 51 und 52, daß Luft entweder vom Außenbereich 20a in die Eintrittschleuse 15a eintritt, oder daß Luft von der Eintrittsschleuse 15a in den Außenbereich 20a ausströmt, je nachdem, ob im Außenbereich 20a ein höherer Luftdruck herrscht als in der Eintrittsschleuse 15a oder umgekehrt.Furthermore, it can be seen according to the flow arrows 51 and 52 that air either from the outside area 20a in the Entry lock 15a enters, or that air from the Entry lock 15a flows out into the outer area 20a, depending after, whether in the outer area 20a, a higher air pressure prevails as in the entrance lock 15a or vice versa.

    Durch den Eintritt von Luft aus dem Außenbereich 20a in die Eintrittsschleuse 15a wird vermieden, daß kontaminierte Prozeßluft in den Außenbereich 20a austritt, was insbesondere bei toxischen Produkten erwünscht ist. In Umkehrung kann bei einem gezielten Ausströmen von Luft aus der Eintrittsschleuse 15a in den Außenbereich 20a ein gezielter Druckabbau des Isolatorinnenraums 12a gegenüber dem Außenbereich 20a stattfinden, so daß weniger Abluft aus der Vorrichtung 10a erzeugt wird, die als Ausgleich als Frischluft wieder zugeführt werden müßte. Dadurch wird der Energiebedarf der Vorrichtung 10a reduziert.By the entry of air from the outer region 20a in the Entry lock 15a prevents contaminated Process air exiting into the outer region 20a, what especially desirable for toxic products. In Reversal can result in a targeted outflow of air the entrance lock 15a in the outer area 20a targeted pressure reduction of the insulator interior 12a opposite take place outside 20 a, so that less exhaust from the device 10a is generated, as a compensation as Fresh air would have to be supplied again. This will be the Energy consumption of the device 10a reduced.

    Ergänzend wird erwähnt, daß die Vorrichtung 10a entsprechend dem ersten Ausführungsbeispiel eine der Eintrittschleuse 15a entsprechende Luftströmung bzw. einen entsprechenden Aufbau ebenfalls auf der Austrittsseite der Vorrichtung 10a aufweist. Weiterhin ist die Luftströmung im Isolatorinnenraum 12a ebenfalls als laminare Luftsrömung ausgebildet, die jedoch die Ampullen 2 im wesentlichen vertikal von oben nach unten umströmt. Eine derartige Luftführung ist in der Isolatortechnik jedoch bereits allgemein bekannt.In addition, it is mentioned that the device 10a accordingly the first embodiment, one of the entrance lock 15a corresponding air flow or a corresponding structure also on the exit side of the device 10a having. Furthermore, the air flow is in Isolator interior 12a also as a laminar air flow formed, however, the ampoules 2 substantially flows vertically from top to bottom. Such However, air ducting is already available in isolator technology well known.

    Claims (10)

    1. Method for guiding air in a treatment space (12; 12a), in which an air flow is generated in a housing (11; 11a), which is closed off from an outside area (20; 20a) with the exception essentially of lock areas (17, 18), which air flow guides air, which has been purified by means of a filter (32; 48), into the treatment space (12; 12a) inside the housing (11; 11a) in particular over the filling and closing area for packaging containers (1; 2), in order to prevent contamination to the contents and the packaging containers (1; 2), and having an intermediate area (25) through which manipulations can be carried out in the treatment space (12; 12a), a first air flow (flow arrow 40) being formed between the treatment space (12; 12a) and the intermediate area (25), and a second air flow (flow arrow 36) being formed between the intermediate area (25) and the filter (32; 48), and a higher air pressure prevailing in the treatment space (12; 12a) than in the intermediate area (25), characterized in that gaps (27) are formed between the intermediate area (25) and the outside area (20; 20a), and in that a higher pressure prevails in the outside area (20; 20a) than in the intermediate area (25), so that air which flows into the intermediate space (25) via the gaps (27) is sucked out and fed to the filter (32; 48).
    2. Method according to Claim 1, characterized in that the lock areas (17, 18) have, for the packaging containers (1; 2), first openings (19; 19a) from the outside area (20; 20a) into the lock areas (17, 18) and second openings (21; 21a) from the treatment space (12; 12a) into the lock areas (17, 18), in that air is sucked out of the lock areas (17, 18) towards the filter (32; 48) (flow arrow 37; 49), and in that air flows out of the treatment space (12; 12a) and the outside area (20; 20a) into the lock areas (17, 18) (flow arrows 39, 40; 50, 51).
    3. Method according to Claim 1, characterized in that the lock areas (17, 18) have, for the packaging containers (2), first openings (19a) from the outside area (20a) into the lock areas (17, 18) and second openings (21a) from the treatment space (12a) into the lock areas (17, 18), in that air is sucked out of the lock areas (17, 18) towards the filter (48) (flow arrows 49), in that air flows out of the treatment space (12a) into the lock areas (17, 18) (flow arrow 50), and in that air flows out of the outside area (20a) into the lock areas (17, 18) (flow arrow 51).
    4. Device (10; 10a) for guiding air in a treatment space (12; 12a), having a housing (11; 11a), through which packaging containers (1; 2) can be passed via locks along a conveying path (13) in order to be filled and closed, having a means (28) for keeping the treatment space (12; 12a) inside the housing (11; 11a) clean, which means comprises at least one fan (31; 31a, 47) and a filter (32; 48), having a movable partition (22) in order to allow interventions from an outside area (20; 20a) into the treatment space (12; 12a), the partition (22) forming an intermediate area (25), which is connected, via gaps (26, 27), to the treatment space (12; 12a) and the outside area (20, 20a), and the intermediate area (25) having means for sucking the air which flows into the intermediate area (25) out to the fan (31; 31a, 47) and to the filter (32; 48).
    5. Device according to Claim 4, characterized in that the housing (11; 11a) has an inlet lock (15; 15a) and an outlet lock (16) for the packaging containers (1; 2), with first openings (19; 19a) leading to the outside area (20; 20a) and second openings (21; 21a) leading to the treatment space (12; 12a), and in that there are means for feeding air from the inlet lock (15; 15a) and the outlet lock (16) to the fan (31; 31a, 47), so that the pressure in the inlet lock (15; 15a) and the outlet lock (16) is lower than the pressure in the treatment space (12; 12a) and in the outside area (20; 20a).
    6. Device according to Claim 4 or 5, characterized in that an air flow (flow arrows 38) which is oriented substantially horizontally and transversely with respect to the conveying direction of the packaging containers (1) can be generated in the treatment space (12) by means of the fan (31).
    7. Device according to Claim 6, characterized in that the fan (31) is arranged on the opposite side from the intermediate area (25), with the conveying path (13) of the packaging containers (1) located between the fan (31) and the intermediate area (25).
    8. Device according to Claim 4 or 5, characterized in that an air flow which is oriented substantially vertically with respect to the conveying direction of the packaging containers (2) can be generated in the treatment space (12a) by means of the fan (47).
    9. Device according to Claim 4, 5 or 8, characterized in that an air flow which flows vertically around the packaging containers (2) can be generated in the lock areas (17, 18) by means of the fan (31a).
    10. Device according to one of Claims 6 to 9,
      characterized in that at least the air flow in the treatment space (12; 12a) (flow arrows 38; 53) is formed as a laminar air flow.
    EP00975809A 1999-10-02 2000-09-27 Method and device for introduction of air into a processing chamber Expired - Lifetime EP1135655B1 (en)

    Applications Claiming Priority (3)

    Application Number Priority Date Filing Date Title
    DE19947781 1999-10-02
    DE19947781A DE19947781C1 (en) 1999-10-02 1999-10-02 Air feed method for clean room work space e.g. for pharmaceuticals packaging, has fan and air filter providing laminar air flow with air pressure ratio preventing contamination between work space and outside air
    PCT/DE2000/003396 WO2001025694A1 (en) 1999-10-02 2000-09-27 Method and device for introduction of air into a processing chamber

    Publications (2)

    Publication Number Publication Date
    EP1135655A1 EP1135655A1 (en) 2001-09-26
    EP1135655B1 true EP1135655B1 (en) 2004-04-21

    Family

    ID=7924458

    Family Applications (1)

    Application Number Title Priority Date Filing Date
    EP00975809A Expired - Lifetime EP1135655B1 (en) 1999-10-02 2000-09-27 Method and device for introduction of air into a processing chamber

    Country Status (7)

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    US (1) US6619901B1 (en)
    EP (1) EP1135655B1 (en)
    JP (1) JP4574929B2 (en)
    CN (1) CN1149356C (en)
    AT (1) ATE265028T1 (en)
    DE (2) DE19947781C1 (en)
    WO (1) WO2001025694A1 (en)

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    Also Published As

    Publication number Publication date
    ATE265028T1 (en) 2004-05-15
    DE19947781C1 (en) 2000-12-21
    EP1135655A1 (en) 2001-09-26
    CN1322285A (en) 2001-11-14
    DE50006147D1 (en) 2004-05-27
    WO2001025694A1 (en) 2001-04-12
    US6619901B1 (en) 2003-09-16
    JP4574929B2 (en) 2010-11-04
    JP2003511646A (en) 2003-03-25
    CN1149356C (en) 2004-05-12

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