EP1072510A2 - Dispositif de remplissage d'un cylindre de séringue et pour mettre un bouchon dans celui-ci - Google Patents

Dispositif de remplissage d'un cylindre de séringue et pour mettre un bouchon dans celui-ci Download PDF

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Publication number
EP1072510A2
EP1072510A2 EP00109845A EP00109845A EP1072510A2 EP 1072510 A2 EP1072510 A2 EP 1072510A2 EP 00109845 A EP00109845 A EP 00109845A EP 00109845 A EP00109845 A EP 00109845A EP 1072510 A2 EP1072510 A2 EP 1072510A2
Authority
EP
European Patent Office
Prior art keywords
centering
sleeve
syringe barrel
filling
cylinder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP00109845A
Other languages
German (de)
English (en)
Other versions
EP1072510B1 (fr
EP1072510A3 (fr
Inventor
Udo J. Vetter
Anton Hecht
Klaus Steinbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotheker Vetter and Company Arzneimittel GmbH Ravensburg
Original Assignee
Apotheker Vetter and Company Arzneimittel GmbH Ravensburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotheker Vetter and Company Arzneimittel GmbH Ravensburg filed Critical Apotheker Vetter and Company Arzneimittel GmbH Ravensburg
Priority to EP10002978A priority Critical patent/EP2230182B1/fr
Publication of EP1072510A2 publication Critical patent/EP1072510A2/fr
Publication of EP1072510A3 publication Critical patent/EP1072510A3/fr
Application granted granted Critical
Publication of EP1072510B1 publication Critical patent/EP1072510B1/fr
Priority to CY20101100952T priority patent/CY1110845T1/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B61/00—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages
    • B65B61/20—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages for adding cards, coupons or other inserts to package contents
    • B65B61/207—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages for adding cards, coupons or other inserts to package contents for inserting partitions between package contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
    • B65B7/2821—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers applying plugs or threadless stoppers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/53—Means to assemble or disassemble
    • Y10T29/53652—Tube and coextensive core
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/53—Means to assemble or disassemble
    • Y10T29/53657—Means to assemble or disassemble to apply or remove a resilient article [e.g., tube, sleeve, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/53—Means to assemble or disassemble
    • Y10T29/53909—Means comprising hand manipulatable tool
    • Y10T29/53943—Hand gripper for direct push or pull

Definitions

  • the invention relates to a device for filling a Syringe barrel and / or to place a stopper in the Syringe barrel, with a barrel attached to one Recording head is arranged and in the axial direction Lumen of the syringe barrel is retractable and through the the syringe barrel is filled or which carries the stopper to be placed inside.
  • Such a device is different Embodiments known from the prior art and comes during the filling process of pre-filled syringes, especially of two-chamber syringes.
  • the advantage of two-chamber syringes is in particular that pharmaceutical substances in aqueous solution are unstable, however in a prefilled form
  • the solvent to withdraw is usually a Freeze drying process applied.
  • the two chambers of the Syringe is usually through a center plug separated from each other.
  • the solution from the a chamber over the so-called by! pass into the cannula-side chamber transferred so that mixing both substances or a reconstitution of the powdery substance can be made.
  • the two-chamber syringe usually consists of one Glass cylinder, the opening on the cannula side is neck-shaped narrowed and according to what is to be absorbed Closure system is shaped.
  • the proximal end serves the Inclusion of a finger rest and is accordingly with a rolled edge.
  • the two chambers Before filling the syringe with the products mentioned the two chambers must be short by inserting the stopper be separated before the by! pass. Putting one Darning is usually done by a thin wall Seat tube, the outer diameter of which is slightly smaller than the inside diameter of the glass cylinder. As soon as the stopper is brought to the axially intended position the plug may be replaced by a stamp expressed what he is looking for after appropriate expansion the glass cylinder!
  • the front chamber is filled with the liquid product.
  • a filling needle moves one Filling device through the neck of the glass cylinder up shortly before the middle plug. Then follows while withdrawing the filling needle at the same time Filling the anterior chamber.
  • Both when retracting the setting tube from the proximal End here as well as when inserting the filling needle through the Neck of the glass cylinder is a centering of the as Filling needle or setting tube serving cylinder sleeve required to enter the syringe barrel To avoid damage to its front end.
  • the invention has for its object a device of the type mentioned at the outset, through which certain is that when retracting the cylinder sleeve in the Inject sufficient coaxial alignment between the syringe barrel and the barrel is, so that damage to the syringe barrel and especially the cylinder sleeve safely excluded are.
  • a device that achieves this object is characterized by a coaxial to the cylinder sleeve and this compared to axially displaceable centering sleeve a conical end of the syringe barrel Centering surface for the front of the syringe barrel has, the free end of the centering sleeve in the Starting position at least slightly above the end of the Protrudes cylinder sleeve.
  • the advantage achieved by the invention is essential in that through the first on the Syringe barrel engaging the centering surface Centering sleeve, the barrel sleeve and the syringe barrel be brought into a swearing position, so that afterwards the cylinder sleeve in the Syringe barrel can retract without! at least face! both come into contact with each other, so mutual sitting with the consequence of damage is avoided.
  • centering sleeve additionally one Centering collar with an inner cone surface. This Centering collar then causes a pre-centering, until the actual centering surface comes into effect.
  • the Cylinder sleeve is fixed on the recording head and the centering sleeve against the force of a spring Recording head is adjustable.
  • the recording head thus makes a movement stroke, whereby initially the centering sleeve comes into contact with the syringe barrel and then! after the subsequent centering! at the further movement stroke of the recording head the cylinder sleeve enters the syringe barrel.
  • a filling needle or as a setting tube Then carry out the filling or the cylinder sleeve Put the stopper.
  • the centering sleeve is for this sequence of movements advantageously in an outer sleeve of the receiving head slidably guided.
  • a suction system When filling the syringe barrel, it is in the As a rule, a suction system, if there is one, is desirable To carry out particles in the area of the filling opening.
  • the plug is placed, the basically also by means of a stamp by the Cylinder tube is possible, preferably by vacuum, with which the syringe barrel is briefly acted on, whereby the plug is "pulled out" of the cylinder sleeve becomes.
  • the invention sees this in an advantageous manner Training before that between the centering sleeve and An annular gap is arranged with a cylindrical sleeve Suction port is connected.
  • centering sleeve on its inside! and or Outer surface with at least one longitudinal groove as Flow channel be provided, which increases the effectiveness of Suction can still be increased.
  • FIGS. 8 and 9 are provided for filling a syringe barrel 1 is.
  • the cylinder sleeve 3 as a riser trained that in the interior of the end setting plug 2 carries. 8 and 9 is against it the cylinder sleeve 3 designed as a filling needle through which through which the syringe barrel 1 is filled.
  • a centering sleeve 5 is coaxial with the cylinder sleeve 3 arranged axially opposite the cylinder sleeve 3 is slidable.
  • This centering sleeve 5 has the Syringe barrel 1 facing end a conical Centering surface 6 for the front of the Syringe barrel 1 on.
  • the free End of the centering sleeve 5 at least slightly above that End of the cylinder sleeve 3 before, so that when approaching the Recording head 4 to the syringe barrel 1, as in 5 and 7 is represented by the arrow 7, first the conical surface of the centering sleeve 5 with the Syringe barrel 1 comes into contact.
  • the centering surface 6 is as Inner cone surface formed, especially for pure cylindrical syringes is advantageous because here the Cone area can be made relatively large and thus a large centering area is reached.
  • the centering surface 6 is, however, as Outer cone surface formed, so that here the cone protrudes slightly into the interior of the syringe barrel 1 and the clear opening cross section of the Syringe barrel 1 reduced accordingly.
  • This Outer cone surface is useful if the Syringe barrel 1, as shown, with a rolled edge 8 or a finger rest is provided because of that The outer contour is usually subject to greater tolerances is. The centering area is naturally considerable limited.
  • FIG. 3 is suitable for this at which the centering sleeve 5 additionally one Centering collar 9 has an inner conical surface, the a pre-adjustment of the syringe barrel 1 over the Makes the outer contour of the rolled edge 8.
  • the cylinder sleeve 3 is fixed on the receiving head 4 arranged while the centering sleeve 5 against the force a spring 10 is adjustable towards the receiving head 4.
  • a spring 10 is adjustable towards the receiving head 4.
  • This ensures that the Centering sleeve 5 under spring force of the end face of the Syringe barrel 1 rests and thus for one constant centering ensures, on the other hand, the Centering sleeve 5 after the plug 2 has been placed or Filling the syringe automatically into the starting position back so that the next step immediately can shoot.
  • the centering sleeve 5 is in one Outer sleeve 11 of the receiving head 4 is slidably guided, how this results directly from the drawings.
  • the centering sleeve 5 on its inside! or Outer surface with at least one longitudinal groove 14 as Flow channel may be provided, as shown in FIGS. 8 and 9 is indicated.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Basic Packing Technique (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
EP00109845A 1999-07-29 2000-05-10 Dispositif de remplissage d'un cylindre de séringue Expired - Lifetime EP1072510B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP10002978A EP2230182B1 (fr) 1999-07-29 2000-05-10 Dispositif de mise en place d'un bouchon dans un cylindre de seringue
CY20101100952T CY1110845T1 (el) 1999-07-29 2010-10-22 Διαταξη για την πληρωση ενος κυλινδρικου στοιχειου συριγγας

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19935681A DE19935681A1 (de) 1999-07-29 1999-07-29 Vorrichtung zum Befüllen eines Spritzenzylinders und/oder zum Setzen eines Stopfens im Spritzenzylinder
DE19935681 1999-07-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP10002978.4 Division-Into 2010-03-20

Publications (3)

Publication Number Publication Date
EP1072510A2 true EP1072510A2 (fr) 2001-01-31
EP1072510A3 EP1072510A3 (fr) 2003-09-10
EP1072510B1 EP1072510B1 (fr) 2010-08-11

Family

ID=7916501

Family Applications (2)

Application Number Title Priority Date Filing Date
EP10002978A Expired - Lifetime EP2230182B1 (fr) 1999-07-29 2000-05-10 Dispositif de mise en place d'un bouchon dans un cylindre de seringue
EP00109845A Expired - Lifetime EP1072510B1 (fr) 1999-07-29 2000-05-10 Dispositif de remplissage d'un cylindre de séringue

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP10002978A Expired - Lifetime EP2230182B1 (fr) 1999-07-29 2000-05-10 Dispositif de mise en place d'un bouchon dans un cylindre de seringue

Country Status (10)

Country Link
US (1) US6223408B1 (fr)
EP (2) EP2230182B1 (fr)
JP (1) JP3407199B2 (fr)
AT (2) ATE477181T1 (fr)
CA (1) CA2314674C (fr)
CY (1) CY1110845T1 (fr)
DE (2) DE19935681A1 (fr)
DK (1) DK1072510T3 (fr)
ES (2) ES2387736T3 (fr)
PT (2) PT1072510E (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011114061A1 (fr) * 2010-03-19 2011-09-22 Equipement Support Radio Pharmaceutique Dispositif hermetique pour la manipulation d'un liquide

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DE60037531T2 (de) 1999-10-22 2008-12-11 ANTARES PHARMA, Inc., Minneapolis Medikamentenkartusche und injektionsvorrichtung
US7093361B2 (en) * 2002-01-23 2006-08-22 Control Products, Inc. Method of assembling an actuator with an internal sensor
ES2314182T3 (es) 2002-02-11 2009-03-16 Antares Pharma, Inc. Inyector intradermico.
WO2003070296A2 (fr) * 2002-02-15 2003-08-28 Antares Pharma, Inc. Injecteur avec canal de derivation
NZ556186A (en) * 2004-12-01 2010-06-25 Acushot Inc Needle-free injector
EP1850892B2 (fr) 2005-01-24 2023-04-19 Antares Pharma, Inc. Injecteur a seringue preremplie assiste d'une aiguille
WO2007131013A1 (fr) 2006-05-03 2007-11-15 Antares Pharma, Inc. Injecteur de reconstitution à deux étages
US8721603B2 (en) 2008-01-15 2014-05-13 West Pharmaceutical Services, Inc. Syringe with co-molded hub and cannula
WO2009091895A2 (fr) * 2008-01-15 2009-07-23 West Pharmaceutical Services, Inc. Mécanisme de serrage et procédé de moulage de canule dans un cylindre de seringue
AU2009279719B2 (en) 2008-08-05 2015-07-23 Antares Pharma, Inc. Multiple dosage injector
JP5732039B2 (ja) 2009-03-20 2015-06-10 アンタレス・ファーマ・インコーポレーテッド 危険有害性薬剤の注入システム
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
USD693002S1 (en) 2011-09-21 2013-11-05 West Pharmaceutical Services, Inc. Hub for medical container
US9242358B2 (en) * 2012-02-09 2016-01-26 Honda Motor Co., Ltd. Looped pin installation apparatus
EP4186545A1 (fr) 2012-04-06 2023-05-31 Antares Pharma, Inc. Administration par injection par jet assistée par aiguille de compositions de testostérone
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
DE202013102257U1 (de) 2012-05-29 2013-06-12 manroland sheetfed GmbH Inkjet-Druckkopf in einer Druckmaschine
USD689188S1 (en) 2012-07-19 2013-09-03 West Pharmaceutical Services, Inc. Syringe plunger rod
EP4349383A2 (fr) 2013-02-11 2024-04-10 Antares Pharma, Inc. Dispositif d'injection par jet assisté par aiguille ayant une force de déclenchement réduite
JP6030803B2 (ja) 2013-03-11 2016-11-24 アンタレス・ファーマ・インコーポレーテッド ピニオンシステムを有する用量注射器
DE102015111525A1 (de) 2014-08-08 2016-02-11 manroland sheetfed GmbH Modulare Inkjet-Druckeinrichtung
US10266293B1 (en) * 2014-09-15 2019-04-23 Automated Systems of Tacoma LLC Method and system for vacuum stoppering of fluid containers
EP3028947A1 (fr) * 2014-12-05 2016-06-08 F. Hoffmann-La Roche AG Fermeture d'une chambre d'un récipient pour un produit pharmaceutique
DE202015102825U1 (de) 2015-06-01 2016-09-02 Kuka Systems Gmbh Stopfenfügewerkzeug
JP2020531057A (ja) 2017-06-29 2020-11-05 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 薬品容器にいっぱいに充填するためのデバイス及び方法
AU2018298768B2 (en) * 2017-07-11 2024-01-11 Becton Dickinson France Device for vacuum and vent tube stoppering a medical container
IT201900007551A1 (it) * 2019-05-30 2020-11-30 Gd Spa Unità di riempimento di un contenitore per prodotti liquidi, in particolare una carpula del settore farmaceutico
WO2023176244A1 (fr) * 2022-03-14 2023-09-21 株式会社京都製作所 Dispositif de confinement de solution chimique et procédé de confinement de solution chimique

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011114061A1 (fr) * 2010-03-19 2011-09-22 Equipement Support Radio Pharmaceutique Dispositif hermetique pour la manipulation d'un liquide
FR2957592A1 (fr) * 2010-03-19 2011-09-23 Equip Support Radio Pharma Dispositif hermetique pour la manipulation d'un liquide

Also Published As

Publication number Publication date
EP2230182A3 (fr) 2010-11-03
ES2346951T3 (es) 2010-10-22
DE19935681A1 (de) 2001-02-15
ATE477181T1 (de) 2010-08-15
PT1072510E (pt) 2010-09-02
CY1110845T1 (el) 2015-06-10
EP2230182A2 (fr) 2010-09-22
DK1072510T3 (da) 2010-11-01
EP1072510B1 (fr) 2010-08-11
EP2230182B1 (fr) 2012-05-09
DE50015971D1 (de) 2010-09-23
CA2314674A1 (fr) 2001-01-29
US6223408B1 (en) 2001-05-01
CA2314674C (fr) 2007-05-01
ES2387736T3 (es) 2012-10-01
EP1072510A3 (fr) 2003-09-10
PT2230182E (pt) 2012-05-29
ATE556941T1 (de) 2012-05-15
JP2001061963A (ja) 2001-03-13
JP3407199B2 (ja) 2003-05-19

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DE3341360A1 (de) Blutentnahmevorrichtung

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