EP1006981B1 - Verbindungsvorrichtung, insbesondere zwischen einem behälter mit durchstossbarem verschluss und einer spritze - Google Patents

Verbindungsvorrichtung, insbesondere zwischen einem behälter mit durchstossbarem verschluss und einer spritze Download PDF

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Publication number
EP1006981B1
EP1006981B1 EP97942082A EP97942082A EP1006981B1 EP 1006981 B1 EP1006981 B1 EP 1006981B1 EP 97942082 A EP97942082 A EP 97942082A EP 97942082 A EP97942082 A EP 97942082A EP 1006981 B1 EP1006981 B1 EP 1006981B1
Authority
EP
European Patent Office
Prior art keywords
perforating
receptacle
stopper
plunger
faucet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP97942082A
Other languages
English (en)
French (fr)
Other versions
EP1006981A1 (de
Inventor
Antoine Aneas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biodome SAS
Original Assignee
Biodome SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biodome SAS filed Critical Biodome SAS
Publication of EP1006981A1 publication Critical patent/EP1006981A1/de
Application granted granted Critical
Publication of EP1006981B1 publication Critical patent/EP1006981B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2086—Filtering means for fluid filtration

Definitions

  • the present invention relates generally the connection between, on one side a first container comprising a neck closed by a perforable plug visco-elastic, and on the other side a second container comprising a male end piece.
  • Such a device allows any relative movement uncontrolled, between the two containers during connection or connected, so that it is difficult to precisely control the amount of liquid medium or liquid, introduced into the first container or extracted from it, through the movement relative between the piston and the tubular body of the syringe (second container) for example.
  • the present invention therefore relates to a solution to better control movement relative between the first container and the second container, when connected, in particular to minimize and make dead volume constant, that is to say liquid which cannot be withdrawn from first container, after connection of the two containers.
  • the perforation means 5 comprises, as shown in Figure 1, a central or axial part 5b ending with a piercing end 5a, a collar 5c allowing the fixing of the perforation means on the piston defined below, in which an opening circumferential 5d is provided, and a female endpiece 6, extending the axial part 5b, and making it possible to ensure a tight junction with the male endpiece 4a of the second container (syringe).
  • a filtration chamber 7 is formed between a recess provided in the piston 15, defined below, and a filter 8, held tight between the collar 5c and a shoulder corresponding provided on the piston 15, and isolating said room compared to the outside.
  • Two channels 9 and 10, independent, are provided in the axial part 5b perforation means 5, to establish communication between the interior of the first container 2 and respectively the female end piece 6 and the filtration chamber 7, in the perforating or perforating position, shown in Figures 2 to 4 for example, in which the means 5 of perforation punctures plug 4, having passed through it completely by its piercing end 5a.
  • the displacement means 11 with guidance of the means of perforation 5 are formed by the cooperation of the tubular flange 12, providing an internal bore 12a, and of the piston 15 mounted in the internal bore 12a, on which is fixed or mounted the perforation means 5.
  • the flange 12 is obtained in a single piece with the attachment means 13, for example made of plastic, and as shown in figure 1 can extend towards the high, beyond the free end of the female end piece 6, to prevent accidental actuation of the piston by the user's fingers.
  • a capsule forming attachment means 13 susceptible to snap in relation to and under the annular rim 2b of the container 2, in contact with the neck 2a, and this thanks to a radial elasticity allowing it to recall the edge circumferential lower in centripetal position.
  • this attachment capsule 13 is constituted by a plurality of hooking teeth, together forming the capsule defined above, and each having the aforementioned radial elasticity.
  • the internal bore 12a leads to the plug 3, and more particularly its upper part accessible to the perforating end Sa perforation means 5.
  • Sealing means 14 of the internal bore 12a, with respect to the outside, and using the viscoelastic properties of the plug 3, are also built in one piece with the flange 12; these means consist in particular of a continuous circumference, relatively hard and penetrating at least partially into the material relatively soft plug 3.
  • the piston 15 has a transverse core 15a comprising a stepped orifice 15b allowing the passage of the axial part 5b of the perforation means 5, with axial retention of said means.
  • the perforation means 5 is also retained so waterproof by its collar 5c, on the shoulder defined by the removal of the filtration chamber 7. Being blocked in rotation relative to the flange 12 by the means defined below, the piston 15, mounted in the internal bore 12a, can slide by a simple push axial, from an inactivated position (see Figures 1 and 2) in which the piercing end 5a is away from the plug 3, and a perforating position (see Figures 3 and 4), in which the piercing end 5a has completely through the plug 3.
  • the locking means 19 at rotation of the piston 15 relative to the collar 12 are obtained by sparing, on the side of the collar 12 on its internal surface, eight grooves parallel to the axis of the device, distributed around the perimeter of said flange, and on the piston side eight ribs corresponding, not shown, likely to engage respectively in the aforementioned grooves.
  • the cap 21 is mounted on the flange 12, of sealingly, to contain the female end piece 6 and the other internal parts of the device, namely the piston 15 and the perforation means 5, in isolation relative to the outside, this by closing so sealing the internal part of the flange 12, opposite the cap 3.
  • This seal is obtained in particular thanks to a succession of circumferential lamellae 19a formed on the external surface of the collar 12, and on which the cap 21 is blocked.
  • sealing is meant sealing by relation at least to liquids, and allowing in particular to maintain sterility conditions at inside the connection device.
  • connection device is permanently fixed on the first container 2.
  • it incorporates means 22 for permanent locking of the device on the first container 2, blocking the hooking means 13 in their position attached to the neck 2a of the container 2.
  • These locking means consist in particular of a outer ring, built in one piece with the cap 21, but separated from the latter by a line weakening 30 allowing the cap to be separated from the connection device.
  • connection device 1 deduced from the representations Figures 2 to 4, explained with reference to the list of figures, and in the second paragraph of the present description.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Stackable Containers (AREA)
  • Quick-Acting Or Multi-Walled Pipe Joints (AREA)

Claims (7)

  1. Vorrichtung (1), um eine Verbindung zwischen einem ersten Gefäß (2) mit einem durch einen viskoelastischen, durchstechbaren Stopfen (3) verschlossenen Hals (2a) einerseits und einem zweiten Gefäß (4), das einen aktiven Anschluss (4a) umfasst, andererseits herzustellen, wobei die genannte Vorrichtung ein Mittel (5) zum Durchstechen des Stopfens aufweist, das auf der dem perforierenden Ende (5a) des genannten Perforationsmittels entgegengesetzten Seite zum einen einen passiven Anschluss (6) zum dichten Verbinden mit dem aktiven Anschluss (4a) des zweiten Gefäßes (4) und zum anderen eine durch einen Filter (8) nach außen hin abgetrennte Filterkammer (7) und zwei in das Perforationsmittel (5) eingebrachte, voneinander unabhängige Kanäle (9, 10) umfasst, um eine Verbindung zwischen dem Inneren des ersten Gefäßes (2) und dem passiven Anschluss (6) beziehungsweise der Filterkammer (7) herzustellen, und zwar in der Position, in der das Perforationsmittel (5) den Stopfen (3) durchstößt, wobei die genannte Vorrichtung des weiteren Verschiebemittel (11) mit einer Führung für das Perforationsmittel (5) aufweist, die zumindest aus einem Bund (12) mit einer Innenbohrung (12a), Mitteln (13) zum Aufsetzen vom Bund (12) auf den Hals (2a) des ersten Gefäßes (2) in eingehakter Position bestehen, in der die Innenbohrung (12a) in den Stopfen (3) mündet, mit Mitteln (14) zur Abdichtung der Innenbohrung (12a) nach außen hin, des weiteren einen Kolben (15) aufweist, auf dem das Perforationsmittel (5) befestigt ist, um durch einfachen Schub aus einer inaktiven Position, bei der das perforierende Ende (5a) vom Stopfen (3) entfernt ist, in eine perforierende Position gebracht zu werden, in der das perforierende Ende (5a) den Stopfen (3) durchstoßen hat, dadurch gekennzeichnet, dass die Vorrichtung außerdem Mittel (16) zum endgültigen Arretieren des Kolbens (15) in der perforierenden Position umfasst, die ein Klinkorgan (17) auf dem Kolben und ein zusätzliches Arretierungsorgan (18) auf dem Bund aufweisen, wobei das Klinkorgan eine Vielzahl von Zähnen (17) besitzt, die über den Umfang der Achse vom Kolben (15) verteilt und elastisch sind, um zentrifugal oder zentripetal zurückgeholt zu werden, und wobei das zusätzliche Arretierungsorgan aus einer ringförmigen Flanke (18) besteht, an der die genannten Zähne (17) blockiert werden.
  2. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Mittel (19) zum Blockieren der Drehbewegung zwischen Kolben (15) und Bund (12) eingebracht sind.
  3. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass das zweite Gefäß (4) eine Spritze und der passive Anschluss ein Kegel (4a) vom Typ "Luer-Lock" ist.
  4. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass der Filter (8) eine Porosität aufweist, die eine sterile Filtration jedes ihn durchströmenden Gas- oder Flüssigkeitsstroms gewährleistet.
  5. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass sie eine Kappe (21) aufweist, die auf den Bund (12) montiert ist, um den passiven Anschluss (6) aufzunehmen, der den dem Stopfen (3) gegenüberliegenden Teil vom Bund (12) dicht abschließen soll.
  6. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass sie Mittel (22) zum endgültigen Verriegeln auf dem ersten Gefäß (2) umfasst, die die Mittel zum Einhaken (13) in eingehakter Position auf dem Hals (2a) des Gefäßes arretieren.
  7. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass der passive Anschluss (6) einen Filter (20) enthält, der jede ihn durchströmende Flüssigkeit filtern soll.
EP97942082A 1996-09-25 1997-09-24 Verbindungsvorrichtung, insbesondere zwischen einem behälter mit durchstossbarem verschluss und einer spritze Expired - Lifetime EP1006981B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9611965 1996-09-25
FR9611965A FR2753624B1 (fr) 1996-09-25 1996-09-25 Dispositif de connexion, en particulier entre un recipient avec bouchon perforable et une seringue
PCT/FR1997/001676 WO1998013006A1 (fr) 1996-09-25 1997-09-24 Dispositif de connexion, en particulier entre un recipient avec bouchon perforable et une seringue

Publications (2)

Publication Number Publication Date
EP1006981A1 EP1006981A1 (de) 2000-06-14
EP1006981B1 true EP1006981B1 (de) 2001-11-14

Family

ID=9496248

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97942082A Expired - Lifetime EP1006981B1 (de) 1996-09-25 1997-09-24 Verbindungsvorrichtung, insbesondere zwischen einem behälter mit durchstossbarem verschluss und einer spritze

Country Status (14)

Country Link
US (1) US6070623A (de)
EP (1) EP1006981B1 (de)
JP (1) JP3340749B2 (de)
CN (1) CN1133411C (de)
AT (1) ATE208597T1 (de)
BR (1) BR9712102A (de)
CA (1) CA2263370C (de)
DE (1) DE69708333T2 (de)
DK (1) DK1006981T3 (de)
ES (1) ES2163196T3 (de)
FR (1) FR2753624B1 (de)
PT (1) PT1006981E (de)
RU (1) RU2190385C2 (de)
WO (1) WO1998013006A1 (de)

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US6070623A (en) 2000-06-06
FR2753624A1 (fr) 1998-03-27
ES2163196T3 (es) 2002-01-16
ATE208597T1 (de) 2001-11-15
DE69708333D1 (de) 2001-12-20
CN1133411C (zh) 2004-01-07
CN1237892A (zh) 1999-12-08
DK1006981T3 (da) 2002-03-25
RU2190385C2 (ru) 2002-10-10
JP2001505083A (ja) 2001-04-17
WO1998013006A1 (fr) 1998-04-02
CA2263370C (fr) 2004-01-20
AU723566B2 (en) 2000-08-31
AU4388597A (en) 1998-04-17
PT1006981E (pt) 2002-04-29
EP1006981A1 (de) 2000-06-14
FR2753624B1 (fr) 1999-04-16
CA2263370A1 (fr) 1998-04-02
DE69708333T2 (de) 2002-05-23
BR9712102A (pt) 1999-08-31
JP3340749B2 (ja) 2002-11-05

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