EP0868178A4 - Antagonistes de la gonadoliberine - Google Patents

Antagonistes de la gonadoliberine

Info

Publication number
EP0868178A4
EP0868178A4 EP96943763A EP96943763A EP0868178A4 EP 0868178 A4 EP0868178 A4 EP 0868178A4 EP 96943763 A EP96943763 A EP 96943763A EP 96943763 A EP96943763 A EP 96943763A EP 0868178 A4 EP0868178 A4 EP 0868178A4
Authority
EP
European Patent Office
Prior art keywords
antagonists
releasing hormone
gonadotropin releasing
gonadotropin
hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96943763A
Other languages
German (de)
English (en)
Other versions
EP0868178A1 (fr
Inventor
Mark Goulet
Robert L Bugianesi
Wallace T Ashton
Lin Chu
Michael H Fisher
Peter Lin
Roy G Smith
Mitree M Ponpipom
Matthew J Wyvratt
Yi Tien Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603370.9A external-priority patent/GB9603370D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0868178A1 publication Critical patent/EP0868178A1/fr
Publication of EP0868178A4 publication Critical patent/EP0868178A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
EP96943763A 1995-12-14 1996-12-10 Antagonistes de la gonadoliberine Withdrawn EP0868178A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US863295P 1995-12-14 1995-12-14
GBGB9603370.9A GB9603370D0 (en) 1996-02-16 1996-02-16 Antagonists of gonadotropin releasing hormone
GB9603370 1996-02-16
PCT/US1996/020004 WO1997021435A1 (fr) 1995-12-14 1996-12-10 Antagonistes de la gonadoliberine
US8632P 2007-12-21

Publications (2)

Publication Number Publication Date
EP0868178A1 EP0868178A1 (fr) 1998-10-07
EP0868178A4 true EP0868178A4 (fr) 2000-03-29

Family

ID=26308743

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96943763A Withdrawn EP0868178A4 (fr) 1995-12-14 1996-12-10 Antagonistes de la gonadoliberine

Country Status (5)

Country Link
EP (1) EP0868178A4 (fr)
JP (2) JP3092947B2 (fr)
AU (1) AU704937B2 (fr)
CA (1) CA2240115A1 (fr)
WO (1) WO1997021435A1 (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997021707A1 (fr) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonistes de la gonadoliberine
AU728988B2 (en) * 1997-06-05 2001-01-25 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
GB9718833D0 (en) * 1997-09-04 1997-11-12 Merck Sharp & Dohme Therapeutic agents
US6232322B1 (en) 1998-05-12 2001-05-15 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
CA2330557A1 (fr) * 1998-05-12 1999-11-18 Robert Emmett Mcdevitt Acides biphenyl-oxo-acetiques utiles dans le traitement de l'insulinoresistance et de l'hyperglycemie
US6346534B1 (en) 1998-09-23 2002-02-12 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
US6310081B1 (en) 1999-05-10 2001-10-30 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6537998B1 (en) 1999-10-15 2003-03-25 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
US6608197B2 (en) 2000-01-25 2003-08-19 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
GB0022670D0 (en) 2000-09-15 2000-11-01 Astrazeneca Ab Molecules
GB0031315D0 (en) * 2000-12-21 2001-02-07 Glaxo Group Ltd Indole derivatives
SE0100566D0 (sv) * 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
SE0101692D0 (sv) * 2001-05-14 2001-05-14 Astrazeneca Ab Compounds
AU2002324586B2 (en) 2001-08-02 2008-04-24 Neurocrine Biosciences, Inc. 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists
JP2005500352A (ja) 2001-08-02 2005-01-06 ニューロクライン バイオサイエンシーズ， インコーポレイテッド ゴナドトロピン放出ホルモンレセプター（ＧｎＲＨ）アンタゴニストとしての１，２，４−トリアジン−３，５−ジオン
EP1411945A1 (fr) 2001-08-02 2004-04-28 Neurocrine Biosciences, Inc. Pyridin-4-ones substituees et leur utilisation en tant qu'antagonistes du recepteur de l'hormone de liberation de la gonadotrophine
EP1412363A1 (fr) 2001-08-02 2004-04-28 Neurocrine Biosciences, Inc. Antagonistes du recepteur de l'hormone liberatrice de la gonadotropine
AU2002321878A1 (en) 2001-08-02 2003-02-17 Neurocrine Biosciences, Inc. Pyridinone and pyridazinone derivatives as gonadotropin-releasing hormone receptor antagonists
FR2833948B1 (fr) 2001-12-21 2004-02-06 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et leur utilisation en tant que medicament
AU2003202115A1 (en) 2002-02-12 2003-09-04 Pfizer Inc. Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh)
MXPA04012566A (es) 2002-06-13 2005-04-19 Pfizer Agentes no peptidicos reguladores de la gnrh, composiciones farmaceuticas y procedimientos para su uso.
TW200413351A (en) 2002-08-21 2004-08-01 Astrazeneca Ab Chemical compounds
DE60314158T2 (de) 2002-08-21 2008-01-31 Astrazeneca Ab Pyrazolderivate als gnrh-inhibitoren
DE60318716T2 (de) 2002-08-21 2009-01-08 Astrazeneca Ab Thieno-pyrrole verbindungen als antagonisten der gonadotropin-freisetzenden hormonrezeptoren
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
GB0219472D0 (en) * 2002-08-21 2002-10-02 Astrazeneca Ab Chemical compounds
CN101229165A (zh) 2003-07-07 2008-07-30 纽罗克里生物科学有限公司 作为促性激素释放激素受体拮抗剂的嘧啶-2,4-二酮衍生物
JP4673847B2 (ja) 2003-07-07 2011-04-20 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストおよびそれに関連する方法
EA010370B1 (ru) 2003-07-07 2008-08-29 Ньюрокрайн Байосайенсиз, Инк. Производные пиримидин-2,4-диона в качестве антагонистов рецептора гонадотропин-высвобождающего гормона
FR2860514A1 (fr) * 2003-10-03 2005-04-08 Sanofi Synthelabo Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
DE102004033902A1 (de) 2004-07-14 2006-02-16 Zentaris Gmbh Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
BRPI0719835A2 (pt) 2006-10-02 2014-05-06 Cortendo Invest Ab Enantiômero de cetoconazol em humanos
EP2095818A1 (fr) 2008-02-29 2009-09-02 AEterna Zentaris GmbH Utilisation d'antagonistes LHRH dans des doses n'impliquant pas de castration
TW201130854A (en) 2009-12-22 2011-09-16 Bayer Schering Pharma Ag Pyridinone derivatives and pharmaceutical compositions thereof
WO2012175514A1 (fr) 2011-06-21 2012-12-27 Bayer Intellectual Property Gmbh Dérivés de pyridinone et compositions pharmaceutiques les contenant
CA2958939A1 (fr) 2014-08-26 2016-03-03 Betanien Hospital Methodes, agents et compositions pour le traitement d'etats inflammatoires
CN105348168B (zh) * 2015-11-06 2018-04-10 厦门大学 1‑(2‑(金刚烷‑1‑基)‑1h‑吲哚‑5‑基)‑3‑取代脲衍生物及制备和用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2181559A1 (en) * 1972-04-28 1973-12-07 Aec Chimie Organique Bio N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity
EP0348341A2 (fr) * 1988-06-23 1989-12-27 Schering Aktiengesellschaft Aminoalkylindoles, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0679642A1 (fr) * 1994-04-28 1995-11-02 Takeda Chemical Industries, Ltd. Dérivés hétérocycliques condensés, leur préparation et utilisation
WO1997021707A1 (fr) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonistes de la gonadoliberine
WO1997021704A1 (fr) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonistes de l'hormone de liberation de la gonadotropine
WO1997021703A1 (fr) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonistes de l'hormone de liberaiton de la gonadotropine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070369A (en) * 1972-12-13 1978-01-24 Schering Corporation 2-Aminomethyl-5-chloro-3-(2,4-dichlorophenyl)indole
US4087444A (en) * 1976-09-08 1978-05-02 Eli Lilly And Company Amides as ovulation inhibitors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2181559A1 (en) * 1972-04-28 1973-12-07 Aec Chimie Organique Bio N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity
EP0348341A2 (fr) * 1988-06-23 1989-12-27 Schering Aktiengesellschaft Aminoalkylindoles, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0679642A1 (fr) * 1994-04-28 1995-11-02 Takeda Chemical Industries, Ltd. Dérivés hétérocycliques condensés, leur préparation et utilisation
WO1997021707A1 (fr) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonistes de la gonadoliberine
WO1997021704A1 (fr) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonistes de l'hormone de liberation de la gonadotropine
WO1997021703A1 (fr) * 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonistes de l'hormone de liberaiton de la gonadotropine

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; RAO, RAVINDRA PRATAP: "Synthesis of some Mannich bases from 2-phenylindole and 5-nitro 2-phenylindole", XP002126977, retrieved from STN Database accession no. 71:91198 *
GARRATT, PETER J. ET AL: "Mapping the Melatonin Receptor. 3. Design and Synthesis of Melatonin Agonists and Antagonists Derived from 2-Phenyltryptamines", J. MED. CHEM. (1995), 38(7), 1132-9, XP002126976 *
LABDEV, PART A (1969), 7(2), 99-100 *
See also references of WO9721435A1 *

Also Published As

Publication number Publication date
CA2240115A1 (fr) 1997-06-19
EP0868178A1 (fr) 1998-10-07
JPH11504040A (ja) 1999-04-06
WO1997021435A1 (fr) 1997-06-19
AU704937B2 (en) 1999-05-06
AU1291997A (en) 1997-07-03
JP3092947B2 (ja) 2000-09-25
JP2001039871A (ja) 2001-02-13

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