EP0901471A4 - Antagonistes de la gonadoliberine - Google Patents
Antagonistes de la gonadoliberineInfo
- Publication number
- EP0901471A4 EP0901471A4 EP97926600A EP97926600A EP0901471A4 EP 0901471 A4 EP0901471 A4 EP 0901471A4 EP 97926600 A EP97926600 A EP 97926600A EP 97926600 A EP97926600 A EP 97926600A EP 0901471 A4 EP0901471 A4 EP 0901471A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- antagonists
- releasing hormone
- gonadotropin releasing
- gonadotropin
- hormone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1715096P | 1996-05-20 | 1996-05-20 | |
US17150P | 1996-05-20 | ||
GB9612084 | 1996-06-10 | ||
GBGB9612084.5A GB9612084D0 (en) | 1996-06-10 | 1996-06-10 | Antagonists of gonadotropin releasing hormone |
PCT/US1997/008479 WO1997044321A1 (fr) | 1996-05-20 | 1997-05-16 | Antagonistes de la gonadoliberine |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0901471A1 EP0901471A1 (fr) | 1999-03-17 |
EP0901471A4 true EP0901471A4 (fr) | 1999-08-25 |
Family
ID=26309477
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97926600A Withdrawn EP0901471A4 (fr) | 1996-05-20 | 1997-05-16 | Antagonistes de la gonadoliberine |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0901471A4 (fr) |
JP (1) | JP2000511533A (fr) |
AU (1) | AU706818B2 (fr) |
CA (1) | CA2254768A1 (fr) |
WO (1) | WO1997044321A1 (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6037326A (en) * | 1996-12-31 | 2000-03-14 | Styczynski; Peter | Reduction of hair growth |
RU2199532C2 (ru) * | 1997-06-27 | 2003-02-27 | Фудзисава Фармасьютикал Ко., Лтд. | Сульфонамидное соединение |
TW436483B (en) * | 1997-08-19 | 2001-05-28 | Otsuka Pharma Co Ltd | Carbostyril derivatives, process for their preparation and pharmaceutical composition or cosmetic composition for inhibiting skin erythema and/or skin pigmentation |
US6346534B1 (en) | 1998-09-23 | 2002-02-12 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
US6537998B1 (en) | 1999-10-15 | 2003-03-25 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
US6608197B2 (en) | 2000-01-25 | 2003-08-19 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
CN1303072C (zh) * | 2000-08-31 | 2007-03-07 | 霍夫曼-拉罗奇有限公司 | 7-氧代吡啶并嘧啶 |
US6583153B2 (en) | 2000-12-12 | 2003-06-24 | Ortho-Mcneil Pharmaceutical, Inc. | 7-heterocyclyl quinoline and thieno[2,3-b]yridine derivatives useful as antagonists of gonadotropin releasing hormone |
EP1411945A1 (fr) | 2001-08-02 | 2004-04-28 | Neurocrine Biosciences, Inc. | Pyridin-4-ones substituees et leur utilisation en tant qu'antagonistes du recepteur de l'hormone de liberation de la gonadotrophine |
AU2002324586B2 (en) | 2001-08-02 | 2008-04-24 | Neurocrine Biosciences, Inc. | 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists |
AU2002321878A1 (en) | 2001-08-02 | 2003-02-17 | Neurocrine Biosciences, Inc. | Pyridinone and pyridazinone derivatives as gonadotropin-releasing hormone receptor antagonists |
EP1412363A1 (fr) | 2001-08-02 | 2004-04-28 | Neurocrine Biosciences, Inc. | Antagonistes du recepteur de l'hormone liberatrice de la gonadotropine |
JP2005500352A (ja) | 2001-08-02 | 2005-01-06 | ニューロクライン バイオサイエンシーズ, インコーポレイテッド | ゴナドトロピン放出ホルモンレセプター(GnRH)アンタゴニストとしての1,2,4−トリアジン−3,5−ジオン |
GB0307777D0 (en) | 2003-04-04 | 2003-05-07 | Medical Res Council | Conjugate compounds |
WO2005049593A2 (fr) * | 2003-11-13 | 2005-06-02 | Abbott Laboratories | Promoteurs de l'apoptose contenant n-acylsulfonamide |
WO2007112347A1 (fr) * | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Inhibiteurs de la dipeptidyl peptidase |
TW201130854A (en) | 2009-12-22 | 2011-09-16 | Bayer Schering Pharma Ag | Pyridinone derivatives and pharmaceutical compositions thereof |
WO2012175514A1 (fr) | 2011-06-21 | 2012-12-27 | Bayer Intellectual Property Gmbh | Dérivés de pyridinone et compositions pharmaceutiques les contenant |
CA2958939A1 (fr) | 2014-08-26 | 2016-03-03 | Betanien Hospital | Methodes, agents et compositions pour le traitement d'etats inflammatoires |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993011115A2 (fr) * | 1991-11-29 | 1993-06-10 | Merck Sharp & Dohme Limited | Derives de quinolone et leur utilisation comme antagonistes des recepteurs de nmda et ampa |
WO1995003289A1 (fr) * | 1993-07-26 | 1995-02-02 | Merck & Co., Inc. | Lactames benzofuses promoteurs de la secretion de l'hormone de croissance |
WO1997044339A1 (fr) * | 1996-05-20 | 1997-11-27 | Merck & Co., Inc. | Antagonistes de la gonadoliberine |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3178434A (en) * | 1965-04-13 | Substituted x-amino-carbostyrils | ||
GB9022785D0 (en) * | 1990-10-19 | 1990-12-05 | Merck Sharp & Dohme | Therapeutic agents |
-
1997
- 1997-05-16 CA CA002254768A patent/CA2254768A1/fr not_active Abandoned
- 1997-05-16 AU AU31322/97A patent/AU706818B2/en not_active Ceased
- 1997-05-16 WO PCT/US1997/008479 patent/WO1997044321A1/fr not_active Application Discontinuation
- 1997-05-16 JP JP09542632A patent/JP2000511533A/ja active Pending
- 1997-05-16 EP EP97926600A patent/EP0901471A4/fr not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993011115A2 (fr) * | 1991-11-29 | 1993-06-10 | Merck Sharp & Dohme Limited | Derives de quinolone et leur utilisation comme antagonistes des recepteurs de nmda et ampa |
WO1995003289A1 (fr) * | 1993-07-26 | 1995-02-02 | Merck & Co., Inc. | Lactames benzofuses promoteurs de la secretion de l'hormone de croissance |
WO1997044339A1 (fr) * | 1996-05-20 | 1997-11-27 | Merck & Co., Inc. | Antagonistes de la gonadoliberine |
Non-Patent Citations (5)
Title |
---|
CARLING, ROBERT W. ET AL: "4-Substituted-3-phenylquinolin-2(1H)-ones: Acidic and Nonacidic Glycine Site N-Methyl-D-aspartate Antagonists with in Vivo Activity", J. MED. CHEM. (1997), 40(5), 754-765 CODEN: JMCMAR;ISSN: 0022-2623, XP002105399 * |
CHEMICAL ABSTRACTS 8TH COLLECTIVE FORMULA INDEX., COLUMBUS US, XP002105400 * |
CHEMICAL ABSTRACTS, vol. 73, no. 15, 12 October 1970, Columbus, Ohio, US; abstract no. 77020w, NISHIMURA, HARUKI ET AL: "Synthesis of 4-hydroxy-2(1H)-quinolone derivatives" XP002105401 * |
See also references of WO9744321A1 * |
YAKUGAKU ZASSHI (1970), 90(7), 818-28 CODEN: YKKZAJ * |
Also Published As
Publication number | Publication date |
---|---|
AU3132297A (en) | 1997-12-09 |
AU706818B2 (en) | 1999-06-24 |
JP2000511533A (ja) | 2000-09-05 |
WO1997044321A1 (fr) | 1997-11-27 |
EP0901471A1 (fr) | 1999-03-17 |
CA2254768A1 (fr) | 1997-11-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19981221 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 6C 07D 215/227 A, 6C 07D 401/12 B, 6A 61K 31/47 B, 6A 61K 31/55 B, 6C 07D 401/06 B, 6C 07D 413/12 B, 6C 07D 215/22 B, 6C 07D 215/46 B, 6C 07D 215/36 B, 6C 07D 453/02 B |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19990713 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
17Q | First examination report despatched |
Effective date: 20000721 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20010201 |