EP0716592A1 - Compositions contre les impuretes de la peau et les formes legeres d'acne contenant de l'acide lanolique ou des composants d'acide lanolique comme principe actif - Google Patents

Compositions contre les impuretes de la peau et les formes legeres d'acne contenant de l'acide lanolique ou des composants d'acide lanolique comme principe actif

Info

Publication number
EP0716592A1
EP0716592A1 EP94924207A EP94924207A EP0716592A1 EP 0716592 A1 EP0716592 A1 EP 0716592A1 EP 94924207 A EP94924207 A EP 94924207A EP 94924207 A EP94924207 A EP 94924207A EP 0716592 A1 EP0716592 A1 EP 0716592A1
Authority
EP
European Patent Office
Prior art keywords
wool wax
wax acid
acids
acid mixtures
acne
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94924207A
Other languages
German (de)
English (en)
Inventor
Sven Gohla
Manfred Klier
Florian Wolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP0716592A1 publication Critical patent/EP0716592A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/0229—Sticks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Definitions

  • the present invention relates to active substances and preparations containing active substances which are effective against impure skin and mild forms of acne.
  • bacterial secondary infections are of etiological importance in addition to other influences.
  • One of the main microorganisms associated with blemished skin is Propionibacterium acnes.
  • Impure skin and / or comedones affect the well-being of those affected, even in mild cases. Since practically everyone or every adolescent is affected by impure skin of any kind, there is a need for many people to remedy this condition.
  • Wool wax or wool fat is the fat-to-wax-like component of raw sheep's wool that arises during raw wool washing.
  • the wool wax consists of a mixture of fatty acid esters of higher alcohols and free fatty acids.
  • the main components of wool wax acids are:
  • N usually takes values from 7 - 31.
  • Representative compositions of the wool wax acids are described, for example, in "Perfumery and Cosmetics", 59th year, No. 12/78, pages 429, 430 and in the "Lexicon of auxiliaries for pharmacy, cosmetics and adjacent areas" by HPFiedler, 1989 , 3rd edition, Editio Cantor Aulendorf.
  • EP-A-273 202 describes that certain ⁇ -hydroxycarboxylic acids are to be used as an agent enhancing the effect of antimicrobial agents in the treatment of acne.
  • the person skilled in the art could not assume that the use of wool wax acid mixtures according to the invention with the parameters described in the claims themselves would lead to preparations which are effective against impure skin or against Propionibacterium acnes and would have considerable advantages over the prior art.
  • Raw wool wax acids are not suitable for cosmetic purposes; instead, distilled wool wax acids are usually used. This fact and corresponding processes for refining the raw wool wax acids are known to the person skilled in the art.
  • Wool wax acids typically consist of approx. 60% saturated, unsubstituted carboxylic acids, approx. 30% ⁇ -hydroxycarboxylic acids and approx. 5% ⁇ -hydroxycarboxylic acids, the rest of approx. 5% being essentially formed by the other aforementioned carboxylic acid types .
  • the wool wax acids according to the invention are advantageously characterized by the following characteristic parameters:
  • n represents a number from 7 to 31
  • cx-hydroxycarboxylic acids which are C lf bodies and which therefore carry a branched or unbranched C-.H chain on the ⁇ -carbon atom. It is also advantageous to use wool wax acid mixtures in which the content of o-hydroxycarboxylic acids is 20-30% by weight, based on the total composition.
  • one or more are used as wool wax acid components
  • n assumes values from 7 to 31, used in combination with other active ingredients (substitute ingredients), auxiliaries, blends and / or additives customary in cosmetics.
  • blends and / or replacement active ingredients are then advantageously present in a concentration of up to 50 parts by weight, preferably up to 35 parts by weight, based on 100 parts by weight of the total amount, which is the sum of the Wool wax acid components and these substitutes and / or blends.
  • the cosmetic preparations according to the invention against impure skin or against mild forms of acne are particularly advantageously characterized in that the wool wax acids or the wool wax acid components in concentrations of 0.05-10.00% by weight, preferably 0.1 5.0% by weight are present, in each case based on the total weight of the preparations.
  • one or more wool wax acids or wool wax acid components in particular one or more wool wax acids or wool wax acid components, in particular
  • n represents a number from 7 to 31
  • the preparations according to the invention which are effective against impure skin or mild forms of acne can be in the form of liquid which can be applied by means of brushes or scrapers or roll-on devices Compositions, as sticks and in the form of W / O or O / W emulsions which can be applied from normal bottles and containers, for example creams or lotions.
  • the preparations according to the invention which are effective against impure skin can advantageously be present in the form of facial tonics, tinctures or cleaning formulations.
  • oleic acid decyl ester oleic acid decyl ester
  • cetyl alcohol cetylstearyl alcohol
  • 2-octyldodecanol skin-caring fatty or fat-like substances
  • skin-caring fatty or fat-like substances such as oleic acid decyl ester, cetyl alcohol, cetylstearyl alcohol and 2-octyldodecanol
  • skin-caring fatty or fat-like substances such as oleic acid decyl ester, cetyl alcohol, cetylstearyl alcohol and 2-octyldodecanol
  • such preparations are used in the usual proportions as well as slime-forming substances and thickeners, for example Hydroxyethyl or hydroxypropyl cellulose, polyacrylic acid, polyvinylpyrrolidone, but also in small quantities cyclic silicone oils (polydimethylsiloxanes) and liquid polymethylphenylsiloxa
  • emulsifiers for the production of the preparations according to the invention against impure skin or against mild forms of acne which are advantageously to be applied as liquid preparations to the desired skin areas, advantageously by means of a cotton swab, and which are less in the preparations
  • Amount e.g. 2 to 5% by weight, based on the total composition
  • non-ionic types such as polyoxyethylene fatty alcohol ethers, e.g. Cetostearyl alcohol polyethylene glycol ether with 12 or 20 attached ethylene oxide units per molecule, cetostearyl alcohol and sorbitan esters and sorbitan ester-ethylene oxide compounds (e.g.
  • Sorbitan monostearate and po- lyoxyethylene sorbitan monostearate) and long-chain higher molecular wax-like polyglycol ethers have been found to be suitable.
  • BHT butylated hydroxytoluene
  • the pH of the preparations according to the invention which are effective against impure skin or against mild forms of acne, is advantageously adjusted in the slightly acidic to neutral range, preferably from 4.0 to 7.0, particularly preferably from 5.0 to 6.5.
  • the amounts of carrier substances to be used can easily be determined by a person skilled in the art by simply trying them out.
  • the preparations according to the invention are prepared with the exception of special preparations which. are noted separately in the examples, in the usual way, mostly by simple mixing with stirring, optionally with gentle heating. It has no difficulties.
  • the fat phase and the water phase are, for example, prepared separately, optionally with heating, and then emulsified. Otherwise, the usual measures for the composition of pharmaceutical formulations, which are known to the person skilled in the art, must be observed.
  • WWS means a wool wax acid fraction which was obtained from raw wool wax acid by short-path distillation at 10 ⁇ bar from the distillation temperature interval of 150-200 ° C.
  • the proportion of o * -hydroxycarboxylic acids is about 22 - 27%
  • the constituents mentioned under (a) are dispersed, water (c) is added, swelled at room temperature, a solution of the constituents mentioned under (b) is added after about 15 minutes. The resulting mixture is homogenized and can be filled.
  • the constituents mentioned under (a) are dispersed, water (c) is added, swelled at room temperature, a solution of the constituents mentioned under (b) is added after about 15 minutes. The resulting mixture is homogenized and can be filled.
  • Facial lotions corresponding to the formulations according to Examples 6 and 7 were tested for their antimicrobial effectiveness. A solution of 10% ethanol and 90% water was used as a control.
  • a mixture of AC medium, 3% tween, 0.3% lecithin, 0.1% histidine was used as the disinhibiting medium.
  • propionibacteria were grown under aerobic conditions up to a germ count of 10 germs / ml. A suspension test was then carried out over a period of 1 hour with the germ suspension thus obtained. Then aliquots of the incubation batches were diluted with ten times the amount of disinhibiting medium and plated out on solid nutrient media. After seven days of incubation under anaerobic conditions, the test was evaluated numerically.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)

Abstract

On utilise des mélanges d'acides lanoliques naturels ou des mélanges d'acides lanoliques préparés par distillation comme principe actif pour le traitement d'impuretés de la peau, de formes légères d'acné et de l'acné due au Propionibacterium acnes.
EP94924207A 1993-09-01 1994-08-23 Compositions contre les impuretes de la peau et les formes legeres d'acne contenant de l'acide lanolique ou des composants d'acide lanolique comme principe actif Withdrawn EP0716592A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4329379A DE4329379C1 (de) 1993-09-01 1993-09-01 Gegen unreine Haut und milde Formen der Akne wirksame Zubereitungen mit einem Gehalt an Wollwachssäuren
DE4329379 1993-09-01
PCT/DE1994/000979 WO1995006457A1 (fr) 1993-09-01 1994-08-23 Compositions contre les impuretes de la peau et les formes legeres d'acne contenant de l'acide lanolique ou des composants d'acide lanolique comme principe actif

Publications (1)

Publication Number Publication Date
EP0716592A1 true EP0716592A1 (fr) 1996-06-19

Family

ID=6496492

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94924207A Withdrawn EP0716592A1 (fr) 1993-09-01 1994-08-23 Compositions contre les impuretes de la peau et les formes legeres d'acne contenant de l'acide lanolique ou des composants d'acide lanolique comme principe actif

Country Status (4)

Country Link
EP (1) EP0716592A1 (fr)
JP (1) JPH09501937A (fr)
DE (1) DE4329379C1 (fr)
WO (1) WO1995006457A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0705604A2 (fr) * 1994-09-30 1996-04-10 Beiersdorf Aktiengesellschaft Compositions dermatologiques contenant un mélange d'acides de laine contre les superinfections
DE4436537A1 (de) * 1994-10-13 1996-04-18 Beiersdorf Ag Dermatologische Zubereitungen mit einem Gehalt an Fettsäuren und Fettsäureglyceriden gegen Superinfektionen
DE4436538A1 (de) * 1994-10-13 1996-04-18 Beiersdorf Ag Wirkstoffkombinationen zur Verwendung gegen Superinfektionen, enthaltend Wollwachssäuregemische und andere Fettsäuren
DE19611602C2 (de) * 1996-03-23 1998-07-16 Juergen Drespe Schellack-Glycerin-Emulgator und seine Verwendung
DE19832888A1 (de) * 1998-07-22 2000-01-27 Beiersdorf Ag Pflegende kosmetische und dermatologische Zubereitungen mit einem Gehalt an Fettsäuren
DE19919481A1 (de) 1999-04-29 2000-11-02 Beiersdorf Ag Stabile, gegen unreine Haut und gegen Akne wirksame Wirkstoffkombinationen mit einem Gehalt an grenzflächenaktiven Glucosederivaten und Hydroxycarbonsäuren
JP2001278764A (ja) * 2000-03-28 2001-10-10 Nof Corp 透明固形腋臭防止剤および製造方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5799M (fr) * 1966-03-22 1968-03-25
DE1955764B2 (de) * 1969-11-06 1973-07-12 Herstellung von wasser-in-oelemulsionen
DE2023786B2 (de) * 1970-05-15 1973-03-01 Wasser-in-oel-emulgatoren
LU62873A1 (fr) * 1971-03-29 1972-12-07
GB1510421A (en) * 1976-02-05 1978-05-10 Woolcombers Ltd Lanolin and more particularly to a process for the production of lanolin rendered hypoallergenic
JPS5341308A (en) * 1976-09-28 1978-04-14 Daiichi Kurooda Kemikaruzu Kk Method of purifying wool grease
FR2381558A1 (fr) * 1977-02-23 1978-09-22 Oreal Nouvelles emulsions du type " eau-dans-l'huile " ou " huile-dans-l'eau " et produits cosmetiques obtenus a l'aide de ces emulsions
US4454118A (en) * 1977-11-07 1984-06-12 Johnson Zelma M Method of treating psoriasis
DE3127639A1 (de) * 1980-07-12 1982-08-19 Pavel 6000 Frankfurt Kozak Creme fuer die behandlung von hautkrankheiten
IT8167096A0 (it) * 1981-01-26 1981-01-26 Unilever Nv Bastoncino cosmetico particolarmente per il trattamento dell acne
FR2514643B1 (fr) * 1981-10-20 1986-07-04 Oreal Lanolate de cuivre et compositions cosmetiques anti-acneiques le contenant
US4450175A (en) * 1982-09-23 1984-05-22 Warshaw Thelma G Method and compositions for treating acne
LU84491A1 (fr) * 1982-11-26 1984-06-13 Oreal Composition anti-acneique contenant en tant que compose actif un derive d'isothiazolo-(5,4b) pyridine one-3
FR2555571B1 (fr) * 1983-11-28 1986-11-28 Interna Rech Dermatolo Centre Derives du naphtalene, leur procede de preparation et leur application dans le domaine therapeutique
FR2604435B1 (fr) * 1986-09-30 1988-12-02 Oreal Peroxydes aromatiques insatures et leur utilisation en therapeutique et cosmetique
FR2604357B1 (fr) * 1986-09-30 1988-12-02 Oreal Composition pharmaceutique et cosmetique anti-acneique
AU618517B2 (en) * 1986-12-23 1992-01-02 Eugene J. Van Scott Additives enhancing topical actions of therapeutic agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9506457A1 *

Also Published As

Publication number Publication date
JPH09501937A (ja) 1997-02-25
DE4329379C1 (de) 1995-02-16
WO1995006457A1 (fr) 1995-03-09

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