EP0684838A1 - Compositions de vaccin contre la grippe, contenant un lipide a de monophosphoryle desacyle en position 3-o - Google Patents
Compositions de vaccin contre la grippe, contenant un lipide a de monophosphoryle desacyle en position 3-oInfo
- Publication number
- EP0684838A1 EP0684838A1 EP94908327A EP94908327A EP0684838A1 EP 0684838 A1 EP0684838 A1 EP 0684838A1 EP 94908327 A EP94908327 A EP 94908327A EP 94908327 A EP94908327 A EP 94908327A EP 0684838 A1 EP0684838 A1 EP 0684838A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- mpl
- vaccine composition
- composition according
- protein
- vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention se rapporte à des compositions de vaccins susceptibles de renforcer une réaction protectrice par rapport à un antigène de la grippe choisi, la composition contenant au moins cet antigène et le lipide A de monophosphoryle désacylé en position 3-O (3D-MPL). Des procédés de renforcement de la réponse immunitaire à la grippe à l'aide de ces compositions sont également décrits.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2153593A | 1993-02-19 | 1993-02-19 | |
US21535 | 1993-02-19 | ||
US11575093A | 1993-09-01 | 1993-09-01 | |
US115570 | 1993-09-01 | ||
PCT/EP1994/000448 WO1994019013A1 (fr) | 1993-02-19 | 1994-02-15 | Compositions de vaccin contre la grippe, contenant un lipide a de monophosphoryle desacyle en position 3-o |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0684838A1 true EP0684838A1 (fr) | 1995-12-06 |
Family
ID=26694802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94908327A Withdrawn EP0684838A1 (fr) | 1993-02-19 | 1994-02-15 | Compositions de vaccin contre la grippe, contenant un lipide a de monophosphoryle desacyle en position 3-o |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0684838A1 (fr) |
AP (1) | AP431A (fr) |
AU (1) | AU6141094A (fr) |
CA (1) | CA2156525A1 (fr) |
IL (1) | IL108681A0 (fr) |
MA (1) | MA23118A1 (fr) |
MX (1) | MX9401225A (fr) |
SI (1) | SI9400085A (fr) |
WO (1) | WO1994019013A1 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9105992D0 (en) * | 1991-03-21 | 1991-05-08 | Smithkline Beecham Biolog | Vaccine |
DE69405551T3 (de) * | 1993-03-23 | 2005-10-20 | Smithkline Beecham Biologicals S.A. | 3-0-deazylierte monophosphoryl lipid a enthaltende impfstoff-zusammensetzungen |
UA56132C2 (uk) * | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
US6306404B1 (en) | 1998-07-14 | 2001-10-23 | American Cyanamid Company | Adjuvant and vaccine compositions containing monophosphoryl lipid A |
GB9820525D0 (en) * | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
US6261573B1 (en) * | 1998-10-30 | 2001-07-17 | Avant Immunotherapeutics, Inc. | Immunoadjuvants |
AT407958B (de) * | 1999-02-11 | 2001-07-25 | Immuno Ag | Inaktivierte influenza-virus-vakzine zur nasalen oder oralen applikation |
US6635261B2 (en) | 1999-07-13 | 2003-10-21 | Wyeth Holdings Corporation | Adjuvant and vaccine compositions containing monophosphoryl lipid A |
GB9923176D0 (en) * | 1999-09-30 | 1999-12-01 | Smithkline Beecham Biolog | Novel composition |
AR032575A1 (es) * | 2001-02-23 | 2003-11-12 | Smithkline Beecham Biolog | Uso de una preparacion antigenica de gripe para la fabricacion de una vacuna intradermica de la gripe y estuche farmaceutico que comprende dicha vacuna |
DE60239594D1 (de) * | 2001-02-23 | 2011-05-12 | Glaxosmithkline Biolog Sa | Influenza vakzinzusammensetzungen zur intradermaler verabreichung |
EP1381344A4 (fr) * | 2001-04-27 | 2008-06-11 | Glaxosmithkline Biolog Sa | Nouveau vaccin |
CA2890962A1 (fr) | 2004-09-09 | 2006-03-16 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | Reduction de risques iatrogenes potentiels associes aux vaccins contre la grippe |
AU2005314563B2 (en) | 2004-11-03 | 2011-06-30 | Seqirus UK Limited | Influenza vaccination |
PE20061428A1 (es) | 2005-03-23 | 2007-01-16 | Glaxosmithkline Biolog Sa | Formulacion de vacuna que comprende un adyuvante de emulsion aceite en agua y 3d-mpl |
MX2009000660A (es) | 2006-07-17 | 2009-04-08 | Glaxosmithkline Biolog Sa | Vacuna de influenza. |
WO2008134830A1 (fr) * | 2007-03-22 | 2008-11-13 | Fundação Butantan | Procédé pour obtenir le lipide monophosphorylé a à partir de bordetella pertussis comme sous-produit de la production du vaccin cellulaire anti-coquelucheux |
US9452209B2 (en) | 2007-04-20 | 2016-09-27 | Glaxosmithkline Biologicals Sa | Influenza vaccine |
JP5518041B2 (ja) * | 2008-03-18 | 2014-06-11 | ノバルティス アーゲー | インフルエンザウイルスワクチン抗原の調製における改良 |
AU2011300402B2 (en) | 2010-09-07 | 2015-01-22 | Novartis Ag | Generic assays for detection of mammalian reovirus |
CN106535929A (zh) * | 2014-03-25 | 2017-03-22 | 美国政府陆军部 | 增强铝盐吸附疫苗的免疫刺激效力的方法 |
WO2020010394A1 (fr) * | 2018-07-10 | 2020-01-16 | Seqirus Pty Ltd | Élimination d'agglomérats |
CN112361796A (zh) * | 2020-11-13 | 2021-02-12 | 安徽省天长市周氏羊业有限公司 | 一种秸秆回收储存前破碎干燥装置 |
CN114989269B (zh) * | 2022-06-30 | 2023-09-19 | 天康制药股份有限公司 | 一种牛赤羽免疫原性抗原及疫苗 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5230899A (en) * | 1985-08-07 | 1993-07-27 | Smithkline Beecham Corporation | Methods and compositions for making liposomes |
IL79114A (en) * | 1985-08-07 | 1990-09-17 | Allergan Pharma | Method and composition for making liposomes |
US4912094B1 (en) * | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
AU631377B2 (en) * | 1988-08-25 | 1992-11-26 | Liposome Company, Inc., The | Affinity associated vaccine |
AU640348B2 (en) * | 1988-08-31 | 1993-08-26 | Smithkline Beecham Corporation | Vaccinal Polypeptides |
DK425789A (da) * | 1988-08-31 | 1990-03-01 | Smithkline Beecham Corp | Vaccinale polypeptider |
KR100194079B1 (ko) * | 1990-09-28 | 1999-06-15 | 장 스테판느 | Hiv 감염 예방 또는 치료용 제약학적 조성물 및 이의 제조방법 |
WO1992011291A1 (fr) * | 1990-12-20 | 1992-07-09 | Smithkline Beecham Biologicals (S.A.) | VACCINS A BASE DE l'ANTIGENE D'ENVELOPPE DU VIRUS DE L'HEPATITE B |
FR2671974A1 (fr) * | 1991-01-24 | 1992-07-31 | Pasteur Merieux Serums Vacc | Composition vaccinale contre la grippe, a effet synergique, contenant comme additif du core de virus grippal. |
GB9105992D0 (en) * | 1991-03-21 | 1991-05-08 | Smithkline Beecham Biolog | Vaccine |
HU219808B (hu) * | 1992-06-25 | 2001-08-28 | Smithkline Beecham Biologicals S.A. | Adjuvánst tartalmazó vakcinakompozíció és eljárás annak előállítására |
-
1994
- 1994-02-15 AU AU61410/94A patent/AU6141094A/en not_active Abandoned
- 1994-02-15 EP EP94908327A patent/EP0684838A1/fr not_active Withdrawn
- 1994-02-15 CA CA002156525A patent/CA2156525A1/fr not_active Abandoned
- 1994-02-15 WO PCT/EP1994/000448 patent/WO1994019013A1/fr not_active Application Discontinuation
- 1994-02-17 IL IL10868194A patent/IL108681A0/xx unknown
- 1994-02-17 MX MX9401225A patent/MX9401225A/es unknown
- 1994-02-17 MA MA23425A patent/MA23118A1/fr unknown
- 1994-02-17 AP APAP/P/1994/000621A patent/AP431A/en active
- 1994-02-18 SI SI9400085A patent/SI9400085A/sl unknown
Non-Patent Citations (1)
Title |
---|
See references of WO9419013A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU6141094A (en) | 1994-09-14 |
IL108681A0 (en) | 1994-05-30 |
SI9400085A (en) | 1994-09-30 |
WO1994019013A1 (fr) | 1994-09-01 |
AP431A (en) | 1995-11-15 |
MX9401225A (es) | 1994-08-31 |
AP9400621A0 (en) | 1994-04-30 |
CA2156525A1 (fr) | 1994-09-01 |
MA23118A1 (fr) | 1994-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19950731 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19980901 |