Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
  • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/0216—Solid or semisolid forms
  • A61K8/0229—Sticks
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/04—Dispersions; Emulsions
  • A61K8/042—Gels
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/345—Alcohols containing more than one hydroxy group
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/347—Phenols
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q15/00—Anti-perspirants or body deodorants
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D9/00—Compositions of detergents based essentially on soap
  • C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
  • C11D9/22—Organic compounds, e.g. vitamins
  • C11D9/26—Organic compounds, e.g. vitamins containing oxygen
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D9/00—Compositions of detergents based essentially on soap
  • C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
  • C11D9/22—Organic compounds, e.g. vitamins
  • C11D9/26—Organic compounds, e.g. vitamins containing oxygen
  • C11D9/262—Organic compounds, e.g. vitamins containing oxygen containing carbohydrates
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D9/00—Compositions of detergents based essentially on soap
  • C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
  • C11D9/22—Organic compounds, e.g. vitamins
  • C11D9/26—Organic compounds, e.g. vitamins containing oxygen
  • C11D9/265—Organic compounds, e.g. vitamins containing oxygen containing glycerol

Definitions

• the invention relates to a shaped preparation for the use of cosmetic and pharmaceutical active ingredients, in particular in stick form, based on a soap gel which, because of its composition at normal temperature, has very good dimensional stability and good abrasion properties and is largely free of lower alcohols .
• Soap gels have long been known as carriers for topical cosmetic and pharmaceutical active ingredients.
• Sodium stearate gels in aqueous lower alcohols and glycols are usually used as be ⁇ fen.
• such gels have the disadvantage that they are usually too stiff and, when used on the skin, give off very little product to the skin.
• US Pat. No. 2,900,306 it had already been proposed according to US Pat. No. 2,900,306 to add a water-soluble myristic acid soap to the preparation.
• the addition of fatty acid esters and ethylene oxide and propylene oxide condensation products had already been recommended to improve the gel time, reduce syneresis and stickiness (US Pat. No. 4,617,185).
• Such additives are sometimes disadvantageous in terms of transparency.
• the object was therefore to find a shaped soap gel preparation which has both good transparency, good dimensional stability and a satisfactory release upon contact with the skin.
• this object was achieved by a soap gel preparation for the topical application of cosmetic and pharmaceutical active ingredients based on a gel containing alkali soaps 3 - 10 wt .-% of a mixture of fatty acids with 16 - 22 carbon atoms in the form of their alkali soaps
• the proportion of soaps of branched-chain fatty acids according to the invention ensures that the preparations retain good strength in the temperature range below 35 ° C., but melt immediately on contact with the skin and become slippery, so that a thin film of the preparation easily forms spread on the skin.
• Suitable linear saturated fatty acids are palmitic acid, stearic acid, arachinic acid and behenic acid or technical mixtures which predominantly consist of such fatty acids, e.g. B. hardened palm oil fatty acid or hardened tallow fatty acid. Stearic acid is preferably used.
• branched saturated fatty acids examples include 2-hexyl-decanoic acid, 2-0ctyl-dodecanoic acid or other branched fatty acids with 16-22 carbon atoms.
• isostearic acid is preferably suitable.
• Isostearic acid is primarily understood to be a mixture of liquid, branched chain isomers of stearic acid which is accessible by hydrogenation of the isomeric, liquid monomeric fatty acids which are obtained as a by-product in the diraerization of unsaturated fatty acids.
• This isostearic acid and further branched fatty acids are described in J.Am.Oil Chem. Soc. November 1979 (Vol 56), pages 823A-827A. So it is a mixture whose main components are methyl branched isomers.
• Isostearic acid is a commercial product and is offered, for example, under the name E ersol 875 (Henkel Corp.).
• the mixture of linear and branched fatty acids is present entirely or predominantly as an alkali salt (alkali soap), preferably as a sodium soap.
• alkali soap preferably as a sodium soap.
• the quantitative ratio of linear to branched fatty acids in the fatty acid mixture to be used according to the invention influences the strength of the soap gel preparation and the abrasion behavior. With increasing proportion of isostearic acid, the firmness decreases and the release to the skin increases. But these parameters are also influenced by the total content of fatty acids in the gel.
• the fatty acid mixture is preferably used in an amount of 5-8% by weight.
• the fatty acid mixture preferably consists of 80-95% by weight of stearic acid and 5-20% by weight of branched saturated fatty acids.
• polyols with 3-6 carbon atoms and 2-6 hydroxyl groups e.g. Ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, glycerin, erythritol, pentaerythritol, trimethylolpropane, sorbitol, anhydrosorbitol, cyclohexanetriol, inositol ⁇ be set.
• Propylene glycols and glycerol alone or mixtures of these polyols with sorbitol and / or butylene glycol are preferred.
• polyols are preferably contained in a total amount of 70-90% by weight of the soap gel preparation. Particularly favorable application properties are obtained if mixtures of 10-80% by weight glycerol, 10-80% by weight propylene glycol and 5-20% by weight sorbitol and / or 1,4-butylene glycol are contained as polyols .
• a particularly stable, transparent soap gel preparation with good release properties to the skin contains:
• the soap gel preparations according to the invention serve the topical application of cosmetic and pharmaceutical active ingredients.
• active ingredients are incorporated into the soap gel preparation depending on the dosage required for the particular application.
• cosmetic active ingredients e.g. antimicrobial, deodorant, skin moisturizing, antiperspirant, depilating, coloring and fragrant substances as well as cosmetic oils.
• pharmaceutical active ingredients e.g. To understand antibiotics, corticosteroids, local anesthetics, and other active substances that are used against skin diseases.
• the amount of cosmetic or pharmaceutical active ingredients will generally be in the order of 0.1-5% by weight of the preparation, preferably in a range of 0.1-1% by weight of the preparation.
• a particularly preferred area of application for the soap gel preparations according to the invention is that of deodorant sticks.
• such products contain deodorising substances as cosmetic active ingredients.
• Suitable deodorant active ingredients are, for example, antimicrobial substances such as, for example, 2 f 4,4 * trichloro-2'-hydroxydiphenyl ether (Irgasan DP300), chlorohexidine digluco ⁇ at or phenoxyethanol, deodorant, antimicrobial essential oils, farnesol, lipase-curing substances such as triethyl citrate or Triacetin, astringent substances such as As sodium aluminum chlorohydroxyl and other known body deodorants or antiperspirant.
• antimicrobial substances such as, for example, 2 f 4,4 * trichloro-2'-hydroxydiphenyl ether (Irgasan DP300), chlorohexidine digluco ⁇ at or phenoxyethanol, deodorant, antimicrobial essential oils, farnesol, lipase-curing substances
• the invention may preparations contain further auxiliaries, which are conducive to improving the off ⁇ unawares and storage stability.
• auxiliaries are, for example complexing agents, Antioxida ⁇ tien, preservatives, fragrances, coloring ⁇ agents, opacifiers, pearlescent or finely divided fumed Kie ⁇ selklare. It has also been shown that turbidity and crystallization phenomena during storage can be prevented by adding a water-soluble salt, preferably sodium chloride, as a further auxiliary. in an amount of approximately 0.1 to 0.3% by weight, based on the preparation of soap gel. Overall, the amount of these auxiliaries should not make up more than 5% by weight of the soap gel preparation; such auxiliaries are preferably present in a total amount of about 1-3% by weight in the preparation.
• the soap gel preparations according to the invention are preferably free of lower alcohols. However, it is optionally possible to use up to 10% by weight of lower alcohols, such as. B. incorporate ethanol or isopropanol into the preparations.
• the soap gel preparations according to the invention are expediently carried out by mixing polyols, water and fatty acid mixtures in a container with heating to about 50-90 ° C., this mixture the alkali metal hydroxide in the form of a concentrated aqueous solution adds and moves the mass until the saponification of the fatty acids with formation of a clear solution is complete. Then the active ingredients and auxiliaries can be mixed in one after the other while cooling. Finally, the mass is converted into a mold, e.g. poured into a pencil sleeve and allowed to cool there to a temperature at which the mass solidifies to form a stable gel.
• a mold e.g. poured into a pencil sleeve and allowed to cool there to a temperature at which the mass solidifies to form a stable gel.
• Soap gel preparations of the composition given in Table I were prepared in the following way:

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Veterinary Medicine (AREA)
• Public Health (AREA)
• General Health & Medical Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• Emergency Medicine (AREA)
• Epidemiology (AREA)
• Birds (AREA)
• Organic Chemistry (AREA)
• Wood Science & Technology (AREA)
• Oil, Petroleum & Natural Gas (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Engineering & Computer Science (AREA)
• Molecular Biology (AREA)
• Dispersion Chemistry (AREA)
• Medicinal Chemistry (AREA)
• Pharmacology & Pharmacy (AREA)
• Cosmetics (AREA)
• Detergent Compositions (AREA)
• Medicinal Preparation (AREA)

Applications Claiming Priority (2)

Publications (1)

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• 1991
  • 1991-03-09 DE DE19914107712 patent/DE4107712A1/de not_active Withdrawn
• 1992
  • 1992-03-02 JP JP4504963A patent/JPH06505245A/ja active Pending
  • 1992-03-02 EP EP19920905575 patent/EP0575373A1/de not_active Withdrawn
  • 1992-03-02 CA CA002105873A patent/CA2105873A1/en not_active Abandoned
  • 1992-03-02 WO PCT/EP1992/000456 patent/WO1992015280A1/de not_active Application Discontinuation
  • 1992-03-02 HU HU9302548A patent/HUT65716A/hu unknown
• 1993
  • 1993-09-06 FI FI933892A patent/FI933892A0/fi not_active Application Discontinuation

Non-Patent Citations (1)

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