EP0525740B1 - Stevia extract-containing liquid internal medicine and method of preparing the same - Google Patents
Stevia extract-containing liquid internal medicine and method of preparing the same Download PDFInfo
- Publication number
- EP0525740B1 EP0525740B1 EP92112929A EP92112929A EP0525740B1 EP 0525740 B1 EP0525740 B1 EP 0525740B1 EP 92112929 A EP92112929 A EP 92112929A EP 92112929 A EP92112929 A EP 92112929A EP 0525740 B1 EP0525740 B1 EP 0525740B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- liquid
- stevia
- internal medicine
- stems
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Definitions
- the present invention relates to a liquid internal medicine which is prepared from a raw material of an extract of Stevia stems, and to a method of preparing the same. More precisely, it relates to a liquid internal medicine which is obtained by fermenting an extract from Stevia stems and is especially effective to disorders of digestive organs, and also to a method of preparing such a liquid internal medicine.
- the present inventor further researched the above-mentioned inventions and developed them, whereupon he has found that a substance obtained by concentrating, fermenting and ripening a Stevia extract is useful as an internal medicine, especially, for preventing and curing disorders of the digestive organs. On the basis of these findings, he has completed the present invention.
- a liquid internal medicine which contains a liquid obtained by ripening a fermented and concentrated liquid extract from the stems of Stevia as an active ingredient.
- a method of preparing a liquid internal medicine in which a liquid extract from the matured stems of Stevia plants is concentrated and fermented, and the resulting liquid is further ripened.
- the most important technical characteristic of the present invention is the point of use of a product, obtained by concentrating, fermenting and further ripening a liquid extract from completely matured stems of Stevia plants, as an internal liquid medicine.
- Stevia stems contain microorganisms which are not in Stevia leaves, that a product obtained by drying and powdering the stems and boiling the powdered stems in water to give a concentrated liquid, followed by heating, fermenting and ripening the liquid, preferably in a closed tank, has an excellent blood circulation promoting function and an excellent pharmaceutical effect as an internal medicine.
- the liquid internal medicine of the present invention may be administered to patients as a drink, whereby the blood circulation of the patients will be promoted and the disorders of their digestive organs may be cured.
- the raw material for preparing the medicine is, as mentioned above, a liquid as obtained by concentrating, fermenting and ripening an extract from only the stems of Stevia so that the medicine has a potent curative effect on various disorders.
- Another characteristic aspect of the present invention is to use completely matured stems of Stevia plants as the raw material for the medicine.
- Stevia as referred to herein is a perennial plant of Compositae (Asteraceae), which is native to Paraguay and Brazil in South America and is called Stevia Rebaudiana Bertoni .
- Stevia seedlings or cuttings are planted from April to May. Seed seedlings of Stevia are harvested two times or three times a year while the leaves thereof are young and weak.
- Stevia stems to be used in the present invention should not be from such young and weak plants, since the pharmaceutical potency of them would not yet be sufficient.
- matured Stevia stems harvested only once a year from October to November are to be used in the present invention.
- the harvested Stevia plants are dried at about 70 to 80°C for 24 hours; they are grouped into leaves, stems and branches; only the stems are powdered to a size of 15 ⁇ m or less, preferably from about 1 to 8 ⁇ m; and the resulting powder is boiled for extraction.
- Stevia Leaves contain components of a sweetener but contain few components having any pharmaceutical effect such as the intended liquid internal medicine. Therefore, the leaves are not suitable for use in the present invention.
- Concentration, fermentation and ripening of the thus harvested Stevia stems may be implemented as described in the example below.
- a multi-stage concentration process comprising two or more concentration steps may be employed for more effective extraction of the active ingredient.
- the performance obtained through four or more concentration steps is not especially significant in view of the concentration of the final extract but is rather economically disadvantageous.
- liquid internal medicine of the present invention may be diluted to a mixture from 1/5 to 1/50, preferably from 1/10 to 1/15, with water or a soft drink before use, in accordance with the condition of the patients.
- the liquid internal medicine of the present invention is totally composed of a natural Stevia extract only, it is free from any harmful side effects when absorbed into the body.
- the internal medicine of the present invention has the effect of promoting the blood circulation so that the disorders of the digestive organs may be cured. Besides, if the medicine is externally applied to the skin, the effect of treating skin disorders can be observed.
- the acute toxicity test (LD50) of the liquid internal medicine of the present invention was carried out by Nippon Foodstuff Sanitation Association, an authorized examination agency as designated by the Welfare Minister, on the basis of the Foodstuff Sanitation Law and the Drugs, Cosmetics and Medical Instruments Law.
- the test result of No. 01-4651-2 is as follows:
- mice Five-week old male ddy-line mice; three groups of ten mice each
- test liquid was administered to each group having ten mice, in an amount of 1 ml/20 g, 0.75 ml/20 g and 0.5 ml/20 g.
- mice After administration of the test liquid (Day 0), the mice were bred under constant temperature and humidity for 7 days, while water and feed were added thereto freely.
- mice in the first group to which the maximum amount of 1 ml/20 g of the test liquid had been administered, displayed depression of spontaneous movement and depression of respiration for 30 minutes immediately after the administration of the test liquid, but all of them recovered to normal condition within 30 minutes thereafter.
- mice in the second group to which 0.75 ml/20 g of the test liquid had been administered, showed slight depression of spontaneous movement immediately after the administration of the test liquid, but they recovered to normal condition within 20 minutes after administration of the same.
- the weight of each mouse bred under the above-mentioned condition was measured every day, and their general condition was observed every day. During the test period, the weight of each mouse increased normally, and there was no special change found in any of the tested mice during the test period of 7 days.
- the value of LD50 of the concentrated Stevia liquid as tested above is 50 ml/kg or more, and the acute toxicity of the liquid is presumed to be extremely low.
- the liquid internal medicine of the present invention was confirmed to have a pharmaceutical and medical effect on the following diseases.
- Anorexia indigestion, bloated feeling, acceleration of digestion, hyperacidity, upset stomach, feeling heaviness in stomach, nausea, disorders by overdrinking, gastralgia, diarrhea, loose passage, stomatitis, constipation, feeling of cold, gastritis, gastric ulcer, and promotion of appetite.
- Matured Stevia plants were harvested at the beginning of November and were dried in a tobacco drier having an area of 6.6 m2, at 75 +/- 3°C for 24 hours under the condition of an air flow rate of 30 m3/min.
- stems were lightly beaten with a bar so as to separate them into stems, leaves, branches and impurities. Only stems were collected.
- the stems were cut with a cutter into small pieces of about 3 to 5 cm, then powdered twice with a Hitachi grinder and thereafter sieved to a fine powder having a mean particle size of 5 ⁇ m.
- the thus obtained first liquid was about 4 liters, which was put in a tank (concentrating pot).
- the tank was heated and the content therein was boiled down. After about 4 hours, the concentrated liquid mixture was boiled down to about 1000 cc. The thus concentrated liquid was filtered through a cotton bag, and the resulting filtrate was put in a storage tank made of stainless-steel. This was then fermented and ripened therein at 25°C for 360 days, whereupon the resulting liquid had a sugar degree of 21 degrees.
- the liquid internal medicine thus obtained was a brownish-green liquid having a sweet aroma and an extremely low viscosity.
- Sex Age Condition Method of Peroral Administration Female 37 Constipation 10 cc of 20 % aqueous solution; once a day (in the morning) She had a motion in two days, and her stool was regulated in 30 days. Female 63 Anorexia 2 cc of undiluted solution; once a day Normal appetite was recovered in two days. Female 53 feeling of cold (serious case) heated 50 cc of 1 % aqueous solution; three times a day The condition was eased in 9 days and cured in 15 days. Male 45 upset stomach 2 cc of undiluted solution; once a day The condition was eased in 3 days and cured in 7 days.
- a liquid internal medicine containing only a fermented and concentrated liquid from an extract of Stevia stems, and the medicine has effective pharmaceutical activities for anorexia, indigestion, feeling of swollen stomach, acceleration of digestion, hyperacidity, bloated stomach, nausia, disorders by overdrinking, gastralgia, diarrhea, loose passage, stomatitis, constipation, feeling of cold, abdominal pain, sore throat, gastritis, gastric ulcer, etc as well as the effect of promoting blood circulation.
- the medicine of the present invention can easily be prepared by powdering stems of Stevia, concentrating an extract from the powder by a multi-stage process, and fermenting and ripening the resulting concentrate.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP193301/91 | 1991-08-01 | ||
JP3193301A JPH0713021B2 (ja) | 1991-08-01 | 1991-08-01 | 消化器系疾患治療用内服薬剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0525740A1 EP0525740A1 (en) | 1993-02-03 |
EP0525740B1 true EP0525740B1 (en) | 1996-05-15 |
Family
ID=16305638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP92112929A Expired - Lifetime EP0525740B1 (en) | 1991-08-01 | 1992-07-29 | Stevia extract-containing liquid internal medicine and method of preparing the same |
Country Status (8)
Country | Link |
---|---|
US (1) | US5250301A (ja) |
EP (1) | EP0525740B1 (ja) |
JP (1) | JPH0713021B2 (ja) |
CN (1) | CN1068961A (ja) |
AU (1) | AU654365B2 (ja) |
BR (1) | BR9202907A (ja) |
CA (1) | CA2075077C (ja) |
DE (1) | DE69210705T2 (ja) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2141126A1 (en) * | 1995-01-26 | 1996-07-27 | Natalie J. Lazarowych | Combinational drug for treating migraine and other illnesses |
US6156318A (en) * | 1997-03-31 | 2000-12-05 | Naohiko Sato | Method of counteracting harmful effects of histamine |
US5958419A (en) * | 1997-03-31 | 1999-09-28 | Naohiko Sato | Antihistaminic substance of stevia origin |
JPH1143443A (ja) * | 1997-05-27 | 1999-02-16 | Naohiko Sato | 食中毒菌に対する選択的殺菌剤 |
JP3404341B2 (ja) | 1999-12-06 | 2003-05-06 | 直彦 佐藤 | 鳥類の卵の破損防止方法 |
EP1121852B1 (en) | 2000-01-31 | 2003-08-06 | Naohiko Sato | Methods of enhancing vitality of plants, trees, and crops with stevia |
JP2005035888A (ja) * | 2001-10-25 | 2005-02-10 | Ta Stevia Co Ltd | アナフィラキシー型アレルギー症状改善物質およびその製造方法 |
AU2003300482A1 (en) * | 2003-11-20 | 2005-06-08 | Branislav Bogicevic | Oral application of extract of stevia rebaudiana or its active substances for the elimination of cellulite |
JPWO2005089782A1 (ja) * | 2004-03-17 | 2008-01-31 | 日本キレート株式会社 | ステビア発酵液の製造方法、家畜用健康飲料、及び家畜用乳房洗浄剤 |
WO2010021001A2 (en) * | 2008-08-19 | 2010-02-25 | Kaushik Ramakrishnan S | Process for preparing sweetener from stevia rebaudiana |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4361697A (en) * | 1981-05-21 | 1982-11-30 | F. K. Suzuki International, Inc. | Extraction, separation and recovery of diterpene glycosides from Stevia rebaudiana plants |
JPH01292076A (ja) * | 1988-05-19 | 1989-11-24 | Nippon Soda Co Ltd | 印刷用インキ組成物 |
JPH02178060A (ja) * | 1988-12-28 | 1990-07-11 | Toshiba Corp | プリンタ装置 |
JPH03127959A (ja) * | 1989-10-14 | 1991-05-31 | Kiyono Takeo | ステビア甘味濃縮液の製造方法 |
JPH03151321A (ja) * | 1989-11-08 | 1991-06-27 | Kiyono Takeo | 浴用剤およびその製造方法 |
JP2577105B2 (ja) * | 1990-01-23 | 1997-01-29 | 文夫 堂園 | 園芸用肥料及びその製造方法 |
JPH0692314B2 (ja) * | 1990-07-04 | 1994-11-16 | 文夫 堂園 | 外用皮膚病治療剤 |
-
1991
- 1991-08-01 JP JP3193301A patent/JPH0713021B2/ja not_active Expired - Fee Related
-
1992
- 1992-01-28 US US07/827,130 patent/US5250301A/en not_active Expired - Lifetime
- 1992-05-11 CN CN92103444A patent/CN1068961A/zh active Pending
- 1992-07-22 AU AU20480/92A patent/AU654365B2/en not_active Ceased
- 1992-07-28 BR BR929202907A patent/BR9202907A/pt not_active Application Discontinuation
- 1992-07-29 EP EP92112929A patent/EP0525740B1/en not_active Expired - Lifetime
- 1992-07-29 DE DE69210705T patent/DE69210705T2/de not_active Expired - Fee Related
- 1992-07-31 CA CA002075077A patent/CA2075077C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH0713021B2 (ja) | 1995-02-15 |
DE69210705D1 (de) | 1996-06-20 |
BR9202907A (pt) | 1993-03-30 |
CA2075077C (en) | 2004-11-23 |
US5250301A (en) | 1993-10-05 |
JPH0532555A (ja) | 1993-02-09 |
AU654365B2 (en) | 1994-11-03 |
DE69210705T2 (de) | 1997-01-23 |
CA2075077A1 (en) | 1993-02-02 |
EP0525740A1 (en) | 1993-02-03 |
CN1068961A (zh) | 1993-02-17 |
AU2048092A (en) | 1993-02-04 |
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