EP0312127A3 - Dérivés de l'insuline glycosylée - Google Patents

Dérivés de l'insuline glycosylée Download PDF

Info

Publication number
EP0312127A3
EP0312127A3 EP19880120072 EP88120072A EP0312127A3 EP 0312127 A3 EP0312127 A3 EP 0312127A3 EP 19880120072 EP19880120072 EP 19880120072 EP 88120072 A EP88120072 A EP 88120072A EP 0312127 A3 EP0312127 A3 EP 0312127A3
Authority
EP
European Patent Office
Prior art keywords
mannopyranosides
gluco
phenyl
insulin derivatives
glycosylated insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19880120072
Other languages
German (de)
English (en)
Other versions
EP0312127A2 (fr
EP0312127B1 (fr
Inventor
James C. Mcrea
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah
Original Assignee
University of Utah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah filed Critical University of Utah
Priority to AT8888120072T priority Critical patent/ATE105296T1/de
Publication of EP0312127A2 publication Critical patent/EP0312127A2/fr
Publication of EP0312127A3 publication Critical patent/EP0312127A3/fr
Application granted granted Critical
Publication of EP0312127B1 publication Critical patent/EP0312127B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B11/00—Communication cables or conductors
    • H01B11/02—Cables with twisted pairs or quads
    • H01B11/04—Cables with twisted pairs or quads with pairs or quads mutually positioned to reduce cross-talk
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B13/00—Apparatus or processes specially adapted for manufacturing conductors or cables
    • H01B13/02—Stranding-up
    • H01B13/04—Mutually positioning pairs or quads to reduce cross-talk
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Manufacturing & Machinery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP88120072A 1982-11-17 1983-11-15 Dérivés de l'insuline glycosylée Expired - Lifetime EP0312127B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT8888120072T ATE105296T1 (de) 1982-11-17 1983-11-15 Glycosylierte insulin-derivate.

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US442362 1982-11-17
US06/442,362 US4444683A (en) 1982-11-17 1982-11-17 Glycosylated insulin derivatives
EP83903886A EP0125299B1 (fr) 1982-11-17 1983-11-15 Derives d'insuline glycosylee

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP83903886A Division EP0125299B1 (fr) 1982-11-17 1983-11-15 Derives d'insuline glycosylee
EP83903886.6 Division 1984-05-30

Publications (3)

Publication Number Publication Date
EP0312127A2 EP0312127A2 (fr) 1989-04-19
EP0312127A3 true EP0312127A3 (fr) 1991-09-25
EP0312127B1 EP0312127B1 (fr) 1994-05-04

Family

ID=23756525

Family Applications (2)

Application Number Title Priority Date Filing Date
EP88120072A Expired - Lifetime EP0312127B1 (fr) 1982-11-17 1983-11-15 Dérivés de l'insuline glycosylée
EP83903886A Expired EP0125299B1 (fr) 1982-11-17 1983-11-15 Derives d'insuline glycosylee

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP83903886A Expired EP0125299B1 (fr) 1982-11-17 1983-11-15 Derives d'insuline glycosylee

Country Status (8)

Country Link
US (2) US4444683A (fr)
EP (2) EP0312127B1 (fr)
JP (1) JPH0613556B2 (fr)
AT (2) ATE105296T1 (fr)
CA (1) CA1216578A (fr)
DE (2) DE3380199D1 (fr)
IT (1) IT1207992B (fr)
WO (1) WO1984001896A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8102194L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
DE3790635B4 (de) * 1986-10-13 2007-11-22 Novartis Ag Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür
HU206890B (en) * 1986-10-13 1993-01-28 Sandoz Ag Process for producing sugar-modified somatostatin peptide derivatives and pharmaceutical compositions containing them as active components
US4885163A (en) * 1987-02-24 1989-12-05 Eli Lilly And Company Topical use of IGF-II for wound healing
DE3829798A1 (de) * 1988-09-02 1990-03-08 Bosch Gmbh Robert Kraftstoffeinspritzpumpe fuer brennkraftmaschinen
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
JP2648584B2 (ja) * 1990-02-16 1997-09-03 株式会社ディ・ディ・エス研究所 グリコシル−蛋白誘導体
JP3318602B2 (ja) * 1997-11-10 2002-08-26 独立行政法人産業技術総合研究所 糖鎖付加型ヘパリン結合性タンパク質、その製造方法およびそれを含有する医薬組成物
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
US7316999B2 (en) * 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US7317000B2 (en) * 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
CN101128284B (zh) * 2004-12-06 2010-04-21 维特罗克斯股份公司 用于磨光硬表面、特别是玻璃表面的装置
US20070099820A1 (en) * 2005-10-19 2007-05-03 Smartcells, Inc. Polymer-drug conjugates
KR100829257B1 (ko) * 2006-06-22 2008-05-14 부경대학교 산학협력단 인간 섬유육종세포에서 메트릭스 메탈로프로테이나제-9의발현 및 활성을 억제하는 카복시화 글루코사민 화합물 및이를 함유한 메트릭스 메탈로프로테이나제-9 억제제
JP2008214256A (ja) * 2007-03-02 2008-09-18 Yaizu Suisankagaku Industry Co Ltd 双頭型配糖化合物の製造方法及び双頭型配糖化合物並びに該双頭型配糖化合物を含有する糖鎖認識タンパク質結合剤
EP2391216A4 (fr) 2009-01-28 2013-06-19 Smartcells Inc Matériaux à libération contrôlée déclenchée de façon exogène et leurs utilisations
BRPI1007466A2 (pt) 2009-01-28 2018-06-12 Smartcells Inc conjugado de insulina cristalina, formulação de liberação prolongada, e, sistema de distribuição de bomba
MA33064B1 (fr) 2009-01-28 2012-02-01 Smartcells Inc Systemes à base de conjugués pour administration contrôlée de médicaments
US8940690B2 (en) 2009-01-28 2015-01-27 National Institutes Of Health (Nih) Synthetic conjugates and uses thereof
WO2010107519A1 (fr) 2009-03-20 2010-09-23 Smartcells, Inc. Conjugués fonctionnalisés aux extrémités et leurs utilisations
WO2010107520A1 (fr) 2009-03-20 2010-09-23 Smartcells, Inc. Conjugués d'insulines non déposées solubles et leurs utilisations
WO2012015691A2 (fr) 2010-07-28 2012-02-02 Smartcells, Inc. Lectines recombinées, lectines à site de liaison modifié et leurs utilisations
EP2598170A4 (fr) 2010-07-28 2016-07-06 Smartcells Inc Conjugués médicaments-ligands, leur synthèse et intermédiaires correspondants
JP2013535467A (ja) 2010-07-28 2013-09-12 スマートセルズ・インコーポレイテツド 組換えにより発現されたインスリンポリペプチドおよびその使用
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
WO2015051052A2 (fr) 2013-10-04 2015-04-09 Merck Sharp & Dohme Corp. Conjugués d'insuline sensibles au glucose

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1927209A1 (de) * 1968-05-29 1969-12-04 American Home Prod Acyl-substituierte Insuline und Verfahren zu ihrer Herstellung
US3755569A (en) * 1972-07-25 1973-08-28 American Home Prod Acyl substituted insulins
US3847890A (en) * 1971-11-01 1974-11-12 A Green Acidic monosaccharide-substituted proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723617A (en) * 1968-12-31 1973-03-27 Smith Kline French Lab Anti-inflammatory compositions containing acylated-{62 -d-glucopyranosides and methods of using them
US4152513A (en) * 1977-06-01 1979-05-01 University Of Delaware Preparation of alkyl glycosides of amino sugars
DE3220427A1 (de) * 1982-05-29 1983-12-01 Behringwerke Ag, 3550 Marburg Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1927209A1 (de) * 1968-05-29 1969-12-04 American Home Prod Acyl-substituierte Insuline und Verfahren zu ihrer Herstellung
US3847890A (en) * 1971-11-01 1974-11-12 A Green Acidic monosaccharide-substituted proteins
US3755569A (en) * 1972-07-25 1973-08-28 American Home Prod Acyl substituted insulins

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 86, no. 23, 6th June 1977, page 191, column 2, abstract no. 166922c, Columbus, Ohio, US; T. MEGA et al.: "Affinity chromatography of glycosidases. II. Studies on specific and non-specific binding", & J. BIOCHEM. (TOKYO), 1977, 81(3), 571-8 *
CHEMICAL ABSTRACTS, vol. 92, no. 8, 25th February 1980, page 375, abstract no. 64621k, Columbus, Ohio, US; M. BROWNLEE et al.: "A glucose-controlled insulin-delivery system: semisynthetic insulin bound to lectin", & SCIENCE (Washington, DC), 1979, 206(4423), 1190-1 *
FEBS LETTERS, vol. 100, no. 1, April 1979, pages 133-136, Amsterdam, NL; D. DOLHOFER et al.: "Preparation and biological properties of glycosylated insulin" *
JOURNAL OF THE CHEMICAL SOCIETY C, 1968, pages 1457-1461; D.H. BUSS et al.: "Protein-carbohydrate interaction. Part XIV. Carbohydrates containing groups for the alkylation of proteins" *

Also Published As

Publication number Publication date
EP0125299A4 (fr) 1986-02-13
JPH0613556B2 (ja) 1994-02-23
CA1216578A (fr) 1987-01-13
EP0125299A1 (fr) 1984-11-21
IT1207992B (it) 1989-06-01
JPS59502065A (ja) 1984-12-13
EP0312127A2 (fr) 1989-04-19
DE3382749T2 (de) 1994-09-29
DE3380199D1 (en) 1989-08-24
ATE105296T1 (de) 1994-05-15
EP0312127B1 (fr) 1994-05-04
ATE44649T1 (de) 1989-08-15
EP0125299B1 (fr) 1989-07-19
DE3382749D1 (de) 1994-06-09
IT8323762A0 (it) 1983-11-17
US4444683A (en) 1984-04-24
WO1984001896A1 (fr) 1984-05-24
US4478746A (en) 1984-10-23

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