ATE105296T1 - Glycosylierte insulin-derivate. - Google Patents
Glycosylierte insulin-derivate.Info
- Publication number
- ATE105296T1 ATE105296T1 AT8888120072T AT88120072T ATE105296T1 AT E105296 T1 ATE105296 T1 AT E105296T1 AT 8888120072 T AT8888120072 T AT 8888120072T AT 88120072 T AT88120072 T AT 88120072T AT E105296 T1 ATE105296 T1 AT E105296T1
- Authority
- AT
- Austria
- Prior art keywords
- mannopyranosides
- gluco
- alpha
- phenyl
- insulin derivatives
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 5
- 102000004877 Insulin Human genes 0.000 abstract 4
- 108090001061 Insulin Proteins 0.000 abstract 4
- 229940125396 insulin Drugs 0.000 abstract 2
- 239000004026 insulin derivative Substances 0.000 abstract 2
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000000881 depressing effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000003147 glycosyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B11/00—Communication cables or conductors
- H01B11/02—Cables with twisted pairs or quads
- H01B11/04—Cables with twisted pairs or quads with pairs or quads mutually positioned to reduce cross-talk
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B13/00—Apparatus or processes specially adapted for manufacturing conductors or cables
- H01B13/02—Stranding-up
- H01B13/04—Mutually positioning pairs or quads to reduce cross-talk
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Manufacturing & Machinery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/442,362 US4444683A (en) | 1982-11-17 | 1982-11-17 | Glycosylated insulin derivatives |
| EP88120072A EP0312127B1 (de) | 1982-11-17 | 1983-11-15 | Glycosylierte Insulin-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE105296T1 true ATE105296T1 (de) | 1994-05-15 |
Family
ID=23756525
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT8888120072T ATE105296T1 (de) | 1982-11-17 | 1983-11-15 | Glycosylierte insulin-derivate. |
| AT83903886T ATE44649T1 (de) | 1982-11-17 | 1983-11-15 | Glykosylierte insulinabkoemmlinge. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83903886T ATE44649T1 (de) | 1982-11-17 | 1983-11-15 | Glykosylierte insulinabkoemmlinge. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US4444683A (de) |
| EP (2) | EP0125299B1 (de) |
| JP (1) | JPH0613556B2 (de) |
| AT (2) | ATE105296T1 (de) |
| CA (1) | CA1216578A (de) |
| DE (2) | DE3382749T2 (de) |
| IT (1) | IT1207992B (de) |
| WO (1) | WO1984001896A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8102194L (sv) * | 1981-04-06 | 1982-10-07 | Pharmacia Ab | Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna |
| DE3790635B4 (de) * | 1986-10-13 | 2007-11-22 | Novartis Ag | Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür |
| HU906341D0 (en) * | 1986-10-13 | 1991-04-29 | Sandoz Ag | Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance |
| US4885163A (en) * | 1987-02-24 | 1989-12-05 | Eli Lilly And Company | Topical use of IGF-II for wound healing |
| DE3829798A1 (de) * | 1988-09-02 | 1990-03-08 | Bosch Gmbh Robert | Kraftstoffeinspritzpumpe fuer brennkraftmaschinen |
| US5218092A (en) * | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
| DK111489D0 (da) * | 1989-03-08 | 1989-03-08 | Novo Nordisk As | Peptider |
| JP2648584B2 (ja) * | 1990-02-16 | 1997-09-03 | 株式会社ディ・ディ・エス研究所 | グリコシル−蛋白誘導体 |
| JP3318602B2 (ja) | 1997-11-10 | 2002-08-26 | 独立行政法人産業技術総合研究所 | 糖鎖付加型ヘパリン結合性タンパク質、その製造方法およびそれを含有する医薬組成物 |
| US6323311B1 (en) | 1999-09-22 | 2001-11-27 | University Of Utah Research Foundation | Synthesis of insulin derivatives |
| US7316999B2 (en) * | 2000-06-02 | 2008-01-08 | Novo Nordisk A/S | Glucose dependent release of insulin from glucose sensing insulin derivatives |
| US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| US7317000B2 (en) * | 2001-12-02 | 2008-01-08 | Novo Nordisk A/S | Glucose-dependent insulins |
| CN101128284B (zh) * | 2004-12-06 | 2010-04-21 | 维特罗克斯股份公司 | 用于磨光硬表面、特别是玻璃表面的装置 |
| US7687608B2 (en) * | 2005-10-19 | 2010-03-30 | Smartcells, Inc. | Methods for reducing the mitogenicity of lectin compositions |
| KR100829257B1 (ko) * | 2006-06-22 | 2008-05-14 | 부경대학교 산학협력단 | 인간 섬유육종세포에서 메트릭스 메탈로프로테이나제-9의발현 및 활성을 억제하는 카복시화 글루코사민 화합물 및이를 함유한 메트릭스 메탈로프로테이나제-9 억제제 |
| JP2008214256A (ja) * | 2007-03-02 | 2008-09-18 | Yaizu Suisankagaku Industry Co Ltd | 双頭型配糖化合物の製造方法及び双頭型配糖化合物並びに該双頭型配糖化合物を含有する糖鎖認識タンパク質結合剤 |
| CA2932926C (en) | 2009-01-28 | 2018-12-18 | Smartcells, Inc. | Conjugate based systems for controlled drug delivery |
| JP2012516340A (ja) | 2009-01-28 | 2012-07-19 | スマートセルズ・インコーポレイテツド | 合成コンジュゲートおよびその使用 |
| EP2391216A4 (de) | 2009-01-28 | 2013-06-19 | Smartcells Inc | Exogen ausgelöste stoffe mit verzögerter freisetzung und ihre verwendung |
| PE20120582A1 (es) | 2009-01-28 | 2012-05-26 | Smartcells Inc | Conjugados de insulina cristalina |
| AU2010226243A1 (en) | 2009-03-20 | 2011-09-22 | Smartcells, Inc. | Terminally-functionalized conjugates and uses thereof |
| US8569231B2 (en) | 2009-03-20 | 2013-10-29 | Smartcells, Inc. | Soluble non-depot insulin conjugates and uses thereof |
| CA2806399A1 (en) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinantly expressed insulin polypeptides and uses thereof |
| EP2598170A4 (de) | 2010-07-28 | 2016-07-06 | Smartcells Inc | Arzneimittel-liganden-konjugate, deren synthese und zwischenprodukte daraus |
| AU2011282987A1 (en) | 2010-07-28 | 2013-02-21 | Smartcells, Inc. | Recombinant lectins, binding-site modified lectins and uses thereof |
| EP2925345B1 (de) | 2012-12-03 | 2018-09-05 | Merck Sharp & Dohme Corp. | Methode zur herstellung von o-glycosyliertem carboxyterminus-peptid (ctp)-basiertem insulin und insulinanaloga |
| US9884125B2 (en) | 2013-10-04 | 2018-02-06 | Merck Sharp & Dohme Corp. | Glucose-responsive insulin conjugates |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3591574A (en) * | 1968-05-29 | 1971-07-06 | American Home Prod | Tri-n-phenylglycyl derivatives of insulin |
| US3723617A (en) * | 1968-12-31 | 1973-03-27 | Smith Kline French Lab | Anti-inflammatory compositions containing acylated-{62 -d-glucopyranosides and methods of using them |
| US3847890A (en) * | 1971-11-01 | 1974-11-12 | A Green | Acidic monosaccharide-substituted proteins |
| US3755569A (en) * | 1972-07-25 | 1973-08-28 | American Home Prod | Acyl substituted insulins |
| US4152513A (en) * | 1977-06-01 | 1979-05-01 | University Of Delaware | Preparation of alkyl glycosides of amino sugars |
| DE3220427A1 (de) * | 1982-05-29 | 1983-12-01 | Behringwerke Ag, 3550 Marburg | Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung |
-
1982
- 1982-11-17 US US06/442,362 patent/US4444683A/en not_active Expired - Lifetime
-
1983
- 1983-11-15 DE DE3382749T patent/DE3382749T2/de not_active Expired - Fee Related
- 1983-11-15 DE DE8383903886T patent/DE3380199D1/de not_active Expired
- 1983-11-15 JP JP59500051A patent/JPH0613556B2/ja not_active Expired - Lifetime
- 1983-11-15 AT AT8888120072T patent/ATE105296T1/de active
- 1983-11-15 EP EP83903886A patent/EP0125299B1/de not_active Expired
- 1983-11-15 EP EP88120072A patent/EP0312127B1/de not_active Expired - Lifetime
- 1983-11-15 WO PCT/US1983/001780 patent/WO1984001896A1/en not_active Ceased
- 1983-11-15 AT AT83903886T patent/ATE44649T1/de not_active IP Right Cessation
- 1983-11-16 CA CA000441330A patent/CA1216578A/en not_active Expired
- 1983-11-17 IT IT8323762A patent/IT1207992B/it active
-
1984
- 1984-02-06 US US06/532,697 patent/US4478746A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE3382749T2 (de) | 1994-09-29 |
| EP0125299B1 (de) | 1989-07-19 |
| DE3382749D1 (de) | 1994-06-09 |
| IT1207992B (it) | 1989-06-01 |
| IT8323762A0 (it) | 1983-11-17 |
| EP0125299A1 (de) | 1984-11-21 |
| US4478746A (en) | 1984-10-23 |
| EP0125299A4 (de) | 1986-02-13 |
| CA1216578A (en) | 1987-01-13 |
| EP0312127B1 (de) | 1994-05-04 |
| JPS59502065A (ja) | 1984-12-13 |
| ATE44649T1 (de) | 1989-08-15 |
| EP0312127A2 (de) | 1989-04-19 |
| JPH0613556B2 (ja) | 1994-02-23 |
| US4444683A (en) | 1984-04-24 |
| WO1984001896A1 (en) | 1984-05-24 |
| DE3380199D1 (en) | 1989-08-24 |
| EP0312127A3 (de) | 1991-09-25 |
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