ATE105296T1 - Glycosylierte insulin-derivate. - Google Patents

Glycosylierte insulin-derivate.

Info

Publication number
ATE105296T1
ATE105296T1 AT8888120072T AT88120072T ATE105296T1 AT E105296 T1 ATE105296 T1 AT E105296T1 AT 8888120072 T AT8888120072 T AT 8888120072T AT 88120072 T AT88120072 T AT 88120072T AT E105296 T1 ATE105296 T1 AT E105296T1
Authority
AT
Austria
Prior art keywords
mannopyranosides
gluco
alpha
phenyl
insulin derivatives
Prior art date
Application number
AT8888120072T
Other languages
English (en)
Inventor
James C Mcrea
Original Assignee
Univ Utah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah filed Critical Univ Utah
Application granted granted Critical
Publication of ATE105296T1 publication Critical patent/ATE105296T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B11/00—Communication cables or conductors
    • H01B11/02—Cables with twisted pairs or quads
    • H01B11/04—Cables with twisted pairs or quads with pairs or quads mutually positioned to reduce cross-talk
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B13/00—Apparatus or processes specially adapted for manufacturing conductors or cables
    • H01B13/02—Stranding-up
    • H01B13/04—Mutually positioning pairs or quads to reduce cross-talk
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Manufacturing & Machinery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT8888120072T 1982-11-17 1983-11-15 Glycosylierte insulin-derivate. ATE105296T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/442,362 US4444683A (en) 1982-11-17 1982-11-17 Glycosylated insulin derivatives
EP88120072A EP0312127B1 (de) 1982-11-17 1983-11-15 Glycosylierte Insulin-Derivate

Publications (1)

Publication Number Publication Date
ATE105296T1 true ATE105296T1 (de) 1994-05-15

Family

ID=23756525

Family Applications (2)

Application Number Title Priority Date Filing Date
AT83903886T ATE44649T1 (de) 1982-11-17 1983-11-15 Glykosylierte insulinabkoemmlinge.
AT8888120072T ATE105296T1 (de) 1982-11-17 1983-11-15 Glycosylierte insulin-derivate.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT83903886T ATE44649T1 (de) 1982-11-17 1983-11-15 Glykosylierte insulinabkoemmlinge.

Country Status (8)

Country Link
US (2) US4444683A (de)
EP (2) EP0312127B1 (de)
JP (1) JPH0613556B2 (de)
AT (2) ATE44649T1 (de)
CA (1) CA1216578A (de)
DE (2) DE3380199D1 (de)
IT (1) IT1207992B (de)
WO (1) WO1984001896A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8102194L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
DE3790635B4 (de) * 1986-10-13 2007-11-22 Novartis Ag Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür
US4885163A (en) * 1987-02-24 1989-12-05 Eli Lilly And Company Topical use of IGF-II for wound healing
DE3829798A1 (de) * 1988-09-02 1990-03-08 Bosch Gmbh Robert Kraftstoffeinspritzpumpe fuer brennkraftmaschinen
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
JP2648584B2 (ja) * 1990-02-16 1997-09-03 株式会社ディ・ディ・エス研究所 グリコシル−蛋白誘導体
JP3318602B2 (ja) * 1997-11-10 2002-08-26 独立行政法人産業技術総合研究所 糖鎖付加型ヘパリン結合性タンパク質、その製造方法およびそれを含有する医薬組成物
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
US7316999B2 (en) * 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US7317000B2 (en) * 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
ES2315934T3 (es) * 2004-12-06 2009-04-01 Vetrox Ag Dispositivo para esmerilar superficies duras, especialmente superficies de vidrio.
WO2007047922A2 (en) * 2005-10-19 2007-04-26 Smartcells, Inc. Polymer-drug conjugates
KR100829257B1 (ko) * 2006-06-22 2008-05-14 부경대학교 산학협력단 인간 섬유육종세포에서 메트릭스 메탈로프로테이나제-9의발현 및 활성을 억제하는 카복시화 글루코사민 화합물 및이를 함유한 메트릭스 메탈로프로테이나제-9 억제제
JP2008214256A (ja) * 2007-03-02 2008-09-18 Yaizu Suisankagaku Industry Co Ltd 双頭型配糖化合物の製造方法及び双頭型配糖化合物並びに該双頭型配糖化合物を含有する糖鎖認識タンパク質結合剤
MA33064B1 (fr) 2009-01-28 2012-02-01 Smartcells Inc Systemes à base de conjugués pour administration contrôlée de médicaments
WO2010088286A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Synthetic conjugates and uses thereof
SG173117A1 (en) 2009-01-28 2011-08-29 Smartcells Inc Crystalline insulin-conjugates
AU2010208381A1 (en) 2009-01-28 2011-08-04 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
EP2408470A4 (de) 2009-03-20 2012-08-29 Smartcells Inc Lösliche nichtdepot-insulinkonjugate und ihre verwendung
WO2010107519A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Terminally-functionalized conjugates and uses thereof
US8933207B2 (en) 2010-07-28 2015-01-13 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
JP2013541500A (ja) 2010-07-28 2013-11-14 スマートセルズ・インコーポレイテツド 組換えレクチン、結合部位修飾レクチンおよびそれらの用途
WO2012015692A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
EP2925345B1 (de) 2012-12-03 2018-09-05 Merck Sharp & Dohme Corp. Methode zur herstellung von o-glycosyliertem carboxyterminus-peptid (ctp)-basiertem insulin und insulinanaloga
MX366852B (es) 2013-10-04 2019-07-25 Merck Sharp & Dohme Conjugados de insulina sensibles a glucosa.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591574A (en) * 1968-05-29 1971-07-06 American Home Prod Tri-n-phenylglycyl derivatives of insulin
US3723617A (en) * 1968-12-31 1973-03-27 Smith Kline French Lab Anti-inflammatory compositions containing acylated-{62 -d-glucopyranosides and methods of using them
US3847890A (en) * 1971-11-01 1974-11-12 A Green Acidic monosaccharide-substituted proteins
US3755569A (en) * 1972-07-25 1973-08-28 American Home Prod Acyl substituted insulins
US4152513A (en) * 1977-06-01 1979-05-01 University Of Delaware Preparation of alkyl glycosides of amino sugars
DE3220427A1 (de) * 1982-05-29 1983-12-01 Behringwerke Ag, 3550 Marburg Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung

Also Published As

Publication number Publication date
IT1207992B (it) 1989-06-01
EP0125299B1 (de) 1989-07-19
US4444683A (en) 1984-04-24
US4478746A (en) 1984-10-23
ATE44649T1 (de) 1989-08-15
JPS59502065A (ja) 1984-12-13
EP0125299A1 (de) 1984-11-21
EP0312127A2 (de) 1989-04-19
DE3382749T2 (de) 1994-09-29
IT8323762A0 (it) 1983-11-17
JPH0613556B2 (ja) 1994-02-23
EP0312127A3 (de) 1991-09-25
EP0312127B1 (de) 1994-05-04
EP0125299A4 (de) 1986-02-13
WO1984001896A1 (en) 1984-05-24
DE3382749D1 (de) 1994-06-09
DE3380199D1 (en) 1989-08-24
CA1216578A (en) 1987-01-13

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