DE3382749T2 - Glycosylierte Insulin-Derivate. - Google Patents

Glycosylierte Insulin-Derivate.

Info

Publication number
DE3382749T2
DE3382749T2 DE3382749T DE3382749T DE3382749T2 DE 3382749 T2 DE3382749 T2 DE 3382749T2 DE 3382749 T DE3382749 T DE 3382749T DE 3382749 T DE3382749 T DE 3382749T DE 3382749 T2 DE3382749 T2 DE 3382749T2
Authority
DE
Germany
Prior art keywords
mannopyranosides
gluco
alpha
phenyl
insulin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3382749T
Other languages
English (en)
Other versions
DE3382749D1 (de
Inventor
James C Mcrea
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah
Original Assignee
University of Utah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah filed Critical University of Utah
Publication of DE3382749D1 publication Critical patent/DE3382749D1/de
Application granted granted Critical
Publication of DE3382749T2 publication Critical patent/DE3382749T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B11/00—Communication cables or conductors
    • H01B11/02—Cables with twisted pairs or quads
    • H01B11/04—Cables with twisted pairs or quads with pairs or quads mutually positioned to reduce cross-talk
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B13/00—Apparatus or processes specially adapted for manufacturing conductors or cables
    • H01B13/02—Stranding-up
    • H01B13/04—Mutually positioning pairs or quads to reduce cross-talk
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Manufacturing & Machinery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE3382749T 1982-11-17 1983-11-15 Glycosylierte Insulin-Derivate. Expired - Fee Related DE3382749T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/442,362 US4444683A (en) 1982-11-17 1982-11-17 Glycosylated insulin derivatives

Publications (2)

Publication Number Publication Date
DE3382749D1 DE3382749D1 (de) 1994-06-09
DE3382749T2 true DE3382749T2 (de) 1994-09-29

Family

ID=23756525

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8383903886T Expired DE3380199D1 (en) 1982-11-17 1983-11-15 Glycosylated insulin derivatives
DE3382749T Expired - Fee Related DE3382749T2 (de) 1982-11-17 1983-11-15 Glycosylierte Insulin-Derivate.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8383903886T Expired DE3380199D1 (en) 1982-11-17 1983-11-15 Glycosylated insulin derivatives

Country Status (8)

Country Link
US (2) US4444683A (de)
EP (2) EP0125299B1 (de)
JP (1) JPH0613556B2 (de)
AT (2) ATE105296T1 (de)
CA (1) CA1216578A (de)
DE (2) DE3380199D1 (de)
IT (1) IT1207992B (de)
WO (1) WO1984001896A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8102194L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
NL194729C (nl) * 1986-10-13 2003-01-07 Novartis Ag Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
DE3790635B4 (de) * 1986-10-13 2007-11-22 Novartis Ag Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür
US4885163A (en) * 1987-02-24 1989-12-05 Eli Lilly And Company Topical use of IGF-II for wound healing
DE3829798A1 (de) * 1988-09-02 1990-03-08 Bosch Gmbh Robert Kraftstoffeinspritzpumpe fuer brennkraftmaschinen
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
JP2648584B2 (ja) * 1990-02-16 1997-09-03 株式会社ディ・ディ・エス研究所 グリコシル−蛋白誘導体
JP3318602B2 (ja) 1997-11-10 2002-08-26 独立行政法人産業技術総合研究所 糖鎖付加型ヘパリン結合性タンパク質、その製造方法およびそれを含有する医薬組成物
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
US7316999B2 (en) * 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US7317000B2 (en) * 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
CA2590563C (en) * 2004-12-06 2014-02-18 Vetrox Ag Device for polishing hard surfaces, especially glass surfaces
US7687608B2 (en) * 2005-10-19 2010-03-30 Smartcells, Inc. Methods for reducing the mitogenicity of lectin compositions
KR100829257B1 (ko) * 2006-06-22 2008-05-14 부경대학교 산학협력단 인간 섬유육종세포에서 메트릭스 메탈로프로테이나제-9의발현 및 활성을 억제하는 카복시화 글루코사민 화합물 및이를 함유한 메트릭스 메탈로프로테이나제-9 억제제
JP2008214256A (ja) * 2007-03-02 2008-09-18 Yaizu Suisankagaku Industry Co Ltd 双頭型配糖化合物の製造方法及び双頭型配糖化合物並びに該双頭型配糖化合物を含有する糖鎖認識タンパク質結合剤
US8846103B2 (en) 2009-01-28 2014-09-30 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
RU2011135730A (ru) 2009-01-28 2013-03-10 Смартселлз, Инк. Кристаллические инсулин-коньюгаты
WO2010088286A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Synthetic conjugates and uses thereof
NZ594248A (en) 2009-01-28 2015-03-27 Smartcells Inc Conjugate based systems for controlled drug delivery
WO2010107520A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
US8623345B2 (en) 2009-03-20 2014-01-07 Smartcells Terminally-functionalized conjugates and uses thereof
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
WO2012015692A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
JP2013541500A (ja) 2010-07-28 2013-11-14 スマートセルズ・インコーポレイテツド 組換えレクチン、結合部位修飾レクチンおよびそれらの用途
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
EP3052134B1 (de) 2013-10-04 2021-05-05 Merck Sharp & Dohme Corp. Auf glucose reagierende insulinkonjugate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591574A (en) * 1968-05-29 1971-07-06 American Home Prod Tri-n-phenylglycyl derivatives of insulin
US3723617A (en) * 1968-12-31 1973-03-27 Smith Kline French Lab Anti-inflammatory compositions containing acylated-{62 -d-glucopyranosides and methods of using them
US3847890A (en) * 1971-11-01 1974-11-12 A Green Acidic monosaccharide-substituted proteins
US3755569A (en) * 1972-07-25 1973-08-28 American Home Prod Acyl substituted insulins
US4152513A (en) * 1977-06-01 1979-05-01 University Of Delaware Preparation of alkyl glycosides of amino sugars
DE3220427A1 (de) * 1982-05-29 1983-12-01 Behringwerke Ag, 3550 Marburg Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung

Also Published As

Publication number Publication date
DE3382749D1 (de) 1994-06-09
JPS59502065A (ja) 1984-12-13
EP0125299A1 (de) 1984-11-21
EP0312127B1 (de) 1994-05-04
JPH0613556B2 (ja) 1994-02-23
ATE44649T1 (de) 1989-08-15
CA1216578A (en) 1987-01-13
EP0125299A4 (de) 1986-02-13
WO1984001896A1 (en) 1984-05-24
IT1207992B (it) 1989-06-01
ATE105296T1 (de) 1994-05-15
IT8323762A0 (it) 1983-11-17
EP0312127A3 (de) 1991-09-25
US4478746A (en) 1984-10-23
DE3380199D1 (en) 1989-08-24
US4444683A (en) 1984-04-24
EP0125299B1 (de) 1989-07-19
EP0312127A2 (de) 1989-04-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee