ATE44649T1 - Glykosylierte insulinabkoemmlinge. - Google Patents

Glykosylierte insulinabkoemmlinge.

Info

Publication number
ATE44649T1
ATE44649T1 AT83903886T AT83903886T ATE44649T1 AT E44649 T1 ATE44649 T1 AT E44649T1 AT 83903886 T AT83903886 T AT 83903886T AT 83903886 T AT83903886 T AT 83903886T AT E44649 T1 ATE44649 T1 AT E44649T1
Authority
AT
Austria
Prior art keywords
combat
mannopyranosides
gluco
alpha
phenyl
Prior art date
Application number
AT83903886T
Other languages
English (en)
Inventor
James C Mcrea
Original Assignee
Univ Utah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah filed Critical Univ Utah
Application granted granted Critical
Publication of ATE44649T1 publication Critical patent/ATE44649T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B11/00—Communication cables or conductors
    • H01B11/02—Cables with twisted pairs or quads
    • H01B11/04—Cables with twisted pairs or quads with pairs or quads mutually positioned to reduce cross-talk
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B13/00—Apparatus or processes specially adapted for manufacturing conductors or cables
    • H01B13/02—Stranding-up
    • H01B13/04—Mutually positioning pairs or quads to reduce cross-talk
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Manufacturing & Machinery (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
AT83903886T 1982-11-17 1983-11-15 Glykosylierte insulinabkoemmlinge. ATE44649T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/442,362 US4444683A (en) 1982-11-17 1982-11-17 Glycosylated insulin derivatives
PCT/US1983/001780 WO1984001896A1 (en) 1982-11-17 1983-11-15 Glycosylated insulin derivatives
EP83903886A EP0125299B1 (de) 1982-11-17 1983-11-15 Glykosylierte insulinabkömmlinge

Publications (1)

Publication Number Publication Date
ATE44649T1 true ATE44649T1 (de) 1989-08-15

Family

ID=23756525

Family Applications (2)

Application Number Title Priority Date Filing Date
AT83903886T ATE44649T1 (de) 1982-11-17 1983-11-15 Glykosylierte insulinabkoemmlinge.
AT8888120072T ATE105296T1 (de) 1982-11-17 1983-11-15 Glycosylierte insulin-derivate.

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT8888120072T ATE105296T1 (de) 1982-11-17 1983-11-15 Glycosylierte insulin-derivate.

Country Status (8)

Country Link
US (2) US4444683A (de)
EP (2) EP0312127B1 (de)
JP (1) JPH0613556B2 (de)
AT (2) ATE44649T1 (de)
CA (1) CA1216578A (de)
DE (2) DE3380199D1 (de)
IT (1) IT1207992B (de)
WO (1) WO1984001896A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8102194L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
DE3790635B4 (de) * 1986-10-13 2007-11-22 Novartis Ag Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür
US4885163A (en) * 1987-02-24 1989-12-05 Eli Lilly And Company Topical use of IGF-II for wound healing
DE3829798A1 (de) * 1988-09-02 1990-03-08 Bosch Gmbh Robert Kraftstoffeinspritzpumpe fuer brennkraftmaschinen
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
JP2648584B2 (ja) * 1990-02-16 1997-09-03 株式会社ディ・ディ・エス研究所 グリコシル−蛋白誘導体
JP3318602B2 (ja) * 1997-11-10 2002-08-26 独立行政法人産業技術総合研究所 糖鎖付加型ヘパリン結合性タンパク質、その製造方法およびそれを含有する医薬組成物
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
US7316999B2 (en) * 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US7317000B2 (en) * 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
ATE409546T1 (de) * 2004-12-06 2008-10-15 Vetrox Ag Vorrichtung zum schleifen von harten oberflächen, insbesondere von glasflächen
WO2007047922A2 (en) * 2005-10-19 2007-04-26 Smartcells, Inc. Polymer-drug conjugates
KR100829257B1 (ko) * 2006-06-22 2008-05-14 부경대학교 산학협력단 인간 섬유육종세포에서 메트릭스 메탈로프로테이나제-9의발현 및 활성을 억제하는 카복시화 글루코사민 화합물 및이를 함유한 메트릭스 메탈로프로테이나제-9 억제제
JP2008214256A (ja) * 2007-03-02 2008-09-18 Yaizu Suisankagaku Industry Co Ltd 双頭型配糖化合物の製造方法及び双頭型配糖化合物並びに該双頭型配糖化合物を含有する糖鎖認識タンパク質結合剤
BRPI1007466A2 (pt) 2009-01-28 2018-06-12 Smartcells Inc conjugado de insulina cristalina, formulação de liberação prolongada, e, sistema de distribuição de bomba
US8940690B2 (en) 2009-01-28 2015-01-27 National Institutes Of Health (Nih) Synthetic conjugates and uses thereof
US9050370B2 (en) 2009-01-28 2015-06-09 Smartcells, Inc. Conjugate based systems for controlled drug delivery
WO2010088268A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
EP2408470A4 (de) 2009-03-20 2012-08-29 Smartcells Inc Lösliche nichtdepot-insulinkonjugate und ihre verwendung
WO2010107519A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Terminally-functionalized conjugates and uses thereof
WO2012015692A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
CA2805902A1 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinant lectins, binding-site modified lectins and uses thereof
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
JP6735561B2 (ja) 2012-12-03 2020-08-05 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｏ−グリコシル化カルボキシ末端部分（ｃｔｐ）ペプチド系のインスリンおよびインスリン類似体
US9884125B2 (en) 2013-10-04 2018-02-06 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591574A (en) * 1968-05-29 1971-07-06 American Home Prod Tri-n-phenylglycyl derivatives of insulin
US3723617A (en) * 1968-12-31 1973-03-27 Smith Kline French Lab Anti-inflammatory compositions containing acylated-{62 -d-glucopyranosides and methods of using them
US3847890A (en) * 1971-11-01 1974-11-12 A Green Acidic monosaccharide-substituted proteins
US3755569A (en) * 1972-07-25 1973-08-28 American Home Prod Acyl substituted insulins
US4152513A (en) * 1977-06-01 1979-05-01 University Of Delaware Preparation of alkyl glycosides of amino sugars
DE3220427A1 (de) * 1982-05-29 1983-12-01 Behringwerke Ag, 3550 Marburg Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung

Also Published As

Publication number Publication date
EP0312127A3 (de) 1991-09-25
EP0125299B1 (de) 1989-07-19
EP0312127B1 (de) 1994-05-04
EP0312127A2 (de) 1989-04-19
WO1984001896A1 (en) 1984-05-24
IT1207992B (it) 1989-06-01
DE3382749T2 (de) 1994-09-29
DE3380199D1 (en) 1989-08-24
US4478746A (en) 1984-10-23
JPS59502065A (ja) 1984-12-13
US4444683A (en) 1984-04-24
ATE105296T1 (de) 1994-05-15
CA1216578A (en) 1987-01-13
JPH0613556B2 (ja) 1994-02-23
IT8323762A0 (it) 1983-11-17
DE3382749D1 (de) 1994-06-09
EP0125299A1 (de) 1984-11-21
EP0125299A4 (de) 1986-02-13

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee