AU574436B2 - 2,5-diaryl tetrahydrothiophenes and analogs thereof as paf-antagonists - Google Patents

2,5-diaryl tetrahydrothiophenes and analogs thereof as paf-antagonists

Info

Publication number
AU574436B2
AU574436B2 AU39194/85A AU3919485A AU574436B2 AU 574436 B2 AU574436 B2 AU 574436B2 AU 39194/85 A AU39194/85 A AU 39194/85A AU 3919485 A AU3919485 A AU 3919485A AU 574436 B2 AU574436 B2 AU 574436B2
Authority
AU
Australia
Prior art keywords
paf
antagonists
analogs
diaryl tetrahydrothiophenes
tetrahydrothiophenes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
AU39194/85A
Other versions
AU3919485A (en
Inventor
Tesfaye Biftu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU3919485A publication Critical patent/AU3919485A/en
Application granted granted Critical
Publication of AU574436B2 publication Critical patent/AU574436B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
AU39194/85A 1984-02-29 1985-02-27 2,5-diaryl tetrahydrothiophenes and analogs thereof as paf-antagonists Expired - Fee Related AU574436B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58469384A 1984-02-29 1984-02-29
US584693 1984-02-29

Publications (2)

Publication Number Publication Date
AU3919485A AU3919485A (en) 1985-09-05
AU574436B2 true AU574436B2 (en) 1988-07-07

Family

ID=24338431

Family Applications (1)

Application Number Title Priority Date Filing Date
AU39194/85A Expired - Fee Related AU574436B2 (en) 1984-02-29 1985-02-27 2,5-diaryl tetrahydrothiophenes and analogs thereof as paf-antagonists

Country Status (12)

Country Link
EP (1) EP0154887B1 (en)
JP (1) JPS60208975A (en)
AU (1) AU574436B2 (en)
CA (1) CA1266271A (en)
DE (1) DE3567865D1 (en)
DK (1) DK91885A (en)
ES (1) ES8607274A1 (en)
GR (1) GR850505B (en)
IL (1) IL74376A (en)
NZ (1) NZ211146A (en)
PT (1) PT79996B (en)
ZA (1) ZA851519B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU618665B2 (en) * 1989-03-31 1992-01-02 Miles Inc. Semi-conducting 2,5-dithienylpyrrole oligomers

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5010100A (en) * 1983-11-14 1991-04-23 Merck & Co. Inc. Certain 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
US4757084A (en) * 1984-02-29 1988-07-12 Merck & Co., Inc. 2,5-diaryl tetrahydrothiophenes and analogs thereof as PAF-antagonists
DE3873278T2 (en) * 1987-09-22 1993-02-25 Merck & Co Inc ARYL-SUBSTITUTED THIOPHEN-3-OLE, THEIR DERIVATIVES AND ANALOGS AS LIPOXYGENASE INHIBITORS.
US4999436A (en) * 1987-09-22 1991-03-12 Merck & Co., Inc. Aryl-substituted thiophene 3-ols, derivatives and analogs useful as lipoxgenase inhibitors
US4996203A (en) * 1987-12-21 1991-02-26 Merck & Co., Inc. 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
US5334592A (en) * 1988-04-27 1994-08-02 Schering Corporation Certain PAF antagonist antihistamine combinations and methods
AU619555B2 (en) * 1988-04-27 1992-01-30 Schering Corporation Certain paf antagonist antihistamine combinations and methods
EP0365089A3 (en) * 1988-10-18 1991-06-05 Merck & Co. Inc. 2-aryl-5(3-methoxy-5-(hydroxypropylsulfonyl)-4-propoxyphenyl) tetrahydrothiophen and analogs
US5001123A (en) * 1989-06-08 1991-03-19 Merck & Co., Inc. 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
US5011847A (en) * 1989-06-08 1991-04-30 Merck & Co., Inc. 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
US5114961A (en) * 1989-06-08 1992-05-19 Merck & Co., Inc. 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
JP2805006B2 (en) * 1991-08-29 1998-09-30 財団法人 工業技術研究院 Pharmaceuticals comprising thiophene compounds and pharmaceutically acceptable salts thereof
EE9600184A (en) * 1994-06-27 1997-06-16 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9003182A (en) * 1979-08-09 1983-02-03 Du Pont Merck Pharmaceutical Company, The 5-bromo-2,3-diarylthiophenes
AU1146083A (en) * 1982-03-03 1983-09-08 E.I. Du Pont De Nemours And Company 2,3-diaryl-5-halo thiophenes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1271082A (en) * 1968-05-07 1972-04-19 Wyeth John & Brother Ltd Furan, pyrrole and thiophene derivatives
CA1086643A (en) * 1976-06-01 1980-09-30 Douglas I. Relyea Thiophenes useful in control of certain arthropods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9003182A (en) * 1979-08-09 1983-02-03 Du Pont Merck Pharmaceutical Company, The 5-bromo-2,3-diarylthiophenes
AU1146083A (en) * 1982-03-03 1983-09-08 E.I. Du Pont De Nemours And Company 2,3-diaryl-5-halo thiophenes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU618665B2 (en) * 1989-03-31 1992-01-02 Miles Inc. Semi-conducting 2,5-dithienylpyrrole oligomers

Also Published As

Publication number Publication date
DK91885A (en) 1985-08-30
AU3919485A (en) 1985-09-05
CA1266271A (en) 1990-02-27
EP0154887A1 (en) 1985-09-18
ZA851519B (en) 1986-10-29
ES540748A0 (en) 1986-05-16
NZ211146A (en) 1987-10-30
PT79996B (en) 1987-01-13
GR850505B (en) 1985-06-26
IL74376A0 (en) 1985-05-31
PT79996A (en) 1985-03-01
EP0154887B1 (en) 1989-01-25
IL74376A (en) 1989-02-28
JPS60208975A (en) 1985-10-21
DK91885D0 (en) 1985-02-28
ES8607274A1 (en) 1986-05-16
DE3567865D1 (en) 1989-03-02

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