EP0299065A1 - Dispositif d'alimentation et de melange constants de matieres granulaires ou pulverulentes - Google Patents

Dispositif d'alimentation et de melange constants de matieres granulaires ou pulverulentes Download PDF

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Publication number
EP0299065A1
EP0299065A1 EP86903566A EP86903566A EP0299065A1 EP 0299065 A1 EP0299065 A1 EP 0299065A1 EP 86903566 A EP86903566 A EP 86903566A EP 86903566 A EP86903566 A EP 86903566A EP 0299065 A1 EP0299065 A1 EP 0299065A1
Authority
EP
European Patent Office
Prior art keywords
powdery particles
mixing
predeterminate
raw material
automatically feeding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86903566A
Other languages
German (de)
English (en)
Other versions
EP0299065A4 (fr
Inventor
Kiyoshi Morimoto
Masuo Moriyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of EP0299065A1 publication Critical patent/EP0299065A1/fr
Publication of EP0299065A4 publication Critical patent/EP0299065A4/fr
Withdrawn legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • B01F35/88—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise
    • B01F35/881—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise by weighing, e.g. with automatic discharge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/0082—Dust eliminating means; Mould or press ram cleaning means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/30—Feeding material to presses
    • B30B15/302—Feeding material in particulate or plastic state to moulding presses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/60—Mixing solids with solids

Definitions

  • This invention relates to an apparatus for feeding predeterminate quantity of powdery particles and mixing thereof, and more particularly to an apparatus for automatically feeding at least two different kinds of raw material powdery particles in predetermined amounts and mixing the powdery particles.
  • Applicable range of compression shaping or processing of various powdery particles into tablets, capsules, etc. have recently been extended to the production of compression moldings of food, electronic parts, mechanical parts, chemicals, etc., to say nothing of the production of tablets of medicaments. Such a remarkable spread is based on the fact that quality and/or function can be improved by shaping (solidifying) the powdery particles.
  • apparatuses for feeding a single kind of raw material into a hopper provided in a tableting machine and automatically tableting the powdery material have been commercially available.
  • they are mixed together in advance, and the mixture is fed into a hopper and tableted.
  • no apparatus for automatically mixing at least two different kinds of raw materials at predeterminate rates and feeding them into a tableting machine has not been developed so far.
  • a process for mixing different kinds of raw material powdery particles for example, main raw material powdery particles and a lubricant (usually inorganic salt of stearic acid, talc and the like are used) in the tableting, is necessary as a preliminary step.
  • a lubricant usually inorganic salt of stearic acid, talc and the like are used
  • the object of mixing in these processes falls into two groups; to unify the content of main components and to uniformly mix, with the other components, the lubricant as added in order to prevent troubles in the tablet production.
  • the former process has relatively few troubles, because the uniformity can be attained by advance mixing before the mixing prior to the tableting, that is, by mixing of the main components with an excipient after the raw material weighing, or the uniformity can be attained in the successive granulation step.
  • the mixing step using these batch-type mixers and the successive step of feeding the powdery particles into a tableting machine have the following problems.
  • a large space is required for installing a mixer and mixing operation, (2) feeding or discharging operation, etc. of the powdery particles into or from the mixer mostly rely on workers, and undesirable environmental troubles such as dust generation, etc. are aroused, (3) separation and segregation of a lubricant, when occurred in batch mixing of main raw materials (powdery particles granulated by a granulator, etc.) with the lubricant and pneumatically conveying the resulting mixture to a hopper in a tableting machine, lead to fluctuation of tablet weight during the tableting, uneven content of the medicament, capping, lamination, sticking, reduced hardness, etc., which debase the quality, (4) a way to convey the powdery particles to a tableting machine is restricted, resulting in a bar to continuation and automation of successive steps, and (5) such risks are incurred as contamination with foreign matters, etc., because the mixing operation mostly relies on manual labor which causes failure of tight sealing.
  • the present invention relates to an apparatuse for automatically feeding predeterminate quantity of powdery particles and mixing thereof, systematically provided with storage vessels for at least two different kinds of raw material powdery particles, a means for weighing desired amounts of the raw material powdery particles from the respective storage vessels, a means for discharging and transporting the weighed powdery particles to a mixing means, a means for mixing the respective weighed powdery particles, and a vessel for holding a predeterminate amount of the mixture (the apparatus is hereinafter referred to as the apparatus of the present invention).
  • the entire system can be made more compact and convenient for processing.
  • FIG. 1 One example of using two kinds of raw materials in an apparatus based on a combination of the apparatus of the present invention with a tableting machine is shown in Fig. 1.
  • One kind of raw material powdery particles is placed in a raw material storage vessel (1) 3, and fed to a weighing vessel (1) 7 provided with a balance 8 through an electromagnetic feeder through 5 by means of an electromagnetic feeder 6.
  • another kind of raw material powdery particles in a raw material storage vessel (2) 16 is fed to a weighing vessel (2) 19 provided with a balance 20 through an electromagnetic feeder through 17 by means of an electromagnetic feeder 18.
  • the predeterminate weights of the raw materials fed to the weighing vessels are confirmed by checking if they are within a range of predetermined error in measurement by a weight-setting comparator 26. After the confirmation of the weighed amounts, the respective raw materials are sent to a mixer 11 by a raw material discharge valve 10 or 22.
  • the presence or absence of the powdery particles remaining in the respective weighing vessels is confirmed by the weight-setting comparator 26 through the respective balances, or by a raw material discharge-checking sensor 9 or 21 provided at the respective weighing vessels.
  • a mixer-stirring motor 13 at the mixer 11 is started to mix the raw materials with stirring blades 14.
  • the mixture is supplied to the vessel 23 for holding the powdery particles mixture with stirring through the powdery particle discharge valve 15 until a predeterminate amount of the powdery particle mixture is defected by a powdery particle-detecting sensor 24 provided at the vessel 23, and then the valve 15 is closed.
  • the mixture in the vessel 23 for holding the powdery particles is supplied to a tableting machine through an appropriate supply means, and tableted.
  • valves, valves, shutters, etc. utilizing electricity or compressed air can be used.
  • a screw feeder, a table feeder, etc. can be used.
  • an electromagnetic feeder, a screw feeder, a table feeder, etc. can be used in place of the raw material-discharge valve.
  • a valve In transferring the raw material from one vessel to another, a valve is convenient as a means for transferring the raw material, when the vessels are to be vertically located, but an electromagnetic valve, etc. are preferable when a control over the feeding of trace amounts of powdery particles is required.
  • the successive operation it is possible to set a time schedule by a timer so as to establish control over the starting of the successive step after the completion of the preceding step has been confirmed, but a software may be set up in a computer so that the start and completion of the respective steps can be confirmed, and such a design can be made very easily by those skilled in the art.
  • the successive control can be made more easily.
  • a circuit When an abnormal state occurs in the steps, a circuit must be set up to emit an alarm and discontinue operation of the apparatus entirely or partially.
  • FIG. 1 An example of a system for automatic control of the apparatus of the present invention connected with a tableting machine is described below, referring to Fig. 1.
  • Various devices can be added to the apparatus of the present invention in order to simplify attachment or detachment of the apparatus to a processing and treating apparatus in the successive step, and to enable the entire apparatus to be washed with water, etc.
  • the contact part with the powdery particles is coated with a special complex resin, and all the corners are made to have round surfaces to eliminate dead spaces.
  • a one-touch coupling is used. All the valves must be of sanitory type and readily washable.
  • the detectors, weighing sections, and bearing sections must be in a water-proof structure.
  • Test examples of the present invention are outlined below.
  • Raw materials and their composition for carrying out the tests are shown in Table 1, characteristics of granulated powdery particles prepared by a fluidized bed granulator in Table 2, and operating conditions of a tableting machine in Table 3.
  • the main raw material powdery particles were prepared by spray-granulating an aqueous solution of HPC-L on a mixture of lactose and potato starch with heating in a fluidized bed ganulator.
  • the apparatus of the-present invention was continuously operated for 5 hours, as connected with the tableting machine to investigate the produced tablets on the tablet characteristics such as fluctuation of tablet weight with the elapse of time, hardness, capping, sticking, etc., and its behavior was observed.
  • Magnesium in the magnesium stearate contained in the tablets obtained in the foregoing Test Example 1 was quantitatively determined by atomic absorption analysis to compare the content in tablets produced by the use of the V-type mixer with that in tablets produced by the use of the apparatus of the present invention. As shown in Table 5, the fluctuation in mixing with the elapse of time is smaller and the apparatus of the present invention is advantageous in uniformity of the content in tablets.
  • Time required for dismantling, washing and drying of the apparatus of the present invention was about 40 minutes, and the apparatus was found to be competent to be practically used.
  • Fig. 1 gives one embodiment illustrating a combination of an apparatus for feeding predeterminate quantity of powdery particles and mixing thereof according to the present invention with a tableting machine, where the respective members are given as follows:

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Dispositif de pesage, alimentation et mélange automatiques de matières brutes granulaires ou pulvérulentes, comportant des cuves de stockage pour au moins deux types de matières différentes. Un organe de pesage de quantités désirées de matières brutes provenant des cuves de stockage, un organe de décharge et de transfert dans une cuve de mélange des matières granulaires ou pulvérulentes pesées, un organe de mélange des matières granulaires ou pulvérulentes pesées, et un organe permettant de maintenir constante la quantité du mélange résultant, tous ces organes étant réunis de manière solidaire.
EP19860903566 1986-05-23 1986-05-23 Dispositif d'alimentation et de melange constants de matieres granulaires ou pulverulentes. Withdrawn EP0299065A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1986/000264 WO1987007182A1 (fr) 1986-05-23 1986-05-23 Dispositif d'alimentation et de melange constants de matieres granulaires ou pulverulentes

Publications (2)

Publication Number Publication Date
EP0299065A1 true EP0299065A1 (fr) 1989-01-18
EP0299065A4 EP0299065A4 (fr) 1989-05-16

Family

ID=13874443

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19860903566 Withdrawn EP0299065A4 (fr) 1986-05-23 1986-05-23 Dispositif d'alimentation et de melange constants de matieres granulaires ou pulverulentes.

Country Status (3)

Country Link
EP (1) EP0299065A4 (fr)
KR (1) KR880701131A (fr)
WO (1) WO1987007182A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627346A (en) * 1990-02-02 1997-05-06 Buhler Ag Plant for continuous mixing and homogenization
WO2003051501A1 (fr) * 2001-12-17 2003-06-26 Glaxo Group Limited Procede et appareil permettant de combiner un materiau vierge et un materiau retraite
WO2005005029A1 (fr) * 2003-07-11 2005-01-20 Charl Marais Appareil pour le melange de materiaux particulaires
CN103127872A (zh) * 2013-02-05 2013-06-05 江苏协诚科技发展有限公司 一种自动配料系统及生产工艺
WO2014207510A1 (fr) 2013-06-27 2014-12-31 Gea Process Engineering Nv Procédé de production en continu de comprimés, système de mise en comprimé selon ledit procédé, et utilisation du système de mise en comprimé pour la production de comprimés d'au moins deux ingrédients contenant des particules de granulométries significativement différentes
EP3926308A1 (fr) * 2020-06-17 2021-12-22 Fette Compacting GmbH Procédé de fonctionnement d'un dispositif de mélange d'une installation

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997021528A1 (fr) 1995-12-11 1997-06-19 Maguire Products, Inc. Melangeur gravimetrique
US6467943B1 (en) * 1997-05-02 2002-10-22 Stephen B. Maguire Reduced size gravimetric blender
US10201915B2 (en) 2006-06-17 2019-02-12 Stephen B. Maguire Gravimetric blender with power hopper cover
US8092070B2 (en) 2006-06-17 2012-01-10 Maguire Stephen B Gravimetric blender with power hopper cover
US10138075B2 (en) 2016-10-06 2018-11-27 Stephen B. Maguire Tower configuration gravimetric blender
CN108144540B (zh) * 2018-03-01 2023-12-19 安徽千乾新材料科技有限公司 一种混料装置
JP2018183817A (ja) * 2018-06-20 2018-11-22 ヘーエーアー プロセス エンジニアリング ナームロゼ フェンノートシャップ 錠剤の連続生産のための方法と、この方法を実行するための錠剤成形システムと、粒径が大きく異なる粒子を含む少なくとも２つの成分の錠剤を生産するためのこの錠剤成形システムの使用
CN114210218B (zh) * 2021-11-02 2023-02-03 深圳逗点生物技术有限公司 一种微量粉末分装方法、粉末混合方法、固化方法及滤芯
CN117358135B (zh) * 2023-12-08 2024-03-12 格莱德(福建)生物科技有限公司 一种可称重定量投加的犬饲料颗粒加工设备

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE459860A (fr) *
GB456852A (en) * 1935-07-20 1936-11-17 Simon Ltd Henry Improvements relating to the blending or mixing of grain or other materials
EP0170322A2 (fr) * 1984-07-31 1986-02-05 "National Forge Europe" Equipement pour mélanger des composants en forme de poudre et/ou de granules d'un corps devant être compressé sous haute pression

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60183028A (ja) * 1984-03-01 1985-09-18 Kubota Ltd 計量配合装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE459860A (fr) *
GB456852A (en) * 1935-07-20 1936-11-17 Simon Ltd Henry Improvements relating to the blending or mixing of grain or other materials
EP0170322A2 (fr) * 1984-07-31 1986-02-05 "National Forge Europe" Equipement pour mélanger des composants en forme de poudre et/ou de granules d'un corps devant être compressé sous haute pression

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8707182A1 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627346A (en) * 1990-02-02 1997-05-06 Buhler Ag Plant for continuous mixing and homogenization
WO2003051501A1 (fr) * 2001-12-17 2003-06-26 Glaxo Group Limited Procede et appareil permettant de combiner un materiau vierge et un materiau retraite
WO2005005029A1 (fr) * 2003-07-11 2005-01-20 Charl Marais Appareil pour le melange de materiaux particulaires
CN103127872A (zh) * 2013-02-05 2013-06-05 江苏协诚科技发展有限公司 一种自动配料系统及生产工艺
CN103127872B (zh) * 2013-02-05 2015-03-25 江苏协诚科技发展有限公司 一种自动配料系统及生产工艺
WO2014207510A1 (fr) 2013-06-27 2014-12-31 Gea Process Engineering Nv Procédé de production en continu de comprimés, système de mise en comprimé selon ledit procédé, et utilisation du système de mise en comprimé pour la production de comprimés d'au moins deux ingrédients contenant des particules de granulométries significativement différentes
EP3013571A1 (fr) * 2013-06-27 2016-05-04 GEA Process Engineering nv Procédé de production en continu de comprimés, système de mise en comprimé selon ledit procédé, et utilisation du système de mise en comprimé pour la production de comprimés d'au moins deux ingrédients contenant des particules de granulométries significativement différentes
US9713910B2 (en) 2013-06-27 2017-07-25 Gea Process Engineering Nv Tabletting system
EP3013571B1 (fr) * 2013-06-27 2023-06-07 GEA Process Engineering nv Procédé de production en continu de comprimés, système de mise en comprimé selon ledit procédé, et utilisation du système de mise en comprimé pour la production de comprimés d'au moins deux ingrédients contenant des particules de granulométries significativement différentes
EP3926308A1 (fr) * 2020-06-17 2021-12-22 Fette Compacting GmbH Procédé de fonctionnement d'un dispositif de mélange d'une installation

Also Published As

Publication number Publication date
KR880701131A (ko) 1988-07-26
WO1987007182A1 (fr) 1987-12-03
EP0299065A4 (fr) 1989-05-16

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Inventor name: MORIMOTO, KIYOSHI