EP0141800B1 - Procédé et dispositif pour l'élution et le dosage d'un générateur d'isotopes - Google Patents
Procédé et dispositif pour l'élution et le dosage d'un générateur d'isotopes Download PDFInfo
- Publication number
- EP0141800B1 EP0141800B1 EP84890135A EP84890135A EP0141800B1 EP 0141800 B1 EP0141800 B1 EP 0141800B1 EP 84890135 A EP84890135 A EP 84890135A EP 84890135 A EP84890135 A EP 84890135A EP 0141800 B1 EP0141800 B1 EP 0141800B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- eluate
- generator
- radiation
- filling
- aspiration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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Images
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
- G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
- G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
Definitions
- the invention relates to a method and a device for eluting and metering a radioactive nucleide, in particular technetium, from a nucleus generator into a storage ampoule or the like, from which the eluate is removed for use.
- the procedure is such that the generator is placed in a lead shield and connected to an eluate vessel containing a NaCl solution, by means of which the nucleus is eluted into an elution vessel which is also connected to the generator.
- a sterile solution of 99 Tc m can be obtained as sodium pertechnetate.
- the lead-coated elution vessel is then removed from the generator and the solution obtained is removed from the vessel for use by means of a syringe.
- a device of the type described above is e.g. B. is shown in AT-B-335 578.
- the invention therefore aims to provide a method and a device intended for carrying it out which enable a complete radiation-safe elution.
- the invention relates to a method for eluting and dosing a radioactive nucleide, in particular technetium, from a nucleus generator into a storage ampoule or the like, from which the nucleus is removed for use, in which the generator arranged in a radiation-proof housing is firstly supplied to a supply for liquid nuclei solvent and on the other hand is connected to an eluate suction and metering device connected to a filling device;
- This method is characterized in that the generator is then flushed under program control with a predeterminable amount of solvent and the eluate is transferred to an intermediate container of the suction device arranged in the radiation-proof housing, whereupon the radiation activity is measured and a predetermined amount of eluate is sent to the dosing device by means of the dosing device arranged in the radiation-proof housing Filling device provided in the radiation-proof housing is
- This working method ensures that the operator is not exposed to radiation during and after the elution process, because all process steps take place fully automatically within a closed housing shielded from radiation.
- the invention also relates to a device for carrying out the method according to the invention, with a housing shielded from radioactive radiation for accommodating a nucleus generator, a storage vessel for a liquid nucleus solvent, a device for connecting the storage vessel to the inlet of the generator, and a device for connecting the storage vessel and the output of the generator with a suction and metering device for the eluate, which in turn is connected to a filling station, in which the eluate or the like in a storage ampoule.
- a housing shielded from radioactive radiation for accommodating a nucleus generator, a storage vessel for a liquid nucleus solvent, a device for connecting the storage vessel to the inlet of the generator, and a device for connecting the storage vessel and the output of the generator with a suction and metering device for the eluate, which in turn is connected to a filling station, in which the eluate or the like in a storage ampoule.
- This device has the features that the storage vessel for liquid nuclei solvent, the connecting devices as well as the suction and metering device and the filling station are also arranged within the radiation-proof housing, and that the suction and metering device has a suction syringe, which has a controllable reusable valve with a storage container for the eluate is connectable to which a measuring device for measuring the radiation activity of the eluate is assigned, the suction and metering device and a rinsing and disinfecting station assigned to the filling station are connected to a waste container, and that a program control device for program control of the entire elution process is provided.
- the filling station has a swivel arm mechanism which carries a filling needle connected to the suction and metering device and a ventilation needle and is pivotable between a filling position and a rinsing and disinfecting position and is slidably mounted for filling and rinsing.
- a housing (not shown) for a nucleus generator 2, in particular technetium generator, is provided in a housing 1 shielded against radioactive radiation, the structure of which is known to the person skilled in the art.
- a NaCl solution or a vessel 3 containing dilute hydrochloric acid is also inserted into the housing and connected to the inlet E of the generator 2 via a hose 4 ', in which a 3-way valve 5' is switched on.
- An air filter 3 ' is also connected to line 4'.
- the vessel 3 containing the NaCl solution is also connected to the via a hose line 4 "and a 3-way valve 5" switched into this line Output of generator 2 in connection.
- a further hose line 4 ′ ′′ extends from the valve 5 ′′ to a suction and metering device, generally designated 6.
- This device can be connected via a 4-way valve 7 to the valve 5 ′′, to an eluate reservoir 8 and to an eluate filling station, generally designated 9.
- a measuring device 10 for determining the radiation activity of the eluate is assigned to the eluate reservoir 8.
- the storage container 8 can be connected on the one hand to the filling station 9 via the valve 7, and on the other hand via a ventilation line 8 'and a 3-way valve 12 connected to an air filter 11 with a waste container 13.
- a swivel arm mechanism 14 for an eluate vessel 15, a piercing ampoule in the example shown.
- the swivel arm 14 can be pivoted in the horizontal direction between a filling position F in the filling station 9 and a rinsing and disinfecting position S in a rinsing and disinfecting station 17 and can be displaced in the vertical direction.
- the swivel arm 14 is provided at its lower end with a carrier 14 'for two needles 16', 16 ". One longer needle 16 'is connected to the valve 7, while the other shorter needle 16" is connected via a hose line 8 " is connected to the waste container 13.
- the station 17 for rinsing and disinfecting the needles 16 ', 16 is connected via a hose line 17' and a pump 19 to a storage vessel 18 for a disinfectant and rinsing liquid, and is connected via a further line 17" in connection with the waste container 13.
- a lock 20 is provided in the wall of the housing 1 for inserting and removing the eluate vessel 15.
- the device is also provided with a program control device, not shown, for program control of the entire workflow.
- program control devices are known to the person skilled in the art and therefore do not need to be explained in more detail.
- the device explained above works as follows: after inserting the nucleus generator 2 and the NaCl vessel 3 into the housing 1 and connecting the hose lines 4 ′, 4 ′′ to the generator 2, for example by closing the housing 1
- the valve 5 ' is brought into a blocking position and the valve 5 "is switched so that the vessel 3 is connected to the 4-way valve 7 .
- the valve 7 is in turn switched so that it is connected to a syringe 6 'arranged in the device 6 so that it can draw in the NaCl solution.
- the valve 12 is switched so that the reservoir 8 is vented or can be flushed to the waste container 13.
- the valve 7 is then switched to release the connection between the syringe 6 'and the storage container 8, whereupon the syringe 6' presses the sucked-in NaCl solution into the storage container 8 until it is filled.
- the valve 12 is then switched so that the reservoir 8 is only connected to the air filter 11, whereupon the syringe 6 'sucks the liquid out of the reservoir 8 again.
- the valve 7 then connects the syringe 6 'to the needle 16' pivoted into the rinsing position 8 and the syringe 6 'rinses the previously sucked-in contents of the storage container 8 via the needle 16' and the line 17 "into the waste container 13.
- the program control is such that the valve 5 'first connects the NaCI vessel 3 to the input E of the generator 2 and the valve 5 "the output A of the generator to the valve 7, which establishes the connection with the syringe 6'.
- the valve 7 then switches to the connection between the syringe 6' and the rinsing station 17, in which the Swivel arm 14 with the needles 16 ', 16 "is in the starting position, and the syringe 6' empties via the needle 16 'and the line 17" into the waste container 13.
- the valve 7 then switches back to connection between the output A of the Generator 2 and the syringe 6 ', so that the predetermined amount of solution can be sucked in, minus the amount that is in the lines between the valve 5', the generator 2 and the valve 5 "to the entrance of the syringe 6 ' indet.
- the generator 2 is drained by repeated suction of air by means of the syringe 6 'via the valve 5', the generator 2, the valve 5 ", the valve 7 and by blowing out the air via the valve 7 and the flushing station 17.
- the NaCl solution is sucked in by the syringe 6 'via the valves 5 "and 7 until the inlet of the syringe 6' is reached, whereupon the syringe 6 'is emptied into the rinsing station 17.
- the desired amount is now removed from the storage container 8 aspirated, if necessary, a dilution amount of NaCI and then pressed up to the filling needles 16, 16 'in order to empty the line 7'.
- the desired eluate bottle 15 has been transported into the filling station 9 via a transport device, not shown, and the bottle cap has been disinfected.
- the needles 16 ′, 16 ′′ which have been conveyed into the filling station are moved downwards against the bottle 15 in this station 9 to such an extent that the first needle 16 ′ pierces the rubber closure cap 15 ′ of the bottle 15 and the filling of the eluate by means of the syringe 6.
- the needles 16', 16 "are moved further downward after a short filling time, so that the second needle 16" pierces the bottle cap and the air - or excess nitrogen discharges via a line 12 'into the waste container 13.
- the needles 16', 16 are pulled out of the closure and pivoted by means of the arm 14 into the rinsing and disinfecting station 17 in order to disinfect them to become.
- the filled vial 15 is conveyed into a rotatable storage station (not shown) arranged in the housing 1, cooled, heated as required or stored at room temperature until it is used.
- the bottle 15 which is provided with a lead shield, is conveyed into the lock 20, in which an opening is provided, through which the required amount can be withdrawn from the vial 15 with an injection needle.
- the device shown can be modified in various ways within the scope of the general inventive concept.
- the suction syringe 6 'of the suction and metering device can be replaced by a vacuum pump, the latter, however, having to be arranged at a different location than the one shown.
- the swivel arm mechanism could also be replaced by another mechanical device. It is further understood that the entire elution process takes place under sterile conditions.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Sampling And Sample Adjustment (AREA)
- Measurement Of Radiation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nuclear Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Claims (4)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT2948/83 | 1983-08-17 | ||
AT0294883A AT379253B (de) | 1983-08-17 | 1983-08-17 | Verfahren und vorrichtung zum eluieren und dosieren eines radioaktiven nukleids |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0141800A1 EP0141800A1 (fr) | 1985-05-15 |
EP0141800B1 true EP0141800B1 (fr) | 1987-10-14 |
Family
ID=3542885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP84890135A Expired EP0141800B1 (fr) | 1983-08-17 | 1984-07-19 | Procédé et dispositif pour l'élution et le dosage d'un générateur d'isotopes |
Country Status (9)
Country | Link |
---|---|
US (1) | US4625118A (fr) |
EP (1) | EP0141800B1 (fr) |
JP (1) | JPH0750200B2 (fr) |
AT (1) | AT379253B (fr) |
CA (1) | CA1220881A (fr) |
DE (1) | DE3466824D1 (fr) |
DK (1) | DK170104B1 (fr) |
ES (1) | ES8605108A1 (fr) |
NO (1) | NO162174C (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4853546A (en) * | 1986-09-16 | 1989-08-01 | Ube Industries, Ltd. | Automatic radioisotope filling apparatus |
AT391763B (de) * | 1988-09-13 | 1990-11-26 | Bender & Co Gmbh | Einrichtung zum messen der aktivitaet und des volumens radioaktiver fluessigkeiten |
US5039863A (en) * | 1988-11-15 | 1991-08-13 | Ube Industries, Ltd. | Automatic radioisotope filling apparatus |
ATE154722T1 (de) * | 1991-05-01 | 1997-07-15 | Mallinckrodt Medical Inc | Verfahren zur förderung von flüssigen materialien und vorrichtung zur automatischen eluierung eines radionuklidgenerators |
CN1035736C (zh) * | 1992-10-14 | 1997-08-27 | 中国核动力研究设计院 | 凝胶型锝-99m发生器自动分装装置 |
GB0305848D0 (en) * | 2003-03-14 | 2003-04-16 | Imaging Res Solutions Ltd | Radiopharmaceutical generation system |
WO2005057589A2 (fr) * | 2003-11-05 | 2005-06-23 | Board Of Regents, The University Of Texas System | Dispositif de synthese de marqueurs radioactifs automatise multifonction |
WO2005083393A1 (fr) * | 2004-01-27 | 2005-09-09 | Arcana International, Inc. | Systeme de commande, de verification et d'enregistrement des performances des operations effectuees par un generateur de radio-isotopes |
US7163031B2 (en) * | 2004-06-15 | 2007-01-16 | Mallinckrodt Inc. | Automated dispensing system and associated method of use |
DE102005031920B4 (de) * | 2005-07-07 | 2007-12-20 | Isotopen Technologien München AG | Vorrichtung und Verfahren zur Herstellung einer geringen Menge einer radioaktiven Substanzverbindung |
CA2618604A1 (fr) * | 2005-08-09 | 2007-03-05 | Mallinckrodt Inc. | Systeme de generation de radio-isotopes partiellement aptes a l'elution |
ITBO20060128A1 (it) * | 2006-02-21 | 2007-08-22 | Tema Sinergie S R L | Macchina dosatrice di liquido radioattivo. |
US7862534B2 (en) * | 2008-06-11 | 2011-01-04 | Bracco Diagnostics Inc. | Infusion circuit subassemblies |
AU2009257432B2 (en) | 2008-06-11 | 2014-11-13 | Bracco Diagnostics Inc. | Infusion systems including computer-facilitated maintenance and/or operation |
US9597053B2 (en) * | 2008-06-11 | 2017-03-21 | Bracco Diagnostics Inc. | Infusion systems including computer-facilitated maintenance and/or operation and methods of use |
US8708352B2 (en) * | 2008-06-11 | 2014-04-29 | Bracco Diagnostics Inc. | Cabinet structure configurations for infusion systems |
US8317674B2 (en) | 2008-06-11 | 2012-11-27 | Bracco Diagnostics Inc. | Shielding assemblies for infusion systems |
US8216181B2 (en) * | 2008-11-19 | 2012-07-10 | Bracco Diagnostics, Inc. | Apparatus and methods for support of a membrane filter in a medical infusion system |
CN102249352B (zh) * | 2011-05-23 | 2013-03-20 | 中国工程物理研究院核物理与化学研究所 | 医用高锝酸盐自动生产装置 |
AU2015229189B2 (en) | 2014-03-13 | 2020-04-09 | Bracco Diagnostics Inc. | Real time nuclear isotope detection |
US11752254B2 (en) | 2016-09-20 | 2023-09-12 | Bracco Diagnostics Inc. | Radioisotope delivery system with multiple detectors to detect gamma and beta emissions |
EP3776599B1 (fr) | 2018-03-28 | 2023-09-13 | Bracco Diagnostics Inc. | Détection précoce de la durée de vie d'un générateur de radio-isotopes |
RU2754815C1 (ru) * | 2020-09-29 | 2021-09-07 | федеральное государственное бюджетное образовательное учреждение высшего образования "Ульяновский государственный университет" | Способ дозирования и фасовки фармацевтических субстанций и устройство для его реализации |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE6944639U (de) * | 1968-11-25 | 1970-06-04 | Squibb & Sons Inc | Geraet zum abgeben von radioaktivem material |
FR2053665A5 (en) * | 1969-07-11 | 1971-04-16 | Commissariat Energie Atomique | Handling short lived radioactive samples automatically |
US3710118A (en) * | 1970-05-25 | 1973-01-09 | Mallinckrodt Chemical Works | Radioisotope generator |
US3774035A (en) * | 1971-07-12 | 1973-11-20 | New England Nuclear Corp | Method and system for generating and collecting a radionuclide eluate |
JPS4928879A (fr) * | 1972-07-14 | 1974-03-14 | ||
DE2236565C3 (de) * | 1972-07-26 | 1979-05-03 | Hoechst Ag, 6000 Frankfurt | Vorrichtung zum Herstellen von sterilen, injizierbaren Eluaten durch Eluieren von Nuklidgeneratoren |
US3997784A (en) * | 1975-06-16 | 1976-12-14 | Union Carbide Corp | Automatic apparatus for dispensing radiodiagnostic agents and method therefor |
JPS5715899A (en) * | 1980-07-02 | 1982-01-27 | Ebara Infilco Co Ltd | Treatment of organic waste water |
US4472299A (en) * | 1981-04-24 | 1984-09-18 | Amersham International Plc | Generator for radionuclide and process of use thereof |
-
1983
- 1983-08-17 AT AT0294883A patent/AT379253B/de not_active IP Right Cessation
-
1984
- 1984-07-19 DE DE8484890135T patent/DE3466824D1/de not_active Expired
- 1984-07-19 EP EP84890135A patent/EP0141800B1/fr not_active Expired
- 1984-07-30 DK DK370684A patent/DK170104B1/da not_active IP Right Cessation
- 1984-08-14 ES ES535121A patent/ES8605108A1/es not_active Expired
- 1984-08-15 US US06/640,965 patent/US4625118A/en not_active Expired - Lifetime
- 1984-08-15 CA CA000461025A patent/CA1220881A/fr not_active Expired
- 1984-08-16 NO NO843284A patent/NO162174C/no unknown
- 1984-08-17 JP JP59170541A patent/JPH0750200B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE3466824D1 (en) | 1987-11-19 |
AT379253B (de) | 1985-12-10 |
DK370684A (da) | 1985-02-18 |
DK370684D0 (da) | 1984-07-30 |
NO162174C (no) | 1989-11-15 |
ES535121A0 (es) | 1986-03-16 |
ES8605108A1 (es) | 1986-03-16 |
EP0141800A1 (fr) | 1985-05-15 |
US4625118A (en) | 1986-11-25 |
ATA294883A (de) | 1985-04-15 |
DK170104B1 (da) | 1995-05-22 |
JPS6070400A (ja) | 1985-04-22 |
NO843284L (no) | 1985-02-18 |
NO162174B (no) | 1989-08-07 |
CA1220881A (fr) | 1987-04-21 |
JPH0750200B2 (ja) | 1995-05-31 |
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