EP0141800A1 - Procédé et dispositif pour l'élution et le dosage d'un générateur d'isotopes - Google Patents

Procédé et dispositif pour l'élution et le dosage d'un générateur d'isotopes Download PDF

Info

Publication number
EP0141800A1
EP0141800A1 EP84890135A EP84890135A EP0141800A1 EP 0141800 A1 EP0141800 A1 EP 0141800A1 EP 84890135 A EP84890135 A EP 84890135A EP 84890135 A EP84890135 A EP 84890135A EP 0141800 A1 EP0141800 A1 EP 0141800A1
Authority
EP
European Patent Office
Prior art keywords
eluate
generator
radiation
suction
filling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP84890135A
Other languages
German (de)
English (en)
Other versions
EP0141800B1 (fr
Inventor
Karl Gärtner
Gert Dr. Kriwetz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim RCV GmbH and Co KG
Original Assignee
Bender and Co GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bender and Co GmbH filed Critical Bender and Co GmbH
Publication of EP0141800A1 publication Critical patent/EP0141800A1/fr
Application granted granted Critical
Publication of EP0141800B1 publication Critical patent/EP0141800B1/fr
Expired legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application

Definitions

  • the invention relates to a method and a device for eluting and metering a radioactive nucleide, in particular technetium, from a nucleus generator into a storage ampoule or the like, from which the eluate is removed for use.
  • the procedure is such that the generator is placed in a lead shield and connected to an eluate vessel containing a NaCl solution, by means of which the nucleus is eluted into an elution vessel which is also connected to the generator.
  • a sterile solution of 99 Tc m can be obtained as sodium pertechnetate.
  • the lead-coated elution vessel is then removed from the generator and the solution obtained is removed from the vessel for use by means of a syringe.
  • a device of the type described above is shown, for example, in AT-B-335 578.
  • the invention therefore aims to provide a method and a device intended for carrying it out which enable a complete radiation-safe elution.
  • the invention relates to a method for eluting and metering a radioactive nucleide, in particular technetium, from a nucleus generator into a storage ampoule or the like, from which the nucleus is removed for use, in which the generator arranged in a radiation-proof housing is firstly supplied to a supply for liquid nuclei solvent and on the other hand to one with a filling device in ver binding eluate suction and dosing device is connected;
  • This method is characterized in that the generator is then flushed under program control with a predeterminable amount of solvent and the eluate is transferred to an intermediate container of the suction device arranged in the radiation-proof housing, whereupon the radiation activity is measured and a predetermined amount of eluate is sent to the dosing device by means of the dosing device arranged in the radiation-proof housing
  • This working method ensures that the operator is not exposed to radiation during and after the elution process, because all process steps take place fully automatically within a closed housing shielded from radiation.
  • the invention also relates to a device for carrying out the method according to the invention, with a housing shielded from radioactive radiation for accommodating a nucleus generator, a storage vessel for a liquid nucleus solvent, a device for connecting the storage vessel to the inlet of the generator, and a device for connecting the storage vessel and the output of the generator with a suction and metering device for the eluate, which in turn is connected to a filling station, in which the eluate or the like in a storage ampoule.
  • a housing shielded from radioactive radiation for accommodating a nucleus generator, a storage vessel for a liquid nucleus solvent, a device for connecting the storage vessel to the inlet of the generator, and a device for connecting the storage vessel and the output of the generator with a suction and metering device for the eluate, which in turn is connected to a filling station, in which the eluate or the like in a storage ampoule.
  • this device has the features that the storage vessel for liquid nuclei solvent, the connecting devices as well as the suction and metering device and the filling station are likewise are arranged within the radiation-proof housing that the suction and metering device has a suction syringe which can be connected via a controllable reusable valve to a reservoir for the eluate, to which a measuring device for measuring the radiation activity of the eluate is assigned, that the suction and Dosing device and a rinsing and disinfecting station assigned to the filling station are connected to a waste container, and that a program control device is provided for program control of the entire elution process.
  • the filling station has a swivel arm mechanism which carries a filling needle connected to the suction and dosing device and a ventilation needle and is pivotable between a filling position and a rinsing and disinfecting position and is slidably mounted for filling and rinsing.
  • a housing (not shown) for a nucleus generator 2, in particular technetium generator, is provided in a housing 1 shielded against radioactive radiation, the structure of which is known to the person skilled in the art.
  • a NaCl solution or a vessel 3 containing dilute hydrochloric acid is also inserted into the housing and connected to the inlet E of the generator 2 via a hose 4 ', in which a 3-way valve 5' is switched on.
  • An air filter 3 ' is also connected to line 4'.
  • the vessel 3 containing the NaCl solution is also connected to the via a hose line 4 "and a 3-way valve 5" switched into this line Output of generator 2 in connection.
  • a further hose line 4 '' extends from the valve 5 "to a suction and metering device, generally designated 6.
  • This device can be connected via a 4-way valve 7 to the valve 5 ′′, to an eluate reservoir 8 and to an eluate filling station, generally designated 9.
  • a measuring device 10 for determining the radiation activity of the eluate is assigned to the eluate reservoir 8.
  • the reservoir 8 is on the one hand via the valve? can be connected to the filling station 9, and on the other hand via a ventilation line 8 ′ and a 3-way valve 12 connected to an air filter 11 with a waste container 13.
  • a swivel arm mechanism 14 for an eluate vessel 15, a piercing ampoule in the example shown.
  • the swivel arm 14 can be pivoted in the horizontal direction between a filling position F in the filling station 9 and a rinsing and disinfecting position S in a rinsing and disinfecting station 17 and can be displaced in the vertical direction.
  • the swivel arm 14 is provided at its lower end with a carrier 14 'for two needles 16', 16 ". One longer needle 16 'is connected to the valve 7, while the other shorter needle 16" is connected via a hose line 8 " is connected to the waste container 13.
  • the station 17 for rinsing and disinfecting the needles 16 ', 16 is connected via a hose line 17' and a pump 19 to a storage vessel 18 for a disinfectant and rinsing liquid, and is connected via a further line 17" in connection with the waste container 13.
  • a lock 20 is provided in the wall of the housing 1 for inserting and removing the eluate container 15.
  • the device is also provided with a program control device, not shown, for program control of the entire workflow. Such control devices are known to the person skilled in the art and therefore do not need to be explained in more detail.
  • the device explained above works as follows: after inserting the nucleus generator 1 and the NaCl vessel 3 into the housing 1 and connecting the hose lines 4 ′, 4 ′′ to the generator 1, which can take place automatically, for example, when the housing 1 is closed
  • the valve 5 ' is brought into a blocking position and the valve 5 "is switched so that the vessel 3 is connected to the 4-way valve 7.
  • the valve 7 is in turn switched so that it is connected to a syringe 6 'arranged in the device 6 so that it can draw in the Nacl solution.
  • the valve 12 is switched so that the reservoir 8 is vented or can be flushed to the waste container 13.
  • the valve 7 is then switched to release the connection between the syringe 6 'and the storage container 8, whereupon the syringe 6' presses the sucked-in NaCl solution into the storage container 8 until it is filled.
  • the valve 12 is then switched so that the reservoir 8 is only connected to the air filter 11, whereupon the syringe 6 'sucks the liquid out of the reservoir 8 again.
  • the valve 7 then connects the syringe 6 'to the needle 16' pivoted into the rinsing position S and the syringe 6 'rinses the previously aspirated contents of the storage container 8 via the needle 16' and the line 17 "into the waste container 13.
  • the pro Gram control is such that the valve 5 'first connects the NaCl vessel 3 to the input E of the generator 2 and the valve 5 "the output A of the generator to the valve 7, which establishes the connection with the syringe 6' Syringe 6 'now draws in until the first drop of the eluate solution obtained appears at the syringe inlet, which is recognized by a light barrier 20 in front of valve 7.
  • Valve 7 then switches to the connection between syringe 6' and flushing station 17 in which the swivel arm is located 14 with the needles 16 ', 16 "in the starting position, and the syringe 6' empties via the needle 16 'and the line 17" into the waste container 13.
  • the valve 7 then switches back to connection between the output A of the generator 1 and the syringe 6 'so that the predetermined amount of solution can be sucked in, minus the amount that is in the lines between the valve 5', the generator 2 and the valve 5 "to the entrance of the syringe 6 '.
  • the generator 2 is drained by repeated suction of air by means of the syringe 6 'via the valve 5', the generator 2, the valve 5 ", the valve 7 and by blowing out the air via the valve 7 and the flushing station 17.
  • the NaCl solution is sucked in by the syringe 6 'via the valves 5 "and 7 until the inlet of the syringe 6' is reached, whereupon the syringe 6 'enters the rinsing station 17 is emptied. Now the desired amount is sucked out of the storage container 8, if necessary a dilution amount of NaCl is sucked in and then pressed up to the filling needles 16, 16 'in order to empty the line 7'. Until then, the desired eluate bottle 15 has been transported into the filling station 9 via a transport device, not shown, and the bottle cap has been disinfected.
  • the needles 16 ′, 16 ′′ which have been conveyed into the filling station are moved downwards against the bottle 15 in this station 9 to such an extent that the first needle 16 ′ pierces the rubber closure cap 15 ′ of the bottle 15 and the filling of the eluate by means of the syringe 6.
  • the needles 16 ', 16 "are moved further downward after a short filling time, so that the second needle 16" also pierces the bottle cap and the air - or excess nitrogen discharges via a line 12 'into the waste container 13.
  • the needles'16','16" are pulled out of the closure and pivoted by means of the arm 14 into the rinsing and disinfecting station 17, to be disinfected.
  • the filled vial 15 is conveyed into a rotatable storage station (not shown) arranged in the housing 1, cooled, heated as required or stored at room temperature until it is used.
  • the bottle 15 which is provided with a lead shield, is conveyed into the lock 20, in which an opening is provided, through which the required amount can be withdrawn from the vial 15 with an injection needle.
  • the device shown can be modified in various ways within the scope of the general inventive concept.
  • the suction syringe 6 'of the suction and metering device to be replaced by a vacuum pump, the latter, however, having to be arranged at a different location than the one shown.
  • the swivel arm mechanism could also be replaced by another mechanical device. It is further understood that the entire elution process takes place under sterile conditions.
EP84890135A 1983-08-17 1984-07-19 Procédé et dispositif pour l'élution et le dosage d'un générateur d'isotopes Expired EP0141800B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0294883A AT379253B (de) 1983-08-17 1983-08-17 Verfahren und vorrichtung zum eluieren und dosieren eines radioaktiven nukleids
AT2948/83 1983-08-17

Publications (2)

Publication Number Publication Date
EP0141800A1 true EP0141800A1 (fr) 1985-05-15
EP0141800B1 EP0141800B1 (fr) 1987-10-14

Family

ID=3542885

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84890135A Expired EP0141800B1 (fr) 1983-08-17 1984-07-19 Procédé et dispositif pour l'élution et le dosage d'un générateur d'isotopes

Country Status (9)

Country Link
US (1) US4625118A (fr)
EP (1) EP0141800B1 (fr)
JP (1) JPH0750200B2 (fr)
AT (1) AT379253B (fr)
CA (1) CA1220881A (fr)
DE (1) DE3466824D1 (fr)
DK (1) DK170104B1 (fr)
ES (1) ES8605108A1 (fr)
NO (1) NO162174C (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992020071A1 (fr) * 1991-05-01 1992-11-12 Mallinckrodt Medical, Inc. Procede de transport de materiaux liquides et dispositif pour l'elution automatisee d'un generateur de radionuclides

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853546A (en) * 1986-09-16 1989-08-01 Ube Industries, Ltd. Automatic radioisotope filling apparatus
AT391763B (de) * 1988-09-13 1990-11-26 Bender & Co Gmbh Einrichtung zum messen der aktivitaet und des volumens radioaktiver fluessigkeiten
US5039863A (en) * 1988-11-15 1991-08-13 Ube Industries, Ltd. Automatic radioisotope filling apparatus
CN1035736C (zh) * 1992-10-14 1997-08-27 中国核动力研究设计院 凝胶型锝-99m发生器自动分装装置
GB0305848D0 (en) * 2003-03-14 2003-04-16 Imaging Res Solutions Ltd Radiopharmaceutical generation system
WO2005057589A2 (fr) * 2003-11-05 2005-06-23 Board Of Regents, The University Of Texas System Dispositif de synthese de marqueurs radioactifs automatise multifonction
EP1738153A1 (fr) * 2004-01-27 2007-01-03 Arcana International, Inc. Systeme de commande, de verification et d'enregistrement des performances des operations effectuees par un generateur de radio-isotopes
US7163031B2 (en) * 2004-06-15 2007-01-16 Mallinckrodt Inc. Automated dispensing system and associated method of use
DE102005031920B4 (de) * 2005-07-07 2007-12-20 Isotopen Technologien München AG Vorrichtung und Verfahren zur Herstellung einer geringen Menge einer radioaktiven Substanzverbindung
US20080191148A1 (en) * 2005-08-09 2008-08-14 Gibson Chad M Radioisotope Generation System Having Partial Elution Capability
ITBO20060128A1 (it) * 2006-02-21 2007-08-22 Tema Sinergie S R L Macchina dosatrice di liquido radioattivo.
KR101696175B1 (ko) * 2008-06-11 2017-01-23 브라코 다이어그노스틱스 아이엔씨. 주입 시스템의 캐비넷 구조물 배열
US7862534B2 (en) * 2008-06-11 2011-01-04 Bracco Diagnostics Inc. Infusion circuit subassemblies
US8317674B2 (en) 2008-06-11 2012-11-27 Bracco Diagnostics Inc. Shielding assemblies for infusion systems
US9597053B2 (en) * 2008-06-11 2017-03-21 Bracco Diagnostics Inc. Infusion systems including computer-facilitated maintenance and/or operation and methods of use
US8708352B2 (en) 2008-06-11 2014-04-29 Bracco Diagnostics Inc. Cabinet structure configurations for infusion systems
US8216181B2 (en) 2008-11-19 2012-07-10 Bracco Diagnostics, Inc. Apparatus and methods for support of a membrane filter in a medical infusion system
CN102249352B (zh) * 2011-05-23 2013-03-20 中国工程物理研究院核物理与化学研究所 医用高锝酸盐自动生产装置
AU2015229189B2 (en) 2014-03-13 2020-04-09 Bracco Diagnostics Inc. Real time nuclear isotope detection
CN109964285B (zh) 2016-09-20 2024-01-09 布拉科诊断公司 产生、输注和控制放射性同位素递送的系统和技术
CN112106148A (zh) 2018-03-28 2020-12-18 布拉科诊断公司 放射性同位素发生器寿命的早期检测
RU2754815C1 (ru) * 2020-09-29 2021-09-07 федеральное государственное бюджетное образовательное учреждение высшего образования "Ульяновский государственный университет" Способ дозирования и фасовки фармацевтических субстанций и устройство для его реализации

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2024182A1 (fr) * 1968-11-25 1970-08-28 Squibb & Sons Inc
FR2053665A5 (en) * 1969-07-11 1971-04-16 Commissariat Energie Atomique Handling short lived radioactive samples automatically
US3710118A (en) * 1970-05-25 1973-01-09 Mallinckrodt Chemical Works Radioisotope generator
US3774035A (en) * 1971-07-12 1973-11-20 New England Nuclear Corp Method and system for generating and collecting a radionuclide eluate
FR2194021A1 (fr) * 1972-07-26 1974-02-22 Hoechst Ag

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4928879A (fr) * 1972-07-14 1974-03-14
US3997784A (en) * 1975-06-16 1976-12-14 Union Carbide Corp Automatic apparatus for dispensing radiodiagnostic agents and method therefor
JPS5715899A (en) * 1980-07-02 1982-01-27 Ebara Infilco Co Ltd Treatment of organic waste water
US4472299A (en) * 1981-04-24 1984-09-18 Amersham International Plc Generator for radionuclide and process of use thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2024182A1 (fr) * 1968-11-25 1970-08-28 Squibb & Sons Inc
FR2053665A5 (en) * 1969-07-11 1971-04-16 Commissariat Energie Atomique Handling short lived radioactive samples automatically
US3710118A (en) * 1970-05-25 1973-01-09 Mallinckrodt Chemical Works Radioisotope generator
US3774035A (en) * 1971-07-12 1973-11-20 New England Nuclear Corp Method and system for generating and collecting a radionuclide eluate
FR2194021A1 (fr) * 1972-07-26 1974-02-22 Hoechst Ag

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992020071A1 (fr) * 1991-05-01 1992-11-12 Mallinckrodt Medical, Inc. Procede de transport de materiaux liquides et dispositif pour l'elution automatisee d'un generateur de radionuclides

Also Published As

Publication number Publication date
US4625118A (en) 1986-11-25
JPH0750200B2 (ja) 1995-05-31
DE3466824D1 (en) 1987-11-19
ES535121A0 (es) 1986-03-16
ATA294883A (de) 1985-04-15
NO843284L (no) 1985-02-18
CA1220881A (fr) 1987-04-21
NO162174C (no) 1989-11-15
EP0141800B1 (fr) 1987-10-14
ES8605108A1 (es) 1986-03-16
JPS6070400A (ja) 1985-04-22
DK370684A (da) 1985-02-18
NO162174B (no) 1989-08-07
DK170104B1 (da) 1995-05-22
AT379253B (de) 1985-12-10
DK370684D0 (da) 1984-07-30

Similar Documents

Publication Publication Date Title
EP0141800B1 (fr) Procédé et dispositif pour l'élution et le dosage d'un générateur d'isotopes
DE3229118C2 (fr)
DE60009724T2 (de) Vorrichtung zum beeinflussen des blutes eines säugetieres
DE69921592T2 (de) Verfahren und Vorrichtung zum Befüllen einer Spritze mit einer chemischen Lösung
DE3038753C2 (fr)
DE102007006189B4 (de) Vorrichtung zum Befüllen eines medizinischen Instruments mit einer radioaktiven Substanz und Verfahren
DE60036721T2 (de) Elektronische luftinjektionen
DE102009027452A1 (de) Vorrichtung zum Füllen und Verschließen von pharmazeutischen Bahältnissen
EP0154002A1 (fr) Dispositif pour prise d'échantillons sanguins pour le diagnostic des fonctions du corps
DE102007022098A1 (de) Automatisch gesteuerte Waschmaschine
EP0587085A2 (fr) Procédé et dispositif pour doser et mélanger du matériau à plusieurs constituants
DE2626802A1 (de) Vorrichtung und verfahren zum automatischen einfuellen einer bestimmten menge einer radioaktiven probenloesung in einen aufnahmebehaelter
DE102007041666B4 (de) Vorrichtung und Verfahren zum Mischen von Knochenzement
DE2236565C3 (de) Vorrichtung zum Herstellen von sterilen, injizierbaren Eluaten durch Eluieren von Nuklidgeneratoren
DE4408498A1 (de) Umfülleinrichtung für die Medizin und die Pharmazie, z.B. eines Wirkstoffes in eine Lösung
DE2626812A1 (de) Tragbare vorrichtung zur abgabe von technetium 99m enthaltenden loesungen
DE3315031A1 (de) Verfahren und vorrichtung zum herstellen von gemischen pharmazeutischer fluessigkeiten
DE102009054388B4 (de) Applikator zum Auftragen einer radioaktiven Schicht auf ein biologisches Gewebe
DE202017103109U1 (de) Vorrichtung zur Dosierung von Infusionsbeuteln für medizinische Zwecke sowie Einrichtung zur Befüllung einer Mehrzahl von Leerbehältern
DE2648330C2 (de) Vorrichtung zur Entnahme einer Probe aus einer abgepumpten begrenzten Menge einer inhomogenen Flüssigkeit
DE102017111207B3 (de) Vorrichtung zur Dosierung von Infusionsbeuteln für medizinische Zwecke sowie Einrichtung zur Befüllung einer Mehrzahl von Leerbehältern
DE2636386A1 (de) Vorrichtung zur erzeugung von sterilen loesungen von tochterradionukliden
DE3035290A1 (de) Vorrichtung zum automatischen aufziehen und messen von nuklearmedizinisch aktiven loesungen
DE102018105737A1 (de) Landwirtschaftliche Feldspritze
DE102009006680A1 (de) Vorrichtung und Verfahren zur Injektion einer Flüssigkeit

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): BE CH DE FR GB IT LI NL SE

ITCL It: translation for ep claims filed

Representative=s name: MODIANO & ASSOCIATI S.R.L.

TCNL Nl: translation of patent claims filed
EL Fr: translation of claims filed
17P Request for examination filed

Effective date: 19850605

17Q First examination report despatched

Effective date: 19860925

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): BE CH DE FR GB IT LI NL SE

REF Corresponds to:

Ref document number: 3466824

Country of ref document: DE

Date of ref document: 19871119

GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)
ITF It: translation for a ep patent filed

Owner name: MODIANO & ASSOCIATI S.R.L.

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
ITTA It: last paid annual fee
EAL Se: european patent in force in sweden

Ref document number: 84890135.1

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 19980629

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 19980710

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 19980713

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 19980716

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 19980721

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 19980727

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 19980731

Year of fee payment: 15

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19990719

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: THE PATENT HAS BEEN ANNULLED BY A DECISION OF A NATIONAL AUTHORITY

Effective date: 19990720

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19990731

Ref country code: FR

Free format text: THE PATENT HAS BEEN ANNULLED BY A DECISION OF A NATIONAL AUTHORITY

Effective date: 19990731

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19990731

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19990731

BERE Be: lapsed

Owner name: BENDER + CO. G.M.B.H.

Effective date: 19990731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20000201

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 19990719

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

EUG Se: european patent has lapsed

Ref document number: 84890135.1

NLV4 Nl: lapsed or anulled due to non-payment of the annual fee

Effective date: 20000201

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20000503

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST