EG23823A - 13-Membered azalides and their use as antibiotic agents - Google Patents

13-Membered azalides and their use as antibiotic agents

Info

Publication number
EG23823A
EG23823A EG147699A EG147699A EG23823A EG 23823 A EG23823 A EG 23823A EG 147699 A EG147699 A EG 147699A EG 147699 A EG147699 A EG 147699A EG 23823 A EG23823 A EG 23823A
Authority
EG
Egypt
Prior art keywords
antibiotic agents
membered azalides
azalides
membered
antibiotic
Prior art date
Application number
EG147699A
Other languages
English (en)
Inventor
Robert J Rafka
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22327457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EG23823(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of EG23823A publication Critical patent/EG23823A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
EG147699A 1998-11-20 1999-11-17 13-Membered azalides and their use as antibiotic agents EG23823A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10939998P 1998-11-20 1998-11-20

Publications (1)

Publication Number Publication Date
EG23823A true EG23823A (en) 2007-09-19

Family

ID=22327457

Family Applications (1)

Application Number Title Priority Date Filing Date
EG147699A EG23823A (en) 1998-11-20 1999-11-17 13-Membered azalides and their use as antibiotic agents

Country Status (46)

Country Link
US (1) US6329345B1 (me)
EP (1) EP1131331B1 (me)
JP (1) JP3842973B2 (me)
KR (1) KR100477774B1 (me)
CN (2) CN1326460A (me)
AP (1) AP2001002142A0 (me)
AR (3) AR019496A1 (me)
AT (1) ATE260927T1 (me)
AU (1) AU766106B2 (me)
BG (1) BG65107B1 (me)
BR (2) BRPI9915480B1 (me)
CA (1) CA2351429C (me)
CO (1) CO5380019A1 (me)
CZ (1) CZ303099B6 (me)
DE (1) DE69915336T2 (me)
DK (1) DK1131331T3 (me)
DZ (1) DZ2944A1 (me)
EA (2) EA009729B1 (me)
EG (1) EG23823A (me)
ES (1) ES2216581T3 (me)
GT (1) GT199900198A (me)
HK (1) HK1041269A1 (me)
HR (1) HRP20010374B1 (me)
HU (1) HU229008B1 (me)
ID (1) ID28548A (me)
IL (3) IL142631A0 (me)
IS (1) IS2350B (me)
MA (1) MA26707A1 (me)
ME (1) ME00467B (me)
MY (1) MY122353A (me)
NO (3) NO319796B1 (me)
NZ (1) NZ511199A (me)
OA (1) OA11713A (me)
PA (1) PA8485601A1 (me)
PE (1) PE20001378A1 (me)
PL (1) PL198580B1 (me)
PT (1) PT1131331E (me)
RS (1) RS50302B (me)
SI (1) SI1131331T1 (me)
SK (1) SK284607B6 (me)
TN (1) TNSN99214A1 (me)
TW (2) TWI243824B (me)
UA (1) UA70972C2 (me)
UY (1) UY25805A1 (me)
WO (1) WO2000031097A1 (me)
ZA (1) ZA200104019B (me)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000086A (es) 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
KR20020016799A (ko) * 1999-05-24 2002-03-06 데이비드 존 우드 13-메틸-에리트로마이신 유도체
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
KR20030031479A (ko) * 2000-04-27 2003-04-21 화이자 프로덕츠 인코포레이티드 포유동물에서 세균 감염 또는 원생생물 감염을 치료 또는 예방하기 위한 아잘라이드 항생제 조성물
EP1383780A1 (en) * 2001-04-27 2004-01-28 Pfizer Products Inc. Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
WO2003014136A1 (en) * 2001-08-08 2003-02-20 Taisho Pharmaceutical Co., Ltd. 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
CA2529817C (en) * 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
WO2004108744A2 (en) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
CN1882360A (zh) * 2003-11-21 2006-12-20 辉瑞产品公司 抗生素作为疫苗佐剂的用途
EP1985620A4 (en) * 2006-02-07 2012-08-15 Taisho Pharmaceutical Co Ltd COMPOUND 10a-AZALIDE
JPWO2009019868A1 (ja) * 2007-08-06 2010-10-28 大正製薬株式会社 １０ａ、１２位架橋型１０ａ−アザライド化合物
WO2009139181A1 (ja) * 2008-05-15 2009-11-19 大正製薬株式会社 ４員環構造を有する１０ａ－アザライド化合物
ES2532455T3 (es) 2010-09-20 2015-03-27 Novartis Tiergesundheit Ag Nuevo procedimiento de preparación de 9-desoxo-9a-aza-9a-homoeritromicina modificada en el C-4'' del anillo de cladinosa por un grupo epóxido
CN102295672B (zh) * 2011-07-13 2014-06-04 武汉回盛生物科技有限公司 一种泰拉菌素的合成方法
WO2013013834A1 (en) 2011-07-27 2013-01-31 Farma Grs, D.O.O. New crystalline forms of tulathromycin
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
EP3027634B1 (en) * 2013-07-31 2018-03-21 Farma GRS, d.o.o. Process for preparation of tulathromycin
CN109748942A (zh) * 2014-05-16 2019-05-14 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
WO2020106627A1 (en) * 2018-11-19 2020-05-28 Zikani Therapeutics, Inc. C10-alkylene substituted 13-membered macrolides and uses thereof
SG11202105228SA (en) * 2018-11-19 2021-06-29 Zikani Therapeutics Inc C11-cyclic substituted 13-membered macrolides and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
SI8611592A8 (en) * 1986-09-12 1995-04-30 Pliva Pharm & Chem Works Process for preparing complexes of N-methyl-11-aza-10-deoxo-10-dihydroeritromicine A and 11-aza-10-deoxo-10-dihydroeritromicine A with metals
US5106961A (en) 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives
SI9011409A (en) 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
HRP931480B1 (en) * 1993-12-08 1997-08-31 Sour Pliva 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
GB2327084A (en) * 1997-07-08 1999-01-13 Merck & Co Inc 9a-Aza-3-ketolide antibiotics
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

Also Published As

Publication number Publication date
NO319796B1 (no) 2005-09-19
SK6632001A3 (en) 2002-07-02
PT1131331E (pt) 2004-06-30
EP1131331B1 (en) 2004-03-03
BR9915480A (pt) 2001-07-31
ES2216581T3 (es) 2004-10-16
TWI243824B (en) 2005-11-21
DE69915336D1 (de) 2004-04-08
NO20012464D0 (no) 2001-05-18
TWI243825B (en) 2005-11-21
NZ511199A (en) 2003-08-29
ID28548A (id) 2001-05-31
BG105600A (en) 2001-12-29
AU766106B2 (en) 2003-10-09
IS5918A (is) 2001-04-17
DE69915336T2 (de) 2005-01-13
BRPI9915480B8 (pt) 2022-05-10
SI1131331T1 (en) 2004-08-31
ATE260927T1 (de) 2004-03-15
WO2000031097A1 (en) 2000-06-02
BRPI9915480B1 (pt) 2015-12-29
JP2002530422A (ja) 2002-09-17
AR019496A1 (es) 2002-02-20
EA009729B1 (ru) 2008-02-28
GT199900198A (es) 2001-05-11
HRP20010374A2 (en) 2002-06-30
YU33401A (sh) 2004-05-12
NO329629B1 (no) 2010-11-22
SK284607B6 (sk) 2005-07-01
CN101367853A (zh) 2009-02-18
IL189430A (en) 2010-05-31
CZ20011754A3 (cs) 2002-03-13
IL142631A (en) 2010-05-31
PL347784A1 (en) 2002-04-22
EA005156B1 (ru) 2004-12-30
MY122353A (en) 2006-04-29
IL142631A0 (en) 2002-03-10
IL189430A0 (en) 2008-06-05
EA200100416A1 (ru) 2001-10-22
OA11713A (en) 2005-01-25
AR059524A2 (es) 2008-04-09
HK1041269A1 (zh) 2002-07-05
UA70972C2 (uk) 2004-11-15
AU1068600A (en) 2000-06-13
CZ303099B6 (cs) 2012-04-04
PA8485601A1 (es) 2000-09-29
ME00467B (me) 2011-10-10
TNSN99214A1 (fr) 2005-11-10
ZA200104019B (en) 2002-06-17
EP1131331A1 (en) 2001-09-12
US6329345B1 (en) 2001-12-11
IS2350B (is) 2008-04-15
BG65107B1 (bg) 2007-02-28
PL198580B1 (pl) 2008-06-30
CA2351429A1 (en) 2000-06-02
CA2351429C (en) 2005-07-12
AP2001002142A0 (en) 2001-05-09
MA26707A1 (fr) 2004-12-20
UY25805A1 (es) 2001-08-27
EA200400701A1 (ru) 2004-12-30
DK1131331T3 (da) 2004-06-14
CO5380019A1 (es) 2004-03-31
KR20010086043A (ko) 2001-09-07
HU229008B1 (en) 2013-07-29
HUP0104313A2 (hu) 2002-02-28
HUP0104313A3 (en) 2003-12-29
JP3842973B2 (ja) 2006-11-08
CN1326460A (zh) 2001-12-12
NO20050904L (no) 2001-07-17
HRP20010374B1 (en) 2006-09-30
DZ2944A1 (fr) 2004-03-15
NO20050893L (no) 2001-07-17
AR059523A2 (es) 2008-04-09
NO330249B1 (no) 2011-03-14
NO20012464L (no) 2001-07-17
RS50302B (sr) 2009-09-08
TW200404077A (en) 2004-03-16
PE20001378A1 (es) 2000-12-14
KR100477774B1 (ko) 2005-03-21

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