EG18079A - Process for preparing of 9-(phosphonylmetoxya-lkyl)adenines and utilisation thereof - Google Patents

Process for preparing of 9-(phosphonylmetoxya-lkyl)adenines and utilisation thereof

Info

Publication number
EG18079A
EG18079A EG243/86A EG24386A EG18079A EG 18079 A EG18079 A EG 18079A EG 243/86 A EG243/86 A EG 243/86A EG 24386 A EG24386 A EG 24386A EG 18079 A EG18079 A EG 18079A
Authority
EG
Egypt
Prior art keywords
sup
adenines
phosphonylmetoxya
lkyl
utilisation
Prior art date
Application number
EG243/86A
Other languages
English (en)
Original Assignee
Ceskoslovenska Akademie Ved
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ceskoslovenska Akademie Ved filed Critical Ceskoslovenska Akademie Ved
Application granted granted Critical
Publication of EG18079A publication Critical patent/EG18079A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EG243/86A 1985-04-25 1986-04-27 Process for preparing of 9-(phosphonylmetoxya-lkyl)adenines and utilisation thereof EG18079A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS853017A CS263951B1 (en) 1985-04-25 1985-04-25 9-(phosponylmethoxyalkyl)adenines and method of their preparation

Publications (1)

Publication Number Publication Date
EG18079A true EG18079A (en) 1992-06-30

Family

ID=5369028

Family Applications (1)

Application Number Title Priority Date Filing Date
EG243/86A EG18079A (en) 1985-04-25 1986-04-27 Process for preparing of 9-(phosphonylmetoxya-lkyl)adenines and utilisation thereof

Country Status (13)

Country Link
US (1) US4808716A (cg-RX-API-DMAC7.html)
EP (1) EP0206459B1 (cg-RX-API-DMAC7.html)
JP (1) JPS61275289A (cg-RX-API-DMAC7.html)
AT (1) ATE78259T1 (cg-RX-API-DMAC7.html)
AU (1) AU580151B2 (cg-RX-API-DMAC7.html)
CA (1) CA1295614C (cg-RX-API-DMAC7.html)
CS (1) CS263951B1 (cg-RX-API-DMAC7.html)
DE (1) DE3686002T2 (cg-RX-API-DMAC7.html)
DK (1) DK173625B1 (cg-RX-API-DMAC7.html)
EG (1) EG18079A (cg-RX-API-DMAC7.html)
HK (1) HK213296A (cg-RX-API-DMAC7.html)
NO (1) NO174510B (cg-RX-API-DMAC7.html)
NZ (1) NZ215925A (cg-RX-API-DMAC7.html)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4845084A (en) * 1984-01-26 1989-07-04 Merck & Co., Inc. Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
US5650510A (en) * 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
AU613592B2 (en) * 1986-11-18 1991-08-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives
IL88518A (en) * 1987-11-30 1994-02-27 Beecham Group Plc 3-(phosphoryl methoxyethoxy) -purine derivatives, their preparation and pharmaceutical compositions containing them
US5247085A (en) * 1987-11-30 1993-09-21 Beecham Group P.L.C. Antiviral purine compounds
EP0335770B1 (en) * 1988-04-01 1997-01-15 Merrell Pharmaceuticals Inc. Novel fluorophosphonate nucleotide derivatives
EP0339161A1 (en) * 1988-04-01 1989-11-02 Merrell Dow Pharmaceuticals Inc. Novel fluorophosphonate nucleotide derivatives
US5284837A (en) * 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
EP0353955A3 (en) * 1988-08-02 1991-08-14 Beecham Group Plc Novel compounds
US5744600A (en) * 1988-11-14 1998-04-28 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Phosphonomethoxy carbocyclic nucleosides and nucleotides
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
CS387190A3 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2r)-2-/di(2-propyl)phosphonylmethoxy/-3-p-toluenesulfonyloxy -1- trimethylacetoxypropane and process for preparing thereof
ATE194142T1 (de) * 1990-08-10 2000-07-15 Acad Of Science Czech Republic Verfahren zur herstellung von nukleotiden
DE10399025I2 (de) * 1990-09-14 2007-11-08 Acad Of Science Czech Republic Wirkstoffvorläufer von Phosphonaten
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
US5656745A (en) * 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
CA2171868A1 (en) * 1993-09-17 1995-03-23 Petr Alexander Method for dosing therapeutic compounds
US5798340A (en) 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US5877166A (en) * 1996-04-29 1999-03-02 Sri International Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents
EP0915894B1 (en) * 1996-07-26 2003-05-14 Gilead Sciences, Inc. Nucleotide analogs
US5733788A (en) * 1996-07-26 1998-03-31 Gilead Sciences, Inc. PMPA preparation
ATE305009T1 (de) * 1997-07-25 2005-10-15 Gilead Sciences Inc Nukleotid-analog zusamensetzung und synthese verfahren
US5935946A (en) * 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
WO2000029414A1 (fr) * 1998-11-18 2000-05-25 Viktor Veniaminovich Tets Dialkyl-1-aryl-1-(2,4-dioxo-5-amino-1,3-pyrimidin-5-yl)methylphosphonates
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
NZ536942A (en) 2000-07-21 2006-03-31 Gilead Sciences Inc Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
MXPA04000138A (es) 2001-06-29 2005-06-06 Acad Of Science Czech Republic Compuestos novedosos y metodos de trabajo.
WO2003087298A2 (en) * 2001-11-14 2003-10-23 Biocryst Pharmaceuticals, Inc. Nucleosides preparation thereof and use as inhibitors of rna viral polymerases
US7388002B2 (en) 2001-11-14 2008-06-17 Biocryst Pharmaceuticals, Inc. Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
CA2485597C (en) 2002-05-13 2013-07-02 Metabasis Therapeutics, Inc. Process for preparation of cyclic prodrugs of pmea and pmpa
NZ536328A (en) * 2002-05-13 2007-11-30 Metabasis Therapeutics Inc Novel phosphonic acid based prodrugs of PMEA and its analogues
US7417036B2 (en) * 2002-11-12 2008-08-26 Tianjin Kinsly Pharmaceutical Co. Ltd. Crystal form of adefovir dipivoxil and its preparation
DE602004014470D1 (de) * 2003-01-14 2008-07-31 Gilead Sciences Inc Zusammensetzungen und verfahren zur antiviralen kombinationstherapie
WO2004111064A1 (en) 2003-06-16 2004-12-23 Institute Of Organic Chemistry And Biochemistry, Academy Of Sciences Of The Czech Republic Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
WO2005012324A2 (en) * 2003-07-30 2005-02-10 Gilead Sciences, Inc. Nucleobase phosphonate analogs for antiviral treatment
EP1753762B1 (en) * 2004-06-08 2014-03-19 Metabasis Therapeutics, Inc. Lewis acid mediated synthesis of cyclic esters
CN100338080C (zh) * 2004-06-16 2007-09-19 山东中科泰斗化学有限公司 9－[2－(膦羧基甲氧基)乙基]腺嘌呤双环醇酯及其制备方法
UA93354C2 (ru) 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат
WO2006066074A2 (en) 2004-12-16 2006-06-22 The Regents Of The University Of California Lung-targeted drugs
US20090156545A1 (en) * 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) * 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
EP2305697A3 (en) 2005-07-25 2011-07-27 Intermune, Inc. Macrocyclic inhibitors of Hepatitis C virus replication
EP1907391A1 (en) * 2005-07-26 2008-04-09 Hetero Drugs Limited Novel process for acyclic phosphonate nucleotide analogs
CA2624333A1 (en) * 2005-10-11 2007-04-19 Intermune, Inc. Compounds and methods for inhibiting hepatitis c viral replication
CA2633603C (en) * 2005-12-14 2016-09-13 Cipla Limited Pharmaceutical combination
FR2908133B1 (fr) 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
PT2159224E (pt) 2007-06-18 2012-10-24 Sunshine Lake Pharma Co Ltd Tiazolil dihidropirimidinas substituídas com bromo-fenilo
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
WO2009120358A1 (en) * 2008-03-27 2009-10-01 Nektar Therapeutics Oligomer-nitrogenous base conjugates
US7935817B2 (en) * 2008-03-31 2011-05-03 Apotex Pharmachem Inc. Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
US8048862B2 (en) * 2008-04-15 2011-11-01 Intermune, Inc. Macrocyclic inhibitors of hepatitis C virus replication
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
TW201010692A (en) 2008-06-19 2010-03-16 Public Univ Corp Nagoya City Univ Pharmaceutical composition for treatment or prevention of hbv infection
CA2740728A1 (en) * 2008-10-15 2010-04-22 Intermune, Inc. Therapeutic antiviral peptides
BRPI0923815A2 (pt) 2008-12-23 2015-07-14 Pharmasset Inc Síntese de nucleosídeos de purina
EP2376514A2 (en) 2008-12-23 2011-10-19 Pharmasset, Inc. Nucleoside analogs
EA019341B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Фосфорамидаты нуклеозидов
WO2010110622A2 (en) 2009-03-26 2010-09-30 Daewoong Pharmaceutical Co., Ltd. Novel crystal forms of adefovir dipivoxil and processes for preparing the same
KR20130026410A (en) * 2009-09-28 2013-03-13 Intermune Inc Cyclic peptide inhibitors of hepatitis c virus replication
WO2011041551A1 (en) * 2009-10-01 2011-04-07 Intermune, Inc. Therapeutic antiviral peptides
LT2609923T (lt) 2010-03-31 2017-09-11 Gilead Pharmasset Llc (s)-izopropilo 2-(((s)-(perfluorfenoksi)(fenoksi)fosforil)amino)-propanoato kristalinimo būdas
EP2579892A2 (en) 2010-06-09 2013-04-17 Vaccine Technologies, Incorporated Therapeutic immunization in hiv infected subjects receiving stable antiretroviral treatment
PT2579871E (pt) 2010-06-11 2015-11-17 Gilead Sciences Inc Formulações antivirais tópicas para a prevenção da transmissão do hsv-2
BR112013014485B1 (pt) 2010-12-10 2021-03-30 Sigmapharm Laboratories, Llc Composições farmacêuticas compreendendo pró-fármacos análogos de nucleotídeos de fosfonato ativos por via oral e sistema de embalagem de recipiente/fechamento contendo as ditas composições
WO2012154698A2 (en) * 2011-05-06 2012-11-15 Mckenna Charles E Method to improve antiviral activity of nucleotide analogue drugs
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
AU2013340559B2 (en) 2012-10-29 2018-03-15 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
CN107056838A (zh) 2013-03-15 2017-08-18 加利福尼亚大学董事会 无环核苷膦酸二酯
CA2937548C (en) 2014-02-13 2022-10-25 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
US10167302B2 (en) * 2014-05-23 2019-01-01 University College Cork Phosphonate nucleosides useful in the treatment of viral diseases
WO2016003812A1 (en) 2014-07-02 2016-01-07 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
KR102589658B1 (ko) 2014-09-15 2023-10-13 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 뉴클레오타이드 유사체
US10377782B2 (en) 2015-09-15 2019-08-13 The Regents Of The University Of California Nucleotide analogs
EP3372227A1 (en) 2017-03-06 2018-09-12 MH10 Spolka z ograniczona odpowiedzialnoscia Tablet formulation of adefovir dipivoxil
RU2020126177A (ru) 2018-01-09 2022-02-10 Лиганд Фармасьютикалз, Инк. Ацетальные соединения и их терапевтическое применение
JP2025526212A (ja) 2022-07-21 2025-08-13 アンティバ バイオサイエンシズ インコーポレイテッド Ｈｐｖ感染症及びｈｐｖ誘発性新生物の治療用の組成物及び剤形

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
DE3490262T1 (de) * 1983-05-24 1985-11-28 Sri International, Menlo Park, Calif. Antivirus-Mittel
AU8092587A (en) * 1986-11-18 1988-05-19 Bristol-Myers Squibb Company Synthesis of purin-9-ylalkylenoxymethyl phosphonic acids

Also Published As

Publication number Publication date
DK167886A (da) 1986-10-26
NO174510B (no) 1994-02-07
CS263951B1 (en) 1989-05-12
DK173625B1 (da) 2001-05-07
AU5632886A (en) 1986-10-30
DE3686002T2 (de) 1992-12-17
US4808716A (en) 1989-02-28
HK213296A (en) 1996-12-06
NO174510C (cg-RX-API-DMAC7.html) 1994-05-18
JPH0433798B2 (cg-RX-API-DMAC7.html) 1992-06-04
EP0206459B1 (en) 1992-07-15
EP0206459A2 (en) 1986-12-30
DE3686002D1 (de) 1992-08-20
EP0206459A3 (en) 1987-05-20
AU580151B2 (en) 1989-01-05
JPS61275289A (ja) 1986-12-05
NO861621L (no) 1986-10-27
ATE78259T1 (de) 1992-08-15
CA1295614C (en) 1992-02-11
DK167886D0 (da) 1986-04-11
NZ215925A (en) 1989-01-27

Similar Documents

Publication Publication Date Title
EG18079A (en) Process for preparing of 9-(phosphonylmetoxya-lkyl)adenines and utilisation thereof
AU557103B2 (en) S-triazine derivatives and their use as sun screen agents
AU586691B2 (en) Diamino-androstane derivatives, process for their preparation and pharmaceutical compositions containing them
ES8101550A1 (es) Un procedimiento para la preparacion de nuevos derivados de 2-pirrolidin-metanol.
DE3264172D1 (en) N-2-hydroxypropyl piperidines and process for preparing the same
PH22418A (en) Triazolyl alcohol derivatives
DE3672446D1 (en) Pantothenolderivate.
AU5847386A (en) Derivatives of 1,1,2,2-tetramethyl-1,2-bis-(2-fluoro-4- hydroxphenyl)-ethane
ES8304972A1 (es) Procedimiento de preparar derivados de acido carboxilico quetienen actividad antibacteriana.
ES8609184A1 (es) Procedimiento de preparar agentes de fluoracion de compuestos organicos.
ES8105300A1 (es) Procedimiento para preparar derivados de benoimidazol
DE3564426D1 (en) Polyprenyl compound, process of producing it and pharmaceutical use
EP0000972A3 (en) 2-substituted-3-phenylindoles, their preparation, and pharmaceutical compositions containing them
DE3477003D1 (en) Process for the preparation of 17-alpha-acyloxy-6-chloro-1-alpha,2-alpha-methylene-4,6-pregnadiene-3-20-diones
ES8302695A1 (es) Procedimiento para la obtencion de nuevos compuestos de poliglicidilurazol n.substituidos.
AU2172688A (en) Preparation of dien-1-ols, 9-hydroxydodec-10-enyl 1-tert-butyl ether and use thereof as an intermediate for synthesizing, 8,10-dodecadienol
FR2442838A1 (fr) Procede de preparation de mercapto-5 triazoles-1,2,3
DE3267690D1 (en) Process for the preparation of 3-alkyl-6-methyl-beta-resorcylic-acid esters
JPS548627A (en) 2-alkoxyalkoxy-5-nitrobenzenesulfonic acid and its salt
ES8201205A1 (es) Procedimiento para la preparacion de nuevos compuestos de aminoantipirina
JPS5416466A (en) Novel 3-hydroxypyrrolldine-3-carboxylic derivative
JO921B1 (en) Process to produce substituted basic alkyl theophylline
ES8304990A1 (es) Procedimiento para la preparacion de derivados espiro-1 farmaceuticamente activos.
ES466032A1 (es) Procedimiento para la preparacion de derivados de alcohil- teofilina, sustituidos con radicales basicos.
JPS5371094A (en) Novel cyclopropyl methylamine derivs. and process for their preparation