ES8304990A1 - Procedimiento para la preparacion de derivados espiro-1 farmaceuticamente activos. - Google Patents

Procedimiento para la preparacion de derivados espiro-1 farmaceuticamente activos.

Info

Publication number
ES8304990A1
ES8304990A1 ES509028A ES509028A ES8304990A1 ES 8304990 A1 ES8304990 A1 ES 8304990A1 ES 509028 A ES509028 A ES 509028A ES 509028 A ES509028 A ES 509028A ES 8304990 A1 ES8304990 A1 ES 8304990A1
Authority
ES
Spain
Prior art keywords
spiro
group
derivatives
isobenzothiophenic
isobenzofuranic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509028A
Other languages
English (en)
Other versions
ES509028A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8101692A external-priority patent/FR2498603A1/fr
Priority claimed from FR8200518A external-priority patent/FR2519636A2/fr
Application filed by Delalande SA filed Critical Delalande SA
Publication of ES8304990A1 publication Critical patent/ES8304990A1/es
Publication of ES509028A0 publication Critical patent/ES509028A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

_(PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS ESPIRO-1 FARMACEUTICAMENTE ACTIVOS . CONSISTE EN TRATAR POR MEDIO DE PENTASULFURO DE FOSFORO, EN PRESENCIA DE UN AGENTE BASICO, COMPUESTOS DE FORMULA GENERAL (II). SE OBTIENEN COMPUESTOS DE FORMULA (I) QUE PUEDEN SOLIFICARSE POR ADICION DE UN ACIDO MINERAL U ORGANICO. EL AGENTE BASICO EMPLEADO ES TRIETILAMINA, PRIDINA O BICARBONATO SODICO. EL DISOLVENTE EMPLEADO ES TOLUENO O ACETONITRILO. R ES UN GRUPO ALQUILO O UN GRUPO FENILO; N PUEDE VALER 1 O 2; R ES HIDROGENO O HALOGENO, UNO O VARIOS GRUPOS METOXI O EL ENCADENAMIENTO BUTADIENO-1,3 ILENO (-CH=CH-CH=CH-) FIJADO EN LA POSICION 5,6 DEL NUCLEO FENILO.
ES509028A 1981-01-29 1982-01-25 Procedimiento para la preparacion de derivados espiro-1 farmaceuticamente activos. Granted ES509028A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8101692A FR2498603A1 (fr) 1981-01-29 1981-01-29 Nouveaux derives spiro-1 isobenzofuranniques et spiro-1 isobenzothiopheniques, leur procede de preparation et leur application en therapeutique
FR8200518A FR2519636A2 (en) 1982-01-14 1982-01-14 Spiro iso:benzofuran and iso:benzothiophene derivs. - with anticonvulsant and analgesic activities

Publications (2)

Publication Number Publication Date
ES8304990A1 true ES8304990A1 (es) 1983-04-01
ES509028A0 ES509028A0 (es) 1983-04-01

Family

ID=26222201

Family Applications (1)

Application Number Title Priority Date Filing Date
ES509028A Granted ES509028A0 (es) 1981-01-29 1982-01-25 Procedimiento para la preparacion de derivados espiro-1 farmaceuticamente activos.

Country Status (12)

Country Link
US (1) US4395416A (es)
AU (1) AU7993382A (es)
BE (1) BE891928A (es)
CA (1) CA1169863A (es)
DE (1) DE3202893A1 (es)
ES (1) ES509028A0 (es)
GB (1) GB2092143B (es)
GR (1) GR75187B (es)
IT (1) IT1190669B (es)
LU (1) LU83893A1 (es)
NL (1) NL8200343A (es)
SE (1) SE8200320L (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2757157B1 (fr) * 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980787A (en) * 1975-08-25 1976-09-14 American Hoechst Corporation 3-Phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives
US4263817A (en) * 1979-07-02 1981-04-28 The Bendix Corporation Support member for rack and pinion assembly

Also Published As

Publication number Publication date
SE8200320L (sv) 1982-07-30
IT8219267A0 (it) 1982-01-25
CA1169863A (en) 1984-06-26
ES509028A0 (es) 1983-04-01
NL8200343A (nl) 1982-08-16
DE3202893A1 (de) 1982-09-23
US4395416A (en) 1983-07-26
BE891928A (fr) 1982-07-28
AU7993382A (en) 1982-08-05
GB2092143A (en) 1982-08-11
GR75187B (es) 1984-07-13
IT1190669B (it) 1988-02-24
LU83893A1 (fr) 1983-09-02
GB2092143B (en) 1985-03-13

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