ES8304990A1 - Procedimiento para la preparacion de derivados espiro-1 farmaceuticamente activos. - Google Patents
Procedimiento para la preparacion de derivados espiro-1 farmaceuticamente activos.Info
- Publication number
- ES8304990A1 ES8304990A1 ES509028A ES509028A ES8304990A1 ES 8304990 A1 ES8304990 A1 ES 8304990A1 ES 509028 A ES509028 A ES 509028A ES 509028 A ES509028 A ES 509028A ES 8304990 A1 ES8304990 A1 ES 8304990A1
- Authority
- ES
- Spain
- Prior art keywords
- spiro
- group
- derivatives
- isobenzothiophenic
- isobenzofuranic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
_(PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS ESPIRO-1 FARMACEUTICAMENTE ACTIVOS . CONSISTE EN TRATAR POR MEDIO DE PENTASULFURO DE FOSFORO, EN PRESENCIA DE UN AGENTE BASICO, COMPUESTOS DE FORMULA GENERAL (II). SE OBTIENEN COMPUESTOS DE FORMULA (I) QUE PUEDEN SOLIFICARSE POR ADICION DE UN ACIDO MINERAL U ORGANICO. EL AGENTE BASICO EMPLEADO ES TRIETILAMINA, PRIDINA O BICARBONATO SODICO. EL DISOLVENTE EMPLEADO ES TOLUENO O ACETONITRILO. R ES UN GRUPO ALQUILO O UN GRUPO FENILO; N PUEDE VALER 1 O 2; R ES HIDROGENO O HALOGENO, UNO O VARIOS GRUPOS METOXI O EL ENCADENAMIENTO BUTADIENO-1,3 ILENO (-CH=CH-CH=CH-) FIJADO EN LA POSICION 5,6 DEL NUCLEO FENILO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8101692A FR2498603A1 (fr) | 1981-01-29 | 1981-01-29 | Nouveaux derives spiro-1 isobenzofuranniques et spiro-1 isobenzothiopheniques, leur procede de preparation et leur application en therapeutique |
FR8200518A FR2519636A2 (en) | 1982-01-14 | 1982-01-14 | Spiro iso:benzofuran and iso:benzothiophene derivs. - with anticonvulsant and analgesic activities |
Publications (2)
Publication Number | Publication Date |
---|---|
ES509028A0 ES509028A0 (es) | 1983-04-01 |
ES8304990A1 true ES8304990A1 (es) | 1983-04-01 |
Family
ID=26222201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES509028A Expired ES8304990A1 (es) | 1981-01-29 | 1982-01-25 | Procedimiento para la preparacion de derivados espiro-1 farmaceuticamente activos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US4395416A (es) |
AU (1) | AU7993382A (es) |
BE (1) | BE891928A (es) |
CA (1) | CA1169863A (es) |
DE (1) | DE3202893A1 (es) |
ES (1) | ES8304990A1 (es) |
GB (1) | GB2092143B (es) |
GR (1) | GR75187B (es) |
IT (1) | IT1190669B (es) |
LU (1) | LU83893A1 (es) |
NL (1) | NL8200343A (es) |
SE (1) | SE8200320L (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2757157B1 (fr) * | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3980787A (en) * | 1975-08-25 | 1976-09-14 | American Hoechst Corporation | 3-Phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives |
US4263817A (en) * | 1979-07-02 | 1981-04-28 | The Bendix Corporation | Support member for rack and pinion assembly |
-
1982
- 1982-01-21 US US06/341,415 patent/US4395416A/en not_active Expired - Fee Related
- 1982-01-21 GR GR67080A patent/GR75187B/el unknown
- 1982-01-21 SE SE8200320A patent/SE8200320L/xx not_active Application Discontinuation
- 1982-01-25 IT IT19267/82A patent/IT1190669B/it active
- 1982-01-25 ES ES509028A patent/ES8304990A1/es not_active Expired
- 1982-01-25 LU LU83893A patent/LU83893A1/fr unknown
- 1982-01-26 CA CA000394968A patent/CA1169863A/en not_active Expired
- 1982-01-26 GB GB8202188A patent/GB2092143B/en not_active Expired
- 1982-01-28 AU AU79933/82A patent/AU7993382A/en not_active Abandoned
- 1982-01-28 BE BE0/207161A patent/BE891928A/fr not_active IP Right Cessation
- 1982-01-29 DE DE19823202893 patent/DE3202893A1/de not_active Withdrawn
- 1982-01-29 NL NL8200343A patent/NL8200343A/nl not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ES509028A0 (es) | 1983-04-01 |
CA1169863A (en) | 1984-06-26 |
SE8200320L (sv) | 1982-07-30 |
DE3202893A1 (de) | 1982-09-23 |
IT8219267A0 (it) | 1982-01-25 |
US4395416A (en) | 1983-07-26 |
BE891928A (fr) | 1982-07-28 |
AU7993382A (en) | 1982-08-05 |
GB2092143B (en) | 1985-03-13 |
GB2092143A (en) | 1982-08-11 |
GR75187B (es) | 1984-07-13 |
NL8200343A (nl) | 1982-08-16 |
LU83893A1 (fr) | 1983-09-02 |
IT1190669B (it) | 1988-02-24 |
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